Published in PLoS Pathog on October 17, 2013
Factors mediating plastid dependency and the origins of parasitism in apicomplexans and their close relatives. Proc Natl Acad Sci U S A (2015) 1.29
Toxoplasma gondii development of its replicative niche: in its host cell and beyond. Eukaryot Cell (2014) 0.89
Lytic Cycle of Toxoplasma gondii: 15 Years Later. Annu Rev Microbiol (2015) 0.88
Isoprenoid metabolism in apicomplexan parasites. Curr Clin Microbiol Rep (2014) 0.83
The intracellular parasite Toxoplasma gondii depends on the synthesis of long-chain and very long-chain unsaturated fatty acids not supplied by the host cell. Mol Microbiol (2015) 0.79
Drug Repurposing Screening Identifies Novel Compounds That Effectively Inhibit Toxoplasma gondii Growth. mSphere (2016) 0.78
Aryloxyethyl Thiocyanates Are Potent Growth Inhibitors of Trypanosoma cruzi and Toxoplasma gondii. ChemMedChem (2015) 0.78
A Systematic Review of In vitro and In vivo Activities of Anti-Toxoplasma Drugs and Compounds (2006-2016). Front Microbiol (2017) 0.75
1. In Vitro and In Vivo Activity of Sulfur-Containing Linear Bisphosphonates against Apicomplexan Parasites. Antimicrob Agents Chemother (2016) 0.75
Topical Simvastatin as Host-Directed Therapy against Severity of Cutaneous Leishmaniasis in Mice. Sci Rep (2016) 0.75
Review of Experimental Compounds Demonstrating Anti-Toxoplasma Activity. Antimicrob Agents Chemother (2016) 0.75
Activity of Fluorine-Containing Analogues of WC-9 and Structurally Related Analogues against Two Intracellular Parasites: Trypanosoma cruzi and Toxoplasma gondii. ChemMedChem (2016) 0.75
Synergistic Activity between Statins and Bisphosphonates against Acute Experimental Toxoplasmosis. Antimicrob Agents Chemother (2017) 0.75
A method for testing for synergy with any number of agents. J Infect Dis (1978) 9.52
Methods of testing combined antibiotic bactericidal action and the significance of the results. J Clin Pathol (1962) 8.54
Inhibitors of the nonmevalonate pathway of isoprenoid biosynthesis as antimalarial drugs. Science (1999) 7.54
Role of Toxoplasma gondii myosin A in powering parasite gliding and host cell invasion. Science (2002) 4.26
Toxoplasmosis in pregnancy. Clin Infect Dis (1994) 3.91
Tagging of endogenous genes in a Toxoplasma gondii strain lacking Ku80. Eukaryot Cell (2009) 3.32
De novo pyrimidine biosynthesis is required for virulence of Toxoplasma gondii. Nature (2002) 3.04
Synergy of antibacterial substances by apparently known mechanisms. Antimicrob Agents Chemother (Bethesda) (1967) 2.56
Toxoplasmic encephalitis in patients with the acquired immunodeficiency syndrome. Members of the ACTG 077p/ANRS 009 Study Team. N Engl J Med (1993) 2.55
Invasion of Toxoplasma gondii occurs by active penetration of the host cell. J Cell Sci (1995) 2.48
Efficient gene replacements in Toxoplasma gondii strains deficient for nonhomologous end joining. Eukaryot Cell (2009) 2.41
Chemical rescue of malaria parasites lacking an apicoplast defines organelle function in blood-stage Plasmodium falciparum. PLoS Biol (2011) 2.21
Ocular toxoplasmosis: a global reassessment. Part II: disease manifestations and management. Am J Ophthalmol (2004) 2.15
Highly potent geminal bisphosphonates. From pamidronate disodium (Aredia) to zoledronic acid (Zometa). J Med Chem (2002) 2.14
Microarray analysis reveals previously unknown changes in Toxoplasma gondii-infected human cells. J Biol Chem (2001) 2.06
Toxoplasma gondii exploits host low-density lipoprotein receptor-mediated endocytosis for cholesterol acquisition. J Cell Biol (2000) 1.96
Apicoplast fatty acid synthesis is essential for organelle biogenesis and parasite survival in Toxoplasma gondii. Proc Natl Acad Sci U S A (2006) 1.93
Host cells: mobilizable lipid resources for the intracellular parasite Toxoplasma gondii. J Cell Sci (2002) 1.54
Toxoplasmosis in patients with cancer. Clin Infect Dis (1993) 1.47
Apicoplast isoprenoid precursor synthesis and the molecular basis of fosmidomycin resistance in Toxoplasma gondii. J Exp Med (2011) 1.43
