Published in Glycobiology on July 13, 2005
Mucin-type O-glycans in human colon and breast cancer: glycodynamics and functions. EMBO Rep (2006) 2.82
Sialic acids in human health and disease. Trends Mol Med (2008) 2.61
Colloquium paper: uniquely human evolution of sialic acid genetics and biology. Proc Natl Acad Sci U S A (2010) 2.30
Molecular mimicry of host sialylated glycans allows a bacterial pathogen to engage neutrophil Siglec-9 and dampen the innate immune response. Blood (2009) 2.24
Defining the in vivo function of Siglec-F, a CD33-related Siglec expressed on mouse eosinophils. Blood (2007) 2.20
Multifarious roles of sialic acids in immunity. Ann N Y Acad Sci (2012) 2.09
Detection and quantitation of eosinophils in the murine respiratory tract by flow cytometry. J Immunol Methods (2007) 2.04
Advances in the biology and chemistry of sialic acids. ACS Chem Biol (2010) 1.96
Siglec-H is an IPC-specific receptor that modulates type I IFN secretion through DAP12. Blood (2005) 1.94
N-glycolylneuraminic acid deficiency in mice: implications for human biology and evolution. Mol Cell Biol (2007) 1.87
Distinct endocytic mechanisms of CD22 (Siglec-2) and Siglec-F reflect roles in cell signaling and innate immunity. Mol Cell Biol (2007) 1.84
Siglecs and immune regulation. Annu Rev Immunol (2012) 1.81
Loss of Siglec expression on T lymphocytes during human evolution. Proc Natl Acad Sci U S A (2006) 1.75
Siglec-F antibody administration to mice selectively reduces blood and tissue eosinophils. Allergy (2008) 1.70
Annotation and structural analysis of sialylated human milk oligosaccharides. J Proteome Res (2011) 1.68
Germinal center marker GL7 probes activation-dependent repression of N-glycolylneuraminic acid, a sialic acid species involved in the negative modulation of B-cell activation. Mol Cell Biol (2007) 1.63
Glycosylation in immune cell trafficking. Immunol Rev (2009) 1.61
Group B streptococcal capsular sialic acids interact with siglecs (immunoglobulin-like lectins) on human leukocytes. J Bacteriol (2006) 1.57
Siglec-8 on human eosinophils and mast cells, and Siglec-F on murine eosinophils, are functionally related inhibitory receptors. Clin Exp Allergy (2009) 1.56
Basic and clinical immunology of Siglecs. Ann N Y Acad Sci (2008) 1.56
Severe preeclampsia-related changes in gene expression at the maternal-fetal interface include sialic acid-binding immunoglobulin-like lectin-6 and pappalysin-2. Endocrinology (2008) 1.47
Decoration of T-independent antigen with ligands for CD22 and Siglec-G can suppress immunity and induce B cell tolerance in vivo. J Exp Med (2009) 1.44
Multiple changes in sialic acid biology during human evolution. Glycoconj J (2008) 1.43
CD24-Siglec G/10 discriminates danger- from pathogen-associated molecular patterns. Trends Immunol (2009) 1.39
Evolution of CD33-related siglecs: regulating host immune functions and escaping pathogen exploitation? Immunology (2010) 1.37
Myelin-associated glycoprotein mediates membrane fusion and entry of neurotropic herpesviruses. Proc Natl Acad Sci U S A (2009) 1.37
Siglec-H protects from virus-triggered severe systemic autoimmunity. J Exp Med (2016) 1.37
Group B Streptococcus suppression of phagocyte functions by protein-mediated engagement of human Siglec-5. J Exp Med (2009) 1.34
Regulation of the metastatic cell phenotype by sialylated glycans. Cancer Metastasis Rev (2012) 1.32
Sialic acids in the brain: gangliosides and polysialic acid in nervous system development, stability, disease, and regeneration. Physiol Rev (2014) 1.32
Interleukin-5 priming of human eosinophils alters siglec-8 mediated apoptosis pathways. Am J Respir Cell Mol Biol (2007) 1.31
Treatment of allergic asthma: modulation of Th2 cells and their responses. Respir Res (2011) 1.31
Identification of Siglec-9 as the receptor for MUC16 on human NK cells, B cells, and monocytes. Mol Cancer (2010) 1.30
