Obstructive sleep apnea syndrome affects liver histology and inflammatory cell activation in pediatric nonalcoholic fatty liver disease, regardless of obesity/insulin resistance.

PubWeight™: 1.60‹?› | Rank: Top 4%

🔗 View Article (PMID 24256086)

Published in Am J Respir Crit Care Med on January 01, 2014

Authors

Valerio Nobili1, Renato Cutrera, Daniela Liccardo, Martino Pavone, Rita Devito, Valentina Giorgio, Elisabetta Verrillo, Giuseppe Baviera, Giovanni Musso

Author Affiliations

1: 1 HepatoMetabolic Diseases Unit.

Articles citing this

Nonalcoholic fatty liver disease: a comprehensive review of a growing epidemic. World J Gastroenterol (2014) 1.02

Translational approaches to understanding metabolic dysfunction and cardiovascular consequences of obstructive sleep apnea. Am J Physiol Heart Circ Physiol (2015) 0.83

Lysyl Oxidase as a Serum Biomarker of Liver Fibrosis in Patients with Severe Obesity and Obstructive Sleep Apnea. Sleep (2015) 0.81

Clinical advances in pediatric nonalcoholic fatty liver disease. Hepatology (2016) 0.81

The Progression and Natural History of Pediatric Nonalcoholic Fatty Liver Disease. Clin Liver Dis (2015) 0.80

OSAS-related inflammatory mechanisms of liver injury in nonalcoholic fatty liver disease. Mediators Inflamm (2015) 0.78

NASPGHAN Clinical Practice Guideline for the Diagnosis and Treatment of Nonalcoholic Fatty Liver Disease in Children: Recommendations from the Expert Committee on NAFLD (ECON) and the North American Society of Pediatric Gastroenterology, Hepatology and Nutrition (NASPGHAN). J Pediatr Gastroenterol Nutr (2017) 0.78

Update on paediatric obstructive sleep apnoea. J Thorac Dis (2016) 0.77

The Crosstalk between Hypoxia and Innate Immunity in the Development of Obesity-Related Nonalcoholic Fatty Liver Disease. Biomed Res Int (2015) 0.76

Reduction of oxidative stress attenuates lipoapoptosis exacerbated by hypoxia in human hepatocytes. Int J Mol Sci (2015) 0.76

Metabolic complications and obstructive sleep apnea in obese children: time to wake up! Am J Respir Crit Care Med (2014) 0.75

Obstructive Sleep Apnea Is Associated with Liver Damage and Atherosclerosis in Patients with Non-Alcoholic Fatty Liver Disease. PLoS One (2015) 0.75

Hepatocyte Hypoxia Inducible Factor-1 Mediates the Development of Liver Fibrosis in a Mouse Model of Nonalcoholic Fatty Liver Disease. PLoS One (2016) 0.75

Adiponectin protects the rats liver against chronic intermittent hypoxia induced injury through AMP-activated protein kinase pathway. Sci Rep (2016) 0.75

Lysyl Oxidase: Its Diversity in Health and Diseases. Indian J Clin Biochem (2016) 0.75

Tumor necrosis factor alpha is a promising circulating biomarker for the development of obstructive sleep apnea syndrome: a meta-analysis. Oncotarget (2017) 0.75

Nocturnal hypoxia-induced oxidative stress promotes progression of pediatric non-alcoholic fatty liver disease. J Hepatol (2016) 0.75

Pediatric Nonalcoholic Fatty Liver Disease: A Report from the Expert Committee on Nonalcoholic Fatty Liver Disease (ECON). J Pediatr (2016) 0.75

Neglected features of lifestyle: Their relevance in non-alcoholic fatty liver disease. World J Hepatol (2016) 0.75

More Frequent Clinic Visits Are Associated with Improved Outcomes for Children with NAFLD. Can J Gastroenterol Hepatol (2016) 0.75

Articles by these authors

Nonalcoholic steatohepatitis, insulin resistance, and metabolic syndrome: further evidence for an etiologic association. Hepatology (2002) 3.29

NAFLD in children: a prospective clinical-pathological study and effect of lifestyle advice. Hepatology (2006) 2.06

Lifestyle intervention and antioxidant therapy in children with nonalcoholic fatty liver disease: a randomized, controlled trial. Hepatology (2008) 2.02

Negative impact of β-arrestin-1 on post-myocardial infarction heart failure via cardiac and adrenal-dependent neurohormonal mechanisms. Hypertension (2013) 1.83

