Published in Respir Res on November 01, 2013
A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem (1976) 903.81
Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary. Am J Respir Crit Care Med (2007) 47.86
Identification of ubiquitin ligases required for skeletal muscle atrophy. Science (2001) 12.98
Foxo transcription factors induce the atrophy-related ubiquitin ligase atrogin-1 and cause skeletal muscle atrophy. Cell (2004) 11.33
Requirement for glycogen synthase kinase-3beta in cell survival and NF-kappaB activation. Nature (2000) 8.37
Association between chronic obstructive pulmonary disease and systemic inflammation: a systematic review and a meta-analysis. Thorax (2004) 8.09
The IGF-1/PI3K/Akt pathway prevents expression of muscle atrophy-induced ubiquitin ligases by inhibiting FOXO transcription factors. Mol Cell (2004) 7.60
Multiple types of skeletal muscle atrophy involve a common program of changes in gene expression. FASEB J (2004) 7.02
Lithium inhibits glycogen synthase kinase-3 activity and mimics wingless signalling in intact cells. Curr Biol (1996) 6.88
Atrogin-1, a muscle-specific F-box protein highly expressed during muscle atrophy. Proc Natl Acad Sci U S A (2001) 6.76
Myogenic satellite cells: physiology to molecular biology. J Appl Physiol (1985) (2001) 6.27
Molecular cloning and expression of glycogen synthase kinase-3/factor A. EMBO J (1990) 6.23
A myogenic cell line with altered serum requirements for differentiation. Differentiation (1977) 5.30
Skeletal muscle hypertrophy and atrophy signaling pathways. Int J Biochem Cell Biol (2005) 3.93
Muscle protein breakdown and the critical role of the ubiquitin-proteasome pathway in normal and disease states. J Nutr (1999) 3.45
Disassociation between the effects of amino acids and insulin on signaling, ubiquitin ligases, and protein turnover in human muscle. Am J Physiol Endocrinol Metab (2008) 3.29
Glycogen synthase kinase 3: more than a namesake. Br J Pharmacol (2009) 2.77
Body composition and mortality in chronic obstructive pulmonary disease. Am J Clin Nutr (2005) 2.74
Lithium and GSK-3: one inhibitor, two inhibitory actions, multiple outcomes. Trends Pharmacol Sci (2003) 2.54
Glucocorticoids activate the ATP-ubiquitin-dependent proteolytic system in skeletal muscle during fasting. Am J Physiol (1993) 2.33
Evidence for a relation between metabolic derangements and increased levels of inflammatory mediators in a subgroup of patients with chronic obstructive pulmonary disease. Thorax (1996) 2.33
Creatine kinase in serum: 1. Determination of optimum reaction conditions. Clin Chem (1976) 2.26
Glucocorticoids and muscle catabolism. Curr Opin Clin Nutr Metab Care (1999) 2.16
Tumor necrosis factor-alpha levels and weight loss in chronic obstructive pulmonary disease. Am J Respir Crit Care Med (1994) 2.06
The glucocorticoid receptor and FOXO1 synergistically activate the skeletal muscle atrophy-associated MuRF1 gene. Am J Physiol Endocrinol Metab (2008) 2.04
Skeletal muscle apoptosis and weight loss in chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2002) 2.01
Chronic bronchitis, COPD, and lung function in farmers: the role of biological agents. Chest (2009) 1.98
Regulation of eukaryotic initiation factor eIF2B: glycogen synthase kinase-3 phosphorylates a conserved serine which undergoes dephosphorylation in response to insulin. FEBS Lett (1998) 1.96
Inflammatory response and body composition in chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2001) 1.94
Muscle satellite cells. Int J Biochem Cell Biol (2003) 1.93
Inflammatory cytokines inhibit myogenic differentiation through activation of nuclear factor-kappaB. FASEB J (2001) 1.88
Dexamethasone represses signaling through the mammalian target of rapamycin in muscle cells by enhancing expression of REDD1. J Biol Chem (2006) 1.78
