PubRank

Zuoshang Xu

Author PubWeight™ 67.61‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Asymmetry in the assembly of the RNAi enzyme complex. Cell 2003 22.18
2 Designing siRNA that distinguish between genes that differ by a single nucleotide. PLoS Genet 2006 3.23
3 Mitochondrial dysfunction and its role in motor neuron degeneration in ALS. Mitochondrion 2005 2.24
4 Spinal cord endoplasmic reticulum stress associated with a microsomal accumulation of mutant superoxide dismutase-1 in an ALS model. Proc Natl Acad Sci U S A 2006 2.10
5 Several rAAV vectors efficiently cross the blood-brain barrier and transduce neurons and astrocytes in the neonatal mouse central nervous system. Mol Ther 2011 1.96
6 Selective silencing by RNAi of a dominant allele that causes amyotrophic lateral sclerosis. Aging Cell 2003 1.88
7 An RNA polymerase II construct synthesizes short-hairpin RNA with a quantitative indicator and mediates highly efficient RNAi. Nucleic Acids Res 2005 1.83
8 Reactive astrocytes secrete lcn2 to promote neuron death. Proc Natl Acad Sci U S A 2013 1.59
9 Mutant Cu, Zn superoxide dismutase that causes motoneuron degeneration is present in mitochondria in the CNS. J Neurosci 2002 1.55
10 Pol II-expressed shRNA knocks down Sod2 gene expression and causes phenotypes of the gene knockout in mice. PLoS Genet 2006 1.49
11 ALS-associated mutant SOD1G93A causes mitochondrial vacuolation by expansion of the intermembrane space and by involvement of SOD1 aggregation and peroxisomes. BMC Neurosci 2003 1.46
12 The C-terminal TDP-43 fragments have a high aggregation propensity and harm neurons by a dominant-negative mechanism. PLoS One 2010 1.32
13 Allele-specific RNAi selectively silences mutant SOD1 and achieves significant therapeutic benefit in vivo. Neurobiol Dis 2006 1.30
14 Aberrantly increased hydrophobicity shared by mutants of Cu,Zn-superoxide dismutase in familial amyotrophic lateral sclerosis. J Biol Chem 2005 1.30
15 Mitochondrial electron transport chain complex dysfunction in a transgenic mouse model for amyotrophic lateral sclerosis. J Neurochem 2002 1.27
16 An enhanced U6 promoter for synthesis of short hairpin RNA. Nucleic Acids Res 2003 1.24
17 Multiple shRNAs expressed by an inducible pol II promoter can knock down the expression of multiple target genes. Biotechniques 2006 1.21
18 Silencing of the Pink1 gene expression by conditional RNAi does not induce dopaminergic neuron death in mice. Int J Biol Sci 2007 1.20
19 S-nitrosothiol depletion in amyotrophic lateral sclerosis. Proc Natl Acad Sci U S A 2006 1.11
20 A construct with fluorescent indicators for conditional expression of miRNA. BMC Biotechnol 2008 1.08
21 Partial loss of TDP-43 function causes phenotypes of amyotrophic lateral sclerosis. Proc Natl Acad Sci U S A 2014 1.08
22 A quantitative histochemical assay for activities of mitochondrial electron transport chain complexes in mouse spinal cord sections. J Neurosci Methods 2002 1.06
23 Widespread spinal cord transduction by intrathecal injection of rAAV delivers efficacious RNAi therapy for amyotrophic lateral sclerosis. Hum Mol Genet 2013 1.02
24 Therapeutic gene silencing delivered by a chemically modified small interfering RNA against mutant SOD1 slows amyotrophic lateral sclerosis progression. J Biol Chem 2008 0.96
25 Promises and challenges in developing RNAi as a research tool and therapy for neurodegenerative diseases. Neurodegener Dis 2005 0.93
26 An RNAi strategy for treatment of amyotrophic lateral sclerosis caused by mutant Cu,Zn superoxide dismutase. J Neurochem 2005 0.92
27 Inhibition of chaperone activity is a shared property of several Cu,Zn-superoxide dismutase mutants that cause amyotrophic lateral sclerosis. J Biol Chem 2005 0.92
28 SMN protects cells against mutant SOD1 toxicity by increasing chaperone activity. Biochem Biophys Res Commun 2007 0.90
29 A non-specific effect associated with conditional transgene expression based on Cre-loxP strategy in mice. PLoS One 2011 0.86
30 Widespread aggregation of mutant VAPB associated with ALS does not cause motor neuron degeneration or modulate mutant SOD1 aggregation and toxicity in mice. Mol Neurodegener 2013 0.85
31 Deficits in the mitochondrial enzyme α-ketoglutarate dehydrogenase lead to Alzheimer's disease-like calcium dysregulation. Neurobiol Aging 2011 0.85
32 Normal dendritic arborization in spinal motoneurons requires neurofilament subunit L. J Comp Neurol 2002 0.84
33 Transgenic RNAi: Accelerating and expanding reverse genetics in mammals. Transgenic Res 2006 0.81
34 Oxidative stress and autophagic alteration in brainstem of SOD1-G93A mouse model of ALS. Mol Neurobiol 2014 0.81
35 Nerve injection of viral vectors efficiently transfers transgenes into motor neurons and delivers RNAi therapy against ALS. Antioxid Redox Signal 2009 0.79
36 Specific gene silencing using RNAi in cell culture. Methods Mol Biol 2011 0.79
37 Identification of human monoclonal antibodies specific for human SOD1 recognizing distinct epitopes and forms of SOD1. PLoS One 2013 0.78