| Rank |
Title |
Journal |
Year |
PubWeight™‹?› |
|
1
|
Synthesis and anti-norovirus activity of pyranobenzopyrone compounds.
|
Bioorg Med Chem Lett
|
2012
|
1.22
|
|
2
|
A novel tricyclic pyrone compound ameliorates cell death associated with intracellular amyloid-beta oligomeric complexes.
|
J Neurochem
|
2006
|
1.18
|
|
3
|
Synthesis and anti-breast cancer activities of substituted quinolines.
|
Bioorg Med Chem Lett
|
2008
|
1.17
|
|
4
|
Biodegradable nanogels for oral delivery of interferon for norovirus infection.
|
Antiviral Res
|
2010
|
1.14
|
|
5
|
Combining the rapid MTT formazan exocytosis assay and the MC65 protection assay led to the discovery of carbazole analogs as small molecule inhibitors of Abeta oligomer-induced cytotoxicity.
|
Brain Res
|
2006
|
1.07
|
|
6
|
Inhibition of Alzheimer's amyloid toxicity with a tricyclic pyrone molecule in vitro and in vivo.
|
J Neurochem
|
2009
|
1.05
|
|
7
|
Inhibition of norovirus 3CL protease by bisulfite adducts of transition state inhibitors.
|
Bioorg Med Chem Lett
|
2012
|
0.98
|
|
8
|
Synthesis and antiviral activity of substituted quercetins.
|
Bioorg Med Chem Lett
|
2011
|
0.94
|
|
9
|
Selective and irreversible inhibitors of mosquito acetylcholinesterases for controlling malaria and other mosquito-borne diseases.
|
PLoS One
|
2009
|
0.91
|
|
10
|
Inhibition of Acyl-CoA: cholesterol acyltransferase (ACAT), overexpression of cholesterol transporter gene, and protection of amyloid β (Aβ) oligomers-induced neuronal cell death by tricyclic pyrone molecules.
|
J Med Chem
|
2012
|
0.91
|
|
11
|
Candidate anti-A beta fluorene compounds selected from analogs of amyloid imaging agents.
|
Neurobiol Aging
|
2008
|
0.90
|
|
12
|
Second-generation substituted quinolines as anticancer drugs for breast cancer.
|
Anticancer Res
|
2010
|
0.88
|
|
13
|
Novel tricyclic pyrone compounds prevent intracellular APP C99-induced cell death.
|
J Mol Neurosci
|
2002
|
0.88
|
|
14
|
Kinetic properties of alternatively spliced isoforms of laccase-2 from Tribolium castaneum and Anopheles gambiae.
|
Insect Biochem Mol Biol
|
2011
|
0.87
|
|
15
|
Novel triacsin C analogs as potential antivirals against rotavirus infections.
|
Eur J Med Chem
|
2012
|
0.86
|
|
16
|
Design, synthesis, and bioevaluation of viral 3C and 3C-like protease inhibitors.
|
Bioorg Med Chem Lett
|
2013
|
0.86
|
|
17
|
The effect of the PQ1 anti-breast cancer agent on normal tissues.
|
Anticancer Drugs
|
2012
|
0.85
|
|
18
|
Synthetic 1,4-anthracenedione analogs induce cytochrome c release, caspase-9, -3, and -8 activities, poly(ADP-ribose) polymerase-1 cleavage and internucleosomal DNA fragmentation in HL-60 cells by a mechanism which involves caspase-2 activation but not Fas signaling.
|
Biochem Pharmacol
|
2004
|
0.85
|
|
19
|
Structure and function of eritadenine and its 3-deaza analogues: potent inhibitors of S-adenosylhomocysteine hydrolase and hypocholesterolemic agents.
|
Biochem Pharmacol
|
2006
|
0.85
|
|
20
|
Electrochemical Protease Biosensor Based on Enhanced AC Voltammetry Using Carbon Nanofiber Nanoelectrode Arrays.
|
J Phys Chem C Nanomater Interfaces
|
2013
|
0.84
|
|
21
|
Macrocyclic inhibitors of 3C and 3C-like proteases of picornavirus, norovirus, and coronavirus.
|
Bioorg Med Chem Lett
|
2013
|
0.84
|
|
22
|
Protection of retinal cells from ischemia by a novel gap junction inhibitor.
|
Biochem Biophys Res Commun
|
2008
|
0.83
|
|
23
|
Combinational treatment of gap junctional activator and tamoxifen in breast cancer cells.
