Published in PLoS One on November 27, 2013
PP242 suppresses cell proliferation, metastasis, and angiogenesis of gastric cancer through inhibition of the PI3K/AKT/mTOR pathway. Anticancer Drugs (2014) 0.88
Transforming Growth Factor-β Is an Upstream Regulator of Mammalian Target of Rapamycin Complex 2-Dependent Bladder Cancer Cell Migration and Invasion. Am J Pathol (2016) 0.82
Amygdalin blocks bladder cancer cell growth in vitro by diminishing cyclin A and cdk2. PLoS One (2014) 0.82
Targeting mTOR and p53 Signaling Inhibits Muscle Invasive Bladder Cancer In Vivo. Cancer Prev Res (Phila) (2015) 0.80
TOR complex 2-Ypk1 signaling regulates actin polarization via reactive oxygen species. Mol Biol Cell (2014) 0.79
Judicious Toggling of mTOR Activity to Combat Insulin Resistance and Cancer: Current Evidence and Perspectives. Front Pharmacol (2016) 0.77
Rictor is an independent prognostic factor for endometrial carcinoma. Int J Clin Exp Pathol (2014) 0.77
Human Dynactin-Associated Protein Transforms NIH3T3 Cells to Generate Highly Vascularized Tumors with Weak Cell-Cell Interaction. PLoS One (2015) 0.75
The TORC1/2 inhibitor TAK228 sensitizes atypical teratoid rhabdoid tumors to cisplatin-induced cytotoxicity. Neuro Oncol (2017) 0.75
Metabolomics analysis reveals distinct profiles of nonmuscle-invasive and muscle-invasive bladder cancer. Cancer Med (2017) 0.75
Global cancer statistics. CA Cancer J Clin (2011) 185.92
mTOR: from growth signal integration to cancer, diabetes and ageing. Nat Rev Mol Cell Biol (2010) 21.16
Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton. Curr Biol (2004) 16.83
Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive. Nat Cell Biol (2004) 12.12
Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity. Genes Dev (2006) 4.78
Activation of mTORC2 by association with the ribosome. Cell (2011) 3.38
PTEN loss contributes to erlotinib resistance in EGFR-mutant lung cancer by activation of Akt and EGFR. Cancer Res (2009) 3.13
mTORC1 and mTORC2 regulate EMT, motility, and metastasis of colorectal cancer via RhoA and Rac1 signaling pathways. Cancer Res (2011) 3.12
Paxillin: a focal adhesion-associated adaptor protein. Oncogene (2001) 3.03
mTORC2 regulates neutrophil chemotaxis in a cAMP- and RhoA-dependent fashion. Dev Cell (2010) 2.56
mTORC2 activity is elevated in gliomas and promotes growth and cell motility via overexpression of rictor. Cancer Res (2007) 2.44
Rac1 regulates the activity of mTORC1 and mTORC2 and controls cellular size. Mol Cell (2011) 2.32
Rictor and integrin-linked kinase interact and regulate Akt phosphorylation and cancer cell survival. Cancer Res (2008) 2.20
Bladder cancer: imperatives for personalized medicine. Oncology (Williston Park) (2011) 2.07
mTORC2 controls actin polymerization required for consolidation of long-term memory. Nat Neurosci (2013) 2.04
TGF-β-induced activation of mTOR complex 2 drives epithelial-mesenchymal transition and cell invasion. J Cell Sci (2012) 1.74
Targeting of mTORC2 prevents cell migration and promotes apoptosis in breast cancer. Breast Cancer Res Treat (2012) 1.71
Rho family proteins in cell adhesion and cell migration. Eur J Cancer (2000) 1.68
Evidence for direct activation of mTORC2 kinase activity by phosphatidylinositol 3,4,5-trisphosphate. J Biol Chem (2011) 1.56
Multiple regulatory steps control mammalian nonmuscle myosin II assembly in live cells. Mol Biol Cell (2008) 1.45
Rapamycin inhibits cytoskeleton reorganization and cell motility by suppressing RhoA expression and activity. J Biol Chem (2010) 1.44
Role of mTOR signaling in tumor cell motility, invasion and metastasis. Curr Protein Pept Sci (2011) 1.37
Activation of the PI3K/Akt/mTOR pathway correlates with tumour progression and reduced survival in patients with urothelial carcinoma of the urinary bladder. Histopathology (2011) 1.30
