Published in Bioorg Med Chem Lett on September 30, 2013
Reversal of the Progression of Fatal Coronavirus Infection in Cats by a Broad-Spectrum Coronavirus Protease Inhibitor. PLoS Pathog (2016) 1.39
Treatment of norovirus infections: moving antivirals from the bench to the bedside. Antiviral Res (2014) 0.94
Structure-guided design and optimization of dipeptidyl inhibitors of norovirus 3CL protease. Structure-activity relationships and biochemical, X-ray crystallographic, cell-based, and in vivo studies. J Med Chem (2015) 0.86
Roles of the Picornaviral 3C Proteinase in the Viral Life Cycle and Host Cells. Viruses (2016) 0.78
Broad-spectrum inhibitors against 3C-like proteases of feline coronaviruses and feline caliciviruses. J Virol (2015) 0.78
Recent Advances in the Discovery of Norovirus Therapeutics. J Med Chem (2015) 0.78
Development of a Gaussia luciferase-based human norovirus protease reporter system: cell type-specific profile of Norwalk virus protease precursors and evaluation of inhibitors. J Virol (2014) 0.78
Structure-based design and synthesis of triazole-based macrocyclic inhibitors of norovirus protease: Structural, biochemical, spectroscopic, and antiviral studies. Eur J Med Chem (2016) 0.77
Current tools for norovirus drug discovery. Expert Opin Drug Discov (2016) 0.76
Anti-norovirus therapeutics: a patent review (2010-2015). Expert Opin Ther Pat (2016) 0.76
A novel coronavirus associated with severe acute respiratory syndrome. N Engl J Med (2003) 29.55
Identification of a novel coronavirus in patients with severe acute respiratory syndrome. N Engl J Med (2003) 27.97
Stable expression of a Norwalk virus RNA replicon in a human hepatoma cell line. Virology (2006) 2.23
Noroviruses: The leading cause of gastroenteritis worldwide. Discov Med (2010) 1.73
Recent advances in the molecular epidemiology and control of human enterovirus 71 infection. Curr Opin Virol (2012) 1.61
Broad-spectrum antivirals against 3C or 3C-like proteases of picornaviruses, noroviruses, and coronaviruses. J Virol (2012) 1.24
Tripeptide aldehyde inhibitors of human rhinovirus 3C protease: design, synthesis, biological evaluation, and cocrystal structure solution of P1 glutamine isosteric replacements. J Med Chem (1998) 1.24
A convenient catalyst for aqueous and protein Suzuki-Miyaura cross-coupling. J Am Chem Soc (2009) 1.23
Impact of lipophilic efficiency on compound quality. J Med Chem (2012) 1.20
Design, synthesis, and evaluation of 3C protease inhibitors as anti-enterovirus 71 agents. Bioorg Med Chem (2008) 1.10
Characterization and inhibition of norovirus proteases of genogroups I and II using a fluorescence resonance energy transfer assay. Virology (2011) 1.04
Inhibition of norovirus 3CL protease by bisulfite adducts of transition state inhibitors. Bioorg Med Chem Lett (2012) 0.98
Potent inhibition of norovirus 3CL protease by peptidyl α-ketoamides and α-ketoheterocycles. Bioorg Med Chem Lett (2012) 0.96
Design and synthesis of new tripeptide-type SARS-CoV 3CL protease inhibitors containing an electrophilic arylketone moiety. Bioorg Med Chem (2012) 0.80
Replication of Norovirus in cell culture reveals a tropism for dendritic cells and macrophages. PLoS Biol (2004) 6.35
Cleavage map and proteolytic processing of the murine norovirus nonstructural polyprotein in infected cells. J Virol (2006) 2.10
Bile acids are essential for porcine enteric calicivirus replication in association with down-regulation of signal transducer and activator of transcription 1. Proc Natl Acad Sci U S A (2004) 1.57
Feline calicivirus VP2 is essential for the production of infectious virions. J Virol (2005) 1.48
Calicivirus 3C-like proteinase inhibits cellular translation by cleavage of poly(A)-binding protein. J Virol (2004) 1.44
Molecular virology of feline calicivirus. Vet Clin North Am Small Anim Pract (2008) 1.28
Broad-spectrum antivirals against 3C or 3C-like proteases of picornaviruses, noroviruses, and coronaviruses. J Virol (2012) 1.24
Synthesis and anti-norovirus activity of pyranobenzopyrone compounds. Bioorg Med Chem Lett (2012) 1.22
The effects of simvastatin or interferon-α on infectivity of human norovirus using a gnotobiotic pig model for the study of antivirals. PLoS One (2012) 1.18
A novel tricyclic pyrone compound ameliorates cell death associated with intracellular amyloid-beta oligomeric complexes. J Neurochem (2006) 1.18
Synthesis and anti-breast cancer activities of substituted quinolines. Bioorg Med Chem Lett (2008) 1.17
Design, synthesis, and evaluation of inhibitors of Norwalk virus 3C protease. Bioorg Med Chem Lett (2011) 1.16
Cell-culture propagation of porcine enteric calicivirus mediated by intestinal contents is dependent on the cyclic AMP signaling pathway. Virology (2002) 1.15
Biodegradable nanogels for oral delivery of interferon for norovirus infection. Antiviral Res (2010) 1.14
Antiviral activity of a small molecule deubiquitinase inhibitor occurs via induction of the unfolded protein response. PLoS Pathog (2012) 1.13
Development of a new microwell hybridization assay and an internal control RNA for the detection of porcine noroviruses and sapoviruses by reverse transcription-PCR. J Virol Methods (2005) 1.08
