Published in J Neurochem on October 24, 2013
Pax6 Inactivation in the Adult Pancreas Reveals Ghrelin as Endocrine Cell Maturation Marker. PLoS One (2015) 0.85
Chaperones in Neurodegeneration. J Neurosci (2015) 0.83
Current pharmacotherapy and putative disease-modifying therapy for Alzheimer's disease. Neurol Sci (2016) 0.77
The neural chaperone proSAAS blocks α-synuclein fibrillation and neurotoxicity. Proc Natl Acad Sci U S A (2016) 0.76
Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins. Proc Natl Acad Sci U S A (1998) 16.04
Physical basis of cognitive alterations in Alzheimer's disease: synapse loss is the major correlate of cognitive impairment. Ann Neurol (1991) 14.25
Synapse loss and microglial activation precede tangles in a P301S tauopathy mouse model. Neuron (2007) 6.07
Mutant presenilins specifically elevate the levels of the 42 residue beta-amyloid peptide in vivo: evidence for augmentation of a 42-specific gamma secretase. Hum Mol Genet (2003) 5.92
Amyloid beta-protein fibrillogenesis. Detection of a protofibrillar intermediate. J Biol Chem (1997) 5.07
The toxic Aβ oligomer and Alzheimer's disease: an emperor in need of clothes. Nat Neurosci (2012) 4.92
Exogenous α-synuclein fibrils induce Lewy body pathology leading to synaptic dysfunction and neuron death. Neuron (2011) 4.74
Cell-produced alpha-synuclein is secreted in a calcium-dependent manner by exosomes and impacts neuronal survival. J Neurosci (2010) 3.81
Atomic force microscopic imaging of seeded fibril formation and fibril branching by the Alzheimer's disease amyloid-beta protein. Chem Biol (1997) 3.05
The Swedish mutation causes early-onset Alzheimer's disease by beta-secretase cleavage within the secretory pathway. Nat Med (1995) 2.44
Cerebrospinal fluid proteomic biomarkers for Alzheimer's disease. Ann Neurol (2007) 2.30
Amyloid seeds formed by cellular uptake, concentration, and aggregation of the amyloid-beta peptide. Proc Natl Acad Sci U S A (2009) 2.14
Detection of biomarkers with a multiplex quantitative proteomic platform in cerebrospinal fluid of patients with neurodegenerative disorders. J Alzheimers Dis (2006) 2.00
The extracellular chaperone clusterin influences amyloid formation and toxicity by interacting with prefibrillar structures. FASEB J (2007) 1.79
RAGE-mediated signaling contributes to intraneuronal transport of amyloid-beta and neuronal dysfunction. Proc Natl Acad Sci U S A (2009) 1.74
7B2 is a neuroendocrine chaperone that transiently interacts with prohormone convertase PC2 in the secretory pathway. Cell (1994) 1.67
Identification and characterization of proSAAS, a granin-like neuroendocrine peptide precursor that inhibits prohormone processing. J Neurosci (2000) 1.43
Interaction of the molecular chaperone alphaB-crystallin with alpha-synuclein: effects on amyloid fibril formation and chaperone activity. J Mol Biol (2004) 1.32
Mass spectrometry-based discovery of circadian peptides. Proc Natl Acad Sci U S A (2008) 1.27
Preparing synthetic Aβ in different aggregation states. Methods Mol Biol (2011) 1.26
Binding of the molecular chaperone αB-crystallin to Aβ amyloid fibrils inhibits fibril elongation. Biophys J (2011) 1.16
Molecular mechanisms used by chaperones to reduce the toxicity of aberrant protein oligomers. Proc Natl Acad Sci U S A (2012) 1.13
The C-terminal region of proSAAS is a potent inhibitor of prohormone convertase 1. J Biol Chem (2000) 1.09
The SAAS granin exhibits structural and functional homology to 7B2 and contains a highly potent hexapeptide inhibitor of PC1. FEBS Lett (2000) 1.09
Peptide fingerprinting of Alzheimer's disease in cerebrospinal fluid: identification and prospective evaluation of new synaptic biomarkers. PLoS One (2011) 1.07
Circadian integration of glutamatergic signals by little SAAS in novel suprachiasmatic circuits. PLoS One (2010) 1.02
7B2 prevents unfolding and aggregation of prohormone convertase 2. Endocrinology (2008) 1.01
Aβ internalization by neurons and glia. Int J Alzheimers Dis (2011) 0.99
Functional characterization of ProSAAS: similarities and differences with 7B2. J Biol Chem (2001) 0.99
