Type, density, and location of immune cells within human colorectal tumors predict clinical outcome.

Immunity, inflammation, and cancer. Cell (2010) 28.27

STATs in cancer inflammation and immunity: a leading role for STAT3. Nat Rev Cancer (2009) 15.45

Colocalization of inflammatory response with B7-h1 expression in human melanocytic lesions supports an adaptive resistance mechanism of immune escape. Sci Transl Med (2012) 13.12

Cancer immunotherapy comes of age. Nature (2011) 12.35

The immune contexture in human tumours: impact on clinical outcome. Nat Rev Cancer (2012) 10.90

PD-1 blockade induces responses by inhibiting adaptive immune resistance. Nature (2014) 10.39

Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm. Nat Immunol (2010) 9.59

Microsatellite instability in colorectal cancer. Gastroenterology (2010) 7.39

Prognostic value of tumor-infiltrating lymphocytes in triple-negative breast cancers from two phase III randomized adjuvant breast cancer trials: ECOG 2197 and ECOG 1199. J Clin Oncol (2014) 5.61

Innate and adaptive immune cells in the tumor microenvironment. Nat Immunol (2013) 5.43

Phenotype, distribution, generation, and functional and clinical relevance of Th17 cells in the human tumor environments. Blood (2009) 4.80

The tumor microenvironment and its role in promoting tumor growth. Oncogene (2008) 4.66

Adenoma-linked barrier defects and microbial products drive IL-23/IL-17-mediated tumour growth. Nature (2012) 4.41

Gene expression profiling and histopathological characterization of triple-negative/basal-like breast carcinomas. Breast Cancer Res (2007) 4.41

The consensus molecular subtypes of colorectal cancer. Nat Med (2015) 4.35

The anticancer immune response: indispensable for therapeutic success? J Clin Invest (2008) 4.01

Melanoma-intrinsic β-catenin signalling prevents anti-tumour immunity. Nature (2015) 3.86

Inflammation and breast cancer. Balancing immune response: crosstalk between adaptive and innate immune cells during breast cancer progression. Breast Cancer Res (2007) 3.76

Cancer micrometastases. Nat Rev Clin Oncol (2009) 3.69

Reporting Recommendations for Tumor Marker Prognostic Studies (REMARK): explanation and elaboration. PLoS Med (2012) 3.62

Adoptive T cell therapy for cancer in the clinic. J Clin Invest (2007) 3.45

The prognostic influence of tumour-infiltrating lymphocytes in cancer: a systematic review with meta-analysis. Br J Cancer (2011) 3.45

Inflammation and cancer: interweaving microRNA, free radical, cytokine and p53 pathways. Carcinogenesis (2009) 3.40

T(H)17 cells in tumour immunity and immunotherapy. Nat Rev Immunol (2010) 3.39

CD4(+) T cells contribute to the remodeling of the microenvironment required for sustained tumor regression upon oncogene inactivation. Cancer Cell (2010) 3.33

The vigorous immune microenvironment of microsatellite instable colon cancer is balanced by multiple counter-inhibitory checkpoints. Cancer Discov (2014) 3.32

Molecular classification and correlates in colorectal cancer. J Mol Diagn (2007) 3.25

Towards the introduction of the 'Immunoscore' in the classification of malignant tumours. J Pathol (2014) 3.21

Phenotypic analysis of prostate-infiltrating lymphocytes reveals TH17 and Treg skewing. Clin Cancer Res (2008) 3.09

Metastasis-Associated Gene Expression Changes Predict Poor Outcomes in Patients with Dukes Stage B and C Colorectal Cancer. Clin Cancer Res (2009) 3.08

Combining radiotherapy and cancer immunotherapy: a paradigm shift. J Natl Cancer Inst (2013) 3.07

Gene expression profile correlates with T-cell infiltration and relative survival in glioblastoma patients vaccinated with dendritic cell immunotherapy. Clin Cancer Res (2010) 3.05

Suppression of autophagy by FIP200 deletion inhibits mammary tumorigenesis. Genes Dev (2011) 3.05

Tumour-infiltrating T-cell subsets, molecular changes in colorectal cancer, and prognosis: cohort study and literature review. J Pathol (2010) 3.03

Macrophages define the invasive microenvironment in breast cancer. J Leukoc Biol (2008) 3.02

Cancer immunology--analysis of host and tumor factors for personalized medicine. Nat Rev Clin Oncol (2011) 2.90

Cancer classification using the Immunoscore: a worldwide task force. J Transl Med (2012) 2.88