Targeting isoprenoid biosynthesis for drug discovery: bench to bedside. Acc Chem Res (2010) 1.40
Salmonella enterica serovar Typhimurium requires nonsterol precursors of the cholesterol biosynthetic pathway for intracellular proliferation. Infect Immun (2004) 1.36
The toxoplasma apicoplast phosphate translocator links cytosolic and apicoplast metabolism and is essential for parasite survival. Cell Host Microbe (2009) 1.34
Metabolic pathways in the apicoplast of apicomplexa. Int Rev Cell Mol Biol (2010) 1.26
Mitochondrial metabolism of glucose and glutamine is required for intracellular growth of Toxoplasma gondii. Cell Host Microbe (2012) 1.22
Inhibition of geranylgeranyl diphosphate synthase by bisphosphonates and diphosphates: a potential route to new bone antiresorption and antiparasitic agents. J Med Chem (2002) 1.22
The plastid-like organelle of apicomplexan parasites as drug target. Curr Pharm Des (2008) 1.17
The farnesyl-diphosphate/geranylgeranyl-diphosphate synthase of Toxoplasma gondii is a bifunctional enzyme and a molecular target of bisphosphonates. J Biol Chem (2007) 1.16
Bisphosphonate inhibitors of Toxoplasma gondi growth: in vitro, QSAR, and in vivo investigations. J Med Chem (2005) 1.13
Toxoplasma gondii Rab5 enhances cholesterol acquisition from host cells. Cell Microbiol (2002) 1.08
Fosmidomycin uptake into Plasmodium and Babesia-infected erythrocytes is facilitated by parasite-induced new permeability pathways. PLoS One (2011) 1.04
Mechanism of action of 4-phenoxyphenoxyethyl thiocyanate (WC-9) against Trypanosoma cruzi, the causative agent of Chagas' disease. Antimicrob Agents Chemother (2003) 1.02
Respiration and oxidative phosphorylation in the apicomplexan parasite Toxoplasma gondii. J Biol Chem (1998) 1.01
Atorvastatin prevents Plasmodium falciparum cytoadherence and endothelial damage. Malar J (2011) 0.96
Lack of predictability of classical animal models for hypolipidemic activity: a good time for mice? Atherosclerosis (1998) 0.95
A Toxoplasma gondii protein with homology to intracellular type Na⁺/H⁺ exchangers is important for osmoregulation and invasion. Exp Cell Res (2011) 0.92
cDNA microarray analysis of host-pathogen interactions in a porcine in vitro model for Toxoplasma gondii infection. Infect Immun (2006) 0.92
Long-term high-dose atorvastatin decreases brain oxidative and nitrosative stress in a preclinical model of Alzheimer disease: a novel mechanism of action. Pharmacol Res (2010) 0.90
Cloning and characterization of bifunctional enzyme farnesyl diphosphate/geranylgeranyl diphosphate synthase from Plasmodium falciparum. Malar J (2013) 0.88
Atorvastatin and pitavastatin protect cerebellar Purkinje cells in AD model mice and preserve the cytokines MCP-1 and TNF-α. Brain Res (2011) 0.80
Overexpression of a cytosolic pyrophosphatase (TgPPase) reveals a regulatory role of PP(i) in glycolysis for Toxoplasma gondii. Biochem J (2011) 0.79
What do human parasites do with a chloroplast anyway? PLoS Biol (2011) 0.77
Dynamics of neutrophil migration in lymph nodes during infection. Immunity (2008) 2.70
High-throughput growth assay for Toxoplasma gondii using yellow fluorescent protein. Antimicrob Agents Chemother (2003) 2.62
CD40 induces macrophage anti-Toxoplasma gondii activity by triggering autophagy-dependent fusion of pathogen-containing vacuoles and lysosomes. J Clin Invest (2006) 2.59
Acidocalcisomes - conserved from bacteria to man. Nat Rev Microbiol (2005) 2.46
Daughter cell assembly in the protozoan parasite Toxoplasma gondii. Mol Biol Cell (2002) 2.19
A MORN-repeat protein is a dynamic component of the Toxoplasma gondii cell division apparatus. J Cell Sci (2006) 2.02
Apicoplast fatty acid synthesis is essential for organelle biogenesis and parasite survival in Toxoplasma gondii. Proc Natl Acad Sci U S A (2006) 1.93
Parasitic infections: Time to tackle cryptosporidiosis. Nature (2013) 1.89
Toxoplasma gondii Tic20 is essential for apicoplast protein import. Proc Natl Acad Sci U S A (2008) 1.78
