Historically significant events in the discovery of RANK/RANKL/OPG.

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Published in World J Orthop on October 18, 2013

Authors

T John Martin1

Author Affiliations

1: T John Martin, Department of Medicine and St Vincent's Institute of Medical Research, University of Melbourne, Fitzroy 3065, Victoria, Australia.

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Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation. Cell (1998) 17.76

Osteoprotegerin: a novel secreted protein involved in the regulation of bone density. Cell (1997) 15.96

Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL. Proc Natl Acad Sci U S A (1998) 12.61

A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function. Nature (1997) 8.59

Modulation of osteoclast differentiation and function by the new members of the tumor necrosis factor receptor and ligand families. Endocr Rev (1999) 7.69

Evidence for osteocyte regulation of bone homeostasis through RANKL expression. Nat Med (2011) 5.66

Osteoblastic cells are involved in osteoclast formation. Endocrinology (1988) 4.37

Modulation of osteoclast differentiation. Endocr Rev (1992) 4.27

Role of osteoblasts in hormonal control of bone resorption--a hypothesis. Calcif Tissue Int (1981) 3.77

TRANCE (tumor necrosis factor [TNF]-related activation-induced cytokine), a new TNF family member predominantly expressed in T cells, is a dendritic cell-specific survival factor. J Exp Med (1997) 3.59

Soluble interleukin-6 receptor triggers osteoclast formation by interleukin 6. Proc Natl Acad Sci U S A (1993) 3.29

Prostaglandins: stimulation of bone resorption in tissue culture. Endocrinology (1970) 3.16

The bone marrow-derived stromal cell lines MC3T3-G2/PA6 and ST2 support osteoclast-like cell differentiation in cocultures with mouse spleen cells. Endocrinology (1989) 2.83

Isolation of a novel cytokine from human fibroblasts that specifically inhibits osteoclastogenesis. Biochem Biophys Res Commun (1997) 2.81

Osteoclast-like cell formation and its regulation by osteotropic hormones in mouse bone marrow cultures. Endocrinology (1988) 2.60

Tumor necrosis factors alpha and beta induce osteoblastic cells to stimulate osteoclastic bone resorption. J Immunol (1987) 2.59

Macrophage colony-stimulating factor is indispensable for both proliferation and differentiation of osteoclast progenitors. J Clin Invest (1993) 2.52

Parathyroid hormone-responsive clonal cell lines from rat osteosarcoma. Endocrinology (1980) 2.46

Osteoclast differentiation factor acts as a multifunctional regulator in murine osteoclast differentiation and function. J Immunol (1999) 1.96

Bone resorption restored in osteopetrotic mice by transplants of normal bone marrow and spleen cells. Science (1975) 1.85

Biochemical characterization with parathormone and calcitonin of isolated bone cells: provisional identification of osteoclasts and osteoblasts. Endocrinology (1976) 1.83

Investigation of cell lineage in bone using a chimaera of chick and quial embryonic tissue. Nature (1975) 1.80

Generation of osteoclast-inductive and osteoclastogenic cell lines from the H-2KbtsA58 transgenic mouse. Proc Natl Acad Sci U S A (1993) 1.80

Osteotropic agents regulate the expression of osteoclast differentiation factor and osteoprotegerin in osteoblastic stromal cells. Endocrinology (1998) 1.75

Ground substance, bone salts, and cellular activity in bone formation and destruction. Am J Anat (1951) 1.74

Abundant calcitonin receptors in isolated rat osteoclasts. Biochemical and autoradiographic characterization. J Clin Invest (1986) 1.73

BONE CELLS: BIOCHEMICAL AND BIOLOGICAL STUDIES AFTER ENZYMATIC ISOLATION. Science (1964) 1.71

Cells of bone: proliferation, differentiation, and hormonal regulation. Physiol Rev (1986) 1.68

