Published in J Biol Chem on September 25, 1985
Molecular characterization of sialophorin (CD43), the lymphocyte surface sialoglycoprotein defective in Wiskott-Aldrich syndrome. Proc Natl Acad Sci U S A (1989) 1.73
Phosphorylation of Alzheimer disease amyloid precursor peptide by protein kinase C and Ca2+/calmodulin-dependent protein kinase II. Proc Natl Acad Sci U S A (1988) 1.47
The protein-tyrosine kinase substrate p36 is also a substrate for protein kinase C in vitro and in vivo. Mol Cell Biol (1986) 1.43
Functionally distinct serine phosphorylation sites of p36, the cellular substrate of retroviral protein kinase; differential inhibition of reassociation with p11. EMBO J (1986) 1.04
Calexcitin: a signaling protein that binds calcium and GTP, inhibits potassium channels, and enhances membrane excitability. Proc Natl Acad Sci U S A (1996) 0.96
Normal cellular and transformation-associated abl proteins share common sites for protein kinase C phosphorylation. Mol Cell Biol (1987) 0.96
Monoclonal antibodies show that kinase C phosphorylation of GAP-43 during axonogenesis is both spatially and temporally restricted in vivo. J Cell Biol (1991) 0.93
A potent and highly selective peptide substrate for protein kinase C assay. Biochem J (1997) 0.82
Protein kinase phosphorylation site sequences and consensus specificity motifs: tabulations. Methods Enzymol (1991) 6.72
Cyclic nucleotide-dependent protein kinases. IV. Widespread occurrence of adenosine 3',5'-monophosphate-dependent protein kinase in various tissues and phyla of the animal kingdom. Proc Natl Acad Sci U S A (1969) 6.02
Cyclic nucleotide-dependent protein kinases. 3. Purification and properties of adenosine 3',5'-monophosphate-dependent protein kinase from bovine brain. J Biol Chem (1969) 5.37
Protein kinase C contains a pseudosubstrate prototope in its regulatory domain. Science (1987) 5.23
Role of multiple basic residues in determining the substrate specificity of cyclic AMP-dependent protein kinase. J Biol Chem (1977) 4.87
A parathyroid hormone-related protein implicated in malignant hypercalcemia: cloning and expression. Science (1987) 4.09
AMP-activated protein kinase phosphorylation of endothelial NO synthase. FEBS Lett (1999) 3.63
Functional domains of the alpha1 catalytic subunit of the AMP-activated protein kinase. J Biol Chem (1998) 3.53
A potent synthetic peptide inhibitor of the cAMP-dependent protein kinase. J Biol Chem (1986) 3.49
Mammalian AMP-activated protein kinase subfamily. J Biol Chem (1996) 3.47
Treatment of advanced Parkinson's disease by posterior GPi pallidotomy: 1-year results of a pilot study. Ann Neurol (1996) 3.45
Role of the posterior parietal cortex in updating reaching movements to a visual target. Nat Neurosci (1999) 3.39
Phosphorylation of Thr(495) regulates Ca(2+)/calmodulin-dependent endothelial nitric oxide synthase activity. Circ Res (2001) 3.18
Calcium-dependent protein kinase: widespread occurrence in various tissues and phyla of the animal kingdom and comparison of effects of phospholipid, calmodulin, and trifluoperazine. Proc Natl Acad Sci U S A (1980) 3.08
Parathyroid hormone-related protein purified from a human lung cancer cell line. Proc Natl Acad Sci U S A (1987) 3.06
Cyclic nucleotide-dependent protein kinases. VI. Isolation and partial purification of a protein kinase activated by guanosine 3',5'-monophosphate. J Biol Chem (1970) 2.89
An adenosine 3',5'-monophosphate-dependent protein kinase from Escherichia coli. J Biol Chem (1969) 2.86
Structural basis of autoregulation of phenylalanine hydroxylase. Nat Struct Biol (1999) 2.67
Mammalian AMP-activated protein kinase shares structural and functional homology with the catalytic domain of yeast Snf1 protein kinase. J Biol Chem (1994) 2.57