A dynamin is required for the biogenesis of secretory organelles in Toxoplasma gondii. Curr Biol (2009) 1.77
Dynamics of T cell, antigen-presenting cell, and pathogen interactions during recall responses in the lymph node. Immunity (2009) 1.71
Toxoplasma gondii microneme secretion involves intracellular Ca(2+) release from inositol 1,4,5-triphosphate (IP(3))/ryanodine-sensitive stores. J Biol Chem (2002) 1.70
Cell division in Apicomplexan parasites is organized by a homolog of the striated rootlet fiber of algal flagella. PLoS Biol (2012) 1.67
Class I major histocompatibility complex presentation of antigens that escape from the parasitophorous vacuole of Toxoplasma gondii. Infect Immun (2005) 1.66
Motile invaded neutrophils in the small intestine of Toxoplasma gondii-infected mice reveal a potential mechanism for parasite spread. Proc Natl Acad Sci U S A (2013) 1.65
Characterization of a novel organelle in Toxoplasma gondii with similar composition and function to the plant vacuole. Mol Microbiol (2010) 1.61
Genetic evidence that an endosymbiont-derived endoplasmic reticulum-associated protein degradation (ERAD) system functions in import of apicoplast proteins. J Biol Chem (2009) 1.55
Identification of organelles in bacteria similar to acidocalcisomes of unicellular eukaryotes. J Biol Chem (2003) 1.47
Targeting a prokaryotic protein in a eukaryotic pathogen: identification of lead compounds against cryptosporidiosis. Chem Biol (2008) 1.43
Apicoplast isoprenoid precursor synthesis and the molecular basis of fosmidomycin resistance in Toxoplasma gondii. J Exp Med (2011) 1.43
Cryptosporidium parvum IMP dehydrogenase: identification of functional, structural, and dynamic properties that can be exploited for drug design. J Biol Chem (2004) 1.43
SVD-based modeling for image texture classification using wavelet transformation. IEEE Trans Image Process (2007) 1.39
Forward genetic analysis of the apicomplexan cell division cycle in Toxoplasma gondii. PLoS Pathog (2008) 1.38
Calcium-mediated protein secretion potentiates motility in Toxoplasma gondii. J Cell Sci (2004) 1.36
Dynamic imaging of T cell-parasite interactions in the brains of mice chronically infected with Toxoplasma gondii. J Immunol (2009) 1.35
The toxoplasma apicoplast phosphate translocator links cytosolic and apicoplast metabolism and is essential for parasite survival. Cell Host Microbe (2009) 1.34
Fluorescent protein tagging in Toxoplasma gondii: identification of a novel inner membrane complex component conserved among Apicomplexa. Mol Biochem Parasitol (2004) 1.34
A systematic screen to discover and analyze apicoplast proteins identifies a conserved and essential protein import factor. PLoS Pathog (2011) 1.29
A screening pipeline for antiparasitic agents targeting cryptosporidium inosine monophosphate dehydrogenase. PLoS Negl Trop Dis (2010) 1.29
Current chemotherapy of human African trypanosomiasis. Parasitol Res (2002) 1.27
Antiapicoplast and gametocytocidal screening to identify the mechanisms of action of compounds within the malaria box. Antimicrob Agents Chemother (2013) 1.25
Mitochondrial metabolism of glucose and glutamine is required for intracellular growth of Toxoplasma gondii. Cell Host Microbe (2012) 1.22
A Toxoplasma MORN1 null mutant undergoes repeated divisions but is defective in basal assembly, apicoplast division and cytokinesis. PLoS One (2010) 1.21
A novel dynamin-related protein has been recruited for apicoplast fission in Toxoplasma gondii. Curr Biol (2009) 1.20
Make it or take it: fatty acid metabolism of apicomplexan parasites. Eukaryot Cell (2007) 1.20
Autophagy protein Atg3 is essential for maintaining mitochondrial integrity and for normal intracellular development of Toxoplasma gondii tachyzoites. PLoS Pathog (2011) 1.19
Evolution of acidocalcisomes and their role in polyphosphate storage and osmoregulation in eukaryotic microbes. Philos Trans R Soc Lond B Biol Sci (2010) 1.19
Acidocalcisomes. Cell Calcium (2011) 1.18
The farnesyl-diphosphate/geranylgeranyl-diphosphate synthase of Toxoplasma gondii is a bifunctional enzyme and a molecular target of bisphosphonates. J Biol Chem (2007) 1.16
