Published in FASEB J on December 05, 2013
Siglec-mediated regulation of immune cell function in disease. Nat Rev Immunol (2014) 2.12
Siglec receptors impact mammalian lifespan by modulating oxidative stress. Elife (2015) 1.20
Host adaptation of a bacterial toxin from the human pathogen Salmonella Typhi. Cell (2014) 1.06
Siglec-5 and Siglec-14 are polymorphic paired receptors that modulate neutrophil and amnion signaling responses to group B Streptococcus. J Exp Med (2014) 1.05
The interplay between Siglecs and sialylated pathogens. Glycobiology (2014) 0.96
Engagement of myelomonocytic Siglecs by tumor-associated ligands modulates the innate immune response to cancer. Proc Natl Acad Sci U S A (2014) 0.91
Convergent and divergent mechanisms of sugar recognition across kingdoms. Curr Opin Struct Biol (2014) 0.89
Glycans and glycan-binding proteins in immune regulation: A concise introduction to glycobiology for the allergist. J Allergy Clin Immunol (2015) 0.84
Immunomodulatory activity of extracellular Hsp70 mediated via paired receptors Siglec-5 and Siglec-14. EMBO J (2015) 0.83
Glycobiology simplified: diverse roles of glycan recognition in inflammation. J Leukoc Biol (2016) 0.83
Mouse mincle: characterization as a model for human mincle and evolutionary implications. Molecules (2015) 0.82
Lectin galactoside-binding soluble 3 binding protein (LGALS3BP) is a tumor-associated immunomodulatory ligand for CD33-related Siglecs. J Biol Chem (2014) 0.80
On the apparent rarity of epithelial cancers in captive chimpanzees. Philos Trans R Soc Lond B Biol Sci (2015) 0.80
9-O-Acetylation of sialic acids is catalysed by CASD1 via a covalent acetyl-enzyme intermediate. Nat Commun (2015) 0.77
Evolutionary inactivation of a sialidase in group B Streptococcus. Sci Rep (2016) 0.77
Protein transduction therapy into cochleae via the round window niche in guinea pigs. Mol Ther Methods Clin Dev (2016) 0.75
Sialylation of N-glycans: mechanism, cellular compartmentalization and function. Histochem Cell Biol (2016) 0.75
Paired Siglec receptors generate opposite inflammatory responses to a human-specific pathogen. EMBO J (2017) 0.75
Siglec-8 and Siglec-9 binding specificities and endogenous airway ligand distributions and properties. Glycobiology (2017) 0.75
Evolution of host adaptation in the Salmonella typhoid toxin. Nat Microbiol (2017) 0.75
Erythrocyte sialoglycoproteins engage Siglec-9 on neutrophils to suppress activation. Blood (2017) 0.75
The danger model: a renewed sense of self. Science (2002) 13.85
Innate immunity: the virtues of a nonclonal system of recognition. Cell (1997) 9.42
Sterile inflammation: sensing and reacting to damage. Nat Rev Immunol (2010) 8.87
Siglecs and their roles in the immune system. Nat Rev Immunol (2007) 7.98
Chemical diversity in the sialic acids and related alpha-keto acids: an evolutionary perspective. Chem Rev (2002) 4.61
Siglecs--the major subfamily of I-type lectins. Glycobiology (2005) 3.25
The origin of malignant malaria. Proc Natl Acad Sci U S A (2009) 2.67
Sialic acid utilization by bacterial pathogens. Microbiology (2007) 2.62
Evolution of human-chimpanzee differences in malaria susceptibility: relationship to human genetic loss of N-glycolylneuraminic acid. Proc Natl Acad Sci U S A (2005) 2.53
Colloquium paper: uniquely human evolution of sialic acid genetics and biology. Proc Natl Acad Sci U S A (2010) 2.30
Glycan array screening reveals a candidate ligand for Siglec-8. J Biol Chem (2004) 2.24
Molecular mimicry of host sialylated glycans allows a bacterial pathogen to engage neutrophil Siglec-9 and dampen the innate immune response. Blood (2009) 2.24
Sialoadhesin, myelin-associated glycoprotein and CD22 define a new family of sialic acid-dependent adhesion molecules of the immunoglobulin superfamily. Curr Biol (1994) 2.05
