Published in N Engl J Med on November 14, 2013
How frequently do the results from completed US clinical trials enter the public domain?--A statistical analysis of the ClinicalTrials.gov database. PLoS One (2014) 3.87
Assessing value in biomedical research: the PQRST of appraisal and reward. JAMA (2014) 2.45
Likelihood of Null Effects of Large NHLBI Clinical Trials Has Increased over Time. PLoS One (2015) 1.73
Impact of National Heart, Lung, and Blood Institute-Supported Cardiovascular Epidemiology Research, 1998 to 2012. Circulation (2015) 1.42
When it comes to trials, do we get what we pay for? N Engl J Med (2013) 1.34
Publication of trials funded by the National Heart, Lung, and Blood Institute. N Engl J Med (2014) 1.10
Sea change in open science and data sharing: leadership by industry. Circ Cardiovasc Qual Outcomes (2014) 1.05
Terminated Trials in the ClinicalTrials.gov Results Database: Evaluation of Availability of Primary Outcome Data and Reasons for Termination. PLoS One (2015) 1.02
Commentary on Vickers. Clin Trials (2014) 0.96
The Mass Production of Redundant, Misleading, and Conflicted Systematic Reviews and Meta-analyses. Milbank Q (2016) 0.86
Multi-state analysis illustrates treatment success after stem cell transplantation for acute myeloid leukemia followed by donor lymphocyte infusion. Haematologica (2016) 0.85
Systematic review protocol assessing the processes for linking clinical trial registries and their published results. BMJ Open (2016) 0.85
Publication of trials funded by the National Heart, Lung, and Blood Institute. N Engl J Med (2014) 0.83
Registry-Based Pragmatic Trials in Heart Failure: Current Experience and Future Directions. Curr Heart Fail Rep (2017) 0.78
Matching taxpayer funding to population health needs: not so simple. Circ Res (2015) 0.77
Publication Speed, Reporting Metrics, and Citation Impact of Cardiovascular Trials Supported by the National Heart, Lung, and Blood Institute. J Am Heart Assoc (2015) 0.76
The Positive and Negative about Positive Airway Pressure Therapy. Am J Respir Crit Care Med (2016) 0.76
Cross-sectional assessment of patient attitudes towards participation in clinical trials: does making results publicly available matter? BMJ Open (2016) 0.75
Positive Airway Pressure Therapies and Hospitalization in Chronic Obstructive Pulmonary Disease. Am J Med (2017) 0.75
Effect Sizes and Primary Outcomes in Large-Budget, Cardiovascular-Related Behavioral Randomized Controlled Trials Funded by NIH Since 1980. Ann Behav Med (2016) 0.75
Opinion: Celebrating R and D expenditures badly misses the point. Proc Natl Acad Sci U S A (2015) 0.75
Avoiding Pitfalls With Implementation of Randomized Controlled Multicenter Trials: Strategies to Achieve Milestones. J Am Heart Assoc (2016) 0.75
Biases in grant proposal success rates, funding rates and award sizes affect the geographical distribution of funding for biomedical research. PeerJ (2016) 0.75
Efficient design of clinical trials and epidemiological research: is it possible? Nat Rev Cardiol (2017) 0.75
Publication bias in clinical research. Lancet (1991) 22.85
Systematic review of the empirical evidence of study publication bias and outcome reporting bias. PLoS One (2008) 13.32
Effect of the statistical significance of results on the time to completion and publication of randomized efficacy trials. JAMA (1998) 9.91
National use of postmenopausal hormone therapy: annual trends and response to recent evidence. JAMA (2004) 7.68
Publication of NIH funded trials registered in ClinicalTrials.gov: cross sectional analysis. BMJ (2012) 6.39
Publication bias in clinical trials due to statistical significance or direction of trial results. Cochrane Database Syst Rev (2009) 5.57
Assumptions of expected benefits in randomized phase III trials evaluating systemic treatments for cancer. J Natl Cancer Inst (2012) 2.46
Identifying important risk factors for survival in patient with systolic heart failure using random survival forests. Circ Cardiovasc Qual Outcomes (2010) 1.48
On the value of portfolio diversity in heart, lung, and blood research. Circ Res (2012) 1.37
