DNA-dependent protein kinase is a context dependent regulator of Lmx1a and midbrain specification.

PubWeight™: 0.75‹?›

🔗 View Article (PMC 3806860)

Published in PLoS One on October 23, 2013

Authors

Cameron P Hunt1, Stewart A Fabb, Colin W Pouton, John M Haynes

Author Affiliations

1: Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University (Parkville), Melbourne, Australia.

Articles cited by this

Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods (2001) 414.27

The ground state of embryonic stem cell self-renewal. Nature (2008) 19.44

Dopamine neurons derived from human ES cells efficiently engraft in animal models of Parkinson's disease. Nature (2011) 7.90

Signalling through the lipid products of phosphoinositide-3-OH kinase. Nature (1997) 7.20

Proneural genes and the specification of neural cell types. Nat Rev Neurosci (2002) 6.79

Small molecule modulation of Smoothened activity. Proc Natl Acad Sci U S A (2002) 6.55

Notch signalling regulates stem cell numbers in vitro and in vivo. Nature (2006) 5.49

Defined conditions for neural commitment and differentiation. Methods Enzymol (2003) 3.99

Notch and EGFR pathway interaction regulates neural stem cell number and self-renewal. Nature (2010) 3.54

Identification of intrinsic determinants of midbrain dopamine neurons. Cell (2006) 3.31

PKBalpha/Akt1 acts downstream of DNA-PK in the DNA double-strand break response and promotes survival. Mol Cell (2008) 3.27

Replication-mediated DNA damage by camptothecin induces phosphorylation of RPA by DNA-dependent protein kinase and dissociates RPA:DNA-PK complexes. EMBO J (1999) 3.13

A discrete period of FGF-induced Erk1/2 signalling is required for vertebrate neural specification. Development (2007) 2.92

The foxa2 gene controls the birth and spontaneous degeneration of dopamine neurons in old age. PLoS Biol (2007) 2.54

ATM activation in normal human tissues and testicular cancer. Cell Cycle (2005) 2.25

Wnt antagonism of Shh facilitates midbrain floor plate neurogenesis. Nat Neurosci (2009) 2.03

Bone morphogenetic protein signalling and vertebrate nervous system development. Nat Rev Neurosci (2005) 1.97

Mammalian target of rapamycin regulates murine and human cell differentiation through STAT3/p63/Jagged/Notch cascade. J Clin Invest (2009) 1.80

The epidermal growth factor receptor: a role in repair of radiation-induced DNA damage. Clin Cancer Res (2007) 1.79

Phospholipase C-gamma as a signal-transducing element. Exp Cell Res (1999) 1.74

Generation of embryonic stem cells and transgenic mice expressing green fluorescence protein in midbrain dopaminergic neurons. Eur J Neurosci (2004) 1.67

Efficient production of mesencephalic dopamine neurons by Lmx1a expression in embryonic stem cells. Proc Natl Acad Sci U S A (2009) 1.57

ATR and H2AX cooperate in maintaining genome stability under replication stress. J Biol Chem (2008) 1.55

Wnt1-lmx1a forms a novel autoregulatory loop and controls midbrain dopaminergic differentiation synergistically with the SHH-FoxA2 pathway. Cell Stem Cell (2009) 1.51

Physical interaction between epidermal growth factor receptor and DNA-dependent protein kinase in mammalian cells. J Biol Chem (1998) 1.48

CSL-MAML-dependent Notch1 signaling controls T lineage-specific IL-7R{alpha} gene expression in early human thymopoiesis and leukemia. J Exp Med (2009) 1.47

The nuclear receptor tailless induces long-term neural stem cell expansion and brain tumor initiation. Genes Dev (2010) 1.45

Small-molecule inhibitors of bone morphogenic protein and activin/nodal signals promote highly efficient neural induction from human pluripotent stem cells. J Neurosci Res (2010) 1.41

Cell type specificity of PI3K signaling in Pdk1- and Pten-deficient brains. Genes Dev (2009) 1.34

