PubRank

Kevan M Shokat

Author PubWeight™ 386.89‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF. Nature 2010 17.31
2 A pharmacological map of the PI3-K family defines a role for p110alpha in insulin signaling. Cell 2006 10.06
3 Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2. PLoS Biol 2009 9.63
4 IRE1 signaling affects cell fate during the unfolded protein response. Science 2007 9.01
5 Targets of the cyclin-dependent kinase Cdk1. Nature 2003 8.05
6 Escape from HER-family tyrosine kinase inhibitor therapy by the kinase-inactive HER3. Nature 2007 6.56
7 A dual PI3 kinase/mTOR inhibitor reveals emergent efficacy in glioma. Cancer Cell 2006 6.15
8 T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR. Proc Natl Acad Sci U S A 2008 5.97
9 The translational landscape of mTOR signalling steers cancer initiation and metastasis. Nature 2012 5.61
10 Structural bioinformatics-based design of selective, irreversible kinase inhibitors. Science 2005 5.53
11 Inhibitor hijacking of Akt activation. Nat Chem Biol 2009 4.91
12 K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions. Nature 2013 4.43
13 The site-specific installation of methyl-lysine analogs into recombinant histones. Cell 2007 4.22
14 Features of selective kinase inhibitors. Chem Biol 2005 4.07
15 Rewiring of genetic networks in response to DNA damage. Science 2010 4.03
16 The unfolded protein response signals through high-order assembly of Ire1. Nature 2008 3.87
17 Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases. Nat Chem Biol 2008 3.84
18 Genetic dissection of the oncogenic mTOR pathway reveals druggable addiction to translational control via 4EBP-eIF4E. Cancer Cell 2010 3.79
19 Targeting the cancer kinome through polypharmacology. Nat Rev Cancer 2010 3.74
20 The Ipl1-Aurora protein kinase activates the spindle checkpoint by creating unattached kinetochores. Nat Cell Biol 2005 3.61
21 Akt and autophagy cooperate to promote survival of drug-resistant glioma. Sci Signal 2010 3.35
22 A chemical-genetic strategy implicates myosin-1c in adaptation by hair cells. Cell 2002 3.34
23 Chemical genetic analysis of the time course of signal transduction by JNK. Mol Cell 2006 3.32
24 Shaping development of autophagy inhibitors with the structure of the lipid kinase Vps34. Science 2010 3.20
25 Functional organization of the S. cerevisiae phosphorylation network. Cell 2009 3.15
26 The p110 delta structure: mechanisms for selectivity and potency of new PI(3)K inhibitors. Nat Chem Biol 2010 3.15
27 Basal subtype and MAPK/ERK kinase (MEK)-phosphoinositide 3-kinase feedback signaling determine susceptibility of breast cancer cells to MEK inhibition. Cancer Res 2009 3.14
28 Chemical genetic screen for AMPKα2 substrates uncovers a network of proteins involved in mitosis. Mol Cell 2011 2.99
29 A chemical-genetic approach to studying neurotrophin signaling. Neuron 2005 2.93
30 Arterial-venous segregation by selective cell sprouting: an alternative mode of blood vessel formation. Science 2009 2.82
31 Control of landmark events in meiosis by the CDK Cdc28 and the meiosis-specific kinase Ime2. Genes Dev 2003 2.79
32 Identifying genotype-dependent efficacy of single and combined PI3K- and MAPK-pathway inhibition in cancer. Proc Natl Acad Sci U S A 2009 2.77
33 The F box protein Dsg1/Mdm30 is a transcriptional coactivator that stimulates Gal4 turnover and cotranscriptional mRNA processing. Cell 2005 2.75
34 Chemical genetic analysis of Apg1 reveals a non-kinase role in the induction of autophagy. Mol Biol Cell 2003 2.72
35 Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species. PLoS Biol 2009 2.67