Expanding therapeutic targets in bladder cancer: the PI3K/Akt/mTOR pathway. Lab Invest (2010) 1.22
PTEN can inhibit in vitro organotypic and in vivo orthotopic invasion of human bladder cancer cells even in the absence of its lipid phosphatase activity. Oncogene (2004) 1.20
Mammalian target of rapamycin (mTOR) regulates cellular proliferation and tumor growth in urothelial carcinoma. Am J Pathol (2010) 1.17
An hTERT-immortalized human urothelial cell line that responds to anti-proliferative factor. In Vitro Cell Dev Biol Anim (2010) 1.10
Myosin II isoform switching mediates invasiveness after TGF-β-induced epithelial-mesenchymal transition. Proc Natl Acad Sci U S A (2011) 1.07
Molecular basis of urinary bladder cancer. Adv Anat Pathol (2013) 0.98
Fibroblast growth factor receptors-1 and -3 play distinct roles in the regulation of bladder cancer growth and metastasis: implications for therapeutic targeting. PLoS One (2013) 0.96
mTOR complex 2 targets Akt for proteasomal degradation via phosphorylation at the hydrophobic motif. J Biol Chem (2011) 0.93
Tyrosine phosphorylation of Rac1: a role in regulation of cell spreading. PLoS One (2011) 0.90
Short hairpin RNA targeting FOXQ1 inhibits invasion and metastasis via the reversal of epithelial-mesenchymal transition in bladder cancer. Int J Oncol (2013) 0.85
Selective regulation of p38β protein and signaling by integrin-linked kinase mediates bladder cancer cell migration. Oncogene (2013) 0.84
Clinicopathologic characteristics of 23 cases of invasive low-grade papillary urothelial carcinoma. Urology (2012) 0.77
Negative regulation of mTORC2 by glycogen synthase kinase-3β: an adaptive process to stress with an anticancer therapeutic potential? Future Oncol (2011) 0.77
Nuclear cytokine-activated IKKalpha controls prostate cancer metastasis by repressing Maspin. Nature (2007) 4.00
High-resolution imaging of the dynamic tumor cell vascular interface in transparent zebrafish. Proc Natl Acad Sci U S A (2007) 2.13
Primary lymphoepithelioma-like carcinoma of the ureter. Ann Diagn Pathol (2009) 2.11
uPAR induces epithelial-mesenchymal transition in hypoxic breast cancer cells. J Cell Biol (2007) 2.11
Lack of pathologic down-staging with neoadjuvant chemotherapy for muscle-invasive urothelial carcinoma of the bladder: a contemporary series. Cancer (2009) 2.02
Diverse roles for the LDL receptor family. Trends Endocrinol Metab (2002) 1.99
Distinct roles of nonmuscle myosin II isoforms in the regulation of MDA-MB-231 breast cancer cell spreading and migration. Cancer Res (2006) 1.96
Inadequacy of biopsy for diagnosis of upper tract urothelial carcinoma: implications for conservative management. Urology (2011) 1.78
Chronic kidney disease after nephroureterectomy for upper tract urothelial carcinoma and implications for the administration of perioperative chemotherapy. Cancer (2010) 1.77
Interobserver reproducibility in the diagnosis of invasive micropapillary carcinoma of the urinary tract among urologic pathologists. Am J Surg Pathol (2010) 1.73
Chemoattractant signaling between tumor cells and macrophages regulates cancer cell migration, metastasis and neovascularization. PLoS One (2009) 1.68
Tissue-type plasminogen activator acts as a cytokine that triggers intracellular signal transduction and induces matrix metalloproteinase-9 gene expression. J Biol Chem (2005) 1.64
The investigational Aurora kinase A inhibitor MLN8237 induces defects in cell viability and cell-cycle progression in malignant bladder cancer cells in vitro and in vivo. Clin Cancer Res (2013) 1.62
The hemopexin domain of matrix metalloproteinase-9 activates cell signaling and promotes migration of schwann cells by binding to low-density lipoprotein receptor-related protein. J Neurosci (2008) 1.60
Epidermal growth factor receptor-dependent and -independent cell-signaling pathways originating from the urokinase receptor. J Biol Chem (2002) 1.50