Neutrophil/lymphocyte ratio predicts chemotherapy outcomes in patients with advanced colorectal cancer. Br J Cancer (2011) 2.88

STING-dependent cytosolic DNA sensing mediates innate immune recognition of immunogenic tumors. Immunity (2014) 2.86

Evidence for a role of the PD-1:PD-L1 pathway in immune resistance of HPV-associated head and neck squamous cell carcinoma. Cancer Res (2013) 2.81

The immune score as a new possible approach for the classification of cancer. J Transl Med (2012) 2.79

Lymphocytic reaction to colorectal cancer is associated with longer survival, independent of lymph node count, microsatellite instability, and CpG island methylator phenotype. Clin Cancer Res (2009) 2.62

Immune surveillance: a balance between protumor and antitumor immunity. Curr Opin Genet Dev (2008) 2.62

TGF-beta and immune cells: an important regulatory axis in the tumor microenvironment and progression. Trends Immunol (2010) 2.61

Transcriptome-wide studies of merkel cell carcinoma and validation of intratumoral CD8+ lymphocyte invasion as an independent predictor of survival. J Clin Oncol (2011) 2.52

The CIMT-monitoring panel: a two-step approach to harmonize the enumeration of antigen-specific CD8+ T lymphocytes by structural and functional assays. Cancer Immunol Immunother (2007) 2.49

The prognostic landscape of genes and infiltrating immune cells across human cancers. Nat Med (2015) 2.48

Immunotype and immunohistologic characteristics of tumor-infiltrating immune cells are associated with clinical outcome in metastatic melanoma. Cancer Res (2012) 2.48

Human breast cancer cells enhance self tolerance by promoting evasion from NK cell antitumor immunity. J Clin Invest (2011) 2.44

Recommendations from the iSBTc-SITC/FDA/NCI Workshop on Immunotherapy Biomarkers. Clin Cancer Res (2011) 2.44

Focus on TILs: prognostic significance of tumor infiltrating lymphocytes in human colorectal cancer. Cancer Immun (2007) 2.44

T-regulatory cells: key players in tumor immune escape and angiogenesis. Cancer Res (2012) 2.43

Inflammation and oncogenesis: a vicious connection. Curr Opin Genet Dev (2009) 2.35

Immune profile and mitotic index of metastatic melanoma lesions enhance clinical staging in predicting patient survival. Proc Natl Acad Sci U S A (2009) 2.32

Evaluation of MHC class I peptide binding prediction servers: applications for vaccine research. BMC Immunol (2008) 2.30

Consensus guidelines for the detection of immunogenic cell death. Oncoimmunology (2014) 2.30

Tumor-infiltrating lymphocytes predict response to anthracycline-based chemotherapy in estrogen receptor-negative breast cancer. Breast Cancer Res (2011) 2.25

Deciphering and reversing tumor immune suppression. Immunity (2013) 2.24

Mechanism-driven biomarkers to guide immune checkpoint blockade in cancer therapy. Nat Rev Cancer (2016) 2.19

CD4⁺ follicular helper T cell infiltration predicts breast cancer survival. J Clin Invest (2013) 2.18

PD-L1 (B7-H1) and PD-1 pathway blockade for cancer therapy: Mechanisms, response biomarkers, and combinations. Sci Transl Med (2016) 2.16

IKK/NF-kappaB and STAT3 pathways: central signalling hubs in inflammation-mediated tumour promotion and metastasis. EMBO Rep (2009) 2.14

Why cancer and inflammation? Yale J Biol Med (2006) 2.13

IL-17 promotes tumor development through the induction of tumor promoting microenvironments at tumor sites and myeloid-derived suppressor cells. J Immunol (2010) 2.12

Fat, fibre and cancer risk in African Americans and rural Africans. Nat Commun (2015) 2.12

CD8 tumor-infiltrating lymphocytes are predictive of survival in muscle-invasive urothelial carcinoma. Proc Natl Acad Sci U S A (2007) 2.11

Linking T-cell receptor sequence to functional phenotype at the single-cell level. Nat Biotechnol (2014) 2.10

A comprehensive analysis of prognostic signatures reveals the high predictive capacity of the proliferation, immune response and RNA splicing modules in breast cancer. Breast Cancer Res (2008) 2.09

Therapeutic cancer vaccines: current status and moving forward. J Natl Cancer Inst (2012) 2.09

For breast cancer prognosis, immunoglobulin kappa chain surfaces to the top. Clin Cancer Res (2012) 2.09

