Prognostic implication of HSPA (HSP70) in breast cancer patients treated with neoadjuvant anthracycline-based chemotherapy.

PubWeight™: 0.77‹?›

🔗 View Article (PMC 4041939)

Published in Cell Stress Chaperones on December 05, 2013

Authors

Silvina B Nadin1, Mayra L Sottile, Maria M Montt-Guevara, Gisel V Gauna, Pedro Daguerre, Marcela Leuzzi, Francisco E Gago, Jorge Ibarra, F Darío Cuello-Carrión, Daniel R Ciocca, Laura M Vargas-Roig

Author Affiliations

1: Tumor Biology Laboratory, Institute of Medicine and Experimental Biology of Cuyo, National Scientific and Technical Research Council, Mendoza, Argentina, snadin@mendoza-conicet.gob.ar.

Articles cited by this

Type, density, and location of immune cells within human colorectal tumors predict clinical outcome. Science (2006) 24.54

The heat-shock proteins. Annu Rev Genet (1988) 22.28

Tolerance, danger, and the extended family. Annu Rev Immunol (1994) 14.94

Toll-like receptor 4-dependent contribution of the immune system to anticancer chemotherapy and radiotherapy. Nat Med (2007) 13.90

Calreticulin exposure dictates the immunogenicity of cancer cell death. Nat Med (2006) 10.54

Anthracyclines: molecular advances and pharmacologic developments in antitumor activity and cardiotoxicity. Pharmacol Rev (2004) 9.28

Tumor-associated lymphocytes as an independent predictor of response to neoadjuvant chemotherapy in breast cancer. J Clin Oncol (2009) 7.21

Immunological aspects of cancer chemotherapy. Nat Rev Immunol (2008) 6.61

Tumor-infiltrating CD8+ lymphocytes predict clinical outcome in breast cancer. J Clin Oncol (2011) 6.13

The humoral immune system has a key prognostic impact in node-negative breast cancer. Cancer Res (2008) 5.69

Heat shock proteins in cancer: diagnostic, prognostic, predictive, and treatment implications. Cell Stress Chaperones (2005) 5.22

Guidelines for the nomenclature of the human heat shock proteins. Cell Stress Chaperones (2008) 4.30

Heat shock proteins in cancer: chaperones of tumorigenesis. Trends Biochem Sci (2006) 4.04

Immunogenic cell death and DAMPs in cancer therapy. Nat Rev Cancer (2012) 3.76

Heat shock proteins 27 and 70: anti-apoptotic proteins with tumorigenic properties. Cell Cycle (2006) 3.21

Mechanisms of pre-apoptotic calreticulin exposure in immunogenic cell death. EMBO J (2009) 2.72

Sequential or alternating doxorubicin and CMF regimens in breast cancer with more than three positive nodes. Ten-year results. JAMA (1995) 2.44

Defining the critical hurdles in cancer immunotherapy. J Transl Med (2011) 2.32

The effects of deregulated DNA damage signalling on cancer chemotherapy response and resistance. Nat Rev Cancer (2012) 2.20

CD8+ lymphocyte infiltration is an independent favorable prognostic indicator in basal-like breast cancer. Breast Cancer Res (2012) 2.11

Heat shock proteins and heat shock factor 1 in carcinogenesis and tumor development: an update. Arch Toxicol (2012) 2.04

GRP78 as a novel predictor of responsiveness to chemotherapy in breast cancer. Cancer Res (2006) 1.96

Heat shock protein expression and drug resistance in breast cancer patients treated with induction chemotherapy. Int J Cancer (1998) 1.94

Mechanisms and strategies to overcome chemotherapy resistance in metastatic breast cancer. Cancer Treat Rev (2008) 1.82

Quercetin, a potent inhibitor against beta-catenin/Tcf signaling in SW480 colon cancer cells. Biochem Biophys Res Commun (2005) 1.78

Molecular interactions between dying tumor cells and the innate immune system determine the efficacy of conventional anticancer therapies. Cancer Res (2008) 1.69

Induction of heat shock proteins by heregulin beta1 leads to protection from apoptosis and anchorage-independent growth. Oncogene (2005) 1.64