Application of photoshop-based image analysis to quantification of hormone receptor expression in breast cancer. J Histochem Cytochem (1997) 1.99
To sialylate, or not to sialylate: that is the question. Trends Microbiol (2002) 1.96
Sialic acids in molecular and cellular interactions. Int Rev Cytol (1997) 1.79
Loss of Siglec expression on T lymphocytes during human evolution. Proc Natl Acad Sci U S A (2006) 1.75
Group B streptococcal capsular sialic acids interact with siglecs (immunoglobulin-like lectins) on human leukocytes. J Bacteriol (2006) 1.57
Sexual selection by female immunity against paternal antigens can fix loss of function alleles. Proc Natl Acad Sci U S A (2011) 1.56
CD24-Siglec G/10 discriminates danger- from pathogen-associated molecular patterns. Trends Immunol (2009) 1.39
Evolution of CD33-related siglecs: regulating host immune functions and escaping pathogen exploitation? Immunology (2010) 1.37
Large-scale sequencing of the CD33-related Siglec gene cluster in five mammalian species reveals rapid evolution by multiple mechanisms. Proc Natl Acad Sci U S A (2004) 1.36
Cloning, characterization, and phylogenetic analysis of siglec-9, a new member of the CD33-related group of siglecs. Evidence for co-evolution with sialic acid synthesis pathways. J Biol Chem (2000) 1.35
Group B Streptococcus suppression of phagocyte functions by protein-mediated engagement of human Siglec-5. J Exp Med (2009) 1.34
Since there are PAMPs and DAMPs, there must be SAMPs? Glycan “self-associated molecular patterns” dampen innate immunity, but pathogens can mimic them. Glycobiology (2011) 1.33
Discovery of Siglec-14, a novel sialic acid receptor undergoing concerted evolution with Siglec-5 in primates. FASEB J (2006) 1.32
Glycosphingolipids: structure, biological source, and properties. Methods Enzymol (1989) 1.28
I-type lectins. J Biol Chem (1995) 1.24
Human-specific evolution of sialic acid targets: explaining the malignant malaria mystery? Proc Natl Acad Sci U S A (2009) 1.23
Cloning and characterization of human Siglec-11. A recently evolved signaling molecule that can interact with SHP-1 and SHP-2 and is expressed by tissue macrophages, including brain microglia. J Biol Chem (2002) 1.20
CD33-related siglecs as potential modulators of inflammatory responses. Ann N Y Acad Sci (2012) 1.18
Siglecs as sensors of self in innate and adaptive immune responses. Ann N Y Acad Sci (2012) 1.08
Cross-comparison of protein recognition of sialic acid diversity on two novel sialoglycan microarrays. J Biol Chem (2012) 1.07
Specific inactivation of two immunomodulatory SIGLEC genes during human evolution. Proc Natl Acad Sci U S A (2012) 1.06
Characterization of expression of glycan ligands for Siglec-F in normal mouse lungs. Am J Respir Cell Mol Biol (2010) 1.05
SIGLEC16 encodes a DAP12-associated receptor expressed in macrophages that evolved from its inhibitory counterpart SIGLEC11 and has functional and non-functional alleles in humans. Eur J Immunol (2008) 1.01
mSiglec-E, a novel mouse CD33-related siglec (sialic acid-binding immunoglobulin-like lectin) that recruits Src homology 2 (SH2)-domain-containing protein tyrosine phosphatases SHP-1 and SHP-2. Biochem J (2001) 0.96
A uniquely human consequence of domain-specific functional adaptation in a sialic acid-binding receptor. Glycobiology (2003) 0.95
I-type lectins. Biochim Biophys Acta (2002) 0.94
Sialoglycoproteins adsorbed by Pseudomonas aeruginosa facilitate their survival by impeding neutrophil extracellular trap through siglec-9. J Leukoc Biol (2012) 0.93
The spectrum of perinatal group B streptococcal disease. Vaccine (2013) 0.92
Expression of de-N-acetyl-gangliosides in human melanoma cells is induced by genistein or nocodazole. J Biol Chem (1995) 0.87
