Inhibition of keratinocyte proliferation by phospholipid-conjugates of a TLR7 ligand in a Myc-induced hyperplastic actinic keratosis model in the absence of systemic side effects.

PubWeight™: 0.77‹?›

🔗 View Article (PMC 3959874)

Published in Eur J Dermatol on December 02, 2013

Authors

Brian Crain1, Shiyin Yao, Vina Keophilaone, Victor Promessi, McNancy Kang, Alcide Barberis, Roberto Maj, Emanuela Mura, Nadia Passini, Johanna Holldack, Ricardo Ochoa, Howard B Cottam, Dennis A Carson, Tomoko Hayashi

Author Affiliations

1: Moores Cancer Center, University California San Diego, La Jolla CA, USA. 92093-0695.

Articles cited by this

Reversible activation of c-Myc in skin: induction of a complex neoplastic phenotype by a single oncogenic lesion. Mol Cell (1999) 4.38

Imiquimod and the imidazoquinolones: mechanism of action and therapeutic potential. Clin Exp Dermatol (2002) 1.88

TLR7/8-mediated activation of human NK cells results in accessory cell-dependent IFN-gamma production. J Immunol (2005) 1.83

TLR7 and TLR8 as targets in cancer therapy. Oncogene (2008) 1.72

Toll-like receptor expression in human keratinocytes: nuclear factor kappaB controlled gene activation by Staphylococcus aureus is toll-like receptor 2 but not toll-like receptor 4 or platelet activating factor receptor dependent. J Invest Dermatol (2003) 1.69

Activation of anti-hepatitis C virus responses via Toll-like receptor 7. Proc Natl Acad Sci U S A (2006) 1.59

Tissue- and stratum-specific expression of the human involucrin promoter in transgenic mice. Proc Natl Acad Sci U S A (1993) 1.57

Aldara activates TLR7-independent immune defence. Nat Commun (2013) 1.34

Distinct indirect pathways govern human NK-cell activation by TLR-7 and TLR-8 agonists. Int Immunol (2006) 1.31

Toll-like receptors in the skin. Semin Immunopathol (2007) 1.27

Synthesis and immunological characterization of toll-like receptor 7 agonistic conjugates. Bioconjug Chem (2009) 1.20

Synthesis and evaluation of 2-substituted 8-hydroxyadenines as potent interferon inducers with improved oral bioavailabilities. Bioorg Med Chem (2004) 1.13

Beyond a decade of 5% imiquimod topical therapy. J Drugs Dermatol (2009) 1.12

Prevention of autoimmune disease by induction of tolerance to Toll-like receptor 7. Proc Natl Acad Sci U S A (2009) 1.10

The role of toll-like receptors in host defenses and their relevance to dermatologic diseases. Am J Clin Dermatol (2010) 1.06

Mast cell-dependent anorexia and hypothermia induced by mucosal activation of Toll-like receptor 7. Am J Physiol Regul Integr Comp Physiol (2008) 1.02

Natural killer cells in atopic and autoimmune diseases of the skin. J Allergy Clin Immunol (2010) 0.93

Imiquimod 2.5% and 3.75% for the treatment of actinic keratoses: results of two placebo-controlled studies of daily application to the face and balding scalp for two 3-week cycles. J Am Acad Dermatol (2010) 0.92

Topical immunomodulation in dermatology: potential of toll-like receptor agonists. Dermatol Surg (2004) 0.91

MYC gene numerical aberrations in actinic keratosis and cutaneous squamous cell carcinoma. Br J Dermatol (2009) 0.89

A randomized, double-blind, vehicle-controlled study to assess 5% imiquimod cream for the treatment of multiple actinic keratoses. Arch Dermatol (2002) 0.89

Synthesis and characterization of PEGylated toll like receptor 7 ligands. Bioconjug Chem (2011) 0.86

Effect of dosing frequency on the safety and efficacy of imiquimod 5% cream for treatment of actinic keratosis on the forearms and hands: a phase II, randomized placebo-controlled trial. Br J Dermatol (2009) 0.84

Natural killer T cells expressing IFN-gamma and IL-4 in lesional skin of atopic eczema. Allergy (2009) 0.83

Cytokine dermatitis and febrile seizure from imiquimod. Pediatrics (2012) 0.83

Additive melanoma suppression with intralesional phospholipid-conjugated TLR7 agonists and systemic IL-2. Melanoma Res (2011) 0.83

Controlling systems of nucleic acid sensing-TLRs restrict homeostatic inflammation. Exp Cell Res (2012) 0.80

Knock down of p53 levels in human keratinocytes increases susceptibility to type I and type II interferon-induced apoptosis mediated by a TRAIL dependent pathway. J Dermatol Sci (2005) 0.79

Articles by these authors

Toll-like receptor 9 signaling mediates the anti-inflammatory effects of probiotics in murine experimental colitis. Gastroenterology (2004) 6.47

Ephrin-B2 controls VEGF-induced angiogenesis and lymphangiogenesis. Nature (2010) 4.85