Molecular mechanisms modulating muscle mass. Trends Mol Med (2003) 1.77
Histochemical and morphological characteristics of the vastus lateralis muscle in patients with chronic obstructive pulmonary disease. Med Sci Sports Exerc (1998) 1.77
The relationship between chronic hypoxemia and activation of the tumor necrosis factor-alpha system in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2000) 1.77
A critical role for muscle ring finger-1 in acute lung injury-associated skeletal muscle wasting. Am J Respir Crit Care Med (2012) 1.74
Glucocorticoid-induced skeletal muscle atrophy is associated with upregulation of myostatin gene expression. Am J Physiol Endocrinol Metab (2003) 1.74
Muscle full effect after oral protein: time-dependent concordance and discordance between human muscle protein synthesis and mTORC1 signaling. Am J Clin Nutr (2010) 1.72
Glycogen synthase kinase-3β is required for the induction of skeletal muscle atrophy. Am J Physiol Cell Physiol (2011) 1.55
Tumor necrosis factor-alpha inhibits myogenic differentiation through MyoD protein destabilization. FASEB J (2004) 1.53
Sepsis upregulates the gene expression of multiple ubiquitin ligases in skeletal muscle. Int J Biochem Cell Biol (2003) 1.48
GSK-3 Inhibitors: Preclinical and Clinical Focus on CNS. Front Mol Neurosci (2011) 1.47
Proinflammatory cytokines and skeletal muscle. Curr Opin Clin Nutr Metab Care (2004) 1.41
Muscle sparing in muscle RING finger 1 null mice: response to synthetic glucocorticoids. J Physiol (2011) 1.41
Muscle wasting and impaired myogenesis in tumor bearing mice are prevented by ERK inhibition. PLoS One (2010) 1.31
Health effects due to endotoxin inhalation (review). Arch Toxicol (2008) 1.26
Glycogen synthase kinase 3beta as a target for the therapy of shock and inflammation. Shock (2007) 1.23
Systemic inflammation in chronic obstructive pulmonary disease: the role of exacerbations. Proc Am Thorac Soc (2007) 1.23
Deconstructing GSK-3: The Fine Regulation of Its Activity. Int J Alzheimers Dis (2011) 1.22
Recent progress toward understanding the molecular mechanisms that regulate skeletal muscle mass. Cell Signal (2011) 1.20
Inhibition of glycogen synthase kinase-3beta activity is sufficient to stimulate myogenic differentiation. Am J Physiol Cell Physiol (2005) 1.17
NF-kappaB activation and iNOS upregulation in skeletal muscle of patients with COPD and low body weight. Thorax (2004) 1.14
Endotoxin disrupts the leucine-signaling pathway involving phosphorylation of mTOR, 4E-BP1, and S6K1 in skeletal muscle. J Cell Physiol (2005) 1.14
Signal transduction pathways that regulate skeletal muscle gene expression. Mol Endocrinol (1993) 1.13
cDNA cloning and properties of glycogen synthase kinase-3. Methods Enzymol (1991) 1.12
Endotoxin-induced decrease in muscle protein synthesis is associated with changes in eIF2B, eIF4E, and IGF-I. Am J Physiol Endocrinol Metab (2000) 1.04
Muscle fiber type IIX atrophy is involved in the loss of fat-free mass in chronic obstructive pulmonary disease. Am J Clin Nutr (2002) 1.02
Muscle wasting and impaired muscle regeneration in a murine model of chronic pulmonary inflammation. Am J Respir Cell Mol Biol (2006) 1.01
Extrapulmonary manifestations of chronic obstructive pulmonary disease in a mouse model of chronic cigarette smoke exposure. Am J Respir Cell Mol Biol (2008) 1.00
Segregation of myoblast fusion and muscle-specific gene expression by distinct ligand-dependent inactivation of GSK-3β. Cell Mol Life Sci (2010) 0.99
The mechanisms of cachexia underlying muscle dysfunction in COPD. J Appl Physiol (1985) (2012) 0.99
GSK-3beta inhibitors reduce protein degradation in muscles from septic rats and in dexamethasone-treated myotubes. Int J Biochem Cell Biol (2005) 0.99