Coordinated control of endothelial nitric-oxide synthase phosphorylation by protein kinase C and the cAMP-dependent protein kinase. J Biol Chem (2001) 2.56
Contraction-induced changes in acetyl-CoA carboxylase and 5'-AMP-activated kinase in skeletal muscle. J Biol Chem (1997) 2.54
AMP-activated protein kinase is highly expressed in neurons in the developing rat brain and promotes neuronal survival following glucose deprivation. J Mol Neurosci (2001) 2.51
The Akt kinase signals directly to endothelial nitric oxide synthase. Curr Biol (1999) 2.42
Cyclic nucleotide-dependent protein kinases. X. An assay method for the measurement of quanosine 3',5'-monophosphate in various biological materials and a study of agents regulating its levels in heart and brain. J Biol Chem (1972) 2.35
Isolation of phosphorylated peptides and proteins on ion exchange papers. Anal Biochem (1978) 2.33
Crystal structure of human T cell leukemia virus type 1 gp21 ectodomain crystallized as a maltose-binding protein chimera reveals structural evolution of retroviral transmembrane proteins. Proc Natl Acad Sci U S A (1999) 2.32
Growth factor-stimulated protein phosphorylation in 3T3-L1 cells. Evidence for protein kinase C-dependent and -independent pathways. J Biol Chem (1985) 2.24
Insulin activation of acetyl-CoA carboxylase accompanied by inhibition of the 5'-AMP-activated protein kinase. J Biol Chem (1992) 2.22
Components of a calmodulin-dependent protein kinase cascade. Molecular cloning, functional characterization and cellular localization of Ca2+/calmodulin-dependent protein kinase kinase beta. J Biol Chem (1998) 2.10
Normalizing motor-related brain activity: subthalamic nucleus stimulation in Parkinson disease. Neurology (2006) 2.05
Reciprocal phosphorylation and regulation of endothelial nitric-oxide synthase in response to bradykinin stimulation. J Biol Chem (2001) 2.04
Cellular distribution and developmental expression of AMP-activated protein kinase isoforms in mouse central nervous system. J Neurochem (1999) 1.99
Regulation of 5'-AMP-activated protein kinase activity by the noncatalytic beta and gamma subunits. J Biol Chem (1996) 1.93
Spontaneous intracranial hypotension causing reversible frontotemporal dementia. Neurology (2002) 1.89
Phospholipid-sensitive Ca2+-dependent protein kinase from heart. I. Purification and general properties. J Biol Chem (1982) 1.88
Inhibition of cystic fibrosis transmembrane conductance regulator by novel interaction with the metabolic sensor AMP-activated protein kinase. J Clin Invest (2000) 1.86
Ca2+/S100 regulation of giant protein kinases. Nature (1996) 1.86
Phospholipid-sensitive Ca2+-dependent protein kinase from heart. II. Substrate specificity and inhibition by various agents. J Biol Chem (1982) 1.83
Identification of an evolutionarily conserved heterotrimeric protein complex involved in protein targeting. J Biol Chem (1998) 1.83
The influence of basic residues on the substrate specificity of protein kinase C. J Biol Chem (1987) 1.80
Substrate specificity of a multifunctional calmodulin-dependent protein kinase. J Biol Chem (1985) 1.80
Synthetic hexapeptide substrates and inhibitors of 3':5'-cyclic AMP-dependent protein kinase. Proc Natl Acad Sci U S A (1976) 1.75
The calmodulin binding domain of chicken smooth muscle myosin light chain kinase contains a pseudosubstrate sequence. J Biol Chem (1987) 1.72
Post-translational modifications of the beta-1 subunit of AMP-activated protein kinase affect enzyme activity and cellular localization. Biochem J (2001) 1.69
Substrate specificity of the cyclic AMP-dependent protein kinase. Proc Natl Acad Sci U S A (1975) 1.68
