Toll-like receptor 9 signaling mediates the anti-inflammatory effects of probiotics in murine experimental colitis.

PubWeight™: 6.47‹?› | Rank: Top 1%

🔗 View Article (PMID 14762789)

Published in Gastroenterology on February 01, 2004

Authors

Daniel Rachmilewitz1, Kyoko Katakura, Fanny Karmeli, Tomoko Hayashi, Constantin Reinus, Bernard Rudensky, Shizuo Akira, Kiyoshi Takeda, Jongdae Lee, Kenji Takabayashi, Eyal Raz

Author Affiliations

1: Division of Medicine, Shaare Zedak Medical Center, Jerusalem, Israel.

Associated clinical trials:

VSL#3 Versus Placebo in Maintenance of Remission in Crohn's Disease | NCT00114465

Articles citing this

(truncated to the top 100)

Faecalibacterium prausnitzii is an anti-inflammatory commensal bacterium identified by gut microbiota analysis of Crohn disease patients. Proc Natl Acad Sci U S A (2008) 14.18

Commensal DNA limits regulatory T cell conversion and is a natural adjuvant of intestinal immune responses. Immunity (2008) 5.82

Toll-like receptor signalling in the intestinal epithelium: how bacterial recognition shapes intestinal function. Nat Rev Immunol (2010) 4.07

Immunomodulatory functions of type I interferons. Nat Rev Immunol (2012) 3.73

Toll-like receptor 9-induced type I IFN protects mice from experimental colitis. J Clin Invest (2005) 3.36

Genes and molecules of lactobacilli supporting probiotic action. Microbiol Mol Biol Rev (2008) 3.12

Enhanced antiinflammatory capacity of a Lactobacillus plantarum mutant synthesizing modified teichoic acids. Proc Natl Acad Sci U S A (2005) 2.82

Predominant role of host genetics in controlling the composition of gut microbiota. PLoS One (2008) 2.33

The impact of perinatal immune development on mucosal homeostasis and chronic inflammation. Nat Rev Immunol (2011) 2.29

Bifidobacterium animalis subsp. lactis fermented milk product reduces inflammation by altering a niche for colitogenic microbes. Proc Natl Acad Sci U S A (2010) 2.10

IL-10-dependent partial refractoriness to Toll-like receptor stimulation modulates gut mucosal dendritic cell function. Eur J Immunol (2008) 1.97

Probiotic Escherichia coli Nissle 1917 inhibits leaky gut by enhancing mucosal integrity. PLoS One (2007) 1.86

Bacterial interactions with cells of the intestinal mucosa: Toll-like receptors and NOD2. Gut (2005) 1.84

Reciprocal expression and signaling of TLR4 and TLR9 in the pathogenesis and treatment of necrotizing enterocolitis. J Immunol (2009) 1.83

Recommendations for improved use of the murine TNBS-induced colitis model in evaluating anti-inflammatory properties of lactic acid bacteria: technical and microbiological aspects. Dig Dis Sci (2006) 1.81

Microbes, immunoregulation, and the gut. Gut (2005) 1.80

Toll-like receptors in inflammatory bowel diseases: a decade later. Inflamm Bowel Dis (2010) 1.79

Probiotics and immunity. J Gastroenterol (2009) 1.79

The role of intestinal microbiota in the development and severity of chemotherapy-induced mucositis. PLoS Pathog (2010) 1.77

Flagellin suppresses epithelial apoptosis and limits disease during enteric infection. Am J Pathol (2006) 1.77

Beyond insulin resistance: Innate immunity in nonalcoholic steatohepatitis. Hepatology (2008) 1.76

Abundant and diverse fungal microbiota in the murine intestine. Appl Environ Microbiol (2006) 1.76

Genetic diversity of viable, injured, and dead fecal bacteria assessed by fluorescence-activated cell sorting and 16S rRNA gene analysis. Appl Environ Microbiol (2005) 1.74

