Published in Nat Neurosci on November 11, 2012
DREADDs for Neuroscientists. Neuron (2016) 1.52
Mechanisms of ephrin-Eph signalling in development, physiology and disease. Nat Rev Mol Cell Biol (2016) 1.05
Structure-guided inhibitor design expands the scope of analog-sensitive kinase technology. ACS Chem Biol (2013) 0.94
Synergistic integration of Netrin and ephrin axon guidance signals by spinal motor neurons. Elife (2015) 0.85
EphB receptor forward signaling regulates area-specific reciprocal thalamic and cortical axon pathfinding. Proc Natl Acad Sci U S A (2014) 0.84
Unidirectional Eph/ephrin signaling creates a cortical actomyosin differential to drive cell segregation. J Cell Biol (2016) 0.81
Staurosporine-derived inhibitors broaden the scope of analog-sensitive kinase technology. J Am Chem Soc (2013) 0.80
Disruption of Gpr45 causes reduced hypothalamic POMC expression and obesity. J Clin Invest (2016) 0.75
To phosphorylate or not to phosphorylate: Selective alterations in tyrosine kinase-inhibited EphB mutant mice. Cell Adh Migr (2013) 0.75
De novo mutations revealed by whole-exome sequencing are strongly associated with autism. Nature (2012) 13.61
A chemical switch for inhibitor-sensitive alleles of any protein kinase. Nature (2000) 10.16
The SH2 and SH3 domains of mammalian Grb2 couple the EGF receptor to the Ras activator mSos1. Nature (1993) 7.11
Eph receptors and ephrins in cancer: bidirectional signalling and beyond. Nat Rev Cancer (2010) 5.26
EphB receptors interact with NMDA receptors and regulate excitatory synapse formation. Cell (2000) 4.34
Modulation of NMDA receptor-dependent calcium influx and gene expression through EphB receptors. Science (2001) 3.61
Ephrin-B2 and EphB1 mediate retinal axon divergence at the optic chiasm. Neuron (2003) 3.39
Reversing EphB2 depletion rescues cognitive functions in Alzheimer model. Nature (2010) 3.36
Nuk controls pathfinding of commissural axons in the mammalian central nervous system. Cell (1996) 3.19
PDZ proteins bind, cluster, and synaptically colocalize with Eph receptors and their ephrin ligands. Neuron (1998) 3.09
Chemical genetic screen for AMPKα2 substrates uncovers a network of proteins involved in mitosis. Mol Cell (2011) 2.99
A chemical-genetic approach to studying neurotrophin signaling. Neuron (2005) 2.93
EphB receptor activity suppresses colorectal cancer progression. Nature (2005) 2.84
Slit1 and Slit2 cooperate to prevent premature midline crossing of retinal axons in the mouse visual system. Neuron (2002) 2.77
Vav family GEFs link activated Ephs to endocytosis and axon guidance. Neuron (2005) 2.72
EphB/syndecan-2 signaling in dendritic spine morphogenesis. Neuron (2001) 2.53
Design of allele-specific inhibitors to probe protein kinase signaling. Curr Biol (1998) 2.36
EphrinB phosphorylation and reverse signaling: regulation by Src kinases and PTP-BL phosphatase. Mol Cell (2002) 2.31
Sek4 and Nuk receptors cooperate in guidance of commissural axons and in palate formation. EMBO J (1996) 2.26
Cell-cell signaling via Eph receptors and ephrins. Curr Opin Cell Biol (2007) 2.24
Multiple EphB receptor tyrosine kinases shape dendritic spines in the hippocampus. J Cell Biol (2003) 2.21
Axon growth and guidance: receptor regulation and signal transduction. Annu Rev Neurosci (2009) 2.20
Eph/ephrin signaling in morphogenesis, neural development and plasticity. Curr Opin Cell Biol (2004) 2.20
Intracellular and trans-synaptic regulation of glutamatergic synaptogenesis by EphB receptors. J Neurosci (2006) 2.17
Chemical genetics: where genetics and pharmacology meet. Cell (2007) 2.09
Kinase-independent requirement of EphB2 receptors in hippocampal synaptic plasticity. Neuron (2001) 2.06
EphB receptors couple dendritic filopodia motility to synapse formation. Neuron (2008) 2.04
The receptor tyrosine kinase EphB2 regulates NMDA-dependent synaptic function. Neuron (2001) 2.02
Synapse development and plasticity: roles of ephrin/Eph receptor signaling. Curr Opin Neurobiol (2009) 1.69