The small heat shock protein hsp27 is correlated with growth and drug resistance in human breast cancer cell lines. Cancer Res (1993) 1.54

Heat shock proteins in oncology: diagnostic biomarkers or therapeutic targets? Biochim Biophys Acta (2011) 1.48

Inhibition of HSP70: a challenging anti-cancer strategy. Cancer Lett (2012) 1.47

Over-expression of hsp70 confers tumorigenicity to mouse fibrosarcoma cells. Int J Cancer (1995) 1.41

Protein misassembly: macromolecular crowding and molecular chaperones. Adv Exp Med Biol (2007) 1.35

Response of human breast cancer cells to heat shock and chemotherapeutic drugs. Cancer Res (1992) 1.30

Heat shock protein 27 enhances the tumorigenicity of immunogenic rat colon carcinoma cell clones. Cancer Res (1998) 1.25

Tumor-infiltrating lymphocytes are important pathologic predictors for neoadjuvant chemotherapy in patients with breast cancer. Hum Pathol (2012) 1.22

Hsp27 overexpression inhibits doxorubicin-induced apoptosis in human breast cancer cells. Breast Cancer Res Treat (1999) 1.21

Anthracyclines: selected new developments. Curr Med Chem Anticancer Agents (2001) 1.18

Reversible nucleolar translocation of Epstein-Barr virus-encoded EBNA-5 and hsp70 proteins after exposure to heat shock or cell density congestion. J Gen Virol (1995) 1.17

Hikeshi, a nuclear import carrier for Hsp70s, protects cells from heat shock-induced nuclear damage. Cell (2012) 1.10

Small heat shock proteins in cancer therapy and prognosis. Int J Biochem Cell Biol (2012) 1.08

A case of mistaken identity: HSPs are no DAMPs but DAMPERs. Cell Stress Chaperones (2011) 1.06

Cellular mechanisms of resistance to anthracyclines and taxanes in cancer: intrinsic and acquired. Semin Oncol (2008) 1.05

Hsp70 translocates to the nuclei and nucleoli, binds to XRCC1 and PARP-1, and protects HeLa cells from single-strand DNA breaks. Cell Stress Chaperones (2008) 1.05

Extracellular Hsp72, an endogenous DAMP, is released by virally infected airway epithelial cells and activates neutrophils via Toll-like receptor (TLR)-4. Respir Res (2009) 1.05

Signal Transduction Pathways Leading to Heat Shock Transcription. Sign Transduct Insights (2010) 1.04

Phenotyping of lymphocytes expressing regulatory and effector markers in infiltrating ductal carcinoma of the breast. Immunol Lett (2005) 1.04

Heat-shock protein 70 as a prognostic marker in node-negative breast cancer. Anticancer Res (2003) 1.03

Heat shock protein 70 stimulation of the deoxyribonucleic acid base excision repair enzyme polymerase beta. Cell Stress Chaperones (2003) 1.00

Heat-shock protein induction in adriamycin and picornavirus-infected cardiocytes. Lab Invest (1992) 0.96

Inducible heat shock protein 70 expression as a potential predictive marker of metastasis in breast tumors. Cell Stress Chaperones (2006) 0.96

Resistance to chemotherapeutic antimetabolites: a function of salvage pathway involvement and cellular response to DNA damage. Br J Cancer (1997) 0.95

The nuclear matrix is a thermolabile cellular structure. Cell Stress Chaperones (2001) 0.94

Overexpression of HSP70 is induced by ionizing radiation in C3H 10T1/2 cells and protects from DNA damage. Toxicol In Vitro (2003) 0.94

Starvation promotes nuclear accumulation of the hsp70 Ssa4p in yeast cells. J Biol Chem (2001) 0.94

Overexpressed heat shock protein 70 protects cells against DNA damage caused by ultraviolet C in a dose-dependent manner. Cell Stress Chaperones (2006) 0.93

Integration of estrogen and progesterone receptors with pathological and molecular prognostic factors in breast cancer patients. J Steroid Biochem Mol Biol (1998) 0.92