|
Anticancer Drugs
|
2010
|
0.83
|
|
24
|
Syntheses of tricyclic pyrones and pyridinones and protection of Abeta-peptide induced MC65 neuronal cell death.
|
Bioorg Med Chem Lett
|
2008
|
0.82
|
|
25
|
Antitumor triptycene bisquinones: a novel synthetic class of dual inhibitors of DNA topoisomerase I and II activities.
|
Anticancer Drugs
|
2003
|
0.82
|
|
26
|
Antitumor triptycene bisquinones induce a caspase-independent release of mitochondrial cytochrome c and a caspase-2-mediated activation of initiator caspase-8 and -9 in HL-60 cells by a mechanism which does not involve Fas signaling.
|
Anticancer Drugs
|
2004
|
0.81
|
|
27
|
Rapid collapse of mitochondrial transmembrane potential in HL-60 cells and isolated mitochondria treated with anti-tumor 1,4-anthracenediones.
|
Anticancer Drugs
|
2005
|
0.81
|
|
28
|
Label-free electrochemical impedance detection of kinase and phosphatase activities using carbon nanofiber nanoelectrode arrays.
|
Anal Chim Acta
|
2012
|
0.80
|
|
29
|
Bioactivity and molecular targets of novel substituted quinolines in murine and human tumor cell lines in vitro.
|
Int J Oncol
|
2010
|
0.80
|
|
30
|
Anti-breast cancer agents, quinolines, targeting gap junction.
|
Med Chem
|
2011
|
0.80
|
|
31
|
Bioavailability and efficacy of a gap junction enhancer (PQ7) in a mouse mammary tumor model.
|
PLoS One
|
2013
|
0.79
|
|
32
|
Antitumor triptycene analogs directly interact with isolated mitochondria to rapidly trigger markers of permeability transition.
|
Anticancer Res
|
2007
|
0.79
|
|
33
|
Synthesis, molecular targets, and antitumor activities of substituted tetrahydro-1-oxopyrano[4,3-b][1]benzopyrans and nanogels for drug delivery.
|
Anticancer Agents Med Chem
|
2009
|
0.79
|
|
34
|
Combination of nanogel polyethylene glycol-polyethylenimine and 6(hydroxymethyl)-1,4-anthracenedione as an anticancer nanomedicine.
|
J Nanosci Nanotechnol
|
2008
|
0.78
|
|
35
|
Redox potentials, laccase oxidation, and antilarval activities of substituted phenols.
|
Bioorg Med Chem
|
2012
|
0.78
|
|
36
|
Induction of poly(ADP-ribose) polymerase-1 cleavage by antitumor triptycene bisquinones in wild-type and daunorubicin-resistant HL-60 cell lines.
|
Cancer Lett
|
2002
|
0.78
|
|
37
|
Transport by OATP1B1 and OATP1B3 enhances the cytotoxicity of epigallocatechin 3-O-gallate and several quercetin derivatives.
|
J Nat Prod
|
2013
|
0.78
|
|
38
|
Tricyclic pyrone compounds prevent aggregation and reverse cellular phenotypes caused by expression of mutant huntingtin protein in striatal neurons.
|
BMC Neurosci
|
2009
|
0.78
|
|
39
|
Among substituted 9,10-dihydro-9,10-[1,2]benzenoanthracene-1,4,5,8-tetraones, the lead antitumor triptycene bisquinone TT24 blocks nucleoside transport, induces apoptotic DNA fragmentation and decreases the viability of L1210 leukemic cells in the nanomolar range of daunorubicin in vitro.
|
Anticancer Drugs
|
2002
|
0.77
|
|
40
|
Novel substituted 1,4-anthracenediones with antitumor activity directly induce permeability transition in isolated mitochondria.
|
Int J Oncol
|
2007
|
0.77
|
|
41
|
Antitumor triptycene analogs induce a rapid collapse of mitochondrial transmembrane potential in HL-60 cells and isolated mitochondria.
|
Int J Oncol
|
2006
|
0.75
|
|
42
|
Correction: Reversal of the Progression of Fatal Coronavirus Infection in Cats by a Broad-Spectrum Coronavirus Protease Inhibitor.
|
PLoS Pathog
|
2016
|
0.75
|
|
43
|
Unexpected differences in the alpha-halogenation and related reactivity of sulfones with perhaloalkanes in KOH-t-BuOH.
|
J Org Chem
|
2003
|
0.75
|
|
44
|
Synthesis of cyclododeciptycene quinones.
|
J Am Chem Soc
|
2010
|
0.75
|