Expression of new KDN-gangliosides in rainbow trout testis during spermatogenesis and their structural identification. Glycobiology (1995) 0.77
Host-bacterial mutualism in the human intestine. Science (2005) 26.39
The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cells. Nat Genet (2006) 20.76
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies. J Clin Invest (2011) 14.22
HIF-1alpha is essential for myeloid cell-mediated inflammation. Cell (2003) 9.12
Siglecs and their roles in the immune system. Nat Rev Immunol (2007) 7.98
Intra- and interspecific variation in primate gene expression patterns. Science (2002) 7.92
ER stress regulation of ATF6 localization by dissociation of BiP/GRP78 binding and unmasking of Golgi localization signals. Dev Cell (2002) 6.95
NF-kappaB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1alpha. Nature (2008) 6.13
ATP release guides neutrophil chemotaxis via P2Y2 and A3 receptors. Science (2006) 6.00
Innate immunity gone awry: linking microbial infections to chronic inflammation and cancer. Cell (2006) 5.97
Serum microRNA signatures identified in a genome-wide serum microRNA expression profiling predict survival of non-small-cell lung cancer. J Clin Oncol (2010) 5.92
Jmjd1a and Jmjd2c histone H3 Lys 9 demethylases regulate self-renewal in embryonic stem cells. Genes Dev (2007) 5.79
Secreted monocytic miR-150 enhances targeted endothelial cell migration. Mol Cell (2010) 5.77
Human embryonic stem cells express an immunogenic nonhuman sialic acid. Nat Med (2005) 5.24
DNase expression allows the pathogen group A Streptococcus to escape killing in neutrophil extracellular traps. Curr Biol (2006) 5.22
Vaccine induction of antibodies against a structurally heterogeneous site of immune pressure within HIV-1 envelope protein variable regions 1 and 2. Immunity (2013) 4.82
ABAD directly links Abeta to mitochondrial toxicity in Alzheimer's disease. Science (2004) 4.81
Experimental observation of the quantum anomalous Hall effect in a magnetic topological insulator. Science (2013) 4.69
Comprehensive analysis of heterochromatin- and RNAi-mediated epigenetic control of the fission yeast genome. Nat Genet (2005) 4.66
Chemical diversity in the sialic acids and related alpha-keto acids: an evolutionary perspective. Chem Rev (2002) 4.61
Expression profile matrix of Arabidopsis transcription factor genes suggests their putative functions in response to environmental stresses. Plant Cell (2002) 4.58
TLR activation of the transcription factor XBP1 regulates innate immune responses in macrophages. Nat Immunol (2010) 4.56
Exogenous plant MIR168a specifically targets mammalian LDLRAP1: evidence of cross-kingdom regulation by microRNA. Cell Res (2011) 4.55
Reciprocal transcriptional regulation of Pou5f1 and Sox2 via the Oct4/Sox2 complex in embryonic stem cells. Mol Cell Biol (2005) 4.54
Microbiota-liberated host sugars facilitate post-antibiotic expansion of enteric pathogens. Nature (2013) 4.43
DNase Sda1 provides selection pressure for a switch to invasive group A streptococcal infection. Nat Med (2007) 4.35
IKKalpha limits macrophage NF-kappaB activation and contributes to the resolution of inflammation. Nature (2005) 4.31
Analysis of a clonal lineage of HIV-1 envelope V2/V3 conformational epitope-specific broadly neutralizing antibodies and their inferred unmutated common ancestors. J Virol (2011) 4.06
HIF-1alpha expression regulates the bactericidal capacity of phagocytes. J Clin Invest (2005) 3.77
Evolution of the mammalian transcription factor binding repertoire via transposable elements. Genome Res (2008) 3.76
Specificity of polysaccharide use in intestinal bacteroides species determines diet-induced microbiota alterations. Cell (2010) 3.70
Invariant natural killer T cells recognize glycolipids from pathogenic Gram-positive bacteria. Nat Immunol (2011) 3.48