Pitx3 regulates tyrosine hydroxylase expression in the substantia nigra and identifies a subgroup of mesencephalic dopaminergic progenitor neurons during mouse development. Dev Biol (2005) 1.25

DNA-PKcs plays a dominant role in the regulation of H2AX phosphorylation in response to DNA damage and cell cycle progression. BMC Mol Biol (2010) 1.19

Retinoic acid orchestrates fibroblast growth factor signalling to drive embryonic stem cell differentiation. Development (2010) 1.15

Specific and integrated roles of Lmx1a, Lmx1b and Phox2a in ventral midbrain development. Development (2011) 1.12

Small molecules in stem cell self-renewal and differentiation. Gene Ther (2007) 1.11

Making a grade: Sonic Hedgehog signalling and the control of neural cell fate. EMBO J (2009) 1.09

Wnt/beta-catenin signaling blockade promotes neuronal induction and dopaminergic differentiation in embryonic stem cells. Stem Cells (2009) 1.08

Interaction of the epidermal growth factor receptor and the DNA-dependent protein kinase pathway following gefitinib treatment. Mol Cancer Ther (2006) 1.08

Identification of transplantable dopamine neuron precursors at different stages of midbrain neurogenesis. Exp Neurol (2009) 1.06

Transcription factor-induced lineage selection of stem-cell-derived neural progenitor cells. Cell Stem Cell (2011) 1.05

Control of roof plate formation by Lmx1a in the developing spinal cord. Development (2004) 1.02

Pax6 defines the di-mesencephalic boundary by repressing En1 and Pax2. Development (2000) 1.01

The transcription factor Lmx1b maintains Wnt1 expression within the isthmic organizer. Development (2000) 1.00

VEGF-expressing human umbilical cord mesenchymal stem cells, an improved therapy strategy for Parkinson's disease. Gene Ther (2010) 0.99

Cdc42-mTOR signaling pathway controls Hes5 and Pax6 expression in retinoic acid-dependent neural differentiation. J Biol Chem (2008) 0.98

Small molecules and future regenerative medicine. Curr Top Med Chem (2005) 0.97

Molecular programming of stem cells into mesodiencephalic dopaminergic neurons. Trends Neurosci (2006) 0.95

Small molecules greatly improve conversion of human-induced pluripotent stem cells to the neuronal lineage. Stem Cells Int (2012) 0.95

Novel indolylmaleimide acts as GSK-3beta inhibitor in human neural progenitor cells. Bioorg Med Chem (2010) 0.94

Expression of the LIM-homeodomain gene Lmx1a (dreher) during development of the mouse nervous system. Mech Dev (2002) 0.93

Vesicular monoamine transporter 2 and dopamine transporter are molecular targets of Pitx3 in the ventral midbrain dopamine neurons. J Neurochem (2009) 0.93

Lmx1a allows context-specific isolation of progenitors of GABAergic or dopaminergic neurons during neural differentiation of embryonic stem cells. Stem Cells (2012) 0.90

In vitro maturation of dopaminergic neurons derived from mouse embryonic stem cells: implications for transplantation. PLoS One (2012) 0.86

Wnt5a-dopamine D2 receptor interactions regulate dopamine neuron development via extracellular signal-regulated kinase (ERK) activation. J Biol Chem (2011) 0.86

Extended periods of neural induction and propagation of embryonic stem cell-derived neural progenitors with EGF and FGF2 enhances Lmx1a expression and neurogenic potential. Neurochem Int (2011) 0.84

The signals of FGFs on the neurogenesis of embryonic stem cells. J Biomed Sci (2010) 0.81

Notch and PI3K: how is the road traveled? Blood (2012) 0.81

Modulation of DNA repair by pharmacological inhibitors of the PIKK protein kinase family. Bioorg Med Chem Lett (2012) 0.81

Spatial and temporal lineage analysis of a Pitx3-driven Cre-recombinase knock-in mouse model. PLoS One (2012) 0.78