Multiple myosin II heavy chain kinases: roles in filament assembly control and proper cytokinesis in Dictyostelium. Mol Biol Cell (2005) 1.48
Multiple regulatory steps control mammalian nonmuscle myosin II assembly in live cells. Mol Biol Cell (2008) 1.45
Sunitinib malate provides activity against murine bladder tumor growth and invasion in a preclinical orthotopic model. Urology (2012) 1.45
Reversibility of epithelial-mesenchymal transition (EMT) induced in breast cancer cells by activation of urokinase receptor-dependent cell signaling. J Biol Chem (2009) 1.44
Primary carcinoid tumors of the testis: a clinicopathologic study of 29 cases. Am J Surg Pathol (2010) 1.41
Utility of a triple antibody cocktail intraurothelial neoplasm-3 (IUN-3-CK20/CD44s/p53) and α-methylacyl-CoA racemase (AMACR) in the distinction of urothelial carcinoma in situ (CIS) and reactive urothelial atypia. Am J Surg Pathol (2013) 1.40
Ligand binding to LRP1 transactivates Trk receptors by a Src family kinase-dependent pathway. Sci Signal (2009) 1.36
Regulation of Rac1 activation by the low density lipoprotein receptor-related protein. J Cell Biol (2002) 1.35
The low-density lipoprotein receptor-related protein is a pro-survival receptor in Schwann cells: possible implications in peripheral nerve injury. J Neurosci (2006) 1.31
Role of cystitis cystica et glandularis and intestinal metaplasia in development of bladder carcinoma. Urology (2008) 1.30
Differentiation of a highly tumorigenic basal cell compartment in urothelial carcinoma. Stem Cells (2009) 1.30
Dynamic assembly of the urokinase-type plasminogen activator signaling receptor complex determines the mitogenic activity of urokinase-type plasminogen activator. J Biol Chem (2005) 1.29
CD24 offers a therapeutic target for control of bladder cancer metastasis based on a requirement for lung colonization. Cancer Res (2011) 1.28
Squamous cell carcinoma of the bladder: a clinicopathologic analysis of 45 cases. Am J Surg Pathol (2007) 1.26
Differences in survival for patients with resectable versus unresectable metastases from pancreatic islet cell cancer. J Gastrointest Surg (2006) 1.22
Signaling pathways regulating Dictyostelium myosin II. J Muscle Res Cell Motil (2002) 1.22
Carcinoma of the collecting ducts of Bellini and renal medullary carcinoma: clinicopathologic analysis of 52 cases of rare aggressive subtypes of renal cell carcinoma with a focus on their interrelationship. Am J Surg Pathol (2012) 1.21
Erythropoietin promotes MCF-7 breast cancer cell migration by an ERK/mitogen-activated protein kinase-dependent pathway and is primarily responsible for the increase in migration observed in hypoxia. J Biol Chem (2005) 1.21
Low density lipoprotein receptor-related protein-1 promotes beta1 integrin maturation and transport to the cell surface. J Biol Chem (2003) 1.20
Strong antibody responses induced by protein antigens conjugated onto the surface of lecithin-based nanoparticles. J Control Release (2009) 1.20
Histopathologic features and clinical outcomes in 71 cases of bladder diverticula. Arch Pathol Lab Med (2009) 1.19
Urethral diverticula in 90 female patients: a study with emphasis on neoplastic alterations. J Urol (2008) 1.19
ICUD-EAU International Consultation on Bladder Cancer 2012: Pathology. Eur Urol (2012) 1.19
Global expression analysis of well-differentiated pancreatic endocrine neoplasms using oligonucleotide microarrays. Clin Cancer Res (2003) 1.18
Cooperativity between the Ras-ERK and Rho-Rho kinase pathways in urokinase-type plasminogen activator-stimulated cell migration. J Biol Chem (2002) 1.17
Mammalian target of rapamycin (mTOR) regulates cellular proliferation and tumor growth in urothelial carcinoma. Am J Pathol (2010) 1.17
The low-density lipoprotein receptor-related protein regulates cancer cell survival and metastasis development. Cancer Res (2007) 1.14