Osteocytic osteolysis. Calcif Tissue Res (1969) 1.65

Osteoclast differentiation factor (ODF) induces osteoclast-like cell formation in human peripheral blood mononuclear cell cultures. Biochem Biophys Res Commun (1998) 1.63

Resorption of dentine by isolated osteoclasts in vitro. Br Dent J (1984) 1.60

Generation of osteoclasts from isolated hematopoietic progenitor cells. Blood (1989) 1.55

Identification of committed mononuclear precursors for osteoclast-like cells formed in long term human marrow cultures. Endocrinology (1990) 1.51

The pathobiology of the osteoclast. J Clin Pathol (1985) 1.48

The ultrastructure of the osteoclast and its functional implications. Clin Orthop Relat Res (1977) 1.45

Cellular biology and biochemical mechanism of bone resorption. A review of recent developments on the formation, activation, and mode of action of osteoclasts. Clin Orthop Relat Res (1988) 1.41

The cellular basis of bone resorption. Clin Orthop Relat Res (1980) 1.38

Morphological and biochemical characterization of four clonal osteogenic sarcoma cell lines of rat origin. Cancer Res (1983) 1.38

Osteoblast-like cells in the presence of parathyroid hormone release soluble factor that stimulates osteoclastic bone resorption. Endocrinology (1986) 1.37

Functional properties of hormonally responsive cultured normal and malignant rat osteoblastic cells. Endocrinology (1981) 1.29

Fibroblastic stromal cells express receptor activator of NF-kappa B ligand and support osteoclast differentiation. J Bone Miner Res (2000) 1.25

Bone cells in culture: morphologic transformation by hormones. Science (1976) 1.24

Role of prostaglandins in interleukin-1-induced bone resorption in mice in vitro. J Bone Miner Res (1991) 1.21

PARATHORMONE-INDUCED OSTEOLYSIS IN DOGS. A MICRORADIOGRAPHIC AND ALPHARADIOGRAPHIC SURVEY. J Bone Joint Surg Am (1964) 1.20

Role of colony-stimulating factors in osteoclast development. J Bone Miner Res (1991) 1.16

Studies on the adrenocorticotropic hormone-activated adenyl cyclase of a functional adrenal tumor. J Biol Chem (1969) 1.15

Human macrophage colony-stimulating factor inhibits bone resorption by osteoclasts disaggregated from rat bone. J Cell Physiol (1988) 1.13

Induction of calcitonin receptors by 1 alpha, 25-dihydroxyvitamin D3 in osteoclast-like multinucleated cells formed from mouse bone marrow cells. Endocrinology (1988) 1.13

Periosteal osteoclasts, skeletal development and ageing. Nature (1960) 1.12

Human osteoclast formation from blood monocytes, peritoneal macrophages, and bone marrow cells. Calcif Tissue Int (1998) 1.12

Interleukin 4, interferon-gamma, and prostaglandin E impact the osteoclastic cell-forming potential of murine bone marrow macrophages. Endocrinology (1995) 1.09

Cloning of an osteoblastic cell line involved in the formation of osteoclast-like cells. J Cell Physiol (1990) 1.08

Osteoblasts mediate thyroid hormone stimulation of osteoclastic bone resorption. Endocrinology (1994) 1.07

1,25-dihydroxycholecalciferol and parathormone: effects on isolated osteoclast-like and osteoblast-like cells. Science (1977) 1.06

Osteoblasts release osteoclasts from calcitonin-induced quiescence. J Cell Sci (1982) 1.04

Rat osteogenic sarcoma cells: comparison of the effects of prostaglandins E1, E2, I2 (prostacyclin), 6-keto F1alpha and thromboxane B2 on cyclic AMP production and adenylate cyclase activity. Biochem Biophys Res Commun (1978) 1.04

Parathyroid hormone-responsive adenylate cyclase in induced transplantable osteogenic rat sarcoma. Nature (1976) 1.03

The receptor activity modifying protein family of G protein coupled receptor accessory proteins. Semin Cell Dev Biol (2004) 1.02

