Polycystin-1 but not polycystin-2 deficiency causes upregulation of the mTOR pathway and can be synergistically targeted with rapamycin and metformin.

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Published in Pflugers Arch on November 06, 2013

Authors

Djalila Mekahli1, Jean-Paul Decuypere, Eva Sammels, Kirsten Welkenhuyzen, Joost Schoeber, Marie-Pierre Audrezet, Anniek Corvelyn, Georges Dechênes, Albert C M Ong, Martijn J Wilmer, Lambertus van den Heuvel, Geert Bultynck, Jan B Parys, Ludwig Missiaen, Elena Levtchenko, Humbert De Smedt

Author Affiliations

1: Laboratory of Molecular and Cellular Signaling, Department of Cellular and Molecular Medicine, KU Leuven, Campus Gasthuisberg O&N I, Leuven, Belgium, Djalila.mekahli@uzleuven.be.

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