Ultrasonographic quantitative estimation of hepatic steatosis in children With NAFLD. J Pediatr Gastroenterol Nutr (2011) 1.59

Noninvasive ventilation in children with spinal muscular atrophy types 1 and 2. Am J Phys Med Rehabil (2007) 1.44

Sleep cyclic alternating pattern in normal preschool-aged children. Sleep (2005) 1.24

Costello syndrome: clinical diagnosis in the first year of life. Eur J Pediatr (2007) 1.21

Sleep in children with autistic spectrum disorder: a questionnaire and polysomnographic study. Sleep Med (2007) 1.18

Endotoxin and plasminogen activator inhibitor-1 serum levels associated with nonalcoholic steatohepatitis in children. J Pediatr Gastroenterol Nutr (2010) 1.18

Metformin use in children with nonalcoholic fatty liver disease: an open-label, 24-month, observational pilot study. Clin Ther (2008) 1.11

The mitochondrial permeability transition pore and cyclophilin D in cardioprotection. Biochim Biophys Acta (2011) 1.07

Redox balance in the pathogenesis of nonalcoholic fatty liver disease: mechanisms and therapeutic opportunities. Antioxid Redox Signal (2011) 1.07

Altered microRNA Expression Patterns in Hepatoblastoma Patients. Transl Oncol (2009) 1.07

Sclerotherapy of primary aneurysmal bone cysts: comment to Lambot-Juhan et al. Pediatr Radiol (2012) 1.06

Adrenal GRK2 lowering is an underlying mechanism for the beneficial sympathetic effects of exercise training in heart failure. Am J Physiol Heart Circ Physiol (2010) 1.06

Sonography and clinical outcome of viable hydatid liver cysts treated with double percutaneous aspiration and ethanol injection as first-line therapy: efficacy and long-term follow-up. AJR Am J Roentgenol (2009) 1.05

Polymorphism in microsomal triglyceride transfer protein: a link between liver disease and atherogenic postprandial lipid profile in NASH? Hepatology (2007) 1.04

Non invasive evaluation of liver fibrosis in paediatric patients with nonalcoholic steatohepatitis. World J Gastroenterol (2006) 1.03

Targeting cardiac β-adrenergic signaling via GRK2 inhibition for heart failure therapy. Front Physiol (2013) 1.02

Survival of patients with spinal muscular atrophy type 1. Pediatrics (2013) 1.02

Leptin, free leptin index, insulin resistance and liver fibrosis in children with non-alcoholic fatty liver disease. Eur J Endocrinol (2006) 1.01

Sleep phenotypes of intellectual disability: a polysomnographic evaluation in subjects with Down syndrome and Fragile-X syndrome. Clin Neurophysiol (2008) 1.01

Targeting the β-adrenergic receptor system through G-protein-coupled receptor kinase 2: a new paradigm for therapy and prognostic evaluation in heart failure: from bench to bedside. Circ Heart Fail (2012) 1.01

Treatment of Wilson's disease with zinc from the time of diagnosis in pediatric patients: a single-hospital, 10-year follow-up study. J Lab Clin Med (2005) 1.00

Vitamin D levels and liver histological alterations in children with nonalcoholic fatty liver disease. Eur J Endocrinol (2014) 0.97

Respiratory complex I is essential to induce a Warburg profile in mitochondria-defective tumor cells. Cancer Metab (2013) 0.96

Effects of montelukast treatment and withdrawal on fractional exhaled nitric oxide and lung function in children with asthma. Chest (2007) 0.96

GRK2 blockade with βARKct is essential for cardiac β2-adrenergic receptor signaling towards increased contractility. Cell Commun Signal (2013) 0.95

Noninvasive assessment of liver disease severity with liver fat score and CK-18 in NAFLD: Prognostic value of liver fat equation goes beyond hepatic fat estimation. Hepatology (2010) 0.93

Usefulness of a program of hospital-supervised physical training in patients with cystic fibrosis. Pediatr Pulmonol (2004) 0.92

Prognostic implications for insulin-sensitive and insulin-resistant normal-weight and obese individuals from a population-based cohort. Am J Clin Nutr (2012) 0.92

Water-immersion technique during standard upper endoscopy may be useful to drive the biopsy sampling of duodenal mucosa in children with celiac disease. J Pediatr Gastroenterol Nutr (2009) 0.92

A child with painful legs. Lancet (2005) 0.92

Sleep breathing and periodic leg movement pattern in Angelman Syndrome: a polysomnographic study. Clin Neurophysiol (2005) 0.90