Siglec-8 as a drugable target to treat eosinophil and mast cell-associated conditions. Pharmacol Ther (2012) 1.29
Signaling defects in anti-tumor T cells. Immunol Rev (2008) 1.28
Polylactosamine on glycoproteins influences basal levels of lymphocyte and macrophage activation. Proc Natl Acad Sci U S A (2007) 1.27
Emerging role of alpha2,6-sialic acid as a negative regulator of galectin binding and function. J Biol Chem (2010) 1.23
Altered granulopoietic profile and exaggerated acute neutrophilic inflammation in mice with targeted deficiency in the sialyltransferase ST6Gal I. Blood (2006) 1.23
CD33 Alzheimer's risk-altering polymorphism, CD33 expression, and exon 2 splicing. J Neurosci (2013) 1.21
Structural implications of Siglec-5-mediated sialoglycan recognition. J Mol Biol (2007) 1.21
Myelin-associated glycoprotein and its axonal receptors. J Neurosci Res (2009) 1.20
Gangliosides and Nogo receptors independently mediate myelin-associated glycoprotein inhibition of neurite outgrowth in different nerve cells. J Biol Chem (2007) 1.19
Interactions between Siglec-7/9 receptors and ligands influence NK cell-dependent tumor immunosurveillance. J Clin Invest (2014) 1.16
Eosinophil-selective binding and proapoptotic effect in vitro of a synthetic Siglec-8 ligand, polymeric 6'-sulfated sialyl Lewis x. J Pharmacol Exp Ther (2009) 1.12
Group B Streptococcus engages an inhibitory Siglec through sialic acid mimicry to blunt innate immune and inflammatory responses in vivo. PLoS Pathog (2014) 1.11
T cell regulation mediated by interaction of soluble CD52 with the inhibitory receptor Siglec-10. Nat Immunol (2013) 1.11
MUC16 (CA125): tumor biomarker to cancer therapy, a work in progress. Mol Cancer (2014) 1.10
An essential role of sialylated O-linked sugar chains in the recognition of mouse CD99 by paired Ig-like type 2 receptor (PILR). J Immunol (2008) 1.09
Bifunctional CD22 ligands use multimeric immunoglobulins as protein scaffolds in assembly of immune complexes on B cells. J Am Chem Soc (2008) 1.09
Molecular basis of the interactions of the Nogo-66 receptor and its homolog NgR2 with myelin-associated glycoprotein: development of NgROMNI-Fc, a novel antagonist of CNS myelin inhibition. J Neurosci (2009) 1.08
Sialidase enhances spinal axon outgrowth in vivo. Proc Natl Acad Sci U S A (2006) 1.08
Specific inactivation of two immunomodulatory SIGLEC genes during human evolution. Proc Natl Acad Sci U S A (2012) 1.06
Campylobacter jejuni lipooligosaccharides modulate dendritic cell-mediated T cell polarization in a sialic acid linkage-dependent manner. Infect Immun (2011) 1.06
Characterization of expression of glycan ligands for Siglec-F in normal mouse lungs. Am J Respir Cell Mol Biol (2010) 1.05
Effect of sialic acid loss on dendritic cell maturation. Immunology (2009) 1.05
Imaging the sialome during zebrafish development with copper-free click chemistry. Chembiochem (2012) 1.05
Glycomics of bone marrow-derived mesenchymal stem cells can be used to evaluate their cellular differentiation stage. Glycoconj J (2008) 1.05
Regulation of B cell functions by the sialic acid-binding receptors siglec-G and CD22. Front Immunol (2012) 1.04
Relative over-reactivity of human versus chimpanzee lymphocytes: implications for the human diseases associated with immune activation. J Immunol (2010) 1.04
Antigen profiles for the quantitative assessment of eosinophils in mouse tissues by flow cytometry. J Immunol Methods (2011) 1.02
Sialoadhesin - a macrophage-restricted marker of immunoregulation and inflammation. Immunology (2013) 1.02
Glycosphingolipid functions. Cold Spring Harb Perspect Biol (2011) 1.02
Rapid evolution of binding specificities and expression patterns of inhibitory CD33-related Siglecs in primates. FASEB J (2013) 1.01
Antibody-based therapy of acute myeloid leukemia with gemtuzumab ozogamicin. Front Biosci (Landmark Ed) (2013) 1.01