IL-22(+)CD4(+) T cells promote colorectal cancer stemness via STAT3 transcription factor activation and induction of the methyltransferase DOT1L. Immunity (2014) 2.08

Chemokine nitration prevents intratumoral infiltration of antigen-specific T cells. J Exp Med (2011) 2.06

In vivo discovery of immunotherapy targets in the tumour microenvironment. Nature (2014) 2.05

Intraepithelial effector (CD3+)/regulatory (FoxP3+) T-cell ratio predicts a clinical outcome of human colon carcinoma. Gastroenterology (2009) 2.04

Stereotactic Radiation Therapy Augments Antigen-Specific PD-1-Mediated Antitumor Immune Responses via Cross-Presentation of Tumor Antigen. Cancer Immunol Res (2014) 2.00

Immune regulation of cancer. J Clin Oncol (2010) 1.99

Epigenetic silencing of TH1-type chemokines shapes tumour immunity and immunotherapy. Nature (2015) 1.98

Tumor masses support naive T cell infiltration, activation, and differentiation into effectors. J Exp Med (2010) 1.97

Tumor-associated Macrophages (TAM) and Inflammation in Colorectal Cancer. Cancer Microenviron (2010) 1.96

Polarized immune responses differentially regulate cancer development. Immunol Rev (2008) 1.95

CD137 accurately identifies and enriches for naturally occurring tumor-reactive T cells in tumor. Clin Cancer Res (2013) 1.90

Endogenous T cell responses to antigens expressed in lung adenocarcinomas delay malignant tumor progression. Cancer Cell (2011) 1.89

Thunder and lightning: immunotherapy and oncolytic viruses collide. Mol Ther (2011) 1.87

Reporting recommendations for tumor marker prognostic studies (REMARK): explanation and elaboration. BMC Med (2012) 1.85

Stage-dependent alterations of the serum cytokine pattern in colorectal carcinoma. Br J Cancer (2012) 1.82

Trial watch: Prognostic and predictive value of the immune infiltrate in cancer. Oncoimmunology (2012) 1.78

A systematic approach to biomarker discovery; preamble to "the iSBTc-FDA taskforce on immunotherapy biomarkers". J Transl Med (2008) 1.77

Myeloid-derived suppressor cells enhance stemness of cancer cells by inducing microRNA101 and suppressing the corepressor CtBP2. Immunity (2013) 1.77

Microsatellite instability, EMAST, and morphology associations with T cell infiltration in colorectal neoplasia. Dig Dis Sci (2011) 1.77

Radiation as an immunological adjuvant: current evidence on dose and fractionation. Front Oncol (2012) 1.76

Analysis of mutations in DNA isolated from plasma and stool of colorectal cancer patients. Gastroenterology (2008) 1.74

B7-H1 (PD-L1, CD274) suppresses host immunity in T-cell lymphoproliferative disorders. Blood (2009) 1.74

Use of tumour-responsive T cells as cancer treatment. Lancet (2009) 1.73

Inhibition of CXCR2 profoundly suppresses inflammation-driven and spontaneous tumorigenesis. J Clin Invest (2012) 1.73

Tumor infiltrating lymphocytes: an intriguing player in the survival of colorectal cancer patients. BMC Immunol (2010) 1.73

Lymph node harvest in colon cancer: influence of microsatellite instability and proximal tumor location. World J Surg (2009) 1.73

Digital genomic quantification of tumor-infiltrating lymphocytes. Sci Transl Med (2013) 1.72

The speed of change: towards a discontinuity theory of immunity? Nat Rev Immunol (2013) 1.72

Cancer and inflammation: promise for biologic therapy. J Immunother (2010) 1.72

Controversies in clinical cancer dormancy. Proc Natl Acad Sci U S A (2011) 1.71

Effector memory T cells, early metastasis, and survival in colorectal cancer. N Engl J Med (2005) 12.64

The immune contexture in human tumours: impact on clinical outcome. Nat Rev Cancer (2012) 10.90

Genesis: cluster analysis of microarray data. Bioinformatics (2002) 10.50

ClueGO: a Cytoscape plug-in to decipher functionally grouped gene ontology and pathway annotation networks. Bioinformatics (2009) 8.60

Histopathologic-based prognostic factors of colorectal cancers are associated with the state of the local immune reaction. J Clin Oncol (2011) 5.63

Clinical impact of different classes of infiltrating T cytotoxic and helper cells (Th1, th2, treg, th17) in patients with colorectal cancer. Cancer Res (2011) 5.30

The Medicago genome provides insight into the evolution of rhizobial symbioses. Nature (2011) 4.94