Defining and setting national goals for cardiovascular health promotion and disease reduction: the American Heart Association's strategic Impact Goal through 2020 and beyond. Circulation (2010) 13.28
2010 ACCF/AHA guideline for assessment of cardiovascular risk in asymptomatic adults: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol (2010) 7.54
The prognostic value of a nomogram for exercise capacity in women. N Engl J Med (2005) 5.03
Inflammation as a risk factor for atrial fibrillation. Circulation (2003) 4.95
Mood disorders in the medically ill: scientific review and recommendations. Biol Psychiatry (2005) 4.81
Evidence-based behavioral medicine: what is it and how do we achieve it? Ann Behav Med (2003) 4.68
2010 ACCF/AHA guideline for assessment of cardiovascular risk in asymptomatic adults: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. Circulation (2010) 4.56
Frequent ventricular ectopy after exercise as a predictor of death. N Engl J Med (2003) 3.87
Constrictive pericarditis: etiology and cause-specific survival after pericardiectomy. J Am Coll Cardiol (2004) 3.50
Outcome of patients who refuse transfusion after cardiac surgery: a natural experiment with severe blood conservation. Arch Intern Med (2012) 3.47
Effects of antidepressant medication on morbidity and mortality in depressed patients after myocardial infarction. Arch Gen Psychiatry (2005) 3.41
Global risk scores and exercise testing for predicting all-cause mortality in a preventive medicine program. JAMA (2004) 3.34
Troponin T levels in patients with acute coronary syndromes, with or without renal dysfunction. N Engl J Med (2002) 3.01
The Scientific Foundation for personal genomics: recommendations from a National Institutes of Health-Centers for Disease Control and Prevention multidisciplinary workshop. Genet Med (2009) 2.91
Association of socioeconomic status with functional capacity, heart rate recovery, and all-cause mortality. JAMA (2006) 2.82
Heart rate recovery after exercise is a predictor of mortality, independent of the angiographic severity of coronary disease. J Am Coll Cardiol (2003) 2.76
Transforming epidemiology for 21st century medicine and public health. Cancer Epidemiol Biomarkers Prev (2013) 2.56
Propensity analysis of long-term survival after surgical or percutaneous revascularization in patients with multivessel coronary artery disease and high-risk features. Circulation (2004) 2.54
Mental stress-induced ischemia and all-cause mortality in patients with coronary artery disease: Results from the Psychophysiological Investigations of Myocardial Ischemia study. Circulation (2002) 2.32
Impact of mitral valve annuloplasty combined with revascularization in patients with functional ischemic mitral regurgitation. J Am Coll Cardiol (2007) 2.20
Assessment and treatment of depression in patients with cardiovascular disease: National Heart, Lung, and Blood Institute Working Group Report. Psychosom Med (2006) 1.96
Peak oxygen consumption as a predictor of death in patients with heart failure receiving beta-blockers. Circulation (2005) 1.88
Time for a creative transformation of epidemiology in the United States. JAMA (2012) 1.70
The rudimentary phase of personalised medicine: coronary risk scores. Lancet (2003) 1.65
Survival after aortic valve replacement for severe aortic stenosis with low transvalvular gradients and severe left ventricular dysfunction. J Am Coll Cardiol (2002) 1.64
Impact of blood transfusion on short- and long-term mortality in patients with ST-segment elevation myocardial infarction. JACC Cardiovasc Interv (2009) 1.64
Depression and late mortality after myocardial infarction in the Enhancing Recovery in Coronary Heart Disease (ENRICHD) study. Psychosom Med (2004) 1.64
Importance of treadmill exercise time as an initial prognostic screening tool in patients with systolic left ventricular dysfunction. Circulation (2009) 1.63
ACCF/ACR/AHA/NASCI/SAIP/SCAI/SCCT 2010 expert consensus document on coronary computed tomographic angiography: a report of the American College of Cardiology Foundation Task Force on Expert Consensus Documents. J Am Coll Cardiol (2010) 1.63
Association of exercise capacity on treadmill with future cardiac events in patients referred for exercise testing. Arch Intern Med (2008) 1.62