Combining the rapid MTT formazan exocytosis assay and the MC65 protection assay led to the discovery of carbazole analogs as small molecule inhibitors of Abeta oligomer-induced cytotoxicity. Brain Res (2006) 1.07
Potent inhibition of Norwalk virus by cyclic sulfamide derivatives. Bioorg Med Chem (2011) 1.06
Norovirus proteinase-polymerase and polymerase are both active forms of RNA-dependent RNA polymerase. J Virol (2005) 1.05
Inhibition of Alzheimer's amyloid toxicity with a tricyclic pyrone molecule in vitro and in vivo. J Neurochem (2009) 1.05
Magnitude of serum and intestinal antibody responses induced by sequential replicating and nonreplicating rotavirus vaccines in gnotobiotic pigs and correlation with protection. Clin Diagn Lab Immunol (2004) 1.05
Characterization and inhibition of norovirus proteases of genogroups I and II using a fluorescence resonance energy transfer assay. Virology (2011) 1.04
Inhibition of influenza virus replication by plant-derived isoquercetin. Antiviral Res (2010) 1.04
Cyclosulfamide-based derivatives as inhibitors of noroviruses. Eur J Med Chem (2011) 1.03
Design and synthesis of inhibitors of noroviruses by scaffold hopping. Bioorg Med Chem (2011) 1.02
Modulation of CD163 receptor expression and replication of porcine reproductive and respiratory syndrome virus in porcine macrophages. Virus Res (2009) 1.00
Inhibition of norovirus 3CL protease by bisulfite adducts of transition state inhibitors. Bioorg Med Chem Lett (2012) 0.98
Inhibitory effects of bile acids and synthetic farnesoid X receptor agonists on rotavirus replication. J Virol (2011) 0.98
Molecular characterization of murine norovirus isolates from South Korea. Virus Res (2009) 0.97
Potent inhibition of norovirus 3CL protease by peptidyl α-ketoamides and α-ketoheterocycles. Bioorg Med Chem Lett (2012) 0.96
Potent inhibition of human leukocyte elastase by 1,2,5-thiadiazolidin-3-one 1,1 dioxide-based sulfonamide derivatives. Arch Biochem Biophys (2004) 0.96
Synthesis and antiviral activity of substituted quercetins. Bioorg Med Chem Lett (2011) 0.94
Expression and stability of foreign tags inserted into nsp2 of porcine reproductive and respiratory syndrome virus (PRRSV). Virus Res (2007) 0.93
Inhibition of noroviruses by piperazine derivatives. Bioorg Med Chem Lett (2011) 0.93
Pharmacokinetic properties and bioequivalence of candesartan cilexetil in Korean healthy volunteers. Drug Dev Ind Pharm (2012) 0.92
Nucleotidylylation of the VPg protein of a human norovirus by its proteinase-polymerase precursor protein. Virology (2008) 0.92
Selective and irreversible inhibitors of mosquito acetylcholinesterases for controlling malaria and other mosquito-borne diseases. PLoS One (2009) 0.91
Candidate anti-A beta fluorene compounds selected from analogs of amyloid imaging agents. Neurobiol Aging (2008) 0.90
Inhibition of Dengue virus and West Nile virus proteases by click chemistry-derived benz[d]isothiazol-3(2H)-one derivatives. Bioorg Med Chem (2011) 0.90
Structural and dynamics characterization of norovirus protease. Protein Sci (2013) 0.90
Antifungal activity of a series of 1,2-benzisothiazol-3(2H)-one derivatives. Bioorg Med Chem (2011) 0.89
Second-generation substituted quinolines as anticancer drugs for breast cancer. Anticancer Res (2010) 0.88
Development and validation of an LC-MS/MS method for determination of compound K in human plasma and clinical application. J Ginseng Res (2013) 0.88
Recent developments in the design of mechanism-based and alternate substrate inhibitors of serine proteases. Curr Top Med Chem (2004) 0.88
Potent norovirus inhibitors based on the acyclic sulfamide scaffold. Bioorg Med Chem (2012) 0.88
Novel tricyclic pyrone compounds prevent intracellular APP C99-induced cell death. J Mol Neurosci (2002) 0.88
X-ray snapshot of the mechanism of inactivation of human neutrophil elastase by 1,2,5-thiadiazolidin-3-one 1,1-dioxide derivatives. J Med Chem (2008) 0.87
Kinetic properties of alternatively spliced isoforms of laccase-2 from Tribolium castaneum and Anopheles gambiae. Insect Biochem Mol Biol (2011) 0.87
Backbone and side-chain ¹H, ¹⁵N, and ¹³C resonance assignments of Norwalk virus protease. Biomol NMR Assign (2011) 0.87
Structure-guided design and optimization of dipeptidyl inhibitors of norovirus 3CL protease. Structure-activity relationships and biochemical, X-ray crystallographic, cell-based, and in vivo studies. J Med Chem (2015) 0.86
Novel triacsin C analogs as potential antivirals against rotavirus infections. Eur J Med Chem (2012) 0.86
Structural and inhibitor studies of norovirus 3C-like proteases. Virus Res (2013) 0.85
Synthetic 1,4-anthracenedione analogs induce cytochrome c release, caspase-9, -3, and -8 activities, poly(ADP-ribose) polymerase-1 cleavage and internucleosomal DNA fragmentation in HL-60 cells by a mechanism which involves caspase-2 activation but not Fas signaling. Biochem Pharmacol (2004) 0.85
Structure and function of eritadenine and its 3-deaza analogues: potent inhibitors of S-adenosylhomocysteine hydrolase and hypocholesterolemic agents. Biochem Pharmacol (2006) 0.85