Eph-ephrin signalling in adult tissues and cancer. Curr Opin Cell Biol (2008) 1.52
Ephrin-B2 reverse signaling is required for axon pathfinding and cardiac valve formation but not early vascular development. Dev Biol (2004) 1.47
Ephrins and Eph receptors in stem cells and cancer. Curr Opin Cell Biol (2010) 1.42
Specification of motor axon trajectory by ephrin-B:EphB signaling: symmetrical control of axonal patterning in the developing limb. Neuron (2008) 1.41
Chemical genetic approaches for the elucidation of signaling pathways. Curr Opin Chem Biol (2001) 1.39
Design and use of analog-sensitive protein kinases. Curr Protoc Mol Biol (2004) 1.37
EphB receptors regulate stem/progenitor cell proliferation, migration, and polarity during hippocampal neurogenesis. J Neurosci (2007) 1.36
EphB receptors regulate dendritic spine morphogenesis through the recruitment/phosphorylation of focal adhesion kinase and RhoA activation. J Biol Chem (2005) 1.30
Specificity and sufficiency of EphB1 in driving the ipsilateral retinal projection. J Neurosci (2009) 1.29
Presynaptic strontium dynamics and synaptic transmission. Biophys J (1999) 1.26
Discovery and structural analysis of Eph receptor tyrosine kinase inhibitors. Bioorg Med Chem Lett (2009) 1.26
Ephrin-B1 and ephrin-B2 mediate EphB-dependent presynaptic development via syntenin-1. Proc Natl Acad Sci U S A (2009) 1.18
Ephrin-B1 regulates axon guidance by reverse signaling through a PDZ-dependent mechanism. Genes Dev (2009) 1.17
Multiple Eph receptors and B-class ephrins regulate midline crossing of corpus callosum fibers in the developing mouse forebrain. J Neurosci (2006) 1.15
Regulation of neural progenitor cell state by ephrin-B. J Cell Biol (2008) 1.13
Ephrins are not only unattractive. Trends Neurosci (2002) 1.07
EphB2 and EphB3 forward signalling are required for palate development. Mech Dev (2008) 1.02
EphB controls NMDA receptor function and synaptic targeting in a subunit-specific manner. J Neurosci (2011) 1.01
The optic chiasm as a midline choice point. Curr Opin Neurobiol (2004) 0.94
EphBs: an integral link between synaptic function and synaptopathies. Trends Neurosci (2012) 0.93
Balanced Vav2 GEF activity regulates neurite outgrowth and branching in vitro and in vivo. Mol Cell Neurosci (2010) 0.87
Hypospadias and anorectal malformations mediated by Eph/ephrin signaling. J Pediatr Urol (2007) 0.86
Forward signaling by EphB1/EphB2 interacting with ephrin-B ligands at the optic chiasm is required to form the ipsilateral projection. Eur J Neurosci (2011) 0.86
Ephrin-B2 elicits differential growth cone collapse and axon retraction in retinal ganglion cells from distinct retinal regions. Dev Neurobiol (2010) 0.81
Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity. Proc Natl Acad Sci U S A (2008) 17.41
Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase. Science (2004) 17.38
RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF. Nature (2010) 17.31
Widespread transcription at neuronal activity-regulated enhancers. Nature (2010) 16.52
Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma. Nature (2010) 16.12
A brain-specific microRNA regulates dendritic spine development. Nature (2006) 10.18
A pharmacological map of the PI3-K family defines a role for p110alpha in insulin signaling. Cell (2006) 10.06
Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2. PLoS Biol (2009) 9.63
IRE1 signaling affects cell fate during the unfolded protein response. Science (2007) 9.01
Derepression of BDNF transcription involves calcium-dependent phosphorylation of MeCP2. Science (2003) 8.48
Natural oligomers of the Alzheimer amyloid-beta protein induce reversible synapse loss by modulating an NMDA-type glutamate receptor-dependent signaling pathway. J Neurosci (2007) 8.27
Targets of the cyclin-dependent kinase Cdk1. Nature (2003) 8.05
Identifying autism loci and genes by tracing recent shared ancestry. Science (2008) 7.72
