A novel experimental method to evaluate motor task control in Parkinson's patients.

Corticomuscular transmission of tremor signals by propriospinal neurons in Parkinson's disease. PLoS One (2013) 0.81

Contribution of inter-muscular synchronization in the modulation of tremor intensity in Parkinson's disease. J Neuroeng Rehabil (2015) 0.76

The sequence of the human genome. Science (2001) 101.55

Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Science (1998) 37.15

Global analysis of protein activities using proteome chips. Science (2001) 13.74

Consistent viral evolutionary changes associated with the progression of human immunodeficiency virus type 1 infection. J Virol (1999) 10.41

The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues. Mol Cell (2000) 8.95

LDL-receptor-related proteins in Wnt signal transduction. Nature (2000) 6.94

Head inducer Dickkopf-1 is a ligand for Wnt coreceptor LRP6. Curr Biol (2001) 5.95

Phosphorylation of serine 256 by protein kinase B disrupts transactivation by FKHR and mediates effects of insulin on insulin-like growth factor-binding protein-1 promoter activity through a conserved insulin response sequence. J Biol Chem (1999) 4.31

Wnt/Frizzled activation of Rho regulates vertebrate gastrulation and requires a novel Formin homology protein Daam1. Cell (2001) 4.22

Chlorination of taurine by human neutrophils. Evidence for hypochlorous acid generation. J Clin Invest (1982) 3.33

Epidemiology of oral candidiasis in HIV-infected patients: colonization, infection, treatment, and emergence of fluconazole resistance. Am J Med (1994) 3.32

I-POU: a POU-domain protein that inhibits neuron-specific gene activation. Nature (1991) 3.15

Autoxidation of substituted phenols catalyzed by cobalt Schiff base complexes in supercritical carbon dioxide. Inorg Chem (2001) 2.95

Multiple microRNAs modulate p21Cip1/Waf1 expression by directly targeting its 3' untranslated region. Oncogene (2010) 2.73

beta-Trcp couples beta-catenin phosphorylation-degradation and regulates Xenopus axis formation. Proc Natl Acad Sci U S A (1999) 2.66

A novel fluorescence-activated cell sorter-based screen for yeast endocytosis mutants identifies a yeast homologue of mammalian eps15. J Cell Biol (1996) 2.62

Destabilization of beta-catenin by mutations in presenilin-1 potentiates neuronal apoptosis. Nature (1998) 2.56

Use of a colorimetric system for yeast susceptibility testing. J Clin Microbiol (1995) 2.54

Isolation and characterization of new fission yeast cytokinesis mutants. Genetics (1998) 2.51

Extending the range of rate constants available from BIACORE: interpreting mass transport-influenced binding data. Biophys J (1998) 2.49

Genetic and physical mapping of the Lps locus: identification of the toll-4 receptor as a candidate gene in the critical region. Blood Cells Mol Dis (1998) 2.46

Degradation of the retinoblastoma tumor suppressor by the human papillomavirus type 16 E7 oncoprotein is important for functional inactivation and is separable from proteasomal degradation of E7. J Virol (2001) 2.43

Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action. Proc Natl Acad Sci U S A (1997) 2.36

Telomerase reverse transcriptase gene is a direct target of c-Myc but is not functionally equivalent in cellular transformation. Oncogene (1999) 2.34

Resistin is not associated with insulin sensitivity or the metabolic syndrome in humans. Diabetologia (2005) 2.23

Inhibition of osteoblast differentiation by tumor necrosis factor-alpha. Endocrinology (2000) 2.13

Specific p53 gene mutations in urinary bladder epithelium after the Chernobyl accident. Cancer Res (1999) 2.07

The human acid ceramidase gene (ASAH): structure, chromosomal location, mutation analysis, and expression. Genomics (1999) 2.04

Resilience and resistance of a lake phosphorus cycle before and after food web manipulation. Am Nat (1992) 2.01

Fatal embryonic bleeding events in mice lacking tissue factor, the cell-associated initiator of blood coagulation. Proc Natl Acad Sci U S A (1996) 1.93

Protective alterations in phase 1 and 2 metabolism of aflatoxin B1 by oltipraz in residents of Qidong, People's Republic of China. J Natl Cancer Inst (1999) 1.92

Cultured melanocytes from dilute mutant mice exhibit dendritic morphology and altered melanosome distribution. Proc Natl Acad Sci U S A (1996) 1.88

Steroid receptor-mediated inhibition of rat prolactin gene expression does not require the receptor DNA-binding domain. Cell (1988) 1.87

Enhancement of chemotherapy by manipulation of tumour pH. Br J Cancer (1999) 1.79