Biological activities of prostaglandin analogues and metabolites on bone in organ culture. Nature (1977) 0.99

Prostaglandins as mediators of bone resorption in renal and breast tumours. Clin Sci (Lond) (1980) 0.99

Osteoclast formation from mononuclear phagocytes: role of bone-forming cells. J Cell Biol (1984) 0.98

Bone cells predispose bone surfaces to resorption by exposure of mineral to osteoclastic contact. J Cell Sci (1985) 0.95

Comparison of the bone-resorbing activity in the supernatants from phytohemagglutinin-stimulated human peripheral blood mononuclear cells with that of cytokines through the use of an antiserum to interleukin 1. Endocrinology (1987) 0.92

Structural requirements for the action of parathyroid hormone-related protein (PTHrP) on bone resorption by isolated osteoclasts. J Bone Miner Res (1991) 0.90

Parathyroid hormone (PTH)-related protein is a potent stimulator of osteoclast-like multinucleated cell formation to the same extent as PTH in mouse marrow cultures. Endocrinology (1989) 0.89

Partial characterization of a parathyroid hormone-stimulated resorption factor(s) from osteoblast-like cells. Endocrinology (1989) 0.87

Long-term culture of disaggregated rat osteoclasts: inhibition of bone resorption and reduction of osteoclast-like cell number by calcitonin and PTHrP[107-139]. J Cell Physiol (1993) 0.85

Identification and characterization of osteoclast progenitors by clonal analysis of hematopoietic cells. Blood (1992) 0.85

Maintenance of parathyroid hormone response in clonal rat osteosarcoma lines. Exp Cell Res (1978) 0.85

Rat osteogenic sarcoma cells:effects of some prostaglandins, their metabolites and analogues on cyclic AMP production. Prostaglandins (1977) 0.85

Activity ratio measurements reflect intracellular activation of adenosine 3',5'-monophosphate-dependent protein kinase in osteoblasts. Endocrinology (1982) 0.82

Protons and osteoclasts. J Bone Miner Res (1990) 0.82

Candida myositis manifesting as a discrete neck mass. Otolaryngol Head Neck Surg (1990) 0.82

Experimental study of changes in osteoblastic shape induced by calcitonin and parathyroid extract in an organ culture system. Cell Tissue Res (1976) 0.82

Membranes from a transplantable osteogenic sarcoma responsive to parathyroid hormone and prostaglandins: regulation of adenylate cyclase and of hormone metabolism. J Endocrinol (1978) 0.81

Rat osteogenic sarcoma cells: isolation and effects of hormones on the production of cyclic AMP and cyclic GMP. Endocrinology (1977) 0.81

Morphological changes of osteoblasts in vitro. Cell Tissue Res (1976) 0.80

Drug and hormone effects on calcium release from bone. Pharmacol Ther (1983) 0.80

Molecular mechanisms of bone resorption: therapeutic implications. Rev Rhum Engl Ed (1996) 0.78

Individualization of antihypertensive therapy. Hypertension (1988) 0.78

Proceedings: Definition, morphological and anatomical study of epileptic foci without apparent clinical manifestation. Electroencephalogr Clin Neurophysiol (1975) 0.77

[Evaluation of metabolic profile tests using a computer]. Vet Med (Praha) (1977) 0.76

[Myelodysplastic syndromes in two young brothers]. Rinsho Ketsueki (1992) 0.76

Nutrition and pregnancy. Pediatr Ann (1990) 0.76

Serological identification of viral and virus-related antigens on DBA/2 mouse leukemia lymphocytes. Arch Immunol Ther Exp (Warsz) (1979) 0.76

Aversive properties of cycloheximide versus memory inhibition in chickens' formation of visually cued food aversions. Pharmacol Biochem Behav (1979) 0.76

EEG in brain abscess: its value in localization compared to other diagnostic tests. Electroencephalogr Clin Neurophysiol (1975) 0.76