A polymorphism in the macrophage migration inhibitory factor promoter is associated with bronchopulmonary dysplasia. Pediatr Res (2011) 0.90

Association of serum interleukin-8 levels with the degree of fibrosis in infants with chronic liver disease. J Pediatr Gastroenterol Nutr (2004) 0.89

Vascular endothelial growth factor blockade prevents the beneficial effects of β-blocker therapy on cardiac function, angiogenesis, and remodeling in heart failure. Circ Heart Fail (2013) 0.89

Radiofrequency thermoablation in chest wall mesenchymal hamartoma of an infant. Ann Thorac Surg (2007) 0.88

Remission of infantile generalized myofibromatosis after interferon alpha therapy. J Pediatr Hematol Oncol (2008) 0.88

Percutaneous treatment of Hydatid Liver Cyst. Recent Pat Antiinfect Drug Discov (2009) 0.87

Severe liver disease in early childhood due to fibrinogen storage and de novo gamma375Arg-->Trp gene mutation. J Pediatr (2006) 0.87

Celiac disease: what's new about it? Dig Dis (2008) 0.87

Comparison of horse and rabbit antithymocyte globulin in immunosuppressive therapy for refractory cytopenia of childhood. Haematologica (2013) 0.87

Sleep cyclic alternating pattern in normal school-age children. Clin Neurophysiol (2002) 0.87

Pleuropulmonary blastoma, a distinctive neoplasm of childhood: report of three cases. Pediatr Radiol (2007) 0.87

Wolman disease and cholesteryl ester storage disease diagnosed by histological and ultrastructural examination of intestinal and liver biopsy. Pathol Res Pract (2004) 0.86

Sleep polygraphy in Angelman syndrome. Clin Neurophysiol (2004) 0.86

Functional and stoichiometric analysis of subunit e in bovine heart mitochondrial F(0)F(1)ATP synthase. J Bioenerg Biomembr (2008) 0.86

Reduction of lymphocyte G protein-coupled receptor kinase-2 (GRK2) after exercise training predicts survival in patients with heart failure. Eur J Prev Cardiol (2013) 0.86

Pulmonary blastomas of childhood: histologic, immunohistochemical, ultrastructural aspects and therapeutic considerations. Ultrastruct Pathol (2005) 0.86

Contrast-enhanced sonography in the characterization of small hepatocellular carcinomas in cirrhotic patients: comparison with contrast-enhanced ultrafast magnetic resonance imaging. Anticancer Res (2008) 0.85

Diagnostic accuracy of adipose insulin resistance index and visceral adiposity index for progressive liver histology and cardiovascular risk in nonalcoholic fatty liver disease. Hepatology (2012) 0.85

Horseshoe lung associated with unique left pulmonary vein: an unreported association. Pediatr Cardiol (2010) 0.85

Different mtDNA mutations modify tumor progression in dependence of the degree of respiratory complex I impairment. Hum Mol Genet (2013) 0.85

Transcription factor 7-like 2 (TCF7L2) polymorphism and hyperglycemia in an adult Italian population-based cohort. Diabetes Care (2010) 0.84

Influence of dietary pattern, physical activity, and I148M PNPLA3 on steatosis severity in at-risk adolescents. Genes Nutr (2014) 0.84

Hepatocellular carcinoma with cirrhosis: are patients with neoplastic main portal vein invasion eligible for percutaneous radiofrequency ablation of both the nodule and the portal venous tumor thrombus? AJR Am J Roentgenol (2009) 0.83

Oral food challenge: safety, adherence to guidelines and predictive value of skin prick testing. Pediatr Allergy Immunol (2012) 0.83

β-adrenergic receptors and G protein-coupled receptor kinase-2 in Alzheimer's disease: a new paradigm for prognosis and therapy? J Alzheimers Dis (2013) 0.83

Ultrastructural characterization of genetic diffuse lung diseases in infants and children: a cohort study and review. Ultrastruct Pathol (2013) 0.83

β1-adrenergic receptor and sphingosine-1-phosphate receptor 1 (S1PR1) reciprocal downregulation influences cardiac hypertrophic response and progression to heart failure: protective role of S1PR1 cardiac gene therapy. Circulation (2013) 0.83

Late diagnosis of double aortic arch: consequences on long-term follow-up. Pediatr Pulmonol (2013) 0.82

Molecular aspects of the cardioprotective effect of exercise in the elderly. Aging Clin Exp Res (2013) 0.82

Isolated contact urticaria caused by immunoglobulin E-mediated fish allergy. Isr Med Assoc J (2012) 0.82