Increased fluid secretion after adenoviral-mediated transfer of the aquaporin-1 cDNA to irradiated rat salivary glands. Proc Natl Acad Sci U S A (1997) 1.76

Overexpression of focal adhesion kinase, a protein tyrosine kinase, in ovarian carcinoma. Cancer (1999) 1.74

Attempts to eradicate methicillin-resistant Staphylococcus aureus from a long-term-care facility with the use of mupirocin ointment. Am J Med (1993) 1.74

Unbalanced placental expression of imprinted genes in human intrauterine growth restriction. Placenta (2005) 1.73

Growth factors regulate the survival and fate of cells derived from human neurospheres. Nat Biotechnol (2001) 1.70

Etiology of childhood diarrhea in Beijing, China. J Clin Microbiol (1991) 1.70

Identification of downstream-initiated c-Myc proteins which are dominant-negative inhibitors of transactivation by full-length c-Myc proteins. Mol Cell Biol (1997) 1.69

Metabolic engineering of Arabidopsis and Brassica for poly(3-hydroxybutyrate-co-3-hydroxyvalerate) copolymer production. Nat Biotechnol (1999) 1.66

Cloning and characterization of human Lnk, an adaptor protein with pleckstrin homology and Src homology 2 domains that can inhibit T cell activation. J Immunol (2000) 1.64

Activation of c-myc gene expression by tumor-derived p53 mutants requires a discrete C-terminal domain. Mol Cell Biol (1998) 1.62

PI-3 kinase and IP3 are both necessary and sufficient to mediate NT3-induced synaptic potentiation. Nat Neurosci (2001) 1.62

Prenatal alcohol exposure: foetal programming, the hypothalamic-pituitary-adrenal axis and sex differences in outcome. J Neuroendocrinol (2008) 1.60

Indoor coal combustion emissions, GSTM1 and GSTT1 genotypes, and lung cancer risk: a case-control study in Xuan Wei, China. Cancer Epidemiol Biomarkers Prev (2000) 1.59

Twin of I-POU: a two amino acid difference in the I-POU homeodomain distinguishes an activator from an inhibitor of transcription. Cell (1992) 1.58

Description and clinical treatment of an early outbreak of severe acute respiratory syndrome (SARS) in Guangzhou, PR China. J Med Microbiol (2003) 1.58

The endothelial cell protein C receptor. Cell surface expression and direct ligand binding by the soluble receptor. J Biol Chem (1996) 1.56

Protein purification and function assignment of the epoxidase catalyzing the formation of fosfomycin. J Am Chem Soc (2001) 1.54

Identification of the same factor V gene mutation in 47 out of 50 thrombosis-prone families with inherited resistance to activated protein C. J Clin Invest (1994) 1.54

The role of microRNAs in liver cancer progression. Br J Cancer (2010) 1.52

SPINE: an integrated tracking database and data mining approach for identifying feasible targets in high-throughput structural proteomics. Nucleic Acids Res (2001) 1.52

Maximal exercise test as a predictor of risk for mortality from coronary heart disease in asymptomatic men. Am J Cardiol (2000) 1.51

Spacing and orientation of bipartite DNA-binding motifs as potential functional determinants for POU domain factors. Genes Dev (1993) 1.50

Do Mexican Americans really have low rates of cardiovascular disease? Prev Med (1999) 1.47

Portable stove use is associated with lower lung cancer mortality risk in lifetime smoky coal users. Br J Cancer (2008) 1.47

Epigenetic heterogeneity at imprinted loci in normal populations. Biochem Biophys Res Commun (2001) 1.47

Localized membrane depolarizations and localized calcium influx during electric field-guided neurite growth. Neuron (1992) 1.46

Regulation of dorsal fate in the neuraxis by Wnt-1 and Wnt-3a. Proc Natl Acad Sci U S A (1997) 1.44

Genetic evaluation of suspected cases of transient HIV-1 infection of infants. Science (1998) 1.43

The diverse roles of integrins and their ligands in angiogenesis. Cold Spring Harb Symp Quant Biol (2002) 1.40

Yeast Dam1p has a role at the kinetochore in assembly of the mitotic spindle. Proc Natl Acad Sci U S A (2001) 1.39

Dis3, implicated in mitotic control, binds directly to Ran and enhances the GEF activity of RCC1. EMBO J (1996) 1.38

Intracellular transport of class I MHC molecules in antigen processing mutant cell lines. J Immunol (1993) 1.38

Magnetic susceptibility induced white matter MR signal frequency shifts--experimental comparison between Lorentzian sphere and generalized Lorentzian approaches. Magn Reson Med (2014) 1.33