Molecular basis for the immunostimulatory activity of guanine nucleoside analogs: activation of Toll-like receptor 7. Proc Natl Acad Sci U S A (2003) 2.91

Activation of the Wnt signaling pathway in chronic lymphocytic leukemia. Proc Natl Acad Sci U S A (2004) 2.60

Retracted Induction of a homeostatic circuit in lung tissue by microbial compounds. Immunity (2006) 2.49

Antisera induced by infusions of autologous Ad-CD154-leukemia B cells identify ROR1 as an oncofetal antigen and receptor for Wnt5a. Proc Natl Acad Sci U S A (2008) 2.41

Bacterial peptidoglycans but not CpG oligodeoxynucleotides activate synovial fibroblasts by toll-like receptor signaling. Arthritis Rheum (2003) 2.21

Immunostimulatory DNA ameliorates experimental and spontaneous murine colitis. Gastroenterology (2002) 2.19

Functional variants within the secreted frizzled-related protein 3 gene are associated with hip osteoarthritis in females. Proc Natl Acad Sci U S A (2004) 2.16

Salinomycin inhibits Wnt signaling and selectively induces apoptosis in chronic lymphocytic leukemia cells. Proc Natl Acad Sci U S A (2011) 2.12

Intravesical Toll-like receptor 7 agonist R-837: optimization of its formulation in an orthotopic mouse model of bladder cancer. Int J Urol (2010) 2.10

Inhibition of experimental asthma by indoleamine 2,3-dioxygenase. J Clin Invest (2004) 1.98

BAFF and APRIL support chronic lymphocytic leukemia B-cell survival through activation of the canonical NF-kappaB pathway. Blood (2006) 1.76

Activation of anti-hepatitis C virus responses via Toll-like receptor 7. Proc Natl Acad Sci U S A (2006) 1.59

Roles of B cells in rheumatoid arthritis. Arthritis Res Ther (2003) 1.57

Pharmacokinetics and toxicity of intravesical TMX-101: a preclinical study in pigs. BJU Int (2011) 1.42

The surface-exposed chaperone, Hsp60, is an agonist of the microglial TREM2 receptor. J Neurochem (2009) 1.38

Identification of soluble TREM-2 in the cerebrospinal fluid and its association with multiple sclerosis and CNS inflammation. Brain (2008) 1.38

Wnt and frizzled receptors as potential targets for immunotherapy in head and neck squamous cell carcinomas. Oncogene (2002) 1.37

Chromatin remodeling by the SWI/SNF-like BAF complex and STAT4 activation synergistically induce IL-12Rbeta2 expression during human Th1 cell differentiation. EMBO J (2007) 1.36

Fibroblast-like synoviocytes of mesenchymal origin express functional B cell-activating factor of the TNF family in response to proinflammatory cytokines. J Immunol (2005) 1.34

Repression of beta-catenin function in malignant cells by nonsteroidal antiinflammatory drugs. Proc Natl Acad Sci U S A (2005) 1.32

DNA looping induced by a transcriptional enhancer in vivo. Nucleic Acids Res (2005) 1.32

IFN-alpha beta promote priming of antigen-specific CD8+ and CD4+ T lymphocytes by immunostimulatory DNA-based vaccines. J Immunol (2002) 1.30

Immunotherapeutic activity of a conjugate of a Toll-like receptor 7 ligand. Proc Natl Acad Sci U S A (2007) 1.28

Direct in vivo screening of intrabody libraries constructed on a highly stable single-chain framework. J Biol Chem (2002) 1.25

Vaccination with irradiated Listeria induces protective T cell immunity. Immunity (2006) 1.23

WISP3-dependent regulation of type II collagen and aggrecan production in chondrocytes. Arthritis Rheum (2004) 1.21

Modulation of the triggering receptor expressed on the myeloid cell type 1 pathway in murine septic shock. Infect Immun (2006) 1.20

Synthesis and immunological characterization of toll-like receptor 7 agonistic conjugates. Bioconjug Chem (2009) 1.20

Ethacrynic acid exhibits selective toxicity to chronic lymphocytic leukemia cells by inhibition of the Wnt/beta-catenin pathway. PLoS One (2009) 1.18

Airway peptidoglycan and immunostimulatory DNA exposures have divergent effects on the development of airway allergen hypersensitivities. J Allergy Clin Immunol (2004) 1.14

Inhibitors of apoptosis in lymphocytes: synthesis and biological evaluation of compounds related to pifithrin-alpha. J Med Chem (2005) 1.14

Amide derivatives of ethacrynic acid: synthesis and evaluation as antagonists of Wnt/beta-catenin signaling and CLL cell survival. Bioorg Med Chem Lett (2008) 1.12

A novel approach for determining cancer genomic breakpoints in the presence of normal DNA. PLoS One (2007) 1.12

Nrf2 responses and the therapeutic selectivity of electrophilic compounds in chronic lymphocytic leukemia. Proc Natl Acad Sci U S A (2010) 1.11

Prevention of autoimmune disease by induction of tolerance to Toll-like receptor 7. Proc Natl Acad Sci U S A (2009) 1.10