Foregut duplication cyst of the stomach. J Gastrointest Surg (2006) 1.14
Soluble urokinase-type plasminogen activator receptor inhibits cancer cell growth and invasion by direct urokinase-independent effects on cell signaling. J Biol Chem (2003) 1.12
Molecular dissection of the human alpha2-macroglobulin subunit reveals domains with antagonistic activities in cell signaling. J Biol Chem (2008) 1.11
A microfluidic imaging chamber for the direct observation of chemotactic transmigration. Biomed Microdevices (2010) 1.09
Low-density lipoprotein receptor-related protein 1 is an essential receptor for myelin phagocytosis. J Cell Sci (2009) 1.09
Myosin II isoform switching mediates invasiveness after TGF-β-induced epithelial-mesenchymal transition. Proc Natl Acad Sci U S A (2011) 1.07
Myosin II recruitment during cytokinesis independent of centralspindlin-mediated phosphorylation. J Biol Chem (2009) 1.07
The urokinase receptor promotes cancer metastasis independently of urokinase-type plasminogen activator in mice. Am J Pathol (2009) 1.07
Inflammatory mediators promote production of shed LRP1/CD91, which regulates cell signaling and cytokine expression by macrophages. J Leukoc Biol (2010) 1.05
Von Hippel Lindau syndrome. Adv Exp Med Biol (2010) 1.04
Comparative gene expression profiling analysis of urothelial carcinoma of the renal pelvis and bladder. BMC Med Genomics (2010) 1.03
Cell signaling by urokinase-type plasminogen activator receptor induces stem cell-like properties in breast cancer cells. Cancer Res (2010) 1.03
LDL receptor-related protein-1 is a sialic-acid-independent receptor for myelin-associated glycoprotein that functions in neurite outgrowth inhibition by MAG and CNS myelin. J Cell Sci (2012) 1.02
The low-density lipoprotein receptor-related protein-1 associates transiently with lipid rafts. J Cell Biochem (2005) 1.02
Schwann cells express erythropoietin receptor and represent a major target for Epo in peripheral nerve injury. Glia (2005) 1.02
Low density lipoprotein receptor-related protein (LRP1) regulates Rac1 and RhoA reciprocally to control Schwann cell adhesion and migration. J Biol Chem (2010) 1.01
Crosstalk between the urokinase-type plasminogen activator receptor and EGF receptor variant III supports survival and growth of glioblastoma cells. Proc Natl Acad Sci U S A (2011) 1.01
Dictyostelium huntingtin controls chemotaxis and cytokinesis through the regulation of myosin II phosphorylation. Mol Biol Cell (2011) 1.01
A shed form of LDL receptor-related protein-1 regulates peripheral nerve injury and neuropathic pain in rodents. J Clin Invest (2008) 0.99
Myeloid cell receptor LRP1/CD91 regulates monocyte recruitment and angiogenesis in tumors. Cancer Res (2013) 0.99
The unfolded protein response is a major mechanism by which LRP1 regulates Schwann cell survival after injury. J Neurosci (2011) 0.98
HER2 gene amplification occurs frequently in the micropapillary variant of urothelial carcinoma: analysis by dual-color in situ hybridization. Mod Pathol (2011) 0.98
LRP1 assembles unique co-receptor systems to initiate cell signaling in response to tissue-type plasminogen activator and myelin-associated glycoprotein. J Biol Chem (2013) 0.97
Lamellipodial localization of Dictyostelium myosin heavy chain kinase A is mediated via F-actin binding by the coiled-coil domain. FEBS Lett (2002) 0.97
Non-epithelial neoplasms of the prostate. Histopathology (2012) 0.97
Clinicopathologic features and utility of immunohistochemical markers in signet-ring cell adenocarcinoma of the bladder. Hum Pathol (2008) 0.97
Aberrant diffuse expression of p63 in adenocarcinoma of the prostate on needle biopsy and radical prostatectomy: report of 21 cases. Am J Surg Pathol (2008) 0.97
Emerging concepts in micropapillary urothelial carcinoma. Adv Anat Pathol (2010) 0.96