The human microbiome and its potential importance to pediatrics. Pediatrics (2012) 1.74

A key role of dendritic cells in probiotic functionality. PLoS One (2007) 1.73

Role of the intestinal barrier in inflammatory bowel disease. World J Gastroenterol (2008) 1.72

Tregs and allergic disease. J Clin Invest (2004) 1.64

Live Lactobacillus rhamnosus [corrected] is essential for the inhibitory effect on tumor necrosis factor alpha-induced interleukin-8 expression. Infect Immun (2004) 1.64

Specific probiotic therapy attenuates antibiotic induced visceral hypersensitivity in mice. Gut (2005) 1.63

Probiotics promote gut health through stimulation of epithelial innate immunity. Proc Natl Acad Sci U S A (2009) 1.61

TLR2-independent induction and regulation of chronic intestinal inflammation. Eur J Immunol (2010) 1.55

Crohn's disease is associated with a toll-like receptor-9 polymorphism. Gastroenterology (2004) 1.55

Oral administration of Parabacteroides distasonis antigens attenuates experimental murine colitis through modulation of immunity and microbiota composition. Clin Exp Immunol (2010) 1.50

Induction of human beta-defensin 2 by the probiotic Escherichia coli Nissle 1917 is mediated through flagellin. Infect Immun (2007) 1.48

Inflammatory bowel disease, past, present and future: lessons from animal models. J Gastroenterol (2008) 1.48

VSL#3 probiotic treatment attenuates fibrosis without changes in steatohepatitis in a diet-induced nonalcoholic steatohepatitis model in mice. Hepatology (2009) 1.47

Necrotizing enterocolitis: a multifactorial disease with no cure. World J Gastroenterol (2008) 1.46

No longer an innocent bystander: epithelial toll-like receptor signaling in the development of mucosal inflammation. Mol Med (2008) 1.46

Differential immunomodulatory properties of Bifidobacterium logum strains: relevance to probiotic selection and clinical applications. Clin Exp Immunol (2007) 1.43

Current and emerging therapeutic targets for IBD. Nat Rev Gastroenterol Hepatol (2017) 1.42

Escherichia coli strain Nissle 1917 ameliorates experimental colitis via toll-like receptor 2- and toll-like receptor 4-dependent pathways. Infect Immun (2006) 1.38

Degranulation of paneth cells via toll-like receptor 9. Am J Pathol (2004) 1.36

Bacterial and fungal microbiota in relation to probiotic therapy (VSL#3) in pouchitis. Gut (2006) 1.36

Probiotics in IBD: mucosal and systemic routes of administration may promote similar effects. Gut (2005) 1.35

Conventional dendritic cells regulate the outcome of colonic inflammation independently of T cells. Proc Natl Acad Sci U S A (2007) 1.35

The role of TLRs, NLRs, and RLRs in mucosal innate immunity and homeostasis. Mucosal Immunol (2009) 1.35

Current concept on the pathogenesis of inflammatory bowel disease-crosstalk between genetic and microbial factors: pathogenic bacteria and altered bacterial sensing or changes in mucosal integrity take "toll" ? World J Gastroenterol (2006) 1.35

Wound healing of intestinal epithelial cells. World J Gastroenterol (2011) 1.35

Impaired enterocyte proliferation in aquaporin-3 deficiency in mouse models of colitis. Gut (2007) 1.33

Expression of Toll-like receptor 9 and response to bacterial CpG oligodeoxynucleotides in human intestinal epithelium. Clin Exp Immunol (2005) 1.32

Synergy between TLR9 and NOD2 innate immune responses is lost in genetic Crohn's disease. Gut (2005) 1.30

Granulocyte macrophage colony-stimulating factor ameliorates DSS-induced experimental colitis. Inflamm Bowel Dis (2008) 1.28

Inhibitory effects of Lactobacillus reuteri on visceral pain induced by colorectal distension in Sprague-Dawley rats. Gut (2005) 1.27