36 A dual phosphoinositide-3-kinase alpha/mTOR inhibitor cooperates with blockade of epidermal growth factor receptor in PTEN-mutant glioma. Cancer Res 2007 2.62
37 Covalent capture of kinase-specific phosphopeptides reveals Cdk1-cyclin B substrates. Proc Natl Acad Sci U S A 2008 2.53
38 A second-site suppressor strategy for chemical genetic analysis of diverse protein kinases. Nat Methods 2005 2.47
39 Structure-guided development of affinity probes for tyrosine kinases using chemical genetics. Nat Chem Biol 2007 2.43
40 Resiliency and vulnerability in the HER2-HER3 tumorigenic driver. Sci Transl Med 2010 2.42
41 A semisynthetic epitope for kinase substrates. Nat Methods 2007 2.40
42 Chemical genetics reveals the requirement for Polo-like kinase 1 activity in positioning RhoA and triggering cytokinesis in human cells. Proc Natl Acad Sci U S A 2007 2.37
43 Phosphoproteomic analysis reveals interconnected system-wide responses to perturbations of kinases and phosphatases in yeast. Sci Signal 2010 2.36
44 Chemical genetic discovery of targets and anti-targets for cancer polypharmacology. Nature 2012 2.33
45 Discovery of drug-resistant and drug-sensitizing mutations in the oncogenic PI3K isoform p110 alpha. Cancer Cell 2008 2.32
46 JNK2 is a positive regulator of the cJun transcription factor. Mol Cell 2006 2.32
47 Recognizing and exploiting differences between RNAi and small-molecule inhibitors. Nat Chem Biol 2007 2.31
48 EGFR phosphorylates tumor-derived EGFRvIII driving STAT3/5 and progression in glioblastoma. Cancer Cell 2013 2.28
49 Two cyclin-dependent kinases promote RNA polymerase II transcription and formation of the scaffold complex. Mol Cell Biol 2004 2.26
50 Calcium-dependent protein kinase 1 is an essential regulator of exocytosis in Toxoplasma. Nature 2010 2.25
51 Requirements for Cdk7 in the assembly of Cdk1/cyclin B and activation of Cdk2 revealed by chemical genetics in human cells. Mol Cell 2007 2.22
52 An integrated platform of genomic assays reveals small-molecule bioactivities. Nat Chem Biol 2008 2.21
53 PIK3CA cooperates with other phosphatidylinositol 3'-kinase pathway mutations to effect oncogenic transformation. Cancer Res 2008 2.20
54 Nuclear HuR accumulation through phosphorylation by Cdk1. Genes Dev 2008 2.14
55 An unbiased cell morphology-based screen for new, biologically active small molecules. PLoS Biol 2005 2.11
56 To stabilize neutrophil polarity, PIP3 and Cdc42 augment RhoA activity at the back as well as signals at the front. J Cell Biol 2006 2.10
57 Chemical genetics: where genetics and pharmacology meet. Cell 2007 2.09
58 Arabidopsis MAP kinase 4 regulates salicylic acid- and jasmonic acid/ethylene-dependent responses via EDS1 and PAD4. Plant J 2006 2.07
59 A Raf-induced allosteric transition of KSR stimulates phosphorylation of MEK. Nature 2011 2.07
60 Mps1 directs the assembly of Cdc20 inhibitory complexes during interphase and mitosis to control M phase timing and spindle checkpoint signaling. J Cell Biol 2010 2.07
61 Tuning the activation threshold of a kinase network by nested feedback loops. Science 2009 2.03
62 A surface on the androgen receptor that allosterically regulates coactivator binding. Proc Natl Acad Sci U S A 2007 1.97
63 A chemical screen in diverse breast cancer cell lines reveals genetic enhancers and suppressors of sensitivity to PI3K isoform-selective inhibition. Biochem J 2008 1.96
64 Inducible protein knockout reveals temporal requirement of CaMKII reactivation for memory consolidation in the brain. Proc Natl Acad Sci U S A 2003 1.93
65 The cyclin-dependent kinase (CDK) family member PNQALRE/CCRK supports cell proliferation but has no intrinsic CDK-activating kinase (CAK) activity. Cell Cycle 2006 1.90