Radiographic examination of 41 cases of odontogenic myxomas on the basis of conventional radiographs. Dentomaxillofac Radiol (2007) 1.33

Prothrombin deficiency results in embryonic and neonatal lethality in mice. Proc Natl Acad Sci U S A (1998) 1.32

Molecular basis of beta thalassemia in south China. Strategy for DNA analysis. Hum Genet (1988) 1.32

Pharmacophore/receptor models for GABA(A)/BzR subtypes (alpha1beta3gamma2, alpha5beta3gamma2, and alpha6beta3gamma2) via a comprehensive ligand-mapping approach. J Med Chem (2000) 1.28

Studies of the biosynthesis of 3,6-dideoxyhexoses: molecular cloning and characterization of the asc (ascarylose) region from Yersinia pseudotuberculosis serogroup VA. J Bacteriol (1994) 1.27

The relationship between ethnicity and advance directives in a frail older population. J Am Geriatr Soc (1996) 1.25

Implication of dysregulation of the canonical wingless-type MMTV integration site (WNT) pathway in diabetic nephropathy. Diabetologia (2011) 1.24

Impact of hypertension on health-related quality of life in a population-based study in Shanghai, China. Public Health (2009) 1.23

MicroRNA-409 suppresses tumour cell invasion and metastasis by directly targeting radixin in gastric cancers. Oncogene (2011) 1.22

Brain 4: a novel mammalian POU domain transcription factor exhibiting restricted brain-specific expression. EMBO J (1992) 1.21

Hepatocellular carcinoma and aflatoxin exposure in Zhuqing Village, Fusui County, People's Republic of China. Cancer Epidemiol Biomarkers Prev (2001) 1.20

Differential regulation of PTEN expression by androgen receptor in prostate and breast cancers. Oncogene (2011) 1.20

The Sirt1 deacetylase modulates the insulin-like growth factor signaling pathway in mammals. Mech Ageing Dev (2005) 1.19

Differential effects of smoking on lung cancer mortality before and after household stove improvement in Xuanwei, China. Br J Cancer (2010) 1.18

Disruption of xCT inhibits cancer cell metastasis via the caveolin-1/beta-catenin pathway. Oncogene (2008) 1.18

Effector function of resting T cells: activation of synovial fibroblasts. J Immunol (2001) 1.18

Molecular epidemiological survey of haemoglobinopathies in the Guangxi Zhuang Autonomous Region of southern China. Clin Genet (2010) 1.17

Growth and dissemination of Lewis lung carcinoma in plasminogen-deficient mice. Blood (1997) 1.17

Crystal structure of the Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein synthase III. J Biol Chem (2001) 1.16

Probing the ground state structure of the green fluorescent protein chromophore using Raman spectroscopy. Biochemistry (2000) 1.16

Measurement of direct photon production in p+p collisions at sqrt[s] = 200 GeV. Phys Rev Lett (2007) 1.16

Cloning and characterization of the full-length cDNA and genomic sequences encoding murine acid ceramidase. Genomics (1998) 1.15

Genomic predictors of response to doxorubicin versus docetaxel in primary breast cancer. Breast Cancer Res Treat (2011) 1.15

Insulin suppresses transactivation by CAAT/enhancer-binding proteins beta (C/EBPbeta). Signaling to p300/CREB-binding protein by protein kinase B disrupts interaction with the major activation domain of C/EBPbeta. J Biol Chem (2000) 1.14

Using DGGE profiling to develop a novel culture medium suitable for oral microbial communities. Mol Oral Microbiol (2010) 1.14

miR-34c works downstream of p53 leading to dairy goat male germline stem-cell (mGSCs) apoptosis. Cell Prolif (2013) 1.13

A family of POU-domain and Pit-1 tissue-specific transcription factors in pituitary and neuroendocrine development. Annu Rev Physiol (1990) 1.13

Immunolocalization of the secretory isoform of Na-K-Cl cotransporter in rat renal intercalated cells. J Am Soc Nephrol (1996) 1.13

Neuralization of the Xenopus embryo by inhibition of p300/ CREB-binding protein function. J Neurosci (1999) 1.13

Sintering effects on the strength of hydroxyapatite. Biomaterials (1995) 1.12

Temporal patterns of aflatoxin-albumin adducts in hepatitis B surface antigen-positive and antigen-negative residents of Daxin, Qidong County, People's Republic of China. Cancer Epidemiol Biomarkers Prev (1996) 1.12

"Skin-CNS-bladder" reflex pathway for micturition after spinal cord injury and its underlying mechanisms. J Urol (1999) 1.11

Enzyme replacement therapy in feline mucopolysaccharidosis I. Mol Genet Metab (2001) 1.11