Toll-like receptor 2 signaling protects mice from tumor development in a mouse model of colitis-induced cancer. PLoS One (2010) 1.26

Lactobacillus probiotic protects intestinal epithelium from radiation injury in a TLR-2/cyclo-oxygenase-2-dependent manner. Gut (2011) 1.26

New targets for mucosal healing and therapy in inflammatory bowel diseases. Mucosal Immunol (2013) 1.25

Anti-inflammatory effects of Lactobacillus casei BL23 producing or not a manganese-dependant catalase on DSS-induced colitis in mice. Microb Cell Fact (2007) 1.25

The probiotic Lactobacillus GG may augment intestinal host defense by regulating apoptosis and promoting cytoprotective responses in the developing murine gut. Pediatr Res (2008) 1.22

Induction of IDO-1 by immunostimulatory DNA limits severity of experimental colitis. J Immunol (2010) 1.22

Is Crohn's disease due to defective immunity? Gut (2007) 1.21

Interleukin 1 receptor signaling regulates DUBA expression and facilitates Toll-like receptor 9-driven antiinflammatory cytokine production. J Exp Med (2010) 1.18

Probiotics and prebiotics in inflammatory bowel disease: microflora 'on the scope'. Br J Clin Pharmacol (2008) 1.18

NOD2 regulation of Toll-like receptor responses and the pathogenesis of Crohn's disease. Gut (2005) 1.17

Therapeutic implications of manipulating and mining the microbiota. J Physiol (2009) 1.16

Mechanisms involved in alleviation of intestinal inflammation by bifidobacterium breve soluble factors. PLoS One (2009) 1.15

Escherichia coli Nissle 1917 distinctively modulates T-cell cycling and expansion via toll-like receptor 2 signaling. Infect Immun (2005) 1.15

Innate immunity in inflammatory bowel disease. World J Gastroenterol (2007) 1.13

Helicobacter pylori DNA decreases pro-inflammatory cytokine production by dendritic cells and attenuates dextran sodium sulphate-induced colitis. Gut (2011) 1.12

The immunomodulatory properties of probiotic microorganisms beyond their viability (ghost probiotics: proposal of paraprobiotic concept). Genes Nutr (2011) 1.12

Strain-specific effects of probiotics on gut barrier integrity following hemorrhagic shock. Infect Immun (2005) 1.10

Cathelicidin signaling via the Toll-like receptor protects against colitis in mice. Gastroenterology (2011) 1.09

Bacteria in the intestine, helpful residents or enemies from within? Infect Immun (2008) 1.07

Th17, gut, and HIV: therapeutic implications. Curr Opin HIV AIDS (2010) 1.05

The role of hepatic fat accumulation in pathogenesis of non-alcoholic fatty liver disease (NAFLD). Lipids Health Dis (2010) 1.03

Nonpathogenic Escherichia coli strain Nissle 1917 inhibits signal transduction in intestinal epithelial cells. Infect Immun (2007) 1.02

Influence of dietary components on regulatory T cells. Mol Med (2012) 1.01

Intestinal microbiota in pathophysiology and management of irritable bowel syndrome. World J Gastroenterol (2014) 1.00

TLR9 agonist protects mice from radiation-induced gastrointestinal syndrome. PLoS One (2012) 1.00

The role of pattern recognition receptors in intestinal inflammation. Mucosal Immunol (2013) 1.00

Role of natural killer and dendritic cell crosstalk in immunomodulation by commensal bacteria probiotics. J Biomed Biotechnol (2011) 0.99

Probiotics in inflammatory bowel disease: is it all gut flora modulation? Gut (2004) 0.99

Toll-like receptor and innate cytokine responses induced by lactobacilli colonization and human rotavirus infection in gnotobiotic pigs. Vet Immunol Immunopathol (2008) 0.99

Mechanisms of gut barrier failure in the pathogenesis of necrotizing enterocolitis: Toll-like receptors throw the switch. Semin Pediatr Surg (2013) 0.98