66 Hierarchical modularity and the evolution of genetic interactomes across species. Mol Cell 2012 1.88
67 A neo-substrate that amplifies catalytic activity of parkinson's-disease-related kinase PINK1. Cell 2013 1.84
68 Phosphorylation of the transcription elongation factor Spt5 by yeast Bur1 kinase stimulates recruitment of the PAF complex. Mol Cell Biol 2009 1.82
69 The evolution of protein kinase inhibitors from antagonists to agonists of cellular signaling. Annu Rev Biochem 2011 1.80
70 Plk1 self-organization and priming phosphorylation of HsCYK-4 at the spindle midzone regulate the onset of division in human cells. PLoS Biol 2009 1.78
71 Isoform-specific phosphoinositide 3-kinase inhibitors from an arylmorpholine scaffold. Bioorg Med Chem 2004 1.77
72 Maintenance of hormone-sensitive phosphoinositide pools in the plasma membrane requires phosphatidylinositol 4-kinase IIIalpha. Mol Biol Cell 2007 1.77
73 Cyclin-dependent kinase control of the initiation-to-elongation switch of RNA polymerase II. Nat Struct Mol Biol 2012 1.74
74 The effect of H3K79 dimethylation and H4K20 trimethylation on nucleosome and chromatin structure. Nat Struct Mol Biol 2008 1.73
75 Cdk1-dependent phosphorylation of Cdc13 coordinates telomere elongation during cell-cycle progression. Cell 2009 1.72
76 Chemical inhibition of the TFIIH-associated kinase Cdk7/Kin28 does not impair global mRNA synthesis. Proc Natl Acad Sci U S A 2007 1.71
77 Cdc28-Clb5 (CDK-S) and Cdc7-Dbf4 (DDK) collaborate to initiate meiotic recombination in yeast. Genes Dev 2008 1.68
78 Suppression of p53-dependent senescence by the JNK signal transduction pathway. Proc Natl Acad Sci U S A 2007 1.67
79 Bio-orthogonal affinity purification of direct kinase substrates. J Am Chem Soc 2005 1.67
80 The protein kinase Kin4 inhibits exit from mitosis in response to spindle position defects. Mol Cell 2005 1.67
81 TFIIH and P-TEFb coordinate transcription with capping enzyme recruitment at specific genes in fission yeast. Mol Cell 2009 1.66
82 EGFR signals to mTOR through PKC and independently of Akt in glioma. Sci Signal 2009 1.66
83 Combining chemical genetics and proteomics to identify protein kinase substrates. Proc Natl Acad Sci U S A 2005 1.63
84 Phosphospecific proteolysis for mapping sites of protein phosphorylation. Nat Biotechnol 2003 1.60
85 Identification of novel ERK2 substrates through use of an engineered kinase and ATP analogs. J Biol Chem 2003 1.60
86 Isoform-selective phosphoinositide 3'-kinase inhibitors inhibit CXCR4 signaling and overcome stromal cell-mediated drug resistance in chronic lymphocytic leukemia: a novel therapeutic approach. Blood 2009 1.58
87 Dissecting the Engrailed homeodomain-DNA interaction by phage-displayed shotgun scanning. Chem Biol 2004 1.56
88 Ablation of PI3K blocks BCR-ABL leukemogenesis in mice, and a dual PI3K/mTOR inhibitor prevents expansion of human BCR-ABL+ leukemia cells. J Clin Invest 2008 1.56
89 Myc and mTOR converge on a common node in protein synthesis control that confers synthetic lethality in Myc-driven cancers. Proc Natl Acad Sci U S A 2013 1.53
90 Phosphatidylinositol 4-kinase IIIbeta regulates the transport of ceramide between the endoplasmic reticulum and Golgi. J Biol Chem 2006 1.52
91 The emerging power of chemical genetics. Curr Opin Cell Biol 2002 1.52
92 Regulation of meiotic recombination via Mek1-mediated Rad54 phosphorylation. Mol Cell 2009 1.51
93 Chemical genetic inhibition of Mps1 in stable human cell lines reveals novel aspects of Mps1 function in mitosis. PLoS One 2010 1.50
94 Protein kinase C epsilon regulates gamma-aminobutyrate type A receptor sensitivity to ethanol and benzodiazepines through phosphorylation of gamma2 subunits. J Biol Chem 2007 1.43