Articles by these authors

A microenvironment-induced myeloproliferative syndrome caused by retinoic acid receptor gamma deficiency. Cell (2007) 4.59

NKX2-5(eGFP/w) hESCs for isolation of human cardiac progenitors and cardiomyocytes. Nat Methods (2011) 2.29

Embryonic stem cells as a source of models for drug discovery. Nat Rev Drug Discov (2007) 1.82

RARgamma is critical for maintaining a balance between hematopoietic stem cell self-renewal and differentiation. J Exp Med (2006) 1.72

Enhancing intestinal drug solubilisation using lipid-based delivery systems. Adv Drug Deliv Rev (2007) 1.61

A targeted NKX2.1 human embryonic stem cell reporter line enables identification of human basal forebrain derivatives. Stem Cells (2011) 1.60

Strategies to address low drug solubility in discovery and development. Pharmacol Rev (2013) 1.32

A microtubule-facilitated nuclear import pathway for cancer regulatory proteins. Traffic (2007) 1.22

Dynein light chain association sequences can facilitate nuclear protein import. Mol Biol Cell (2007) 1.08

Pharmaceutical applications of embryonic stem cells. Adv Drug Deliv Rev (2005) 1.03

Overcoming biological barriers to in vivo efficacy of antisense oligonucleotides. Expert Rev Mol Med (2009) 0.99

Evaluation of the impact of surfactant digestion on the bioavailability of danazol after oral administration of lipidic self-emulsifying formulations to dogs. J Pharm Sci (2008) 0.97

Design of lipid-based formulations for oral administration of poorly water-soluble drugs: precipitation of drug after dispersion of formulations in aqueous solution. J Pharm Sci (2009) 0.96

Using polymeric precipitation inhibitors to improve the absorption of poorly water-soluble drugs: A mechanistic basis for utility. J Drug Target (2010) 0.95

Cooperative cardioprotection through adenosine A1 and A2A receptor agonism in ischemia-reperfused isolated mouse heart. J Cardiovasc Pharmacol (2010) 0.93

Protein kinase G II-mediated proliferative effects in human cultured prostatic stromal cells. Cell Signal (2004) 0.92

Increasing the proportional content of surfactant (Cremophor EL) relative to lipid in self-emulsifying lipid-based formulations of danazol reduces oral bioavailability in beagle dogs. Pharm Res (2007) 0.91

Toward the establishment of standardized in vitro tests for lipid-based formulations, part 1: method parameterization and comparison of in vitro digestion profiles across a range of representative formulations. J Pharm Sci (2012) 0.91

Modulation of nucleocytoplasmic trafficking by retention in cytoplasm or nucleus. J Cell Biochem (2009) 0.91

Protein kinase G activation of K(ATP) channels in human-cultured prostatic stromal cells. Cell Signal (2002) 0.91

Mechanism of microtubule-facilitated "fast track" nuclear import. J Biol Chem (2011) 0.91

Lmx1a allows context-specific isolation of progenitors of GABAergic or dopaminergic neurons during neural differentiation of embryonic stem cells. Stem Cells (2012) 0.90

Characterization of forebrain neurons derived from late-onset Huntington's disease human embryonic stem cell lines. Front Cell Neurosci (2013) 0.86

In vitro maturation of dopaminergic neurons derived from mouse embryonic stem cells: implications for transplantation. PLoS One (2012) 0.86

Lipid digestion as a trigger for supersaturation: evaluation of the impact of supersaturation stabilization on the in vitro and in vivo performance of self-emulsifying drug delivery systems. Mol Pharm (2012) 0.85

Toward the establishment of standardized in vitro tests for lipid-based formulations, part 3: understanding supersaturation versus precipitation potential during the in vitro digestion of type I, II, IIIA, IIIB and IV lipid-based formulations. Pharm Res (2013) 0.84