Tissue distribution and processing of proSAAS by proprotein convertases. J Neurochem (2001) 0.99
The propeptide precursor proSAAS is involved in fetal neuropeptide processing and body weight regulation. J Neurochem (2010) 0.96
Processing of proSAAS in neuroendocrine cell lines. Biochem J (2002) 0.93
Studies of the pathophysiological mechanisms in frontotemporal dementia by proteome analysis of CSF proteins. Brain Res Mol Brain Res (2002) 0.93
Distribution of proSAAS-derived peptides in rat neuroendocrine tissues. Neuroscience (2001) 0.92
The neuroendocrine protein 7B2 suppresses the aggregation of neurodegenerative disease-related proteins. J Biol Chem (2012) 0.91
The neuroendocrine protein 7B2 acts as a molecular chaperone in the in vitro folding of human insulin-like growth factor-1 secreted from yeast. Biochem Biophys Res Commun (1995) 0.90
ProSAAS-derived peptides are colocalized with neuropeptide Y and function as neuropeptides in the regulation of food intake. PLoS One (2011) 0.89
Coexpression of proprotein convertase SPC3 and the neuroendocrine precursor proSAAS. Endocrinology (2001) 0.87
Dealing with misfolded proteins: examining the neuroprotective role of molecular chaperones in neurodegeneration. Molecules (2010) 0.86
Embryonic gene expression and pro-protein processing of proSAAS during rodent development. J Neurochem (2005) 0.86
Proteomic analysis of the cerebrospinal fluid of patients with lumbar disk herniation. Proteomics (2006) 0.86
Investigation of the mechanism of beta-amyloid fibril formation by kinetic and thermodynamic analyses. Langmuir (2008) 0.86
Proinsulin processing in the diabetic Goto-Kakizaki rat. J Endocrinol (2002) 0.85
An N-terminal fragment of ProSAAS (a granin-like neuroendocrine peptide precursor) is associated with tau inclusions in Pick's disease. Biochem Biophys Res Commun (2003) 0.82
A human granin-like neuroendocrine peptide precursor (proSAAS) immunoreactivity in tau inclusions of Alzheimer's disease and parkinsonism-dementia complex on Guam. Neurosci Lett (2004) 0.80
Diverse compounds mimic Alzheimer disease-causing mutations by augmenting Abeta42 production. Nat Med (2005) 4.00
Common variation in the miR-659 binding-site of GRN is a major risk factor for TDP43-positive frontotemporal dementia. Hum Mol Genet (2008) 2.48
The crystal structure of the proprotein processing proteinase furin explains its stringent specificity. Nat Struct Biol (2003) 2.42
Evidence that nonsteroidal anti-inflammatory drugs decrease amyloid beta 42 production by direct modulation of gamma-secretase activity. J Biol Chem (2003) 2.31
Disruption of PC1/3 expression in mice causes dwarfism and multiple neuroendocrine peptide processing defects. Proc Natl Acad Sci U S A (2002) 2.19
β2-Adrenoceptor agonists are required for development of the asthma phenotype in a murine model. Am J Respir Cell Mol Biol (2012) 1.73
Proprotein convertase models based on the crystal structures of furin and kexin: explanation of their specificity. J Mol Biol (2005) 1.57
Cleavage targets and the D-arginine-based inhibitors of the West Nile virus NS3 processing proteinase. Biochem J (2006) 1.49
Chronic administration of R-flurbiprofen attenuates learning impairments in transgenic amyloid precursor protein mice. BMC Neurosci (2007) 1.48
Defective transport of the obesity mutant PC1/3 N222D contributes to loss of function. Endocrinology (2014) 1.40
Inhibition of furin by polyarginine-containing peptides: nanomolar inhibition by nona-D-arginine. J Biol Chem (2004) 1.26
Protection against anthrax toxemia by hexa-D-arginine in vitro and in vivo. Infect Immun (2004) 1.10
The furin inhibitor hexa-D-arginine blocks the activation of Pseudomonas aeruginosa exotoxin A in vivo. Infect Immun (2002) 1.09
Processing of proaugurin is required to suppress proliferation of tumor cell lines. Mol Endocrinol (2011) 1.06
Potent inhibitors of furin and furin-like proprotein convertases containing decarboxylated P1 arginine mimetics. J Med Chem (2010) 1.05