95 Access denied: Snf1 activation loop phosphorylation is controlled by availability of the phosphorylated threonine 210 to the PP1 phosphatase. J Biol Chem 2007 1.42
96 A complex-based reconstruction of the Saccharomyces cerevisiae interactome. Mol Cell Proteomics 2009 1.42
97 A coupled chemical-genetic and bioinformatic approach to Polo-like kinase pathway exploration. Chem Biol 2007 1.42
98 A genetically selective inhibitor demonstrates a function for the kinase Zap70 in regulatory T cells independent of its catalytic activity. Nat Immunol 2010 1.42
99 Small molecule recognition of c-Src via the Imatinib-binding conformation. Chem Biol 2008 1.41
100 Kinetics of inhibitor cycling underlie therapeutic disparities between EGFR-driven lung and brain cancers. Cancer Discov 2012 1.41
101 Human carbonyl reductase 1 is an S-nitrosoglutathione reductase. J Biol Chem 2008 1.40
102 Design and use of analog-sensitive protein kinases. Curr Protoc Mol Biol 2004 1.37
103 Dynamic regulation of a metabolic multi-enzyme complex by protein kinase CK2. J Biol Chem 2010 1.36
104 A chemical genetic screen for direct v-Src substrates reveals ordered assembly of a retrograde signaling pathway. Chem Biol 2002 1.35
105 Dichotomous but stringent substrate selection by the dual-function Cdk7 complex revealed by chemical genetics. Nat Struct Mol Biol 2005 1.35
106 A kinase sequence database: sequence alignments and family assignment. Bioinformatics 2002 1.33
107 Construction of conditional analog-sensitive kinase alleles in the fission yeast Schizosaccharomyces pombe. Nat Protoc 2007 1.32
108 Protein kinase Cdelta regulates ethanol intoxication and enhancement of GABA-stimulated tonic current. J Neurosci 2008 1.32
109 Distinct activation pathways confer cyclin-binding specificity on Cdk1 and Cdk2 in human cells. Mol Cell 2008 1.32
110 Structure and substrate recruitment of the human spindle checkpoint kinase Bub1. Mol Cell 2008 1.32
111 A membrane capture assay for lipid kinase activity. Nat Protoc 2007 1.32
112 Combinatorial efficacy achieved through two-point blockade within a signaling pathway-a chemical genetic approach. Cancer Res 2003 1.32
113 Constitutive mTORC1 activation by a herpesvirus Akt surrogate stimulates mRNA translation and viral replication. Genes Dev 2010 1.29
114 Orm protein phosphoregulation mediates transient sphingolipid biosynthesis response to heat stress via the Pkh-Ypk and Cdc55-PP2A pathways. Mol Biol Cell 2012 1.28
115 Dynamic phosphoregulation of the cortical actin cytoskeleton and endocytic machinery revealed by real-time chemical genetic analysis. J Cell Biol 2003 1.27
116 HIV-1 Nef assembles a Src family kinase-ZAP-70/Syk-PI3K cascade to downregulate cell-surface MHC-I. Cell Host Microbe 2007 1.26
117 A kinase cascade leading to Rab11-FIP5 controls transcytosis of the polymeric immunoglobulin receptor. Nat Cell Biol 2010 1.25
118 The mammalian target of rapamycin regulates cholesterol biosynthetic gene expression and exhibits a rapamycin-resistant transcriptional profile. Proc Natl Acad Sci U S A 2011 1.24
119 Chemical genetic identification of NDR1/2 kinase substrates AAK1 and Rabin8 Uncovers their roles in dendrite arborization and spine development. Neuron 2012 1.22
120 Switching Cdk2 on or off with small molecules to reveal requirements in human cell proliferation. Mol Cell 2011 1.21
121 Optimizing small molecule inhibitors of calcium-dependent protein kinase 1 to prevent infection by Toxoplasma gondii. J Med Chem 2013 1.19
122 Tissue-specific PKA inhibition using a chemical genetic approach and its application to studies on sperm capacitation. Proc Natl Acad Sci U S A 2008 1.18