Galactose 6-O-sulfotransferases are not required for the generation of Siglec-F ligands in leukocytes or lung tissue. J Biol Chem (2013) 0.99
A lesson for cancer research: placental microarray gene analysis in preeclampsia. Oncotarget (2012) 0.99
Glycan structures of ocular surface mucins in man, rabbit and dog display species differences. Glycoconj J (2008) 0.99
IL-33 enhances Siglec-8 mediated apoptosis of human eosinophils. Cytokine (2011) 0.99
Biological modulation by lectins and their ligands in tumor progression and metastasis. Anticancer Agents Med Chem (2008) 0.98
Leukocyte inflammatory responses provoked by pneumococcal sialidase. MBio (2012) 0.98
Microglial immunoreceptor tyrosine-based activation and inhibition motif signaling in neuroinflammation. Int J Alzheimers Dis (2010) 0.98
Mice deficient in the St3gal3 gene product α2,3 sialyltransferase (ST3Gal-III) exhibit enhanced allergic eosinophilic airway inflammation. J Allergy Clin Immunol (2013) 0.98
The interplay between Siglecs and sialylated pathogens. Glycobiology (2014) 0.96
Loss of Siglec-14 reduces the risk of chronic obstructive pulmonary disease exacerbation. Cell Mol Life Sci (2013) 0.94
Comparative genomics indicates the mammalian CD33rSiglec locus evolved by an ancient large-scale inverse duplication and suggests all Siglecs share a common ancestral region. Immunogenetics (2009) 0.93
Sialic acid involved in hypermucoviscosity phenotype of Klebsiella pneumoniae and associated with resistance to neutrophil phagocytosis. Virulence (2014) 0.92
Developmental, malignancy-related, and cross-species analysis of eosinophil, mast cell, and basophil siglec-8 expression. J Clin Immunol (2011) 0.92
Where catabolism meets signalling: neuraminidase 1 as a modulator of cell receptors. Glycoconj J (2011) 0.92
SIGLEC12, a human-specific segregating (pseudo)gene, encodes a signaling molecule expressed in prostate carcinomas. J Biol Chem (2011) 0.91
Role of siglecs and related glycan-binding proteins in immune responses and immunoregulation. J Allergy Clin Immunol (2015) 0.90
Binding of the sialic acid-binding lectin, Siglec-9, to the membrane mucin, MUC1, induces recruitment of β-catenin and subsequent cell growth. J Biol Chem (2013) 0.90
Natural ligands for CD33-related Siglecs? Glycobiology (2009) 0.89
Noninvasive imaging of dendrimer-type N-glycan clusters: in vivo dynamics dependence on oligosaccharide structure. Angew Chem Int Ed Engl (2010) 0.89
The Inflammatory Role of Platelets via Their TLRs and Siglec Receptors. Front Immunol (2015) 0.88
Mechanisms of Siglec-F-induced eosinophil apoptosis: a role for caspases but not for SHP-1, Src kinases, NADPH oxidase or reactive oxygen. PLoS One (2013) 0.88
Negative regulation of Toll-like receptor-4 signaling through the binding of glycosylphosphatidylinositol-anchored glycoprotein, CD14, with the sialic acid-binding lectin, CD33. J Biol Chem (2014) 0.87
Differences in the constitutive and SIV infection induced expression of Siglecs by hematopoietic cells from non-human primates. Cell Immunol (2008) 0.87
Evolution of siglec-11 and siglec-16 genes in hominins. Mol Biol Evol (2012) 0.86
Expression of CD24 and Siglec-10 in first trimester placenta: implications for immune tolerance at the fetal-maternal interface. Histochem Cell Biol (2016) 0.85
Genetics ignite focus on microglial inflammation in Alzheimer's disease. Mol Neurodegener (2015) 0.85
Structural basis for substrate specificity of mammalian neuraminidases. PLoS One (2014) 0.84
Human Siglec-5 inhibitory receptor and immunoglobulin A (IgA) have separate binding sites in streptococcal beta protein. J Biol Chem (2011) 0.84
Synthesis of biologically active N- and O-linked glycans with multisialylated poly-N-acetyllactosamine extensions using P. damsela α2-6 sialyltransferase. J Am Chem Soc (2013) 0.84
Live-attenuated lentivirus immunization modulates innate immunity and inflammation while protecting rhesus macaques from vaginal simian immunodeficiency virus challenge. J Virol (2012) 0.83