Regulation of iron homeostasis by the hypoxia-inducible transcription factors (HIFs). J Clin Invest (2007) 3.40
Staphylococcus aureus golden pigment impairs neutrophil killing and promotes virulence through its antioxidant activity. J Exp Med (2005) 3.36
Participatory medicine: A home score for streptococcal pharyngitis enabled by real-time biosurveillance: a cohort study. Ann Intern Med (2013) 3.32
The Ashwell receptor mitigates the lethal coagulopathy of sepsis. Nat Med (2008) 3.31
A NOD2-NALP1 complex mediates caspase-1-dependent IL-1beta secretion in response to Bacillus anthracis infection and muramyl dipeptide. Proc Natl Acad Sci U S A (2008) 3.27
Siglecs--the major subfamily of I-type lectins. Glycobiology (2005) 3.25
Sall4 interacts with Nanog and co-occupies Nanog genomic sites in embryonic stem cells. J Biol Chem (2006) 3.24
Discovery of a widely distributed toxin biosynthetic gene cluster. Proc Natl Acad Sci U S A (2008) 3.20
Human uptake and incorporation of an immunogenic nonhuman dietary sialic acid. Proc Natl Acad Sci U S A (2003) 3.13
Synergistic effects of L- and P-selectin in facilitating tumor metastasis can involve non-mucin ligands and implicate leukocytes as enhancers of metastasis. Proc Natl Acad Sci U S A (2002) 3.10
Streptolysin S and necrotising infections produced by group G streptococcus. Lancet (2002) 3.02
A cholesterol biosynthesis inhibitor blocks Staphylococcus aureus virulence. Science (2008) 2.96
Mitochondrial Abeta: a potential focal point for neuronal metabolic dysfunction in Alzheimer's disease. FASEB J (2005) 2.91
Serum microRNA profiles serve as novel biomarkers for HBV infection and diagnosis of HBV-positive hepatocarcinoma. Cancer Res (2010) 2.85
Phosphorylation of FOXP3 controls regulatory T cell function and is inhibited by TNF-α in rheumatoid arthritis. Nat Med (2013) 2.85
A five-microRNA signature identified from genome-wide serum microRNA expression profiling serves as a fingerprint for gastric cancer diagnosis. Eur J Cancer (2010) 2.84
The cerebrospinal fluid provides a proliferative niche for neural progenitor cells. Neuron (2011) 2.83
Molecular insight into invasive group A streptococcal disease. Nat Rev Microbiol (2011) 2.81
Cutting edge: Essential role of hypoxia inducible factor-1alpha in development of lipopolysaccharide-induced sepsis. J Immunol (2007) 2.76
Attention training in individuals with generalized social phobia: A randomized controlled trial. J Consult Clin Psychol (2009) 2.76
High-throughput isolation of immunoglobulin genes from single human B cells and expression as monoclonal antibodies. J Virol Methods (2009) 2.75
Antibody-dependent cellular cytotoxicity-mediating antibodies from an HIV-1 vaccine efficacy trial target multiple epitopes and preferentially use the VH1 gene family. J Virol (2012) 2.74
Vaccine-induced plasma IgA specific for the C1 region of the HIV-1 envelope blocks binding and effector function of IgG. Proc Natl Acad Sci U S A (2013) 2.69
T-bet represses T(H)17 differentiation by preventing Runx1-mediated activation of the gene encoding RORγt. Nat Immunol (2010) 2.68
Diversity in cell surface sialic acid presentations: implications for biology and disease. Lab Invest (2007) 2.64
The membrane-anchored BOTRYTIS-INDUCED KINASE1 plays distinct roles in Arabidopsis resistance to necrotrophic and biotrophic pathogens. Plant Cell (2005) 2.57
Evolution of human-chimpanzee differences in malaria susceptibility: relationship to human genetic loss of N-glycolylneuraminic acid. Proc Natl Acad Sci U S A (2005) 2.53
Serum microRNA expression profile as a biomarker in the diagnosis and prognosis of pancreatic cancer. Clin Chem (2011) 2.42
Sequencing the chimpanzee genome: insights into human evolution and disease. Nat Rev Genet (2003) 2.41