123 Glucose sensor O-GlcNAcylation coordinates with phosphorylation to regulate circadian clock. Cell Metab 2013 1.16
124 Characterization of structurally distinct, isoform-selective phosphoinositide 3'-kinase inhibitors in combination with radiation in the treatment of glioblastoma. Mol Cancer Ther 2008 1.16
125 Chemical inactivation of cdc7 kinase in budding yeast results in a reversible arrest that allows efficient cell synchronization prior to meiotic recombination. Genetics 2006 1.15
126 Inhibition of ZAP-70 kinase activity via an analog-sensitive allele blocks T cell receptor and CD28 superagonist signaling. J Biol Chem 2008 1.15
127 Cofactor-mediated conformational control in the bifunctional kinase/RNase Ire1. BMC Biol 2011 1.14
128 New inhibitors of the PI3K-Akt-mTOR pathway: insights into mTOR signaling from a new generation of Tor Kinase Domain Inhibitors (TORKinibs). Curr Top Microbiol Immunol 2010 1.14
129 Targeting the gatekeeper residue in phosphoinositide 3-kinases. Bioorg Med Chem 2005 1.13
130 mTOR complex-2 activates ENaC by phosphorylating SGK1. J Am Soc Nephrol 2010 1.12
131 Structural and functional basis for RNA cleavage by Ire1. BMC Biol 2011 1.12
132 Hyperphosphorylation of RNA polymerase II in response to topoisomerase I cleavage complexes and its association with transcription- and BRCA1-dependent degradation of topoisomerase I. J Mol Biol 2008 1.11
133 Chemical genetic approach for kinase-substrate mapping by covalent capture of thiophosphopeptides and analysis by mass spectrometry. Curr Protoc Chem Biol 2010 1.09
134 Dual inhibition of PI3Kalpha and mTOR as an alternative treatment for Kaposi's sarcoma. Cancer Res 2008 1.08
135 Generation of a set of conditional analog-sensitive alleles of essential protein kinases in the fission yeast Schizosaccharomyces pombe. Cell Cycle 2011 1.07
136 A mechanism-based cross-linker for the identification of kinase-substrate pairs. J Am Chem Soc 2004 1.07
137 Chemical genetic blockade of transformation reveals dependence on aberrant oncogenic signaling. Curr Biol 2002 1.07
138 Inhibitor scaffolds as new allele specific kinase substrates. J Am Chem Soc 2002 1.06
139 SHIP prevents lipopolysaccharide from triggering an antiviral response in mice. Blood 2009 1.05
140 Discovery of dual inhibitors of the immune cell PI3Ks p110delta and p110gamma: a prototype for new anti-inflammatory drugs. Chem Biol 2010 1.05
141 TrkB and protein kinase Mζ regulate synaptic localization of PSD-95 in developing cortex. J Neurosci 2011 1.04
142 Chemical genomic profiling to identify intracellular targets of a multiplex kinase inhibitor. Proc Natl Acad Sci U S A 2005 1.04
143 Feedback circuits monitor and adjust basal Lck-dependent events in T cell receptor signaling. Sci Signal 2011 1.04
144 Protein engineering of protein kinase A catalytic subunits results in the acquisition of novel inhibitor sensitivity. J Biol Chem 2002 1.02
145 Mutant tyrosine kinases with unnatural nucleotide specificity retain the structure and phospho-acceptor specificity of the wild-type enzyme. Chem Biol 2002 1.02
146 A Cdk7-Cdk4 T-loop phosphorylation cascade promotes G1 progression. Mol Cell 2013 1.02
147 Transforming growth factor beta1 inhibits cystic fibrosis transmembrane conductance regulator-dependent cAMP-stimulated alveolar epithelial fluid transport via a phosphatidylinositol 3-kinase-dependent mechanism. J Biol Chem 2009 1.02
148 Chemical genetic strategy for targeting protein kinases based on covalent complementarity. Proc Natl Acad Sci U S A 2011 1.01
149 Genetic or pharmaceutical blockade of p110delta phosphoinositide 3-kinase enhances IgE production. J Allergy Clin Immunol 2008 1.00
150 GABAA receptor trafficking is regulated by protein kinase C(epsilon) and the N-ethylmaleimide-sensitive factor. J Neurosci 2010 0.99