Role of muscarinic cholinergic receptors in regulation of guanosine 3':5'-cyclic monophosphate content in mammalian brain, heart muscle, and intestinal smooth muscle. Proc Natl Acad Sci U S A (1972) 1.66
Phospholipid-sensitive calcium-dependent protein kinase: inhibition by antipsychotic drugs. Biochem Biophys Res Commun (1981) 1.65
An activating mutation in the gamma1 subunit of the AMP-activated protein kinase. FEBS Lett (2001) 1.65
Adenosine 3',5'-monophosphate-dependent protein kinase from brain. Science (1968) 1.64
Cardiac troponin I mutants. Phosphorylation by protein kinases C and A and regulation of Ca(2+)-stimulated MgATPase of reconstituted actomyosin S-1. J Biol Chem (1995) 1.64
Regulatory and structural motifs of chicken gizzard myosin light chain kinase. Proc Natl Acad Sci U S A (1990) 1.62
Calcium/calmodulin-dependent protein kinase II. Characterization of distinct calmodulin binding and inhibitory domains. J Biol Chem (1988) 1.60
A comparison of the effects of lipolytic and antilipolytic agents on adenosine 3',5'-monophosphate levels in adipose cells as determined by prior labeling with adenine-8-14C. J Biol Chem (1969) 1.56
Insights into autoregulation from the crystal structure of twitchin kinase. Nature (1994) 1.55
Mammalian 5'-AMP-activated protein kinase non-catalytic subunits are homologs of proteins that interact with yeast Snf1 protein kinase. J Biol Chem (1994) 1.50
Phosphorylation specificities of protein kinase C isozymes for bovine cardiac troponin I and troponin T and sites within these proteins and regulation of myofilament properties. J Biol Chem (1996) 1.49
Posttranslational modifications of the 5'-AMP-activated protein kinase beta1 subunit. J Biol Chem (1997) 1.49
Functional analysis of a complementary DNA for the 50-kilodalton subunit of calmodulin kinase II. Science (1987) 1.48
Mutagenesis of the pseudosubstrate site of protein kinase C leads to activation. Eur J Biochem (1990) 1.47
Adenylate cyclase in islets of Langerhans. Isolation of islets and regulation of adenylate cyclase activity by various hormones and agents. J Biol Chem (1973) 1.45
The X11alpha protein slows cellular amyloid precursor protein processing and reduces Abeta40 and Abeta42 secretion. J Biol Chem (1998) 1.45
Crystallization of a trimeric human T cell leukemia virus type 1 gp21 ectodomain fragment as a chimera with maltose-binding protein. Protein Sci (1998) 1.45
Human neurons derived from a teratocarcinoma cell line express solely the 695-amino acid amyloid precursor protein and produce intracellular beta-amyloid or A4 peptides. Proc Natl Acad Sci U S A (1993) 1.42
AMPK signaling in contracting human skeletal muscle: acetyl-CoA carboxylase and NO synthase phosphorylation. Am J Physiol Endocrinol Metab (2000) 1.41
Proteolysis of smooth muscle myosin light chain kinase. Formation of inactive and calmodulin-independent fragments. J Biol Chem (1987) 1.39
Regulation of protein kinase C by lysophospholipids. Potential role in signal transduction. J Biol Chem (1988) 1.38
Polymyxin B is a more selective inhibitor for phospholipid-sensitive Ca2+-dependent protein kinase than for calmodulin-sensitive Ca2+-dependent protein kinase. Biochem Biophys Res Commun (1982) 1.37
Non-catalytic beta- and gamma-subunit isoforms of the 5'-AMP-activated protein kinase. J Biol Chem (1996) 1.37
Active site-directed protein regulation. Nature (1999) 1.37
Protein kinases 1988: a current perspective. FASEB J (1988) 1.36
Identification of sites phosphorylated in bovine cardiac troponin I and troponin T by protein kinase C and comparative substrate activity of synthetic peptides containing the phosphorylation sites. J Biol Chem (1989) 1.34
Stimulation by phosphatidylserine and calmodulin of calcium-dependent phosphorylation of endogenous proteins from cerebral cortex. J Biol Chem (1980) 1.32