In vivo activities of farnesyl pyrophosphate synthase inhibitors against Leishmania donovani and Toxoplasma gondii. Antimicrob Agents Chemother (2002) 1.14
Toxoplasma gondii sequesters centromeres to a specific nuclear region throughout the cell cycle. Proc Natl Acad Sci U S A (2011) 1.14
The acidocalcisome Ca2+-ATPase (TgA1) of Toxoplasma gondii is required for polyphosphate storage, intracellular calcium homeostasis and virulence. Mol Microbiol (2005) 1.14
Bisphosphonate inhibitors of Toxoplasma gondi growth: in vitro, QSAR, and in vivo investigations. J Med Chem (2005) 1.13
The algal past and parasite present of the apicoplast. Annu Rev Microbiol (2013) 1.11
Mining the Plasmodium genome database to define organellar function: what does the apicoplast do? Philos Trans R Soc Lond B Biol Sci (2002) 1.09
Optimization of benzoxazole-based inhibitors of Cryptosporidium parvum inosine 5'-monophosphate dehydrogenase. J Med Chem (2013) 1.09
Apicoplast and endoplasmic reticulum cooperate in fatty acid biosynthesis in apicomplexan parasite Toxoplasma gondii. J Biol Chem (2011) 1.09
Identification of a sporozoite-specific member of the Toxoplasma SAG superfamily via genetic complementation. Mol Microbiol (2004) 1.07
Intraepithelial gammadelta+ lymphocytes maintain the integrity of intestinal epithelial tight junctions in response to infection. Gastroenterology (2006) 1.07
Expression variance, biochemical and immunological properties of Toxoplasma gondii dense granule protein GRA7. Microbes Infect (2002) 1.05
The acidocalcisome as a target for chemotherapeutic agents in protozoan parasites. Curr Pharm Des (2008) 1.05
Identification of contractile vacuole proteins in Trypanosoma cruzi. PLoS One (2011) 1.05
Characterization of isolated acidocalcisomes from Toxoplasma gondii tachyzoites reveals a novel pool of hydrolyzable polyphosphate. J Biol Chem (2002) 1.04
A lipid-modified phosphoinositide-specific phospholipase C (TcPI-PLC) is involved in differentiation of trypomastigotes to amastigotes of Trypanosoma cruzi. J Biol Chem (2005) 1.03
Validation of IMP dehydrogenase inhibitors in a mouse model of cryptosporidiosis. Antimicrob Agents Chemother (2013) 1.03
Formation and remodeling of inositolphosphoceramide during differentiation of Trypanosoma cruzi from trypomastigote to amastigote. Eukaryot Cell (2003) 1.01
Selective and potent urea inhibitors of cryptosporidium parvum inosine 5'-monophosphate dehydrogenase. J Med Chem (2012) 1.01
Plastid segregation and cell division in the apicomplexan parasite Sarcocystis neurona. J Cell Sci (2005) 1.00
Artemisinin-resistant mutants of Toxoplasma gondii have altered calcium homeostasis. Antimicrob Agents Chemother (2007) 1.00
Structure-activity relationship study of selective benzimidazole-based inhibitors of Cryptosporidium parvum IMPDH. Bioorg Med Chem Lett (2012) 1.00
Acylation-dependent export of Trypanosoma cruzi phosphoinositide-specific phospholipase C to the outer surface of amastigotes. J Biol Chem (2010) 0.98
Magic-angle spinning (31)P NMR spectroscopy of condensed phosphates in parasitic protozoa: visualizing the invisible. FEBS Lett (2002) 0.98
The cell biology of secondary endosymbiosis--how parasites build, divide and segregate the apicoplast. Mol Microbiol (2006) 0.97
Acidocalcisomes of Trypanosoma brucei have an inositol 1,4,5-trisphosphate receptor that is required for growth and infectivity. Proc Natl Acad Sci U S A (2013) 0.97
Acidocalcisomes in Apicomplexan parasites. Exp Parasitol (2007) 0.96
Lipid synthesis in protozoan parasites: a comparison between kinetoplastids and apicomplexans. Prog Lipid Res (2013) 0.96
cDNA cloning and expression of UDP-N-acetyl-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase T1 from Toxoplasma gondii. Mol Biochem Parasitol (2003) 0.95
Genetic rescue of a Toxoplasma gondii conditional cell cycle mutant. Mol Microbiol (2005) 0.94