Discussion on toll-like receptor 9 signaling mediates the anti-inflammatory effects of probiotics in murine experimental colitis. Gastroenterology (2004) 0.98

Commensal Escherichia coli reduces epithelial apoptosis through IFN-alphaA-mediated induction of guanylate binding protein-1 in human and murine models of developing intestine. J Immunol (2010) 0.97

Galectin-4 controls intestinal inflammation by selective regulation of peripheral and mucosal T cell apoptosis and cell cycle. PLoS One (2008) 0.97

Bacterial-mucosal interactions in inflammatory bowel disease: an alliance gone bad. Am J Physiol Gastrointest Liver Physiol (2008) 0.96

Probiotics and prebiotics in chronic inflammatory bowel diseases. World J Gastroenterol (2006) 0.96

In vivo CpG DNA/toll-like receptor 9 interaction induces regulatory properties in CD4+CD62L+ T cells which prevent intestinal inflammation in the SCID transfer model of colitis. Gut (2005) 0.96

Gut bacteria in health and disease. Gastroenterol Hepatol (N Y) (2013) 0.95

Fecal Transplants: What Is Being Transferred? PLoS Biol (2016) 0.95

Lactobacillus rhamnosus HN001 decreases the severity of necrotizing enterocolitis in neonatal mice and preterm piglets: evidence in mice for a role of TLR9. Am J Physiol Gastrointest Liver Physiol (2014) 0.94

Eubacterium limosum ameliorates experimental colitis and metabolite of microbe attenuates colonic inflammatory action with increase of mucosal integrity. World J Gastroenterol (2006) 0.94

Campylobacter jejuni disrupts protective Toll-like receptor 9 signaling in colonic epithelial cells and increases the severity of dextran sulfate sodium-induced colitis in mice. Infect Immun (2012) 0.93

Role of probiotics in urogenital healthcare. J Midlife Health (2011) 0.92

Microbe-dendritic cell dialog controls regulatory T-cell fate. Immunol Rev (2010) 0.92

Differential induction of antimicrobial REGIII by the intestinal microbiota and Bifidobacterium breve NCC2950. Appl Environ Microbiol (2013) 0.92

Combined carriership of TLR9-1237C and CD14-260T alleles enhances the risk of developing chronic relapsing pouchitis. World J Gastroenterol (2005) 0.91

Bacillus polyfermenticus ameliorates colonic inflammation by promoting cytoprotective effects in colitic mice. J Nutr (2009) 0.91

Multifunctional role of dextran sulfate sodium for in vivo modeling of intestinal diseases. BMC Immunol (2012) 0.91

Articles by these authors

Toll-like receptor signalling. Nat Rev Immunol (2004) 34.74

The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses. Nat Immunol (2004) 26.12

Toll-like receptors. Annu Rev Immunol (2001) 26.06

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors. Nat Immunol (2010) 24.08

Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses. Nature (2006) 22.65

Pattern recognition receptors and inflammation. Cell (2010) 21.05

Induction of intestinal Th17 cells by segmented filamentous bacteria. Cell (2009) 20.29

Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08

IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction. Nat Immunol (2005) 18.32

Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway. Science (2003) 17.57

Induction of colonic regulatory T cells by indigenous Clostridium species. Science (2010) 16.71

Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA. Science (2004) 16.26

5'-Triphosphate RNA is the ligand for RIG-I. Science (2006) 15.78

Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8. Science (2004) 14.80

Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway. Nat Immunol (2002) 13.10

Toll-like receptors in innate immunity. Int Immunol (2005) 12.24

Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1beta production. Nature (2008) 11.39

Toll-like receptors and their crosstalk with other innate receptors in infection and immunity. Immunity (2011) 11.15

Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin/Nalp3. Nature (2006) 9.77

Innate immune recognition of viral infection. Nat Immunol (2006) 9.59

Lipocalin 2 mediates an innate immune response to bacterial infection by sequestrating iron. Nature (2004) 9.40