Cell-selective inhibition of NF-κB signaling improves therapeutic index in a melanoma chemotherapy model. Cancer Discov (2011) 1.08

A sensitive array-based assay for identifying multiple TMPRSS2:ERG fusion gene variants. Nucleic Acids Res (2008) 1.06

Discovery of cell-permeable non-peptide inhibitors of beta-secretase by high-throughput docking and continuum electrostatics calculations. J Med Chem (2005) 1.05

The marine lipopeptide somocystinamide A triggers apoptosis via caspase 8. Proc Natl Acad Sci U S A (2008) 1.05

Inhibition of HER-kinase activation prevents ERK-mediated degradation of PPARgamma. Cancer Cell (2004) 1.04

Necessity of oligonucleotide aggregation for toll-like receptor 9 activation. J Biol Chem (2004) 1.04

The R-enantiomer of the nonsteroidal antiinflammatory drug etodolac binds retinoid X receptor and induces tumor-selective apoptosis. Proc Natl Acad Sci U S A (2005) 1.03

Immunostimulatory DNA sequences influence the course of adjuvant arthritis. J Immunol (2002) 1.03

Mast cell-dependent anorexia and hypothermia induced by mucosal activation of Toll-like receptor 7. Am J Physiol Regul Integr Comp Physiol (2008) 1.02

Repression of beta-catenin signaling by PPAR gamma ligands. Eur J Pharmacol (2010) 1.01

In silico discovery of beta-secretase inhibitors. J Am Chem Soc (2006) 1.01

Identification of substituted pyrimido[5,4-b]indoles as selective Toll-like receptor 4 ligands. J Med Chem (2013) 0.99

Characterization of N-(adamantan-1-ylmethyl)-5-[(3R-amino-pyrrolidin-1-yl)methyl]-2-chloro-benzamide, a P2X7 antagonist in animal models of pain and inflammation. J Pharmacol Exp Ther (2008) 0.99

Organ polarity in Arabidopsis. NOZZLE physically interacts with members of the YABBY family. Plant Physiol (2004) 0.97

Regulation of fibronectin and metalloproteinase expression by Wnt signaling in rheumatoid arthritis synoviocytes. Arthritis Rheum (2002) 0.95

Antigen-independent selection of intracellular stable antibody frameworks. Methods (2004) 0.94

Calcitriol derivatives with two different side chains at C-20 III. An epimeric pair of the gemini family with unprecedented antiproliferative effects on tumor cells and renin mRNA expression inhibition. J Steroid Biochem Mol Biol (2007) 0.93

Role of IL-1 receptor-associated kinase-M (IRAK-M) in priming of immune and inflammatory responses by nitrogen bisphosphonates. Proc Natl Acad Sci U S A (2011) 0.93

The WNT receptor FZD7 is required for maintenance of the pluripotent state in human embryonic stem cells. Proc Natl Acad Sci U S A (2014) 0.92

Enhancement of the infectivity of SARS-CoV in BALB/c mice by IMP dehydrogenase inhibitors, including ribavirin. Antiviral Res (2006) 0.92

Modulation of cytokine production and enhancement of cell viability by TLR7 and TLR9 ligands during anthrax infection of macrophages. FEMS Immunol Med Microbiol (2006) 0.91

Bacterial sensor triggering receptor expressed on myeloid cells-2 regulates the mucosal inflammatory response. Gastroenterology (2012) 0.90

Apoptosis induced by molecular targeting therapy in hematological malignancies. Acta Haematol (2004) 0.90

Antitumor Efficacy of the Dual PI3K/mTOR Inhibitor PF-04691502 in a Human Xenograft Tumor Model Derived from Colorectal Cancer Stem Cells Harboring a PIK3CA Mutation. PLoS One (2013) 0.89

Analyses of the interaction of WRNIP1 with Werner syndrome protein (WRN) in vitro and in the cell. DNA Repair (Amst) (2006) 0.89

Quinolinium salt as a potent inhibitor of lymphocyte apoptosis. Bioorg Med Chem Lett (2005) 0.88

STP debate on the desirability of an international mechanism for recognizing qualified toxicologic pathologists. Toxicol Pathol (2009) 0.88

NOTCH1 signaling promotes human T-cell acute lymphoblastic leukemia initiating cell regeneration in supportive niches. PLoS One (2012) 0.87

Selection of oligonucleotide aptamers with enhanced uptake and activation of human leukemia B cells. Hum Gene Ther (2003) 0.87

Inhibition of Wnt signaling and cancer stem cells. Oncotarget (2011) 0.87

Assay principle for modulators of protein-protein interactions and its application to non-ATP-competitive ligands targeting protein kinase A. Anal Chem (2006) 0.87

Cell growth selection system to detect extracellular and transmembrane protein interactions. Biochim Biophys Acta (2003) 0.86

Synthesis and characterization of PEGylated toll like receptor 7 ligands. Bioconjug Chem (2011) 0.86

Importance of Toll-like receptor 9 in host defense against M1T1 group A Streptococcus infections. J Innate Immun (2011) 0.86