The BOTRYTIS SUSCEPTIBLE1 gene encodes an R2R3MYB transcription factor protein that is required for biotic and abiotic stress responses in Arabidopsis. Plant Cell (2003) 2.39
Molecular genetic analysis of a group A Streptococcus operon encoding serum opacity factor and a novel fibronectin-binding protein, SfbX. J Bacteriol (2003) 2.38
Hypoxia and serum deprivation-induced apoptosis in mesenchymal stem cells. Stem Cells (2005) 2.37
Electronic origin of high-temperature superconductivity in single-layer FeSe superconductor. Nat Commun (2012) 2.37
Syphilis among female sex workers in southwestern China: potential for HIV transmission. Sex Transm Dis (2006) 2.34
Expression profile of microRNAs in serum: a fingerprint for esophageal squamous cell carcinoma. Clin Chem (2010) 2.34
Phase diagram and electronic indication of high-temperature superconductivity at 65 K in single-layer FeSe films. Nat Mater (2013) 2.34
Nuclease expression by Staphylococcus aureus facilitates escape from neutrophil extracellular traps. J Innate Immun (2010) 2.34
RAGE, carboxylated glycans and S100A8/A9 play essential roles in colitis-associated carcinogenesis. Carcinogenesis (2008) 2.33
Innate immunity turned inside-out: antimicrobial defense by phagocyte extracellular traps. J Mol Med (Berl) (2009) 2.33
Mutational analysis of the group A streptococcal operon encoding streptolysin S and its virulence role in invasive infection. Mol Microbiol (2005) 2.30
Statins enhance formation of phagocyte extracellular traps. Cell Host Microbe (2010) 2.28
Effect of a bacterial pheromone peptide on host chemokine degradation in group A streptococcal necrotising soft-tissue infections. Lancet (2004) 2.25
Molecular mimicry of host sialylated glycans allows a bacterial pathogen to engage neutrophil Siglec-9 and dampen the innate immune response. Blood (2009) 2.24
A multifunctional Pasteurella multocida sialyltransferase: a powerful tool for the synthesis of sialoside libraries. J Am Chem Soc (2005) 2.22
Defining the in vivo function of Siglec-F, a CD33-related Siglec expressed on mouse eosinophils. Blood (2007) 2.20
Disease manifestations and pathogenic mechanisms of group a Streptococcus. Clin Microbiol Rev (2014) 2.20
Use of antistaphylococcal beta-lactams to increase daptomycin activity in eradicating persistent bacteremia due to methicillin-resistant Staphylococcus aureus: role of enhanced daptomycin binding. Clin Infect Dis (2011) 2.19
A graphene platform for sensing biomolecules. Angew Chem Int Ed Engl (2009) 2.19
Human milk oligosaccharides protect bladder epithelial cells against uropathogenic Escherichia coli invasion and cytotoxicity. J Infect Dis (2013) 2.18
Mechanism of uptake and incorporation of the non-human sialic acid N-glycolylneuraminic acid into human cells. J Biol Chem (2004) 2.17
Recognizing falls from silhouettes. Conf Proc IEEE Eng Med Biol Soc (2006) 2.16
Pharmacological promotion of autophagy alleviates steatosis and injury in alcoholic and non-alcoholic fatty liver conditions in mice. J Hepatol (2013) 2.14
Group B streptococcal beta-hemolysin/cytolysin activates neutrophil signaling pathways in brain endothelium and contributes to development of meningitis. J Clin Invest (2003) 2.14
Hand, foot, and mouth disease in China: patterns of spread and transmissibility. Epidemiology (2011) 2.13
Selective antimicrobial action is provided by phenol-soluble modulins derived from Staphylococcus epidermidis, a normal resident of the skin. J Invest Dermatol (2010) 2.13
Human cholesterol 7alpha-hydroxylase (CYP7A1) deficiency has a hypercholesterolemic phenotype. J Clin Invest (2002) 2.12
Incorporation of a non-human glycan mediates human susceptibility to a bacterial toxin. Nature (2008) 2.11
Functionally defective germline variants of sialic acid acetylesterase in autoimmunity. Nature (2010) 2.10