RAS mutations in cutaneous squamous-cell carcinomas in patients treated with BRAF inhibitors. N Engl J Med (2012) 6.93
Influenza-associated deaths among children in the United States, 2003-2004. N Engl J Med (2005) 6.83
Escape from HER-family tyrosine kinase inhibitor therapy by the kinase-inactive HER3. Nature (2007) 6.56
Brain-specific phosphorylation of MeCP2 regulates activity-dependent Bdnf transcription, dendritic growth, and spine maturation. Neuron (2006) 6.50
A dual PI3 kinase/mTOR inhibitor reveals emergent efficacy in glioma. Cancer Cell (2006) 6.15
T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR. Proc Natl Acad Sci U S A (2008) 5.97
Microglia sculpt postnatal neural circuits in an activity and complement-dependent manner. Neuron (2012) 5.84
The translational landscape of mTOR signalling steers cancer initiation and metastasis. Nature (2012) 5.61
Structural bioinformatics-based design of selective, irreversible kinase inhibitors. Science (2005) 5.53
Signaling mechanisms linking neuronal activity to gene expression and plasticity of the nervous system. Annu Rev Neurosci (2008) 5.12
Inhibitor hijacking of Akt activation. Nat Chem Biol (2009) 4.91
DNA repair pathway stimulated by the forkhead transcription factor FOXO3a through the Gadd45 protein. Science (2002) 4.88
The Drosophila forkhead transcription factor FOXO mediates the reduction in cell number associated with reduced insulin signaling. J Biol (2003) 4.85
BAD and glucokinase reside in a mitochondrial complex that integrates glycolysis and apoptosis. Nature (2003) 4.80
A critical assessment of Mus musculus gene function prediction using integrated genomic evidence. Genome Biol (2008) 4.78
The Angelman Syndrome protein Ube3A regulates synapse development by ubiquitinating arc. Cell (2010) 4.72
Genome-wide analysis of PTB-RNA interactions reveals a strategy used by the general splicing repressor to modulate exon inclusion or skipping. Mol Cell (2009) 4.71
Activity-dependent regulation of MEF2 transcription factors suppresses excitatory synapse number. Science (2006) 4.68
Mouse brain organization revealed through direct genome-scale TF expression analysis. Science (2004) 4.55
K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions. Nature (2013) 4.43
The many forks in FOXO's road. Sci STKE (2003) 4.23
The site-specific installation of methyl-lysine analogs into recombinant histones. Cell (2007) 4.22
Activity-dependent regulation of inhibitory synapse development by Npas4. Nature (2008) 4.10
Features of selective kinase inhibitors. Chem Biol (2005) 4.07
Rewiring of genetic networks in response to DNA damage. Science (2010) 4.03
From synapse to nucleus: calcium-dependent gene transcription in the control of synapse development and function. Neuron (2008) 4.02
The unfolded protein response signals through high-order assembly of Ire1. Nature (2008) 3.87
Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases. Nat Chem Biol (2008) 3.84
Genetic dissection of the oncogenic mTOR pathway reveals druggable addiction to translational control via 4EBP-eIF4E. Cancer Cell (2010) 3.79
Targeting the cancer kinome through polypharmacology. Nat Rev Cancer (2010) 3.74
Bypassing a kinase activity with an ATP-competitive drug. Science (2003) 3.71
Genome-wide analysis of MEF2 transcriptional program reveals synaptic target genes and neuronal activity-dependent polyadenylation site selection. Neuron (2008) 3.65
The Ipl1-Aurora protein kinase activates the spindle checkpoint by creating unattached kinetochores. Nat Cell Biol (2005) 3.61
Modulation of NMDA receptor-dependent calcium influx and gene expression through EphB receptors. Science (2001) 3.61
Nuclear envelope budding enables large ribonucleoprotein particle export during synaptic Wnt signaling. Cell (2012) 3.50
A functional screen implicates microRNA-138-dependent regulation of the depalmitoylation enzyme APT1 in dendritic spine morphogenesis. Nat Cell Biol (2009) 3.44