Anthracyclines and ellipticines as DNA-damaging anticancer drugs: recent advances. Pharmacol Ther (2011) 0.91

The role of the tumour inflammatory cell infiltrate in predicting recurrence and survival in patients with primary operable breast cancer. Cancer Treat Rev (2012) 0.90

Molecular chaperones: toward new therapeutic tools. Biomed Pharmacother (2011) 0.89

Downregulation of Hsp27 (HSPB1) in MCF-7 human breast cancer cells induces upregulation of PTEN. Cell Stress Chaperones (2012) 0.88

Molecular chaperones regulate p53 and suppress senescence programs. FEBS Lett (2007) 0.87

Deoxyribonucleic acid damage induced by doxorubicin in peripheral blood mononuclear cells: possible roles for the stress response and the deoxyribonucleic acid repair process. Cell Stress Chaperones (2003) 0.86

Major heat shock protein Hsp72 controls oncogene-induced senescence. Ann N Y Acad Sci (2010) 0.82

Oxygen free radicals as inducers of heat shock protein synthesis in cultured human neuroblastoma cells: relevance to neurodegenerative disease. Eur Arch Psychiatry Clin Neurosci (1993) 0.82

Nucleo-cytoplasmic trafficking of TRIM8, a novel oncogene, is involved in positive regulation of TNF induced NF-κB pathway. PLoS One (2012) 0.81

Different conformations of phosphatase and tensin homolog, deleted on chromosome 10 (PTEN) protein within the nucleus and cytoplasm of neurons. PLoS One (2011) 0.81

HspBP1 levels are elevated in breast tumor tissue and inversely related to tumor aggressiveness. Cell Stress Chaperones (2008) 0.81

Controlled access of p53 to the nucleus regulates its proteasomal degradation by MDM2. Mol Pharm (2013) 0.81

Effects of hyperthermia on Hsp27 (HSPB1), Hsp72 (HSPA1A) and DNA repair proteins hMLH1 and hMSH2 in human colorectal cancer hMLH1-deficient and hMLH1-proficient cell lines. Int J Hyperthermia (2012) 0.80

Hsp27, Hsp70 and mismatch repair proteins hMLH1 and hMSH2 expression in peripheral blood lymphocytes from healthy subjects and cancer patients. Cancer Lett (2007) 0.78

Cancer is not just a disease of a tissue: it is a host disease. How to reactivate host defense against tumors using conventional therapies of cancer? Ann Endocrinol (Paris) (2008) 0.76

Articles by these authors

Heat shock proteins in cancer: chaperones of tumorigenesis. Trends Biochem Sci (2006) 4.04

Stromal cell expression of caveolin-1 predicts outcome in breast cancer. Am J Pathol (2009) 2.44

Heat shock proteins: stress proteins with Janus-like properties in cancer. Int J Hyperthermia (2008) 1.40

Co-expression of steroid receptors (estrogen receptor alpha and/or progesterone receptors) and Her-2/neu: Clinical implications. J Steroid Biochem Mol Biol (2006) 1.09

Hsp27 as a prognostic and predictive factor in cancer. Prog Mol Subcell Biol (2002) 1.06

P-cadherin and beta-catenin are useful prognostic markers in breast cancer patients; beta-catenin interacts with heat shock protein Hsp27. Cell Stress Chaperones (2008) 1.01

DNA damage and repair in peripheral blood lymphocytes from healthy individuals and cancer patients: a pilot study on the implications in the clinical response to chemotherapy. Cancer Lett (2005) 0.91

Simultaneous analysis of the methylation profile of 26 cancer related regions in invasive breast carcinomas by MS-MLPA and drMS-MLPA. Mol Cell Probes (2010) 0.90

Downregulation of Hsp27 (HSPB1) in MCF-7 human breast cancer cells induces upregulation of PTEN. Cell Stress Chaperones (2012) 0.88

Co-expression of steroid hormone receptors (estrogen receptor alpha and/or progesterone receptors) and Her2/neu (c-erbB-2) in breast cancer: clinical outcome following tamoxifen-based adjuvant therapy. J Steroid Biochem Mol Biol (2005) 0.88