151 The brain-derived neurotrophic factor receptor TrkB is critical for the acquisition but not expression of conditioned incentive value. Eur J Neurosci 2008 0.98
152 The yeast LATS/Ndr kinase Cbk1 regulates growth via Golgi-dependent glycosylation and secretion. Mol Biol Cell 2008 0.98
153 Integrin α9β1 in airway smooth muscle suppresses exaggerated airway narrowing. J Clin Invest 2012 0.98
154 A chemical genetic approach for the identification of direct substrates of protein kinases. Methods Mol Biol 2003 0.98
155 Chemical-genetic analysis of cyclin dependent kinase 2 function reveals an important role in cellular transformation by multiple oncogenic pathways. Proc Natl Acad Sci U S A 2012 0.97
156 Chemical genetic engineering of G protein-coupled receptor kinase 2. J Biol Chem 2005 0.97
157 Structure of the human autophagy initiating kinase ULK1 in complex with potent inhibitors. ACS Chem Biol 2015 0.97
158 Glutathione traps formaldehyde by formation of a bicyclo[4.4.1]undecane adduct. Org Biomol Chem 2007 0.97
159 Tuning a three-component reaction for trapping kinase substrate complexes. J Am Chem Soc 2008 0.96
160 Development of a chemical genetic approach for human aurora B kinase identifies novel substrates of the chromosomal passenger complex. Mol Cell Proteomics 2012 0.96
161 A chemical-genetic strategy reveals distinct temporal requirements for SAD-1 kinase in neuronal polarization and synapse formation. Neural Dev 2008 0.96
162 Chemical-genetic inhibition of a sensitized mutant myosin Vb demonstrates a role in peripheral-pericentriolar membrane traffic. Proc Natl Acad Sci U S A 2004 0.95
163 Structure-guided inhibitor design expands the scope of analog-sensitive kinase technology. ACS Chem Biol 2013 0.94
164 Effect of combined DNA repair inhibition and G2 checkpoint inhibition on cell cycle progression after DNA damage. Mol Cancer Ther 2006 0.93
165 Human carbonyl reductase 1 upregulated by hypoxia renders resistance to apoptosis in hepatocellular carcinoma cells. J Hepatol 2010 0.92
166 Chemical genetics reveals a specific requirement for Cdk2 activity in the DNA damage response and identifies Nbs1 as a Cdk2 substrate in human cells. PLoS Genet 2012 0.92
167 A chemical genomics study identifies Snf1 as a repressor of GCN4 translation. J Biol Chem 2008 0.92
168 The p110delta structure: mechanisms for selectivity and potency of new PI(3)K inhibitors. Nat Chem Biol 2010 0.92
169 Specific inhibition of Elm1 kinase activity reveals functions required for early G1 events. Mol Cell Biol 2003 0.91
170 A chemical genetic approach reveals distinct EphB signaling mechanisms during brain development. Nat Neurosci 2012 0.91
171 Rapid structure-activity and selectivity analysis of kinase inhibitors by BioMAP analysis in complex human primary cell-based models. Assay Drug Dev Technol 2004 0.91
172 Selective kinase inhibition by exploiting differential pathway sensitivity. Chem Biol 2006 0.91
173 Dual blockade of lipid and cyclin-dependent kinases induces synthetic lethality in malignant glioma. Proc Natl Acad Sci U S A 2012 0.90
174 The AMP-activated protein kinase Snf1 regulates transcription factor binding, RNA polymerase II activity, and mRNA stability of glucose-repressed genes in Saccharomyces cerevisiae. J Biol Chem 2012 0.89
175 A phage display selection of engrailed homeodomain mutants and the importance of residue Q50. Nucleic Acids Res 2004 0.89
176 Bypassing kinase activity of the tomato Pto resistance protein with small molecule ligands. J Biol Chem 2009 0.89
177 Modified AutoDock for accurate docking of protein kinase inhibitors. J Comput Aided Mol Des 2002 0.89