Myocardial viability testing and the effect of early intervention in patients with advanced left ventricular systolic dysfunction. Circulation (2006) 1.61
On the value of portfolio diversity in heart, lung, and blood research. Am J Respir Crit Care Med (2012) 1.57
Transdisciplinary cardiovascular and cancer health disparities training: experiences of the centers for population health and health disparities. Am J Public Health (2015) 1.54
Midcourse correction to a clinical trial when the event rate is underestimated: the Look AHEAD (Action for Health in Diabetes) Study. Clin Trials (2012) 1.54
Predictors of revascularization method and long-term outcome of percutaneous coronary intervention or repeat coronary bypass surgery in patients with multivessel coronary disease and previous coronary bypass surgery. Eur Heart J (2005) 1.54
Left ventricular hypertrophy: the next treatable, silent killer? JAMA (2004) 1.53
Association of an abnormal exercise heart rate recovery with pulmonary function abnormalities. Chest (2004) 1.52
Heart rate recovery and impact of myocardial revascularization on long-term mortality. Circulation (2004) 1.52
Screening for left ventricular systolic dysfunction among patients with risk factors for heart failure. Am Heart J (2003) 1.50
Comparison of results of carotid stenting followed by open heart surgery versus combined carotid endarterectomy and open heart surgery (coronary bypass with or without another procedure). Am J Cardiol (2005) 1.49
National Heart, Lung, and Blood Institute and the American Recovery and Reinvestment Act of 2009: 1 year later. J Am Coll Cardiol (2010) 1.49
Identifying important risk factors for survival in patient with systolic heart failure using random survival forests. Circ Cardiovasc Qual Outcomes (2010) 1.48
ACCF/ACR/AHA/NASCI/SAIP/SCAI/SCCT 2010 expert consensus document on coronary computed tomographic angiography: a report of the American College of Cardiology Foundation Task Force on Expert Consensus Documents. Circulation (2010) 1.45
Association of fasting plasma glucose with heart rate recovery in healthy adults: a population-based study. Diabetes (2002) 1.42
Severe frequent ventricular ectopy after exercise as a predictor of death in patients with heart failure. J Am Coll Cardiol (2004) 1.42
Should we screen for abdominal aortic aneurysms? Cleve Clin J Med (2006) 1.38
On the value of portfolio diversity in heart, lung, and blood research. Circ Res (2012) 1.37
Prognostic value of normal exercise and adenosine (99m)Tc-tetrofosmin SPECT imaging: results from the multicenter registry of 4,728 patients. J Nucl Med (2003) 1.35
The prognostic value of estimated creatinine clearance alongside functional capacity in ambulatory patients with chronic congestive heart failure. J Am Coll Cardiol (2002) 1.34
Exercise electrocardiogram testing: beyond the ST segment. Circulation (2006) 1.32
Comorbidity of depression with other medical diseases in the elderly. Biol Psychiatry (2002) 1.32
Refocusing the agenda on cardiovascular guidelines: an announcement from the National Heart, Lung, and Blood Institute. J Am Coll Cardiol (2013) 1.32
Usefulness of tissue doppler and color M-mode indexes of left ventricular diastolic function in predicting outcomes in systolic left ventricular heart failure (from the ADEPT study). Am J Cardiol (2005) 1.31
Heart rate recovery following maximal exercise testing as a predictor of cardiovascular disease and all-cause mortality in men with diabetes. Diabetes Care (2003) 1.29
Social Determinants of Risk and Outcomes for Cardiovascular Disease: A Scientific Statement From the American Heart Association. Circulation (2015) 1.25
Report of the National Heart, Lung, and Blood Institute working group on the translation of cardiovascular molecular imaging. Circulation (2011) 1.23
Predictors of mortality in patients with heart failure and preserved systolic function in the Digitalis Investigation Group trial. J Am Coll Cardiol (2004) 1.23
Chronotropic incompetence as a predictor of death among patients with normal electrograms taking beta blockers (metoprolol or atenolol). Am J Cardiol (2005) 1.19
