Published in Trends Endocrinol Metab on May 05, 2014
Targeting of Runx2 by miR-135 and miR-203 Impairs Progression of Breast Cancer and Metastatic Bone Disease. Cancer Res (2015) 1.09
MicroRNAs and Osteolytic Bone Metastasis: The Roles of MicroRNAs in Tumor-Induced Osteoclast Differentiation. J Clin Med (2015) 0.86
MiRNA-320 in the human follicular fluid is associated with embryo quality in vivo and affects mouse embryonic development in vitro. Sci Rep (2015) 0.85
Tumour-derived miRNAs and bone metastasis. Bonekey Rep (2015) 0.83
Epigenetic pathways regulating bone homeostasis: potential targeting for intervention of skeletal disorders. Curr Osteoporos Rep (2014) 0.82
The prognostic significance of RUNX2 and miR-10a/10b and their inter-relationship in breast cancer. J Transl Med (2014) 0.80
A microRNA/Runx1/Runx2 network regulates prostate tumor progression from onset to adenocarcinoma in TRAMP mice. Oncotarget (2016) 0.79
MicroRNA-378-mediated suppression of Runx1 alleviates the aggressive phenotype of triple-negative MDA-MB-231 human breast cancer cells. Tumour Biol (2016) 0.77
The role of microRNAs in bone metastasis. J Bone Oncol (2016) 0.75
Antagonizing miR-218-5p attenuates Wnt signaling and reduces metastatic bone disease of triple negative breast cancer cells. Oncotarget (2016) 0.75
Serum microRNA-17 functions as a prognostic biomarker in osteosarcoma. Oncol Lett (2016) 0.75
MicroRNA-466 inhibits tumor growth and bone metastasis in prostate cancer by direct regulation of osteogenic transcription factor RUNX2. Cell Death Dis (2017) 0.75
Loss of miR-449a-caused PrLZ overexpression promotes prostate cancer metastasis. Int J Oncol (2017) 0.75
A microRNA expression signature of human solid tumors defines cancer gene targets. Proc Natl Acad Sci U S A (2006) 40.09
Frequent deletions and down-regulation of micro- RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia. Proc Natl Acad Sci U S A (2002) 32.26
MicroRNA gene expression deregulation in human breast cancer. Cancer Res (2005) 27.56
Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis. Nature (2010) 23.55
Tumour invasion and metastasis initiated by microRNA-10b in breast cancer. Nature (2007) 21.53
Microenvironmental regulation of metastasis. Nat Rev Cancer (2008) 15.76
The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2. Genes Dev (2008) 15.01
Endogenous human microRNAs that suppress breast cancer metastasis. Nature (2008) 14.37
The miR-200 family inhibits epithelial-mesenchymal transition and cancer cell migration by direct targeting of E-cadherin transcriptional repressors ZEB1 and ZEB2. J Biol Chem (2008) 10.08
Genomic loss of microRNA-101 leads to overexpression of histone methyltransferase EZH2 in cancer. Science (2008) 7.59
The microRNA miR-34a inhibits prostate cancer stem cells and metastasis by directly repressing CD44. Nat Med (2011) 6.85
MicroRNA expression profiling of human breast cancer identifies new markers of tumor subtype. Genome Biol (2007) 6.41
Distinct organ-specific metastatic potential of individual breast cancer cells and primary tumors. J Clin Invest (2005) 6.10
The miR-15a-miR-16-1 cluster controls prostate cancer by targeting multiple oncogenic activities. Nat Med (2008) 5.74
Long non-coding RNA ANRIL is required for the PRC2 recruitment to and silencing of p15(INK4B) tumor suppressor gene. Oncogene (2010) 4.81
Human prostate cancer metastases target the hematopoietic stem cell niche to establish footholds in mouse bone marrow. J Clin Invest (2011) 4.43
The epigenetics of epithelial-mesenchymal plasticity in cancer. Nat Med (2013) 3.96
Direct targeting of Sec23a by miR-200s influences cancer cell secretome and promotes metastatic colonization. Nat Med (2011) 3.82
A microRNA regulon that mediates endothelial recruitment and metastasis by cancer cells. Nature (2011) 3.60
Contextual extracellular cues promote tumor cell EMT and metastasis by regulating miR-200 family expression. Genes Dev (2009) 3.58
Loss of mir-146a function in hormone-refractory prostate cancer. RNA (2008) 3.35
Selection of bone metastasis seeds by mesenchymal signals in the primary tumor stroma. Cell (2013) 3.33
Tumor-derived JAGGED1 promotes osteolytic bone metastasis of breast cancer by engaging notch signaling in bone cells. Cancer Cell (2011) 3.32
MicroRNA expression profiling of human metastatic cancers identifies cancer gene targets. J Pathol (2009) 3.29