NF-κB activation is required for the transition of pulmonary inflammation to muscle atrophy. Am J Respir Cell Mol Biol (2012) 0.95
A cell-autonomous role for the glucocorticoid receptor in skeletal muscle atrophy induced by systemic glucocorticoid exposure. Am J Physiol Endocrinol Metab (2012) 0.94
Protection against dexamethasone-induced muscle atrophy is related to modulation by testosterone of FOXO1 and PGC-1α. Biochem Biophys Res Commun (2010) 0.92
Effects of ethanol on neutrophil recruitment and lung host defense in nitric oxide synthase I and nitric oxide synthase II knockout mice. Alcohol Clin Exp Res (1999) 0.92
Optimising pharmacological maintenance treatment for COPD in primary care. Prim Care Respir J (2011) 0.92
Protein breakdown in muscle from burned rats is blocked by insulin-like growth factor i and glycogen synthase kinase-3beta inhibitors. Endocrinology (2005) 0.91
Skeletal muscle dysfunction in COPD: clinical and laboratory observations. Clin Sci (Lond) (2009) 0.90
GSK-3beta activity is increased in skeletal muscle after burn injury in rats. Am J Physiol Regul Integr Comp Physiol (2007) 0.89
Enhanced myogenic differentiation by extracellular matrix is regulated at the early stages of myogenesis. In Vitro Cell Dev Biol Anim (2003) 0.89
Decreased Jun-D and myogenin expression in muscle wasting of human cachexia. Am J Physiol Endocrinol Metab (2009) 0.88
3-(2,4-dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione (SB216763), a glycogen synthase kinase-3 inhibitor, displays therapeutic properties in a mouse model of pulmonary inflammation and fibrosis. J Pharmacol Exp Ther (2009) 0.86
Insulin-like growth factor-I inhibits dexamethasone-induced proteolysis in cultured L6 myotubes through PI3K/Akt/GSK-3beta and PI3K/Akt/mTOR-dependent mechanisms. Int J Biochem Cell Biol (2005) 0.86
Gene expression profiling in vastus lateralis muscle during an acute exacerbation of COPD. Cell Physiol Biochem (2010) 0.85
Skeletal muscle response to inflammation--lessons for chronic obstructive pulmonary disease. Crit Care Med (2009) 0.81
Regulation of skeletal muscle plasticity by glycogen synthase kinase-3β: a potential target for the treatment of muscle wasting. Curr Pharm Des (2013) 0.78
Endotoxin transiently inhibits protein synthesis through Akt and MAPK mediating pathways in C2C12 myotubes. Am J Physiol Cell Physiol (2011) 0.77
Synergistic stimulation of myogenesis by glucocorticoid and IGF-I signaling. J Appl Physiol (1985) (2012) 0.77
Interaction of glucocorticoids and activity patterns affect muscle function. Muscle Nerve (1995) 0.77
Endogenous glucocorticoids in inflammation: contributions of systemic and local responses. Swiss Med Wkly (2012) 0.77
Pharmacological inhibition of GSK-3 in a guinea pig model of LPS-induced pulmonary inflammation: I. Effects on lung remodeling and pathology. Respir Res (2013) 0.76
Bioelectrical impedance analysis--part I: review of principles and methods. Clin Nutr (2004) 7.24
An official American Thoracic Society/European Respiratory Society statement: key concepts and advances in pulmonary rehabilitation. Am J Respir Crit Care Med (2013) 4.49
Mortality and mortality-related factors after hospitalization for acute exacerbation of COPD. Chest (2003) 2.90
Pulmonary function in diabetes: a metaanalysis. Chest (2010) 1.96
An official American Thoracic Society/European Respiratory Society statement: update on limb muscle dysfunction in chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2014) 1.73
Interruption of Wnt signaling attenuates the onset of pressure overload-induced cardiac hypertrophy. Hypertension (2007) 1.65
Efficacy of nutritional supplementation therapy in depleted patients with chronic obstructive pulmonary disease. Nutrition (2003) 1.60