Structural basis of the intrasteric regulation of myosin light chain kinases. Science (1992) 1.31
Phosphorylation site sequence of smooth muscle myosin light chain (Mr = 20 000). FEBS Lett (1984) 1.31
Human immunodeficiency virus type 1 envelope glycoprotein oligomerization requires the gp41 amphipathic alpha-helical/leucine zipper-like sequence. J Virol (1997) 1.31
Effects of modulators of myosin light-chain kinase activity in single smooth muscle cells. Nature (1989) 1.30
Functional properties of hormonally responsive cultured normal and malignant rat osteoblastic cells. Endocrinology (1981) 1.29
Parathyroid hormone-related protein: immunohistochemical localization in cancers and in normal skin. J Bone Miner Res (1989) 1.28
AMP-activated protein kinase isoenzyme family: subunit structure and chromosomal location. FEBS Lett (1997) 1.28
Design and use of peptide substrates for protein kinases. Methods Enzymol (1991) 1.28
Purification to homogeneity, characterization and monoclonal antibodies of phospholipid-sensitive Ca2+-dependent protein kinase from spleen. Biochem J (1983) 1.27
Protein kinase C in fibroblasts. Characteristics of its intracellular location during growth and after exposure to phorbol esters and other mitogens. J Biol Chem (1987) 1.27
Role of basic residues in the phosphorylation of synthetic peptides by myosin light chain kinase. Proc Natl Acad Sci U S A (1983) 1.26
Human factor H-related protein 5 (FHR-5). A new complement-associated protein. J Biol Chem (2000) 1.26
Protein kinase C-mediated phosphorylation of troponin I and C-protein in isolated myocardial cells is associated with inhibition of myofibrillar actomyosin MgATPase. J Biol Chem (1993) 1.26
Stimulation of AMP-activated protein kinase (AMPK) is associated with enhancement of Glut1-mediated glucose transport. Arch Biochem Biophys (2000) 1.25
Giant protein kinases: domain interactions and structural basis of autoregulation. EMBO J (1996) 1.24
Guanosine 3':5'-monophosphate-dependent protein kinases in mammalian tissues. Proc Natl Acad Sci U S A (1974) 1.24
Substrate specificities for yeast and mammalian cAMP-dependent protein kinases are similar but not identical. J Biol Chem (1991) 1.24
Role of protein kinase C in the phosphorylation of cardiac myosin light chain 2. Biochem J (1993) 1.24
Phosphorylation of cardiac troponin inhibitory subunit (troponin I) and tropomyosin-binding subunit (troponin T) by cardiac phospholipid-sensitive Ca2+-dependent protein kinase. Biochem J (1983) 1.24
Autoregulation of enzymes by pseudosubstrate prototopes: myosin light chain kinase. Science (1988) 1.23
Proteomic-based identification of haptoglobin-1 precursor as a novel circulating biomarker of ovarian cancer. Br J Cancer (2004) 1.23
Cyclic nucleotide-dependent protein kinases. V. Preparation and properties of adenosine 3',5'-monophosphate-dependent protein kinase from various bovine tissues. Biochim Biophys Acta (1970) 1.23
Molecular analysis of the X11-mLin-2/CASK complex in brain. J Neurosci (1999) 1.22
Protein kinase C phosphorylation of cardiac troponin I or troponin T inhibits Ca2(+)-stimulated actomyosin MgATPase activity. J Biol Chem (1991) 1.22
Identification of substrate specificity determinants for the cell cycle-regulated NIMA protein kinase. J Biol Chem (1994) 1.21
X11 interaction with beta-amyloid precursor protein modulates its cellular stabilization and reduces amyloid beta-protein secretion. J Biol Chem (1998) 1.21
Differential regulation of cardiac actomyosin S-1 MgATPase by protein kinase C isozyme-specific phosphorylation of specific sites in cardiac troponin I and its phosphorylation site mutants. Biochemistry (1996) 1.20