Long noncoding RNAs and the genetics of cancer. Br J Cancer (2013) 2.98
MicroRNA-antagonism regulates breast cancer stemness and metastasis via TET-family-dependent chromatin remodeling. Cell (2013) 2.92
Systemic delivery of synthetic microRNA-16 inhibits the growth of metastatic prostate tumors via downregulation of multiple cell-cycle genes. Mol Ther (2009) 2.92
MicroRNAs and their target gene networks in breast cancer. Breast Cancer Res (2010) 2.83
A pilot study of circulating miRNAs as potential biomarkers of early stage breast cancer. PLoS One (2010) 2.64
Secreted microRNAs: a new form of intercellular communication. Trends Cell Biol (2012) 2.62
Gap junction-mediated import of microRNA from bone marrow stromal cells can elicit cell cycle quiescence in breast cancer cells. Cancer Res (2011) 2.31
Localization of parathyroid hormone-related protein in breast cancer metastases: increased incidence in bone compared with other sites. Cancer Res (1991) 2.26
MicroRNAs in the pathogenesis of cancer. Semin Oncol (2011) 2.15
Breast cancer signatures for invasiveness and prognosis defined by deep sequencing of microRNA. Proc Natl Acad Sci U S A (2012) 2.07
Regulatory Role of mir-203 in Prostate Cancer Progression and Metastasis. Clin Cancer Res (2010) 2.07
MicroRNA control of bone formation and homeostasis. Nat Rev Endocrinol (2012) 2.05
MicroRNA-335 inhibits tumor reinitiation and is silenced through genetic and epigenetic mechanisms in human breast cancer. Genes Dev (2011) 1.85
Extracellular miRNAs: the mystery of their origin and function. Trends Biochem Sci (2012) 1.82
Expression of microRNA-221 is progressively reduced in aggressive prostate cancer and metastasis and predicts clinical recurrence. Int J Cancer (2010) 1.76
Inhibition of rho-associated kinase signaling prevents breast cancer metastasis to human bone. Cancer Res (2009) 1.74
Control of metastatic progression by microRNA regulatory networks. Nat Cell Biol (2013) 1.73
Retracted Concurrent suppression of integrin alpha5, radixin, and RhoA phenocopies the effects of miR-31 on metastasis. Cancer Res (2010) 1.73
Hypoxia and TGF-beta drive breast cancer bone metastases through parallel signaling pathways in tumor cells and the bone microenvironment. PLoS One (2009) 1.72
Control of tumor and microenvironment cross-talk by miR-15a and miR-16 in prostate cancer. Oncogene (2011) 1.69
First microRNA mimic enters clinic. Nat Biotechnol (2013) 1.65
The complexities of microRNA regulation: mirandering around the rules. Int J Biochem Cell Biol (2009) 1.65
Tumor-induced osteoclast miRNA changes as regulators and biomarkers of osteolytic bone metastasis. Cancer Cell (2013) 1.62
A destructive cascade mediated by CCL2 facilitates prostate cancer growth in bone. Cancer Res (2009) 1.61
Disseminated prostate cancer cells can instruct hematopoietic stem and progenitor cells to regulate bone phenotype. Mol Cancer Res (2012) 1.55
Myeloid-derived suppressor cells function as novel osteoclast progenitors enhancing bone loss in breast cancer. Cancer Res (2012) 1.55
Identification of miRs-143 and -145 that is associated with bone metastasis of prostate cancer and involved in the regulation of EMT. PLoS One (2011) 1.55
Signaling networks in RUNX2-dependent bone development. J Cell Biochem (2011) 1.53
miR-31: a crucial overseer of tumor metastasis and other emerging roles. Cell Cycle (2010) 1.51
A microRNA expression signature of osteoclastogenesis. Blood (2011) 1.49
Retracted Activation of miR-31 function in already-established metastases elicits metastatic regression. Genes Dev (2011) 1.40
miR-218 directs a Wnt signaling circuit to promote differentiation of osteoblasts and osteomimicry of metastatic cancer cells. J Biol Chem (2012) 1.39
MicroRNA-1 is a candidate tumor suppressor and prognostic marker in human prostate cancer. Nucleic Acids Res (2011) 1.39
Dysregulation of circulating microRNAs and prediction of aggressive prostate cancer. Prostate (2012) 1.39
Regulation of epithelial-mesenchymal and mesenchymal-epithelial transitions by microRNAs. Curr Opin Cell Biol (2013) 1.39
Pathogenesis of osteoblastic bone metastases from prostate cancer. Cancer (2010) 1.33
Change in expression of miR-let7c, miR-100, and miR-218 from high grade localized prostate cancer to metastasis. Urol Oncol (2009) 1.33