Abeta42-lowering nonsteroidal anti-inflammatory drugs preserve intramembrane cleavage of the amyloid precursor protein (APP) and ErbB-4 receptor and signaling through the APP intracellular domain. J Biol Chem (2003) 1.04
The cystatin-related epididymal spermatogenic protein inhibits the serine protease prohormone convertase 2. Endocrinology (2003) 1.02
Caudo-rostral brain spreading of α-synuclein through vagal connections. EMBO Mol Med (2013) 1.02
7B2 prevents unfolding and aggregation of prohormone convertase 2. Endocrinology (2008) 1.01
Biosynthesis of proopiomelanocortin-derived peptides in prohormone convertase 2 and 7B2 null mice. Endocrinology (2003) 1.00
Functional characterization of ProSAAS: similarities and differences with 7B2. J Biol Chem (2001) 0.99
Congenital proprotein convertase 1/3 deficiency causes malabsorptive diarrhea and other endocrinopathies in a pediatric cohort. Gastroenterology (2013) 0.99
Hexa-D-arginine treatment increases 7B2•PC2 activity in hyp-mouse osteoblasts and rescues the HYP phenotype. J Bone Miner Res (2013) 0.99
Cross-inhibition between furin and lethal factor inhibitors. Biochem Biophys Res Commun (2004) 0.98
Highly potent inhibitors of proprotein convertase furin as potential drugs for treatment of infectious diseases. J Biol Chem (2012) 0.98
Functional characterisation of UCP1 in the common carp: uncoupling activity in liver mitochondria and cold-induced expression in the brain. J Comp Physiol B (2007) 0.95
A study of human furin specificity using synthetic peptides derived from natural substrates, and effects of potassium ions. Arch Biochem Biophys (2009) 0.93
Deorphanization of novel peptides and their receptors. AAPS J (2010) 0.92
The neuroendocrine protein 7B2 suppresses the aggregation of neurodegenerative disease-related proteins. J Biol Chem (2012) 0.91
Short polybasic peptide sequences are potent inhibitors of PC5/6 and PC7: Use of positional scanning-synthetic peptide combinatorial libraries as a tool for the optimization of inhibitory sequences. Mol Pharmacol (2006) 0.90
Functional consequences of a novel variant of PCSK1. PLoS One (2013) 0.90
Strain-dependent influences on the hypothalamo-pituitary-adrenal axis profoundly affect the 7B2 and PC2 null phenotypes. Endocrinology (2005) 0.90
Generation and characterization of non-competitive furin-inhibiting nanobodies. Biochem J (2012) 0.89
Production of bioactive peptides in an in vitro system. Anal Biochem (2007) 0.88
Prohormone convertase 1 (PC1) processing and sorting: effect of PC1 propeptide and proSAAS. J Endocrinol (2004) 0.87
Modulation of PC1/3 activity by self-interaction and substrate binding. Endocrinology (2011) 0.87
The lethal form of Cushing's in 7B2 null mice is caused by multiple metabolic and hormonal abnormalities. Endocrinology (2002) 0.86
Overexpression of Scg5 increases enzymatic activity of PCSK2 and is inversely correlated with body weight in congenic mice. BMC Genet (2008) 0.86
Intravenous delivery of targeted liposomes to amyloid-β pathology in APP/PSEN1 transgenic mice. PLoS One (2012) 0.86
Synthetic small-molecule prohormone convertase 2 inhibitors. Mol Pharmacol (2008) 0.86
Treadmill exercise prevents learning and memory impairment in Alzheimer's disease-like pathology. Curr Alzheimer Res (2013) 0.85
Cleavage of recombinant proenkephalin and blockade mutants by prohormone convertases 1 and 2: an in vitro specificity study. J Neurochem (2003) 0.85
Inhibition of prohormone convertases PC1/3 and PC2 by 2,5-dideoxystreptamine derivatives. Mol Pharmacol (2011) 0.85
Increased synthesis but decreased processing of neuronal proCCK in prohormone convertase 2 and 7B2 knockout animals. J Neurochem (2002) 0.84
Intrapituitary adenoviral administration of 7B2 can extend life span and reverse endocrinological deficiencies in 7B2 null mice. Endocrinology (2002) 0.84
Neuron-to-neuron α-synuclein propagation in vivo is independent of neuronal injury. Acta Neuropathol Commun (2015) 0.84
Peptides derived from the prohormone proNPQ/spexin are potent central modulators of cardiovascular and renal function and nociception. FASEB J (2011) 0.83