Early interplay of intra-hepatic iron and insulin resistance in children with non-alcoholic fatty liver disease. J Hepatol (2010) 0.81

Prader-Willi syndrome: sorting out the relationships between obesity, hypersomnia, and sleep apnea. Curr Opin Pulm Med (2010) 0.81

Protein glutathionylation increases in the liver of patients with non-alcoholic fatty liver disease. J Gastroenterol Hepatol (2007) 0.81

Percutaneous treatment of hydatid liver cysts: an update. Recent Pat Antiinfect Drug Discov (2012) 0.81

Leukotriene synthesis during respiratory syncytial virus bronchiolitis: influence of age and atopy. Pediatr Pulmonol (2005) 0.81

Diagnostic role of US for biliary atresia. Radiology (2008) 0.81

Non-alcoholic fatty liver and metabolic syndrome in children: a vicious circle. Horm Res Paediatr (2014) 0.80

Prothymosin alpha protects cardiomyocytes against ischemia-induced apoptosis via preservation of Akt activation. Apoptosis (2013) 0.80

Respiratory insufficiency in a newborn with congenital hypothyroidism due to a new mutation of TTF-1/NKX2.1 gene. Pediatr Pulmonol (2013) 0.80

Type 1 autoimmune hepatitis and adipokines: new markers for activity and disease progression? J Gastroenterol (2009) 0.80

Autoimmune hepatitis type 1 after Epstein-Barr virus infection. Pediatr Infect Dis J (2003) 0.80

Probiotics, prebiotics, energy balance, and obesity: mechanistic insights and therapeutic implications. Gastroenterol Clin North Am (2012) 0.79

Sleep characteristics in children with growth hormone deficiency. Neuroendocrinology (2011) 0.79

Association between postprandial LDL conjugated dienes and the severity of liver fibrosis in NASH. Hepatology (2006) 0.79

Macrophages and fibrosis in adipose tissue are linked to liver damage and metabolic risk in obese children. Obesity (Silver Spring) (2014) 0.79

Polythelia: still a marker of urinary tract anomalies in children? Scand J Urol Nephrol (2009) 0.79

Night-to-night consistency of at-home nocturnal pulse oximetry testing for obstructive sleep apnea in children. Pediatr Pulmonol (2013) 0.79

Clinical value of immunoglobulin A antitransglutaminase assay in the diagnosis of celiac disease. Pediatrics (2006) 0.78

Encephalocraniocutaneous lipomatosis (ECCL): neuroradiological findings in three patients and a new association with fibrous dysplasia. Am J Med Genet A (2011) 0.78

The Finnish Diabetes Risk Score (FINDRISC) and other non-invasive scores for screening of hepatic steatosis and associated cardiometabolic risk. Ann Med (2011) 0.78

Pigmented villonodular synovitis in a patient with Noonan syndrome and SOS1 gene mutation. Am J Med Genet A (2008) 0.78

Association between mannose-binding lectin gene polymorphisms and necrotizing enterocolitis in preterm infants. J Pediatr Gastroenterol Nutr (2012) 0.78

Radiofrequency ablation for intrahepatic cholangiocarcinoma: retrospective analysis of a single centre experience. Anticancer Res (2011) 0.78

Characterization of dysplastic nodules, early hepatocellular carcinoma and progressed hepatocellular carcinoma in cirrhosis with contrast-enhanced ultrasound. Anticancer Res (2011) 0.78

Adenotonsillectomy for obstructive sleep apnea in children with Prader-Willi syndrome. Pediatr Pulmonol (2006) 0.77

Early Glucose Derangement Detected by Continuous Glucose Monitoring and Progression of Liver Fibrosis in Nonalcoholic Fatty Liver Disease: An Independent Predictive Factor? Horm Res Paediatr (2015) 0.77

Misdiagnosis of intrahepatic cholangiocarcinoma in cirrhosis at contrast-enhanced ultrasound: a real new clinical entity or just an exaggerated fear? Liver Int (2013) 0.77

Analysis of NREM sleep in children with Prader-Willi syndrome and the effect of growth hormone treatment. Sleep Med (2008) 0.77

Mechanical determinants of early acute ventilatory failure in COPD patients: a physiologic study. Intensive Care Med (2008) 0.77

Hepatic fibrosis in Kabuki syndrome. Am J Med Genet A (2004) 0.77

L -5-Hydroxytryptophan treatment of sleep terrors in children. Eur J Pediatr (2004) 0.77