Is age-related decline in lean mass and physical function accelerated by obstructive lung disease or smoking? Thorax (2011) 1.60
Glycogen synthase kinase-3β is required for the induction of skeletal muscle atrophy. Am J Physiol Cell Physiol (2011) 1.55
Tumor necrosis factor-alpha inhibits myogenic differentiation through MyoD protein destabilization. FASEB J (2004) 1.53
Nutritional recommendations for the management of sarcopenia. J Am Med Dir Assoc (2010) 1.51
Measuring body composition in chronic heart failure: a comparison of methods. Eur J Heart Fail (2005) 1.48
Reference values for vastus lateralis fiber type proportions and fiber size. J Appl Physiol (1985) (2013) 1.40
Muscle fibre type shifting in the vastus lateralis of patients with COPD is associated with disease severity: a systematic review and meta-analysis. Thorax (2007) 1.32
Requirement of nuclear factor of activated T-cells in calcineurin-mediated cardiomyocyte hypertrophy. J Biol Chem (2002) 1.23
Airway structural components drive airway smooth muscle remodeling in asthma. Proc Am Thorac Soc (2009) 1.21
Tumor necrosis factor-alpha inhibits myogenesis through redox-dependent and -independent pathways. Am J Physiol Cell Physiol (2002) 1.19
Systemic effects in COPD. Chest (2002) 1.19
Inhibition of glycogen synthase kinase-3beta activity is sufficient to stimulate myogenic differentiation. Am J Physiol Cell Physiol (2005) 1.17
Telomere shortening in chronic obstructive pulmonary disease. Respir Med (2008) 1.16
Rehabilitation decreases exercise-induced oxidative stress in chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2005) 1.16
Activation of WNT/β-catenin signaling in pulmonary fibroblasts by TGF-β₁ is increased in chronic obstructive pulmonary disease. PLoS One (2011) 1.16
The WNT signaling pathway from ligand secretion to gene transcription: molecular mechanisms and pharmacological targets. Pharmacol Ther (2013) 1.14
Striking similarities in systemic factors contributing to decreased exercise capacity in patients with severe chronic heart failure or COPD. Chest (2003) 1.12
Noncanonical WNT-5A signaling regulates TGF-β-induced extracellular matrix production by airway smooth muscle cells. FASEB J (2012) 1.11
Differences in walking pattern during 6-min walk test between patients with COPD and healthy subjects. PLoS One (2012) 1.04
Nuclear transcription factor κ B activation and protein turnover adaptations in skeletal muscle of patients with progressive stages of lung cancer cachexia. Am J Clin Nutr (2013) 1.03
Heterogeneity of quadriceps muscle phenotype in chronic obstructive pulmonary disease (Copd); implications for stratified medicine? Muscle Nerve (2013) 1.03
Fatty acid-induced NF-kappaB activation and insulin resistance in skeletal muscle are chain length dependent. Am J Physiol Endocrinol Metab (2008) 1.03
A role for anabolic steroids in the rehabilitation of patients with COPD? A double-blind, placebo-controlled, randomized trial. Chest (2003) 1.03
Muscle fiber type IIX atrophy is involved in the loss of fat-free mass in chronic obstructive pulmonary disease. Am J Clin Nutr (2002) 1.02
Task-related oxygen uptake during domestic activities of daily life in patients with COPD and healthy elderly subjects. Chest (2011) 1.02
Cross-talk between transforming growth factor-β₁ and muscarinic M₂ receptors augments airway smooth muscle proliferation. Am J Respir Cell Mol Biol (2013) 1.02
GSK-3/beta-catenin signaling axis in airway smooth muscle: role in mitogenic signaling. Am J Physiol Lung Cell Mol Physiol (2008) 1.01
Muscle wasting and impaired muscle regeneration in a murine model of chronic pulmonary inflammation. Am J Respir Cell Mol Biol (2006) 1.01