Biochemical and cell biological properties of the human prohormone convertase 1/3 Ser357Gly mutation: a PC1/3 hypermorph. Endocrinology (2014) 0.83
Inhibitory neuron and hippocampal circuit dysfunction in an aged mouse model of Alzheimer's disease. PLoS One (2013) 0.83
Photoperiodic regulation of insulin receptor mRNA and intracellular insulin signaling in the arcuate nucleus of the Siberian hamster, Phodopus sungorus. Am J Physiol Regul Integr Comp Physiol (2006) 0.83
Neuroendocrine protein 7B2 can be inactivated by phosphorylation within the secretory pathway. J Biol Chem (2005) 0.83
Exome sequencing finds a novel PCSK1 mutation in a child with generalized malabsorptive diarrhea and diabetes insipidus. J Pediatr Gastroenterol Nutr (2013) 0.82
Dynamic modulation of prohormone convertase 2 (PC2)-mediated precursor processing by 7B2 protein: preferential effect on glucagon synthesis. J Biol Chem (2011) 0.81
The neuroendocrine protein 7B2 is intrinsically disordered. Biochemistry (2012) 0.81
Blockade of islet amyloid polypeptide fibrillation and cytotoxicity by the secretory chaperones 7B2 and proSAAS. FEBS Lett (2013) 0.81
Prohormone convertase 2 enzymatic activity and its regulation in neuro-endocrine cells and tissues. Regul Pept (2003) 0.81
Purification of the proprotein convertase furin by affinity chromatography based on PC-specific inhibitors. Biol Chem (2011) 0.79
Seasonal regulation of cocaine- and amphetamine-regulated transcript in the arcuate nucleus of Djungarian hamster (Phodopus sungorus). Gen Comp Endocrinol (2008) 0.79
Chronic treatment with DCPCX, an adenosine A(1) antagonist, worsens long-term memory. Neurosci Lett (2013) 0.79
Strain-specific steroidal control of pituitary function. J Endocrinol (2007) 0.78
Processing and trafficking of a prohormone convertase 2 active site mutant. Biochem Biophys Res Commun (2007) 0.78
Enzymatic characterization of a human acyltransferase activity. PLoS One (2009) 0.78
Phosphorylation and Alternative Splicing of 7B2 Reduce Prohormone Convertase 2 Activation. Mol Endocrinol (2015) 0.78
New furin inhibitors based on weakly basic amidinohydrazones. Bioorg Med Chem Lett (2010) 0.78
Seasonal leptin resistance is associated with impaired signalling via JAK2-STAT3 but not ERK, possibly mediated by reduced hypothalamic GRB2 protein. J Comp Physiol B (2011) 0.77
Progastrin processing differs in 7B2 and PC2 knockout animals: a role for 7B2 independent of action on PC2. FEBS Lett (2002) 0.77
Recent insights into the involvement of progranulin in frontotemporal dementia. Curr Neuropharmacol (2011) 0.76
Modulation of prohormone convertase 1/3 properties using site-directed mutagenesis. Endocrinology (2010) 0.76
Effects of magnesium ions on recombinant human furin: selective activation of hydrolytic activity upon substrates derived from virus envelope glycoprotein. Biol Chem (2010) 0.76
Mutations of the PC2 substrate binding pocket alter enzyme specificity. J Biol Chem (2005) 0.76
Cysteine based novel noncompetitive inhibitors of urease(s)--distinctive inhibition susceptibility of microbial and plant ureases. Bioorg Med Chem (2006) 0.76
Identification of a small molecule that selectively inhibits mouse PC2 over mouse PC1/3: a computational and experimental study. PLoS One (2013) 0.75
Mini-RIA: adaptation of conventional 125I-labeled radioimmunoassay to a 96-tube format. Anal Biochem (2002) 0.75
Regulation of neuropeptide processing enzymes by catecholamines in endocrine cells. Mol Pharmacol (2011) 0.75
Elevated prostacyclin biosynthesis in mice impacts memory and anxiety-like behavior. Behav Brain Res (2013) 0.75
Effects of ethanol and ipsapirone on the development of midline raphe glial cells and astrocytes. Alcohol (2003) 0.75
A Novel Liposomal Nanoparticle for the Imaging of Amyloid Plaque by Magnetic Resonance Imaging. J Alzheimers Dis (2016) 0.75
Optimization of substrate-analog furin inhibitors. ChemMedChem (2017) 0.75
Proteolytic processing of chromogranins is modified in brains of transgenic mice. Ann N Y Acad Sci (2002) 0.75
Balancing risk and recovery. Science (2005) 0.75