Oxidative phosphorylation and rotenone-insensitive malate- and NADH-quinone oxidoreductases in Plasmodium yoelii yoelii mitochondria in situ. J Biol Chem (2003) 0.94
Polyphosphate content and fine structure of acidocalcisomes of Plasmodium falciparum. Microsc Microanal (2004) 0.94
Prodrug activation by Cryptosporidium thymidine kinase. J Biol Chem (2010) 0.94
Phthalazinone inhibitors of inosine-5'-monophosphate dehydrogenase from Cryptosporidium parvum. Bioorg Med Chem Lett (2012) 0.94
Squalene synthase as a target for Chagas disease therapeutics. PLoS Pathog (2014) 0.93
Synthesis and biological evaluation of 2-alkylaminoethyl-1,1-bisphosphonic acids against Trypanosoma cruzi and Toxoplasma gondii targeting farnesyl diphosphate synthase. Bioorg Med Chem (2007) 0.93
A Toxoplasma gondii protein with homology to intracellular type Na⁺/H⁺ exchangers is important for osmoregulation and invasion. Exp Cell Res (2011) 0.92
More membranes, more proteins: complex protein import mechanisms into secondary plastids. Protist (2010) 0.92
A requirement for the Vgamma1+ subset of peripheral gammadelta T cells in the control of the systemic growth of Toxoplasma gondii and infection-induced pathology. J Immunol (2005) 0.92
A Toxoplasma gondii phosphoinositide phospholipase C (TgPI-PLC) with high affinity for phosphatidylinositol. Biochem J (2006) 0.91
Isolation and characterization of TgVP1, a type I vacuolar H+-translocating pyrophosphatase from Toxoplasma gondii. The dynamics of its subcellular localization and the cellular effects of a diphosphonate inhibitor. J Biol Chem (2002) 0.91
Tic22 is an essential chaperone required for protein import into the apicoplast. J Biol Chem (2012) 0.91
Plastid-targeting peptides from the chlorarachniophyte Bigelowiella natans. J Eukaryot Microbiol (2004) 0.89
Calcium uptake and proton transport by acidocalcisomes of Toxoplasma gondii. PLoS One (2011) 0.88
Synthesis and biological evaluation of new 2-alkylaminoethyl-1,1-bisphosphonic acids against Trypanosoma cruzi and Toxoplasma gondii targeting farnesyl diphosphate synthase. Bioorg Med Chem (2011) 0.88
Design, synthesis and biological evaluation of sulfur-containing 1,1-bisphosphonic acids as antiparasitic agents. Eur J Med Chem (2012) 0.87
IMP dehydrogenase from the protozoan parasite Toxoplasma gondii. Antimicrob Agents Chemother (2005) 0.87
TgVTC2 is involved in polyphosphate accumulation in Toxoplasma gondii. Mol Biochem Parasitol (2010) 0.87
Fluorine-containing aryloxyethyl thiocyanate derivatives are potent inhibitors of Trypanosoma cruzi and Toxoplasma gondii proliferation. Bioorg Med Chem Lett (2007) 0.86
Sarcocystis neurona merozoites express a family of immunogenic surface antigens that are orthologues of the Toxoplasma gondii surface antigens (SAGs) and SAG-related sequences. Infect Immun (2005) 0.86
An apicoplast localized ubiquitylation system is required for the import of nuclear-encoded plastid proteins. PLoS Pathog (2013) 0.86
Adenosine kinase from Cryptosporidium parvum. Mol Biochem Parasitol (2006) 0.86
1-(Fluoroalkylidene)-1,1-bisphosphonic acids are potent and selective inhibitors of the enzymatic activity of Toxoplasma gondii farnesyl pyrophosphate synthase. Org Biomol Chem (2012) 0.84
A nucleolar AAA-NTPase is required for parasite division. Mol Microbiol (2013) 0.83
The role of acidocalcisomes in the stress response of Trypanosoma cruzi. Adv Parasitol (2011) 0.83
Studying the cell biology of apicomplexan parasites using fluorescent proteins. Microsc Microanal (2004) 0.82
Protein sorting in complex plastids. Biochim Biophys Acta (2012) 0.82
Lipid kinases are essential for apicoplast homeostasis in Toxoplasma gondii. Cell Microbiol (2014) 0.81
Developmental expression of a Trypanosoma cruzi phosphoinositide-specific phospholipase C in amastigotes and stimulation of host phosphoinositide hydrolysis. Infect Immun (2010) 0.81
A malaria parasite-encoded vacuolar H(+)-ATPase is targeted to the host erythrocyte. J Biol Chem (2005) 0.80
Design, synthesis and biological evaluation of WC-9 analogs as antiparasitic agents. Eur J Med Chem (2013) 0.80