Published in Nucleic Acids Res on April 19, 2014
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Improving CRISPR-Cas nuclease specificity using truncated guide RNAs. Nat Biotechnol (2014) 6.85
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Generation of gene-modified cynomolgus monkey via Cas9/RNA-mediated gene targeting in one-cell embryos. Cell (2014) 6.11
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Dynamic imaging of genomic loci in living human cells by an optimized CRISPR/Cas system. Cell (2013) 5.40
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Structures of Cas9 endonucleases reveal RNA-mediated conformational activation. Science (2014) 5.13
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Efficient multiplex biallelic zebrafish genome editing using a CRISPR nuclease system. Proc Natl Acad Sci U S A (2013) 4.57
CRISPR/Cas9 systems targeting β-globin and CCR5 genes have substantial off-target activity. Nucleic Acids Res (2013) 4.11
Multiplex and homologous recombination-mediated genome editing in Arabidopsis and Nicotiana benthamiana using guide RNA and Cas9. Nat Biotechnol (2013) 3.84
Efficient gene targeting in Drosophila by direct embryo injection with zinc-finger nucleases. Proc Natl Acad Sci U S A (2008) 3.70
Engineering the Caenorhabditis elegans genome using Cas9-triggered homologous recombination. Nat Methods (2013) 3.59
Efficient genome engineering in human pluripotent stem cells using Cas9 from Neisseria meningitidis. Proc Natl Acad Sci U S A (2013) 3.53
Programmable repression and activation of bacterial gene expression using an engineered CRISPR-Cas system. Nucleic Acids Res (2013) 3.51
Multiplexed activation of endogenous genes by CRISPR-on, an RNA-guided transcriptional activator system. Cell Res (2013) 3.50
Targeted mutagenesis in the model plant Nicotiana benthamiana using Cas9 RNA-guided endonuclease. Nat Biotechnol (2013) 3.20
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Highly specific and efficient CRISPR/Cas9-catalyzed homology-directed repair in Drosophila. Genetics (2014) 3.07
Demonstration of CRISPR/Cas9/sgRNA-mediated targeted gene modification in Arabidopsis, tobacco, sorghum and rice. Nucleic Acids Res (2013) 2.99
Highly efficient genome modifications mediated by CRISPR/Cas9 in Drosophila. Genetics (2013) 2.87
Heritable and precise zebrafish genome editing using a CRISPR-Cas system. PLoS One (2013) 2.74
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Highly efficient CRISPR/Cas9-mediated knock-in in zebrafish by homology-independent DNA repair. Genome Res (2013) 2.60
Highly improved gene targeting by germline-specific Cas9 expression in Drosophila. Genetics (2013) 2.50
Heritable gene knockout in Caenorhabditis elegans by direct injection of Cas9-sgRNA ribonucleoproteins. Genetics (2013) 2.44
Generation of mutant mice by pronuclear injection of circular plasmid expressing Cas9 and single guided RNA. Sci Rep (2013) 2.41
Highly efficient gene knockout in mice and zebrafish with RNA-guided endonucleases. Genome Res (2013) 2.28
Genetic analysis of zinc-finger nuclease-induced gene targeting in Drosophila. Genetics (2009) 2.27
RNA-guided genome editing in plants using a CRISPR-Cas system. Mol Plant (2013) 2.25
Precise and heritable genome editing in evolutionarily diverse nematodes using TALENs and CRISPR/Cas9 to engineer insertions and deletions. Genetics (2013) 2.22
Efficient nonmeiotic allele introgression in livestock using custom endonucleases. Proc Natl Acad Sci U S A (2013) 2.22
Efficient CRISPR/Cas9 genome editing with low off-target effects in zebrafish. Development (2013) 2.22
Optimized gene editing technology for Drosophila melanogaster using germ line-specific Cas9. Proc Natl Acad Sci U S A (2013) 2.13
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Synthesis-dependent microhomology-mediated end joining accounts for multiple types of repair junctions. Nucleic Acids Res (2010) 1.89
Simple and efficient CRISPR/Cas9-mediated targeted mutagenesis in Xenopus tropicalis. Genesis (2013) 1.84
Efficient generation of large-scale genome-modified mice using gRNA and CAS9 endonuclease. Nucleic Acids Res (2013) 1.83
CRISPR/Cas9-targeted mutagenesis in Caenorhabditis elegans. Genetics (2013) 1.79
Heritable custom genomic modifications in Caenorhabditis elegans via a CRISPR-Cas9 system. Genetics (2013) 1.72
Bidirectional resection of DNA double-strand breaks by Mre11 and Exo1. Nature (2011) 1.69
Targeted heritable mutation and gene conversion by Cas9-CRISPR in Caenorhabditis elegans. Genetics (2013) 1.69
End-joining repair of double-strand breaks in Drosophila melanogaster is largely DNA ligase IV independent. Genetics (2004) 1.68
RNA-guided genome editing for target gene mutations in wheat. G3 (Bethesda) (2013) 1.64
Dual roles for DNA polymerase theta in alternative end-joining repair of double-strand breaks in Drosophila. PLoS Genet (2010) 1.55
Accelerated homologous recombination and subsequent genome modification in Drosophila. Development (2013) 1.55
Endo-siRNAs depend on a new isoform of loquacious and target artificially introduced, high-copy sequences. EMBO J (2009) 1.49
Efficient genome editing in Caenorhabditis elegans by CRISPR-targeted homologous recombination. Nucleic Acids Res (2013) 1.49
A simplified and efficient germline-specific CRISPR/Cas9 system for Drosophila genomic engineering. Fly (Austin) (2013) 1.44
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Effective gene targeting in rabbits using RNA-guided Cas9 nucleases. J Mol Cell Biol (2014) 1.41
Efficient genetic method for establishing Drosophila cell lines unlocks the potential to create lines of specific genotypes. PLoS Genet (2008) 1.30
A small RNA response at DNA ends in Drosophila. Nucleic Acids Res (2012) 1.25
One-step generation of different immunodeficient mice with multiple gene modifications by CRISPR/Cas9 mediated genome engineering. Int J Biochem Cell Biol (2013) 1.24
Loqs-PD and R2D2 define independent pathways for RISC generation in Drosophila. Nucleic Acids Res (2011) 1.19
Targeted genome engineering techniques in Drosophila. Methods (2014) 1.09
Heritable gene-targeting with gRNA/Cas9 in rats. Cell Res (2013) 1.06
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Development of the Twin-Strep-tag® and its application for purification of recombinant proteins from cell culture supernatants. Protein Expr Purif (2013) 0.93
Systematic screening of a Drosophila ORF library in vivo uncovers Wnt/Wg pathway components. Dev Cell (2013) 0.92
The retrohoming of linear group II intron RNAs in Drosophila melanogaster occurs by both DNA ligase 4-dependent and -independent mechanisms. PLoS Genet (2012) 0.89
Monitoring miRNA-mediated silencing in Drosophila melanogaster S2-cells. Biochim Biophys Acta (2008) 0.89
Loss of the bloom syndrome helicase increases DNA ligase 4-independent genome rearrangements and tumorigenesis in aging Drosophila. Genome Biol (2011) 0.83
CRISPR/Cas-induced double-strand breaks boost the frequency of gene replacements for humanizing the mouse Cnr2 gene. Biochem Biophys Res Commun (2013) 0.81