A biological function for the neuronal activity-dependent component of Bdnf transcription in the development of cortical inhibition. Neuron (2008) 3.40
Akt and autophagy cooperate to promote survival of drug-resistant glioma. Sci Signal (2010) 3.35
A chemical-genetic strategy implicates myosin-1c in adaptation by hair cells. Cell (2002) 3.34
Regulation of transcription factors by neuronal activity. Nat Rev Neurosci (2002) 3.33
Chemical genetic analysis of the time course of signal transduction by JNK. Mol Cell (2006) 3.32
SK channels and NMDA receptors form a Ca2+-mediated feedback loop in dendritic spines. Nat Neurosci (2005) 3.31
Basic helix-loop-helix factors in cortical development. Neuron (2003) 3.21
Shaping development of autophagy inhibitors with the structure of the lipid kinase Vps34. Science (2010) 3.20
Functional organization of the S. cerevisiae phosphorylation network. Cell (2009) 3.15
The p110 delta structure: mechanisms for selectivity and potency of new PI(3)K inhibitors. Nat Chem Biol (2010) 3.15
Basal subtype and MAPK/ERK kinase (MEK)-phosphoinositide 3-kinase feedback signaling determine susceptibility of breast cancer cells to MEK inhibition. Cancer Res (2009) 3.14
Vemurafenib: the first drug approved for BRAF-mutant cancer. Nat Rev Drug Discov (2012) 3.09
Cocaine regulates MEF2 to control synaptic and behavioral plasticity. Neuron (2008) 3.01
Chemical genetic screen for AMPKα2 substrates uncovers a network of proteins involved in mitosis. Mol Cell (2011) 2.99
14-3-3 transits to the nucleus and participates in dynamic nucleocytoplasmic transport. J Cell Biol (2002) 2.97
Survival factor-mediated BAD phosphorylation raises the mitochondrial threshold for apoptosis. Dev Cell (2002) 2.96
A chemical-genetic approach to studying neurotrophin signaling. Neuron (2005) 2.93
Trans-synaptic transmission of vesicular Wnt signals through Evi/Wntless. Cell (2009) 2.91
The Rac1-GEF Tiam1 couples the NMDA receptor to the activity-dependent development of dendritic arbors and spines. Neuron (2005) 2.91
Arterial-venous segregation by selective cell sprouting: an alternative mode of blood vessel formation. Science (2009) 2.82
Control of landmark events in meiosis by the CDK Cdc28 and the meiosis-specific kinase Ime2. Genes Dev (2003) 2.79
Dual role of proapoptotic BAD in insulin secretion and beta cell survival. Nat Med (2008) 2.78
Identifying genotype-dependent efficacy of single and combined PI3K- and MAPK-pathway inhibition in cancer. Proc Natl Acad Sci U S A (2009) 2.77
The F box protein Dsg1/Mdm30 is a transcriptional coactivator that stimulates Gal4 turnover and cotranscriptional mRNA processing. Cell (2005) 2.75
Using whole-exome sequencing to identify inherited causes of autism. Neuron (2013) 2.74
Chemical genetic analysis of Apg1 reveals a non-kinase role in the induction of autophagy. Mol Biol Cell (2003) 2.72
Vav family GEFs link activated Ephs to endocytosis and axon guidance. Neuron (2005) 2.72
Genome-wide activity-dependent MeCP2 phosphorylation regulates nervous system development and function. Neuron (2011) 2.71
Selective amygdalohippocampectomy versus anterior temporal lobectomy in the management of mesial temporal lobe epilepsy: a meta-analysis of comparative studies. J Neurosurg (2013) 2.71
Loss of inhibitory interneurons in the dorsal spinal cord and elevated itch in Bhlhb5 mutant mice. Neuron (2010) 2.69
Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species. PLoS Biol (2009) 2.67
A calcium-responsive transcription factor, CaRF, that regulates neuronal activity-dependent expression of BDNF. Neuron (2002) 2.65
Mef2-mediated transcription of the miR379-410 cluster regulates activity-dependent dendritogenesis by fine-tuning Pumilio2 protein levels. EMBO J (2009) 2.65
A dual phosphoinositide-3-kinase alpha/mTOR inhibitor cooperates with blockade of epidermal growth factor receptor in PTEN-mutant glioma. Cancer Res (2007) 2.62
Developmental axon pruning mediated by BDNF-p75NTR-dependent axon degeneration. Nat Neurosci (2008) 2.61