178 A positive feedback loop links opposing functions of P-TEFb/Cdk9 and histone H2B ubiquitylation to regulate transcript elongation in fission yeast. PLoS Genet 2012 0.89
179 Engineering the serine/threonine protein kinase Raf-1 to utilise an orthogonal analogue of ATP substituted at the N6 position. FEBS Lett 2004 0.88
180 Activity of the p110-alpha subunit of phosphatidylinositol-3-kinase is required for activation of epithelial sodium transport. Am J Physiol Renal Physiol 2008 0.88
181 PTEN expression is consistent in colorectal cancer primaries and metastases and associates with patient survival. Cancer Med 2013 0.88
182 Forebrain overexpression of CaMKII abolishes cingulate long term depression and reduces mechanical allodynia and thermal hyperalgesia. Mol Pain 2006 0.88
183 Use of a semisynthetic epitope to probe histidine kinase activity and regulation. Anal Biochem 2009 0.88
184 Separate domains of fission yeast Cdk9 (P-TEFb) are required for capping enzyme recruitment and primed (Ser7-phosphorylated) Rpb1 carboxyl-terminal domain substrate recognition. Mol Cell Biol 2012 0.87
185 The in vivo response of stem and other undifferentiated spermatogonia to the reversible inhibition of glial cell line-derived neurotrophic factor signaling in the adult. Stem Cells 2012 0.87
186 Synthesis and evaluation of indazole based analog sensitive Akt inhibitors. Mol Biosyst 2010 0.86
187 Combination of ATP-competitive mammalian target of rapamycin inhibitors with standard chemotherapy for colorectal cancer. Invest New Drugs 2012 0.86
188 A remodelled protease that cleaves phosphotyrosine substrates. J Am Chem Soc 2007 0.85
189 Generation of a novel system for studying spleen tyrosine kinase function in macrophages and B cells. J Immunol 2009 0.85
190 Carbonyl reductase 1 offers a novel therapeutic target to enhance leukemia treatment by arsenic trioxide. Cancer Res 2012 0.85
191 Engineering a "methionine clamp" into Src family kinases enhances specificity toward unnatural ATP analogues. Biochemistry 2003 0.85
192 Generation of a patient-derived chordoma xenograft and characterization of the phosphoproteome in a recurrent chordoma. J Neurosurg 2013 0.84
193 Small-molecule kinase-inhibitor target assessment. Chembiochem 2005 0.82
194 Adaptability at a protein-DNA interface: re-engineering the engrailed homeodomain to recognize an unnatural nucleotide. J Am Chem Soc 2004 0.80
195 Staurosporine-derived inhibitors broaden the scope of analog-sensitive kinase technology. J Am Chem Soc 2013 0.80
196 Covalent cross-linking of kinases with their corresponding peptide substrates. Methods Mol Biol 2012 0.77
197 In vivo conditions to identify Prkci phosphorylation targets using the analog-sensitive kinase method in zebrafish. PLoS One 2012 0.77
198 Chemical genomics: dialed in transcriptional network control with non-steroidal glucocorticoid receptor modulators. ACS Chem Biol 2006 0.76
199 A method to site-specifically incorporate methyl-lysine analogues into recombinant proteins. Methods Enzymol 2012 0.75
200 Conformational restraint is a critical determinant of unnatural nucleotide recognition by protein kinases. Bioorg Med Chem Lett 2002 0.75
201 Sensitizing plant protein kinases to specific inhibition by ATP-competitive molecules. Methods Mol Biol 2011 0.75
202 Structure and properties of a re-engineered homeodomain protein-DNA interface. ACS Chem Biol 2006 0.75
203 Ablation of PI3K blocks BCR-ABL leukemogenesis in mice, and a dual PI3K/mTOR inhibitor prevents expansion of human BCR-ABL+ leukemia cells. J Clin Invest 2017 0.75
204 Methods in Enzymology. Protein kinase inhibitors in research and medicine. Preface. Methods Enzymol 2014 0.75