Extended periods of neural induction and propagation of embryonic stem cell-derived neural progenitors with EGF and FGF2 enhances Lmx1a expression and neurogenic potential. Neurochem Int (2011) 0.84

Digestion of phospholipids after secretion of bile into the duodenum changes the phase behavior of bile components. Mol Pharm (2014) 0.84

Toward the establishment of standardized in vitro tests for lipid-based formulations. 2. The effect of bile salt concentration and drug loading on the performance of type I, II, IIIA, IIIB, and IV formulations during in vitro digestion. Mol Pharm (2012) 0.84

Cardioprotection induced by adenosine A1 receptor agonists in a cardiac cell ischemia model involves cooperative activation of adenosine A2A and A2B receptors by endogenous adenosine. J Cardiovasc Pharmacol (2009) 0.83

A novel highly selective adenosine A1 receptor agonist VCP28 reduces ischemia injury in a cardiac cell line and ischemia-reperfusion injury in isolated rat hearts at concentrations that do not affect heart rate. J Cardiovasc Pharmacol (2010) 0.83

Stable micro-dystrophin gene transfer using an integrating adeno-retroviral hybrid vector ameliorates the dystrophic pathology in mdx mouse muscle. Hum Mol Genet (2002) 0.83

Interaction of viruses with host cell molecular motors. Curr Opin Biotechnol (2010) 0.82

Preparation and in vitro evaluation of novel lipopeptide transfection agents for efficient gene delivery. Bioconjug Chem (2008) 0.82

Adenovirus: a blueprint for non-viral gene delivery. Curr Opin Biotechnol (2010) 0.81

Heterogeneous population of dopaminergic neurons derived from mouse embryonic stem cells: preliminary phenotyping based on receptor expression and function. Eur J Neurosci (2007) 0.81

Using molecular dynamics to study liquid phase behavior: simulations of the ternary sodium laurate/sodium oleate/water system. Langmuir (2011) 0.81

The residual nonadrenergic contractile response to nerve stimulation of the mouse prostate is mediated by acetylcholine but not ATP in a comparison with the mouse vas deferens. J Pharmacol Exp Ther (2010) 0.80

Comparison of 5-HT4 and 5-HT7 receptor expression and function in the circular muscle of the human colon. Life Sci (2007) 0.80

In vitro digestion testing of lipid-based delivery systems: calcium ions combine with fatty acids liberated from triglyceride rich lipid solutions to form soaps and reduce the solubilization capacity of colloidal digestion products. Int J Pharm (2012) 0.79

Synthesis and biological evaluation of N-substituted noscapine analogues. ChemMedChem (2012) 0.79

PEGylation does not significantly change the initial intravenous or subcutaneous pharmacokinetics or lymphatic exposure of trastuzumab in rats but increases plasma clearance after subcutaneous administration. Mol Pharm (2015) 0.79

Glyceride lipid formulations: molecular dynamics modeling of phase behavior during dispersion and molecular interactions between drugs and excipients. Pharm Res (2013) 0.79

Structure and dynamics of glyceride lipid formulations, with propylene glycol and water. Mol Pharm (2009) 0.79

Directed expression of Gata2, Mash1, and Foxa2 synergize to induce the serotonergic neuron phenotype during in vitro differentiation of embryonic stem cells. Stem Cells (2011) 0.79

Synthesis and evaluation of new N6-substituted adenosine-5'-N-methylcarboxamides as A3 adenosine receptor agonists. Bioorg Med Chem (2010) 0.78

Toward the establishment of standardized in vitro tests for lipid-based formulations, part 6: effects of varying pancreatin and calcium levels. AAPS J (2014) 0.78

Investigations into the binding affinities of different human 5-HT4 receptor splice variants. Pharmacology (2010) 0.78

Lipid-based formulations and drug supersaturation: harnessing the unique benefits of the lipid digestion/absorption pathway. Pharm Res (2013) 0.78