Autologous skeletal myoblast transplantation for severe postinfarction left ventricular dysfunction. J Am Coll Cardiol (2003) 4.91

Antibody-mediated vascular rejection of kidney allografts: a population-based study. Lancet (2012) 4.85

Long-term survival for patients with non-small-cell lung cancer with intratumoral lymphoid structures. J Clin Oncol (2008) 4.30

In situ cytotoxic and memory T cells predict outcome in patients with early-stage colorectal cancer. J Clin Oncol (2009) 3.97

Mutations in myosin heavy chain 11 cause a syndrome associating thoracic aortic aneurysm/aortic dissection and patent ductus arteriosus. Nat Genet (2006) 3.65

A survey of tools for variant analysis of next-generation genome sequencing data. Brief Bioinform (2013) 3.60

Spatiotemporal dynamics of intratumoral immune cells reveal the immune landscape in human cancer. Immunity (2013) 3.50

Towards the introduction of the 'Immunoscore' in the classification of malignant tumours. J Pathol (2014) 3.21

Interleukin 15: a key to disrupted intraepithelial lymphocyte homeostasis and lymphomagenesis in celiac disease. Gastroenterology (2003) 3.05

Gene expression classification of colon cancer into molecular subtypes: characterization, validation, and prognostic value. PLoS Med (2013) 2.96

CARMAweb: comprehensive R- and bioconductor-based web service for microarray data analysis. Nucleic Acids Res (2006) 2.93

Cancer classification using the Immunoscore: a worldwide task force. J Transl Med (2012) 2.88

The immune score as a new possible approach for the classification of cancer. J Transl Med (2012) 2.79

PTH-independent regulation of blood calcium concentration by the calcium-sensing receptor. J Clin Invest (2012) 2.61

Prognostic value of tumor-infiltrating CD4+ T-cell subpopulations in head and neck cancers. Clin Cancer Res (2006) 2.56

PD-1-expressing tumor-infiltrating T cells are a favorable prognostic biomarker in HPV-associated head and neck cancer. Cancer Res (2012) 2.43

Coordination of intratumoral immune reaction and human colorectal cancer recurrence. Cancer Res (2009) 2.37

Transplantation of cardiac-committed mouse embryonic stem cells to infarcted sheep myocardium: a preclinical study. Lancet (2005) 2.36

The adaptive immunologic microenvironment in colorectal cancer: a novel perspective. Cancer Res (2007) 2.34

miR-17, miR-19b, miR-20a, and miR-106a are down-regulated in human aging. Aging Cell (2010) 2.31

Intimal sarcoma is the most frequent primary cardiac sarcoma: clinicopathologic and molecular retrospective analysis of 100 primary cardiac sarcomas. Am J Surg Pathol (2014) 2.23

Focal segmental glomerulosclerosis plays a major role in the progression of IgA nephropathy. II. Light microscopic and clinical studies. Kidney Int (2010) 2.22

Cardiac stem cells in the real world. J Thorac Cardiovasc Surg (2008) 2.19

Prognostic and predictive impact of intra- and peritumoral immune infiltrates. Cancer Res (2011) 2.16

Histopathology of septic shock induced acute kidney injury: apoptosis and leukocytic infiltration. Intensive Care Med (2010) 2.15

MARS: microarray analysis, retrieval, and storage system. BMC Bioinformatics (2005) 2.14

Global gene expression profiling reveals widespread yet distinctive translational responses to different eukaryotic translation initiation factor 2B-targeting stress pathways. Mol Cell Biol (2005) 2.13

PathwayExplorer: web service for visualizing high-throughput expression data on biological pathways. Nucleic Acids Res (2005) 2.12

Sleeve gastrectomy severe complications: is it always a reasonable surgical option? Obes Surg (2013) 2.08

Tracheal regeneration: evidence of bone marrow mesenchymal stem cell involvement. J Thorac Cardiovasc Surg (2012) 2.07

Can erythropoietin improve skeletal myoblast engraftment in infarcted myocardium? Interact Cardiovasc Thorac Surg (2007) 2.07

A purified population of multipotent cardiovascular progenitors derived from primate pluripotent stem cells engrafts in postmyocardial infarcted nonhuman primates. J Clin Invest (2010) 2.06

Triggering of TLR7 and TLR8 expressed by human lung cancer cells induces cell survival and chemoresistance. J Clin Invest (2010) 2.02

Biomolecular network reconstruction identifies T-cell homing factors associated with survival in colorectal cancer. Gastroenterology (2009) 2.01