Immunomodulatory activity of extracellular Hsp70 mediated via paired receptors Siglec-5 and Siglec-14. EMBO J (2015) 0.83
Endothelial functions of platelet/endothelial cell adhesion molecule-1 (CD31). Curr Opin Hematol (2016) 0.83
Evolutional and clinical implications of the epigenetic regulation of protein glycosylation. Clin Epigenetics (2011) 0.82
Siglec-9 and SHP-1 are differentially expressed in neonatal and adult neutrophils. Pediatr Res (2009) 0.82
Ganglioside GM3 levels are altered in a mouse model of HIBM: GM3 as a cellular marker of the disease. PLoS One (2010) 0.82
Defining the in vivo function of Siglec-F, a CD33-related Siglec expressed on mouse eosinophils. Blood (2007) 2.20
A human-specific gene in microglia. Science (2005) 1.26
Glycoconjugate microarray based on an evanescent-field fluorescence-assisted detection principle for investigation of glycan-binding proteins. Glycobiology (2008) 1.25
Simultaneous determination of nucleotide sugars with ion-pair reversed-phase HPLC. Glycobiology (2010) 1.16
Deletion polymorphism of SIGLEC14 and its functional implications. Glycobiology (2009) 1.07
CD33/Siglec-3 binding specificity, expression pattern, and consequences of gene deletion in mice. Mol Cell Biol (2003) 1.03
Rapid evolution of binding specificities and expression patterns of inhibitory CD33-related Siglecs in primates. FASEB J (2013) 1.01
SIGLEC12, a human-specific segregating (pseudo)gene, encodes a signaling molecule expressed in prostate carcinomas. J Biol Chem (2011) 0.91
Multilectin assay for detecting fibrosis-specific glyco-alteration by means of lectin microarray. Clin Chem (2010) 0.91
Strategy for simulation of CID spectra of N-linked oligosaccharides toward glycomics. J Proteome Res (2006) 0.90
The interaction between Siglec-15 and tumor-associated sialyl-Tn antigen enhances TGF-β secretion from monocytes/macrophages through the DAP12-Syk pathway. Glycobiology (2012) 0.89
A single dose of lipopolysaccharide into mice with emphysema mimics human chronic obstructive pulmonary disease exacerbation as assessed by micro-computed tomography. Am J Respir Cell Mol Biol (2013) 0.88
Hypoxic regulation of glycosylation via the N-acetylglucosamine cycle. J Clin Biochem Nutr (2010) 0.87
Evolution of siglec-11 and siglec-16 genes in hominins. Mol Biol Evol (2012) 0.86
Siglec-15 regulates osteoclast differentiation by modulating RANKL-induced phosphatidylinositol 3-kinase/Akt and Erk pathways in association with signaling Adaptor DAP12. J Bone Miner Res (2013) 0.86
Strategy for glycoproteomics: identification of glyco-alteration using multiple glycan profiling tools. J Proteome Res (2009) 0.84
Flagellin/Toll-like receptor 5 response was specifically attenuated by keratan sulfate disaccharide via decreased EGFR phosphorylation in normal human bronchial epithelial cells. Biochem Biophys Res Commun (2013) 0.82
Mass isotopomer analysis of metabolically labeled nucleotide sugars and N- and O-glycans for tracing nucleotide sugar metabolisms. Mol Cell Proteomics (2013) 0.81
Metabolically programmed quality control system for dolichol-linked oligosaccharides. Proc Natl Acad Sci U S A (2013) 0.80
Detection of anti-Siglec-14 alloantibodies in blood components implicated in nonhaemolytic transfusion reactions. Br J Haematol (2011) 0.78
Human C21orf63 is a heparin-binding protein. J Biochem (2009) 0.77
Glycoproteomic discovery of serological biomarker candidates for HCV/HBV infection-associated liver fibrosis and hepatocellular carcinoma. J Proteome Res (2013) 0.77
α1,6-Fucosyltransferase (Fut8) is implicated in vulnerability to elastase-induced emphysema in mice and a possible non-invasive predictive marker for disease progression and exacerbations in chronic obstructive pulmonary disease (COPD). Biochem Biophys Res Commun (2012) 0.76