Phenotype and functional plasticity of airway smooth muscle: role of caveolae and caveolins. Proc Am Thorac Soc (2008) 1.01
Allergic sensitization enhances the contribution of Rho-kinase to airway smooth muscle contraction. Br J Pharmacol (2004) 1.00
Extrapulmonary manifestations of chronic obstructive pulmonary disease in a mouse model of chronic cigarette smoke exposure. Am J Respir Cell Mol Biol (2008) 1.00
Supplementation of soy protein with branched-chain amino acids alters protein metabolism in healthy elderly and even more in patients with chronic obstructive pulmonary disease. Am J Clin Nutr (2007) 1.00
Limb muscle dysfunction in COPD: effects of muscle wasting and exercise training. Med Sci Sports Exerc (2005) 1.00
De novo synthesis of {beta}-catenin via H-Ras and MEK regulates airway smooth muscle growth. FASEB J (2009) 0.99
Objective physical activity assessment in patients with chronic organ failure: a validation study of a new single-unit activity monitor. Arch Phys Med Rehabil (2011) 0.99
Glycogen synthase kinase 3 suppresses myogenic differentiation through negative regulation of NFATc3. J Biol Chem (2007) 0.99
Problematic activities of daily life are weakly associated with clinical characteristics in COPD. J Am Med Dir Assoc (2011) 0.98
The influence of abdominal visceral fat on inflammatory pathways and mortality risk in obstructive lung disease. Am J Clin Nutr (2012) 0.97
Advances in understanding and assessing malnutrition. Curr Opin Clin Nutr Metab Care (2009) 0.97
Loss of quadriceps muscle oxidative phenotype and decreased endurance in patients with mild-to-moderate COPD. J Appl Physiol (1985) (2012) 0.96
Efficacy and costs of nutritional rehabilitation in muscle-wasted patients with chronic obstructive pulmonary disease in a community-based setting: a prespecified subgroup analysis of the INTERCOM trial. J Am Med Dir Assoc (2010) 0.96
Cigarette smoke and lipopolysaccharide induce a proliferative airway smooth muscle phenotype. Respir Res (2010) 0.95
Role of aberrant WNT signalling in the airway epithelial response to cigarette smoke in chronic obstructive pulmonary disease. Thorax (2013) 0.95
NF-κB activation is required for the transition of pulmonary inflammation to muscle atrophy. Am J Respir Cell Mol Biol (2012) 0.95
Lung inflammation is associated with reduced pulmonary nucleotide excision repair in vivo. Mutagenesis (2009) 0.95
Characterization of the inflammatory and metabolic profile of adipose tissue in a mouse model of chronic hypoxia. J Appl Physiol (1985) (2013) 0.94
Regulation of airway inflammation and remodeling by muscarinic receptors: perspectives on anticholinergic therapy in asthma and COPD. Life Sci (2012) 0.94
Insulin increases the expression of contractile phenotypic markers in airway smooth muscle. Am J Physiol Cell Physiol (2007) 0.94
The integrin-blocking peptide RGDS inhibits airway smooth muscle remodeling in a guinea pig model of allergic asthma. Am J Respir Crit Care Med (2009) 0.94
Bronchoconstriction Induces TGF-β Release and Airway Remodelling in Guinea Pig Lung Slices. PLoS One (2013) 0.94
PKA and Epac cooperate to augment bradykinin-induced interleukin-8 release from human airway smooth muscle cells. Respir Res (2009) 0.93
Inhibition of LPS-induced pulmonary inflammation by specific flavonoids. Biochem Biophys Res Commun (2009) 0.92
Distinct responses of protein turnover regulatory pathways in hypoxia- and semistarvation-induced muscle atrophy. Am J Physiol Lung Cell Mol Physiol (2013) 0.91
β-Catenin signaling is required for TGF-β1-induced extracellular matrix production by airway smooth muscle cells. Am J Physiol Lung Cell Mol Physiol (2011) 0.91
Similarities in skeletal muscle strength and exercise capacity between renal transplant and hemodialysis patients. Am J Transplant (2005) 0.91