Metastatic bone disease: role of transcription factors and future targets. Bone (2010) 1.30
Epithelial plasticity, cancer stem cells and bone metastasis formation. Bone (2010) 1.27
Biology of bone metastases. Cancer Control (2012) 1.25
Circulating microRNAs predict biochemical recurrence in prostate cancer patients. Br J Cancer (2013) 1.25
Long non-coding RNA HOTAIR is targeted and regulated by miR-141 in human cancer cells. J Biol Chem (2014) 1.21
miR-23b regulates cytoskeletal remodeling, motility and metastasis by directly targeting multiple transcripts. Nucleic Acids Res (2013) 1.21
TGF-β in cancer and bone: implications for treatment of bone metastases. Bone (2010) 1.20
MicroRNAs in breast cancer initiation and progression. Cell Mol Life Sci (2012) 1.17
Mechanisms in endocrinology: micro-RNAs: targets for enhancing osteoblast differentiation and bone formation. Eur J Endocrinol (2011) 1.16
Breast cancer metastasis to the bone: mechanisms of bone loss. Breast Cancer Res (2010) 1.15
Tumor expressed PTHrP facilitates prostate cancer-induced osteoblastic lesions. Int J Cancer (2008) 1.15
The ups and downs of miR-205: identifying the roles of miR-205 in mammary gland development and breast cancer. RNA Biol (2010) 1.15
The microRNA -23b/-27b cluster suppresses the metastatic phenotype of castration-resistant prostate cancer cells. PLoS One (2012) 1.14
MicroRNA-106b-25 cluster expression is associated with early disease recurrence and targets caspase-7 and focal adhesion in human prostate cancer. Oncogene (2012) 1.13
MicroRNA biogenesis and regulation of bone remodeling. Arthritis Res Ther (2011) 1.11
MiR-221 promotes the development of androgen independence in prostate cancer cells via downregulation of HECTD2 and RAB1A. Oncogene (2013) 1.09
Control of mesenchymal lineage progression by microRNAs targeting skeletal gene regulators Trps1 and Runx2. J Biol Chem (2012) 1.09
Osteocyte-driven bone remodeling. Calcif Tissue Int (2013) 1.08
The role of TGF-β in bone metastasis: novel therapeutic perspectives. Bonekey Rep (2012) 1.06
Historically significant events in the discovery of RANK/RANKL/OPG. World J Orthop (2013) 1.02
Runt-related transcription factor 2 (RUNX2) inhibits p53-dependent apoptosis through the collaboration with HDAC6 in response to DNA damage. Cell Death Dis (2013) 0.99
Serum overexpression of microRNA-10b in patients with bone metastatic primary breast cancer. J Int Med Res (2012) 0.98
Identification of recurrence-related microRNAs in the bone marrow of breast cancer patients. Int J Oncol (2011) 0.96
Genes associate with abnormal bone cell activity in bone metastasis. Cancer Metastasis Rev (2012) 0.95
HEF1 promotes epithelial mesenchymal transition and bone invasion in prostate cancer under the regulation of microRNA-145. J Cell Biochem (2013) 0.95
Oncogenic cooperation between PI3K/Akt signaling and transcription factor Runx2 promotes the invasive properties of metastatic breast cancer cells. J Cell Physiol (2013) 0.93
Myeloid-derived suppressor cells as osteoclast progenitors: a novel target for controlling osteolytic bone metastasis. Cancer Res (2013) 0.93
Identification of microRNAs inhibiting TGF-β-induced IL-11 production in bone metastatic breast cancer cells. PLoS One (2012) 0.91
The mix of two worlds: non-coding RNAs and hormones. Nucleic Acid Ther (2012) 0.90
A method for conducting highly sensitive microRNA in situ hybridization and immunohistochemical analysis in pancreatic cancer. Methods Mol Biol (2013) 0.90
The multifaceted actions of PTHrP in skeletal metastasis. Future Oncol (2012) 0.89
Bicalutamide-induced hypoxia potentiates RUNX2-mediated Bcl-2 expression resulting in apoptosis resistance. Br J Cancer (2012) 0.88
Wnt and Wnt inhibitors in bone metastasis. Bonekey Rep (2012) 0.87
A short account of metastatic bone disease. Cancer Cell Int (2011) 0.84
Parathyroid hormone-related protein expression, in combination with nodal status, predicts bone metastasis and prognosis of breast cancer patients. Exp Ther Med (2012) 0.84
PTHrP and breast cancer: more than hypercalcemia and bone metastases. Breast Cancer Res (2012) 0.82
Cellular complexity of the bone marrow hematopoietic stem cell niche. Calcif Tissue Int (2013) 0.80
Hierarchical organization and regulation of the hematopoietic stem cell osteoblastic niche. Crit Rev Oncol Hematol (2012) 0.78