Cardiovascular epidemiology in a changing world--challenges to investigators and the National Heart, Lung, and Blood Institute. Am J Epidemiol (2012) 1.17
In search of fewer independent risk factors. Arch Intern Med (2005) 1.17
In-hospital initiation of lipid-lowering therapy after coronary intervention as a predictor of long-term utilization: a propensity analysis. Arch Intern Med (2003) 1.17
Short- and long-term risk stratification in acute coronary syndromes: the added value of quantitative ST-segment depression and multiple biomarkers. J Am Coll Cardiol (2006) 1.16
Psychosocial treatment within sex by ethnicity subgroups in the Enhancing Recovery in Coronary Heart Disease clinical trial. Psychosom Med (2004) 1.10
Exercise, depression, and mortality after myocardial infarction in the ENRICHD trial. Med Sci Sports Exerc (2004) 1.10
Use of hundreds of electrocardiographic biomarkers for prediction of mortality in postmenopausal women: the Women's Health Initiative. Circ Cardiovasc Qual Outcomes (2011) 1.10
Future directions for cardiovascular disease comparative effectiveness research: report of a workshop sponsored by the National Heart, Lung, and Blood Institute. J Am Coll Cardiol (2012) 1.09
Readability of informed-consent forms. N Engl J Med (2003) 1.07
Mortality outcomes in pediatric rheumatology in the US. Arthritis Rheum (2010) 1.05
In unstable angina or non-ST-segment acute coronary syndrome, should patients with multivessel coronary artery disease undergo multivessel or culprit-only stenting? J Am Coll Cardiol (2007) 1.04
Prognostic importance of presenting symptoms in patients undergoing exercise testing for evaluation of known or suspected coronary disease. Am J Med (2004) 1.03
Invitation to a dialogue between researchers and clinicians about evidence-based behavioral medicine. Ann Behav Med (2005) 1.01
Refocusing the agenda on cardiovascular guidelines: an announcement from the National Heart, Lung, and Blood Institute. Circulation (2013) 1.01
Primary prevention of atherosclerotic cardiovascular disease: the high public burden of low individual risk. JAMA (2007) 0.99
Association of triglyceride-to-HDL cholesterol ratio with heart rate recovery. Diabetes Care (2004) 0.99
Discovery of a 2,4-disubstituted pyrrolo[1,2-f][1,2,4]triazine inhibitor (BMS-754807) of insulin-like growth factor receptor (IGF-1R) kinase in clinical development. J Med Chem (2009) 0.98
CT angiography: first things first. Circ Cardiovasc Imaging (2009) 0.98
COCATS 4 Task Force 15: Training in Cardiovascular Research and Scholarly Activity. J Am Coll Cardiol (2015) 0.97
External prognostic validations and comparisons of age- and gender-adjusted exercise capacity predictions. J Am Coll Cardiol (2007) 0.95
Clinical trials--multiple treatments, multiple end points, and multiple lessons. JAMA (2003) 0.92
Usefulness of plasma brain natriuretic peptide levels in predicting dobutamine-induced myocardial ischemia. Am J Cardiol (2004) 0.92
Recommendations of the National Heart, Lung, and Blood Institute Working Group on Future Direction in Cardiac Surgery. Circulation (2005) 0.92
ACCF/ACR/AHA/NASCI/SAIP/SCAI/SCCT 2010 expert consensus document on coronary computed tomographic angiography: a report of the American College of Cardiology Foundation Task Force on Expert Consensus Documents. Catheter Cardiovasc Interv (2010) 0.92
34th Bethesda Conference: Task force #5--Is atherosclerosis imaging cost effective? J Am Coll Cardiol (2003) 0.91
Value of exercise capacity and heart rate recovery in older people. J Am Geriatr Soc (2003) 0.90
Assessment and treatment of depression in patients with cardiovascular disease: National Heart, Lung, and Blood Institute working group report. Ann Behav Med (2006) 0.90
Long-term prognostic value of peak oxygen consumption in women versus men with heart failure and severely impaired left ventricular systolic function. Am J Cardiol (2007) 0.90
Abnormal heart-rate recovery after exercise. Lancet (2002) 0.88
The cardiovascular programs of the National Heart, Lung, and Blood Institute: from vision to action to impact. J Am Coll Cardiol (2009) 0.86
From hot hands to declining effects: the risks of small numbers. J Am Coll Cardiol (2012) 0.86