Phosphorylation of the PKG substrate, vasodilator-stimulated phosphoprotein (VASP), in human cultured prostatic stromal cells. Nitric Oxide (2006) 0.78

Dual acting antioxidant A1 adenosine receptor agonists. Bioorg Med Chem Lett (2007) 0.77

Methotrexate-conjugated PEGylated dendrimers show differential patterns of deposition and activity in tumor-burdened lymph nodes after intravenous and subcutaneous administration in rats. Mol Pharm (2015) 0.77

Enhanced extravasation, stability and in vivo cardiac gene silencing via in situ siRNA-albumin conjugation. Mol Pharm (2011) 0.77

Non-linear increases in danazol exposure with dose in older vs. younger beagle dogs: the potential role of differences in bile salt concentration, thermodynamic activity, and formulation digestion. Pharm Res (2014) 0.77

The synthesis and biological evaluation of multifunctionalised derivatives of noscapine as cytotoxic agents. ChemMedChem (2013) 0.77

In vitro assessment of drug-free and fenofibrate-containing lipid formulations using dispersion and digestion testing gives detailed insights into the likely fate of formulations in the intestine. Eur J Pharm Sci (2013) 0.77

Contractions of the mouse prostate elicited by acetylcholine are mediated by M(3) muscarinic receptors. J Pharmacol Exp Ther (2011) 0.77

A stably engineered, suicidal strain of listeria monocytogenes delivers protein and/or DNA to fully differentiated intestinal epithelial monolayers. Mol Pharm (2009) 0.76

Androgens regulate adenylate cyclase activity and intracellular calcium in stromal cells derived from human prostate. Prostate (2010) 0.76

Commercially Supplied Amine-Modified siRNAs May Require Ultrafiltration prior to Conjugation with Amine-Reactive Compounds. J Nucleic Acids (2011) 0.75

Saw palmetto is an indirectly acting sympathomimetic in the rat-isolated prostate gland. Prostate (2006) 0.75

Computational and experimental models of the gastrointestinal environment 2. Phase behavior and drug solubilisation capacity of a Type I lipid-based drug formulation after digestion. Mol Pharm (2016) 0.75

Toward the establishment of standardized in vitro tests for lipid-based formulations. 5. Lipolysis of representative formulations by gastric lipase. Pharm Res (2014) 0.75

Colloidal characteristics and formulation of pure protein particulate vaccines. J Pharm Pharmacol (2012) 0.75

Troubleshooting immunohistochemical labelling of proliferating cell nuclear antigen (PCNA) in cryocut tissue sections of mouse prostate. J Pharmacol Toxicol Methods (2009) 0.75

Synthesis and biological evaluation of adenosines with heterobicyclic and polycyclic N(6)-substituents as adenosine A(1) receptor agonists. ChemMedChem (2012) 0.75

An in vitro digestion test that reflects rat intestinal conditions to probe the importance of formulation digestion vs first pass metabolism in Danazol bioavailability from lipid based formulations. Mol Pharm (2014) 0.75

Evaluation of the structural determinants of polymeric precipitation inhibitors using solvent shift methods and principle component analysis. Mol Pharm (2013) 0.75

Toward the establishment of standardized in vitro tests for lipid-based formulations, part 4: proposing a new lipid formulation performance classification system. J Pharm Sci (2014) 0.75

Computational Models of the Intestinal Environment. 3. The Impact of Cholesterol Content and pH on Mixed Micelle Colloids. Mol Pharm (2017) 0.75

Choice of nonionic surfactant used to formulate type IIIA self-emulsifying drug delivery systems and the physicochemical properties of the drug have a pronounced influence on the degree of drug supersaturation that develops during in vitro digestion. J Pharm Sci (2014) 0.75

Synthesis and pharmacological evaluation of dual acting antioxidant A(2A) adenosine receptor agonists. J Med Chem (2012) 0.75

Computational models of the gastrointestinal environment 1. The effect of digestion on the phase behaviour of intestinal fluids. Mol Pharm (2017) 0.75