One-step generation of different immunodeficient mice with multiple gene modifications by CRISPR/Cas9 mediated genome engineering.

A co-CRISPR strategy for efficient genome editing in Caenorhabditis elegans. Genetics (2014) 1.60

sgRNAcas9: a software package for designing CRISPR sgRNA and evaluating potential off-target cleavage sites. PLoS One (2014) 1.54

Efficient chromosomal gene modification with CRISPR/cas9 and PCR-based homologous recombination donors in cultured Drosophila cells. Nucleic Acids Res (2014) 1.23

Efficient in vivo deletion of a large imprinted lncRNA by CRISPR/Cas9. RNA Biol (2014) 1.16

Dual sgRNA-directed gene knockout using CRISPR/Cas9 technology in Caenorhabditis elegans. Sci Rep (2014) 1.12

An efficient genotyping method for genome-modified animals and human cells generated with CRISPR/Cas9 system. Sci Rep (2014) 1.02

Mouse genome engineering via CRISPR-Cas9 for study of immune function. Immunity (2015) 1.02

Quantitative evaluation of the immunodeficiency of a mouse strain by tumor engraftments. J Hematol Oncol (2015) 0.95

One-step generation of phenotype-expressing triple-knockout mice with heritable mutated alleles by the CRISPR/Cas9 system. J Reprod Dev (2014) 0.92

Efficient Generation of Myostatin Mutations in Pigs Using the CRISPR/Cas9 System. Sci Rep (2015) 0.90

Detailed phenotypic and molecular analyses of genetically modified mice generated by CRISPR-Cas9-mediated editing. PLoS One (2015) 0.89

BTG4 is a meiotic cell cycle-coupled maternal-zygotic-transition licensing factor in oocytes. Nat Struct Mol Biol (2016) 0.89

Asymmetric parental genome engineering by Cas9 during mouse meiotic exit. Sci Rep (2014) 0.86

Mouse Genome Editing Using the CRISPR/Cas System. Curr Protoc Hum Genet (2014) 0.84

Using CRISPR/Cas to study gene function and model disease in vivo. FEBS J (2016) 0.82

Synthetic biology and therapeutic strategies for the degenerating brain: Synthetic biology approaches can transform classical cell and gene therapies, to provide new cures for neurodegenerative diseases. Bioessays (2014) 0.80

CRISPR/Cas9-mediated gene editing in human zygotes using Cas9 protein. Mol Genet Genomics (2017) 0.79

ASXL1 mutation correction by CRISPR/Cas9 restores gene function in leukemia cells and increases survival in mouse xenografts. Oncotarget (2015) 0.78

iPSC-based drug screening for Huntington׳s disease. Brain Res (2015) 0.77

Survival and Evolution of CRISPR-Cas System in Prokaryotes and Its Applications. Front Immunol (2016) 0.75

Efficient generation of FVII gene knockout mice using CRISPR/Cas9 nuclease and truncated guided RNAs. Sci Rep (2016) 0.75

From hacking the human genome to editing organs. Organogenesis (2015) 0.75

Leveraging premalignant biology for immune-based cancer prevention. Proc Natl Acad Sci U S A (2016) 0.75

Generation of VDR Knock-Out Mice via Zygote Injection of CRISPR/Cas9 System. PLoS One (2016) 0.75

CRISPR/Cas9-mediated somatic and germline gene correction to restore hemostasis in hemophilia B mice. Hum Genet (2017) 0.75

Mitochondrial complex I deficiency leads to the retardation of early embryonic development in Ndufs4 knockout mice. PeerJ (2017) 0.75

Generation of gene-modified cynomolgus monkey via Cas9/RNA-mediated gene targeting in one-cell embryos. Cell (2014) 6.11

Efficient generation of gene-modified pigs via injection of zygote with Cas9/sgRNA. Sci Rep (2015) 1.07

CRISPR-Cas9 mediated efficient PD-1 disruption on human primary T cells from cancer patients. Sci Rep (2016) 0.93