Prognostic value of Bcl-2 in breast cancer patients treated with neoadjuvant anthracycline based chemotherapy. Mol Oncol (2008) 0.88

Heat shock proteins HSP27 and HSP70 in unilateral obstructed kidneys. Pediatr Nephrol (2003) 0.87

Deoxyribonucleic acid damage induced by doxorubicin in peripheral blood mononuclear cells: possible roles for the stress response and the deoxyribonucleic acid repair process. Cell Stress Chaperones (2003) 0.86

DNA methylation index and methylation profile of invasive ductal breast tumors. J Mol Diagn (2012) 0.86

Cortical, brainstem and autonomic nervous system dysfunction in infants with post-hemorrhagic hydrocephalus. Rev Invest Clin (2002) 0.85

11,13-dihydro-dehydroleucodine, a derivative of dehydroleucodine with an inactivated alkylating function conserves the anti-proliferative activity in G2 but does not cause cytotoxicity. Eur J Pharmacol (2006) 0.84

Aberrant DNA methylation of cancer-related genes in giant breast fibroadenoma: a case report. J Med Case Rep (2011) 0.82

Effects of hyperthermia on Hsp27 (HSPB1), Hsp72 (HSPA1A) and DNA repair proteins hMLH1 and hMSH2 in human colorectal cancer hMLH1-deficient and hMLH1-proficient cell lines. Int J Hyperthermia (2012) 0.80

MLPA mutation detection in Argentine HNPCC and FAP families. Fam Cancer (2008) 0.79

Absence of caveolin-1 alters heat shock protein expression in spontaneous mammary tumors driven by Her-2/neu expression. Histochem Cell Biol (2011) 0.79

Heat shock protein 70 expression is associated with inhibition of renal tubule epithelial cell apoptosis during recovery from low-protein feeding. Cell Stress Chaperones (2006) 0.79

Amikacin alters auditory brainstem conduction time in newborns. J Perinat Med (2003) 0.78

A pilot study with a therapeutic vaccine based on hydroxyapatite ceramic particles and self-antigens in cancer patients. Cell Stress Chaperones (2007) 0.78

Estrogens regulate the expression of NHERF1 in normal colon during the reproductive cycle of Wistar rats. Histochem Cell Biol (2010) 0.78

Hsp27, Hsp70 and mismatch repair proteins hMLH1 and hMSH2 expression in peripheral blood lymphocytes from healthy subjects and cancer patients. Cancer Lett (2007) 0.78

The sesquiterpene lactone dehydroleucodine triggers senescence and apoptosis in association with accumulation of DNA damage markers. PLoS One (2013) 0.78

HER2 and β-catenin protein location: importance in the prognosis of breast cancer patients and their correlation when breast cancer cells suffer stressful situations. Clin Exp Metastasis (2015) 0.77

Isolation of heat shock protein complexes. Methods Mol Biol (2011) 0.76

Effects of prenatal exposure to carbamazepine on brainstem auditory evoked potentials in infants of epileptic mothers. J Child Neurol (2002) 0.76

Hsp27 (HSPB1): a possible surrogate molecular marker for loss of heterozygosity (LOH) of chromosome 1p in oligodendrogliomas but not in astrocytomas. Cell Stress Chaperones (2012) 0.76

In MMTV-Her-2/neu transgenic mammary tumors the absence of caveolin-1-/- alters PTEN and NHERF1 but not β-catenin expression. Cell Stress Chaperones (2013) 0.75

Luteal expression of thyroid hormone receptors during gestation and postpartum in the rat. Thyroid (2014) 0.75

Hyperthermia effects on Hsp27 and Hsp72 associations with mismatch repair (MMR) proteins and cisplatin toxicity in MMR-deficient/proficient colon cancer cell lines. Int J Hyperthermia (2015) 0.75

[Detection of a founder mutation in an Argentine family with hereditary non polyposis colorectal cancer]. Medicina (B Aires) (2010) 0.75

Anterior corneal profile with variable asphericity. Appl Opt (2009) 0.75

Promotores As Advocates for Community Improvement: Experiences of the Western States REACH Su Comunidad Consortium. J Ambul Care Manage (2015) 0.75