Cell type-specific involvement of RIG-I in antiviral response. Immunity (2005) 9.37

Shared and unique functions of the DExD/H-box helicases RIG-I, MDA5, and LGP2 in antiviral innate immunity. J Immunol (2005) 9.17

TLR signaling pathways. Semin Immunol (2004) 9.08

Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid-inducible gene-I and melanoma differentiation-associated gene 5. J Exp Med (2008) 9.00

TRIM25 RING-finger E3 ubiquitin ligase is essential for RIG-I-mediated antiviral activity. Nature (2007) 8.87

TLR signaling. Semin Immunol (2007) 8.16

ATP drives lamina propria T(H)17 cell differentiation. Nature (2008) 8.02

A Toll-like receptor-independent antiviral response induced by double-stranded B-form DNA. Nat Immunol (2005) 7.94

TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-beta. Nat Immunol (2008) 7.87

ER stress triggers apoptosis by activating BH3-only protein Bim. Cell (2007) 7.50

Collaborative induction of inflammatory responses by dectin-1 and Toll-like receptor 2. J Exp Med (2003) 7.38

Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages. Nat Cell Biol (2009) 7.35

Toll-like receptor 9-mediated recognition of Herpes simplex virus-2 by plasmacytoid dendritic cells. J Exp Med (2003) 7.26

Identification of a key pathway required for the sterile inflammatory response triggered by dying cells. Nat Med (2007) 7.25

Distinct RIG-I and MDA5 signaling by RNA viruses in innate immunity. J Virol (2007) 7.18

Sequence-specific potent induction of IFN-alpha by short interfering RNA in plasmacytoid dendritic cells through TLR7. Nat Med (2005) 7.18

Cutting edge: a novel Toll/IL-1 receptor domain-containing adapter that preferentially activates the IFN-beta promoter in the Toll-like receptor signaling. J Immunol (2002) 7.07

Innate immunity to virus infection. Immunol Rev (2009) 7.04

Involvement of linear polyubiquitylation of NEMO in NF-kappaB activation. Nat Cell Biol (2009) 6.62

Signaling to NF-kappaB by Toll-like receptors. Trends Mol Med (2007) 6.52

Targeted disruption of the Chop gene delays endoplasmic reticulum stress-mediated diabetes. J Clin Invest (2002) 6.48

TANK-binding kinase-1 delineates innate and adaptive immune responses to DNA vaccines. Nature (2008) 6.40

Identification of oxidative stress and Toll-like receptor 4 signaling as a key pathway of acute lung injury. Cell (2008) 6.37

Essential function for the kinase TAK1 in innate and adaptive immune responses. Nat Immunol (2005) 6.13

Toll-like receptors on hematopoietic progenitor cells stimulate innate immune system replenishment. Immunity (2006) 5.98

Toll-like receptor and RIG-I-like receptor signaling. Ann N Y Acad Sci (2008) 5.95

Pathogen recognition by the innate immune system. Int Rev Immunol (2011) 5.76

Specificity in Toll-like receptor signalling through distinct effector functions of TRAF3 and TRAF6. Nature (2005) 5.72

Interferon-alpha induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6. Nat Immunol (2004) 5.71

Regulation of innate antiviral defenses through a shared repressor domain in RIG-I and LGP2. Proc Natl Acad Sci U S A (2006) 5.70

Recognition of 5' triphosphate by RIG-I helicase requires short blunt double-stranded RNA as contained in panhandle of negative-strand virus. Immunity (2009) 5.70

Th17 functions as an osteoclastogenic helper T cell subset that links T cell activation and bone destruction. J Exp Med (2006) 5.63

Lack of Toll-like receptor 4 or myeloid differentiation factor 88 reduces atherosclerosis and alters plaque phenotype in mice deficient in apolipoprotein E. Proc Natl Acad Sci U S A (2004) 5.58

TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo. Genes Dev (2005) 5.56

Cutting edge: role of Toll-like receptor 1 in mediating immune response to microbial lipoproteins. J Immunol (2002) 5.48

Essential role of MD-2 in LPS responsiveness and TLR4 distribution. Nat Immunol (2002) 5.41

The roles of TLRs, RLRs and NLRs in pathogen recognition. Int Immunol (2009) 5.21

Regulation of Legionella phagosome maturation and infection through flagellin and host Ipaf. J Biol Chem (2006) 5.11

Regulation of humoral and cellular gut immunity by lamina propria dendritic cells expressing Toll-like receptor 5. Nat Immunol (2008) 5.10

Essential role of IPS-1 in innate immune responses against RNA viruses. J Exp Med (2006) 5.01

TRAM is specifically involved in the Toll-like receptor 4-mediated MyD88-independent signaling pathway. Nat Immunol (2003) 4.94

Nucleic acids of mammalian origin can act as endogenous ligands for Toll-like receptors and may promote systemic lupus erythematosus. J Exp Med (2005) 4.92

Stimulation of the vagus nerve attenuates macrophage activation by activating the Jak2-STAT3 signaling pathway. Nat Immunol (2005) 4.91

RNA-associated autoantigens activate B cells by combined B cell antigen receptor/Toll-like receptor 7 engagement. J Exp Med (2005) 4.85

The RNA helicase Lgp2 inhibits TLR-independent sensing of viral replication by retinoic acid-inducible gene-I. J Immunol (2005) 4.83

Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4. Nature (2002) 4.81

Toll-like receptor 2 controls expansion and function of regulatory T cells. J Clin Invest (2006) 4.72

The Jmjd3-Irf4 axis regulates M2 macrophage polarization and host responses against helminth infection. Nat Immunol (2010) 4.66

TLR9-dependent recognition of MCMV by IPC and DC generates coordinated cytokine responses that activate antiviral NK cell function. Immunity (2004) 4.50

Atg9a controls dsDNA-driven dynamic translocation of STING and the innate immune response. Proc Natl Acad Sci U S A (2009) 4.48

Mitochondrial DNA that escapes from autophagy causes inflammation and heart failure. Nature (2012) 4.46

Dectin-1 is required for host defense against Pneumocystis carinii but not against Candida albicans. Nat Immunol (2006) 4.37

Toll-like receptors and innate immunity. Biochem Biophys Res Commun (2009) 4.26

IL-6 induces an anti-inflammatory response in the absence of SOCS3 in macrophages. Nat Immunol (2003) 4.25

Yellow fever vaccine YF-17D activates multiple dendritic cell subsets via TLR2, 7, 8, and 9 to stimulate polyvalent immunity. J Exp Med (2006) 4.23

Deletion of TLR5 results in spontaneous colitis in mice. J Clin Invest (2007) 4.18

Autophagy in infection, inflammation and immunity. Nat Rev Immunol (2013) 4.16

Detection of pathogenic intestinal bacteria by Toll-like receptor 5 on intestinal CD11c+ lamina propria cells. Nat Immunol (2006) 4.15

The roles of two IkappaB kinase-related kinases in lipopolysaccharide and double stranded RNA signaling and viral infection. J Exp Med (2004) 4.14

Host innate immune receptors and beyond: making sense of microbial infections. Cell Host Microbe (2008) 4.14

Stat3/Socs3 activation by IL-6 transsignaling promotes progression of pancreatic intraepithelial neoplasia and development of pancreatic cancer. Cancer Cell (2011) 4.12

MDA5/RIG-I and virus recognition. Curr Opin Immunol (2008) 4.05

Quantitative proteomics reveals subset-specific viral recognition in dendritic cells. Immunity (2010) 4.03

Key function for the Ubc13 E2 ubiquitin-conjugating enzyme in immune receptor signaling. Nat Immunol (2006) 4.01

Herpes simplex virus type 1 activates murine natural interferon-producing cells through toll-like receptor 9. Blood (2003) 3.98