Mutation of NIMA-related kinase 1 (NEK1) leads to chromosome instability. Mol Cancer (2011) 0.96
Identification and characterization of a novel alpha-kinase with a von Willebrand factor A-like motif localized to the contractile vacuole and Golgi complex in Dictyostelium discoideum. Mol Biol Cell (2005) 0.95
Regulation of the composition of the extracellular matrix by low density lipoprotein receptor-related protein-1: activities based on regulation of mRNA expression. J Biol Chem (2006) 0.95
N-methyl-D-aspartate receptor subunits are non-myosin targets of myosin regulatory light chain. J Biol Chem (2008) 0.93
A proteomic study of myosin II motor proteins during tumor cell migration. J Mol Biol (2011) 0.93
Folate hydrolase (prostate-specific membrane [corrected] antigen) 1 expression in bladder cancer subtypes and associated tumor neovasculature. Mod Pathol (2011) 0.93
Myosin heavy chain kinase B participates in the regulation of myosin assembly into the cytoskeleton. J Cell Biochem (2003) 0.92
Mutation of lysine 1370 in full-length human alpha2-macroglobulin blocks binding to the low density lipoprotein receptor-related protein-1. Arch Biochem Biophys (2005) 0.91
Selective immunohistochemical markers to distinguish between metastatic high-grade urothelial carcinoma and primary poorly differentiated invasive squamous cell carcinoma of the lung. Arch Pathol Lab Med (2012) 0.91
Diagnostic use of antibody to smoothelin in the recognition of muscularis propria in transurethral resection of urinary bladder tumor (TURBT) specimens. Am J Surg Pathol (2010) 0.91
Generation of double gene disruptions in Dictyostelium discoideum using a single antibiotic marker selection. Biotechniques (2004) 0.91
The low density lipoprotein receptor-related protein mediates fibronectin catabolism and inhibits fibronectin accumulation on cell surfaces. J Biol Chem (2002) 0.91
Ganglioneuroma of the adrenal gland. J Urol (2009) 0.90
Analysis of the role of Ser1/Ser2/Thr9 phosphorylation on myosin II assembly and function in live cells. BMC Cell Biol (2011) 0.90
Maspin, the molecular bridge between the plasminogen activator system and beta1 integrin that facilitates cell adhesion. J Biol Chem (2011) 0.90
Myosin II dynamics in Dictyostelium: determinants for filament assembly and translocation to the cell cortex during chemoattractant responses. Cell Motil Cytoskeleton (2002) 0.89
The relationship of vascular endothelial growth factor and coagulation factor (fibrin and fibrinogen) expression in clear cell renal cell carcinoma. Urology (2009) 0.89
Identification of the low density lipoprotein (LDL) receptor-related protein-1 interactome in central nervous system myelin suggests a role in the clearance of necrotic cell debris. J Biol Chem (2012) 0.89
Prognostic value of cell-cycle regulation biomarkers in bladder cancer. Semin Oncol (2012) 0.88
Cyclic depsipeptides, grassypeptolides D and E and Ibu-epidemethoxylyngbyastatin 3, from a Red Sea Leptolyngbya cyanobacterium. J Nat Prod (2011) 0.88
Soy phytochemicals decrease nonsmall cell lung cancer growth in female athymic mice. J Nutr (2008) 0.88
Comparison of diagnostic accuracies in outpatients and hospitalized patients of D-dimer testing for the evaluation of suspected pulmonary embolism. Clin Chem (2003) 0.88
Distinct binding sites in the structure of alpha 2-macroglobulin mediate the interaction with beta-amyloid peptide and growth factors. J Biol Chem (2002) 0.87
Mandelalides A-D, cytotoxic macrolides from a new Lissoclinum species of South African tunicate. J Org Chem (2012) 0.87
Dynamic phosphorylation of tyrosine 665 in pseudopodium-enriched atypical kinase 1 (PEAK1) is essential for the regulation of cell migration and focal adhesion turnover. J Biol Chem (2012) 0.86
Characterization of the interaction between alpha2-macroglobulin and fibroblast growth factor-2: the role of hydrophobic interactions. Biochem J (2003) 0.86