Expression of the dystrophin-glycoprotein complex is a marker for human airway smooth muscle phenotype maturation. Am J Physiol Lung Cell Mol Physiol (2007) 0.90
Reactive nitrogen species and cell signaling: implications for death or survival of lung epithelium. Am J Respir Crit Care Med (2002) 0.90
Muscarinic receptors on airway mesenchymal cells: novel findings for an ancient target. Pulm Pharmacol Ther (2012) 0.90
The functional, metabolic, and anabolic responses to exercise training in renal transplant and hemodialysis patients. Transplantation (2007) 0.90
Muscarinic receptor stimulation augments TGF-β1-induced contractile protein expression by airway smooth muscle cells. Am J Physiol Lung Cell Mol Physiol (2012) 0.90
Rapid pulmonary expression of acute-phase reactants after local lipopolysaccharide exposure in mice is followed by an interleukin-6 mediated systemic acute-phase response. Exp Lung Res (2006) 0.90
Enhanced myogenic differentiation by extracellular matrix is regulated at the early stages of myogenesis. In Vitro Cell Dev Biol Anim (2003) 0.89
Effects of whole-body exercise training on body composition and functional capacity in normal-weight patients with COPD. Chest (2004) 0.89
β-catenin as a regulator and therapeutic target for asthmatic airway remodeling. Expert Opin Ther Targets (2014) 0.89
Skeletal muscle glutamate metabolism in health and disease: state of the art. Curr Opin Clin Nutr Metab Care (2005) 0.89
Novel non-canonical TGF-β signaling networks: emerging roles in airway smooth muscle phenotype and function. Pulm Pharmacol Ther (2012) 0.89
Cellular protein breakdown and systemic inflammation are unaffected by pulmonary rehabilitation in COPD. Thorax (2006) 0.88
Role of contractile prostaglandins and Rho-kinase in growth factor-induced airway smooth muscle contraction. Respir Res (2005) 0.88
Energy balance in depleted ambulatory patients with chronic obstructive pulmonary disease: the effect of physical activity and oral nutritional supplementation. Br J Nutr (2003) 0.88
Altered interorgan response to feeding in patients with chronic obstructive pulmonary disease. Am J Clin Nutr (2005) 0.88
Greater whole-body myofibrillar protein breakdown in cachectic patients with chronic obstructive pulmonary disease. Am J Clin Nutr (2006) 0.88
Altered antioxidant status in peripheral skeletal muscle of patients with COPD. Respir Med (2005) 0.87
Central fat and peripheral muscle: partners in crime in chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2013) 0.87
Myogenic differentiation during regrowth of atrophied skeletal muscle is associated with inactivation of GSK-3beta. Am J Physiol Cell Physiol (2006) 0.87
Low-grade adipose tissue inflammation in patients with mild-to-moderate chronic obstructive pulmonary disease. Am J Clin Nutr (2011) 0.87
Abdominal fat mass contributes to the systemic inflammation in chronic obstructive pulmonary disease. Clin Nutr (2010) 0.87
Bronchial smooth muscle cells of asthmatics promote angiogenesis through elevated secretion of CXC-chemokines (ENA-78, GRO-α, and IL-8). PLoS One (2013) 0.87
Pro-inflammatory mechanisms of muscarinic receptor stimulation in airway smooth muscle. Respir Res (2010) 0.87
Rho kinase inhibitors: a novel therapeutical intervention in asthma? Eur J Pharmacol (2008) 0.87
Bronchoprotection by olodaterol is synergistically enhanced by tiotropium in a guinea pig model of allergic asthma. J Pharmacol Exp Ther (2013) 0.87
Autophagy in locomotor muscles of patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2013) 0.86
Arm mechanical efficiency and arm exercise capacity are relatively preserved in chronic obstructive pulmonary disease. Med Sci Sports Exerc (2002) 0.86