An hTERT-immortalized human urothelial cell line that responds to anti-proliferative factor.

PubWeight™: 1.10‹?› | Rank: Top 10%

🔗 View Article (PMC 3029472)

Published in In Vitro Cell Dev Biol Anim on December 07, 2010

Authors

Jayoung Kim1, Mihee Ji, Joseph A DiDonato, Raymond R Rackley, Mei Kuang, Provash C Sadhukhan, Joshua R Mauney, Susan K Keay, Michael R Freeman, Louis S Liou, Rosalyn M Adam

Author Affiliations

1: Urological Diseases Research Center, Children's Hospital Boston, Boston, MA 02115, USA.

Articles citing this

Hypoxia suppresses conversion from proliferative arrest to cellular senescence. Proc Natl Acad Sci U S A (2012) 1.83

The ubiquitin-specific protease USP2a enhances tumor progression by targeting cyclin A1 in bladder cancer. Cell Cycle (2012) 1.56

Loss of Glycogen Debranching Enzyme AGL Drives Bladder Tumor Growth via Induction of Hyaluronic Acid Synthesis. Clin Cancer Res (2015) 1.42

Metabolomics insights into pathophysiological mechanisms of interstitial cystitis. Int Neurourol J (2014) 1.12

Pannexin 1 involvement in bladder dysfunction in a multiple sclerosis model. Sci Rep (2013) 0.98

Quantitative proteomics identifies a beta-catenin network as an element of the signaling response to Frizzled-8 protein-related antiproliferative factor. Mol Cell Proteomics (2011) 0.94

Mammalian target of rapamycin complex 2 (mTORC2) is a critical determinant of bladder cancer invasion. PLoS One (2013) 0.92

'Omics' approaches to understanding interstitial cystitis/painful bladder syndrome/bladder pain syndrome. Int Neurourol J (2012) 0.90

Urinary metabolite profiling combined with computational analysis predicts interstitial cystitis-associated candidate biomarkers. J Proteome Res (2014) 0.87

Pannexin 1 channels play essential roles in urothelial mechanotransduction and intercellular signaling. PLoS One (2014) 0.86

Evaluation of silk biomaterials in combination with extracellular matrix coatings for bladder tissue engineering with primary and pluripotent cells. PLoS One (2013) 0.85

Scaffold attachment factor B1 regulates the androgen receptor in concert with the growth inhibitory kinase MST1 and the methyltransferase EZH2. Oncogene (2013) 0.85

Loss of Sh3gl2/endophilin A1 is a common event in urothelial carcinoma that promotes malignant behavior. Neoplasia (2013) 0.85

Integration analysis of quantitative proteomics and transcriptomics data identifies potential targets of frizzled-8 protein-related antiproliferative factor in vivo. BJU Int (2012) 0.83

Cross-contamination of a UROtsa stock with T24 cells--molecular comparison of different cell lines and stocks. PLoS One (2013) 0.80

Intravital imaging of mouse urothelium reveals activation of extracellular signal-regulated kinase by stretch-induced intravesical release of ATP. Physiol Rep (2016) 0.78

The c-MET Network as Novel Prognostic Marker for Predicting Bladder Cancer Patients with an Increased Risk of Developing Aggressive Disease. PLoS One (2015) 0.78

Hexavalent chromium induces chromosome instability in human urothelial cells. Toxicol Appl Pharmacol (2016) 0.77

A synthetic form of frizzled 8-associated antiproliferative factor enhances p53 stability through USP2a and MDM2. PLoS One (2012) 0.77

Articles cited by this

Oncosome formation in prostate cancer: association with a region of frequent chromosomal deletion in metastatic disease. Cancer Res (2009) 2.07

Expression of hTERT immortalises normal human urothelial cells without inactivation of the p16/Rb pathway. Oncogene (2006) 2.03

Bladder epithelial cells from patients with interstitial cystitis produce an inhibitor of heparin-binding epidermal growth factor-like growth factor production. J Urol (2000) 1.50

Decreased in vitro proliferation of bladder epithelial cells from patients with interstitial cystitis. Urology (2003) 1.30

Prediction of drug combination chemosensitivity in human bladder cancer. Mol Cancer Ther (2007) 1.29

Heparin-binding EGF-like growth factor is an autocrine growth factor for human urothelial cells and is synthesized by epithelial and smooth muscle cells in the human bladder. J Clin Invest (1997) 1.21

Genes involved in differentiation, stem cell renewal, and tumorigenesis are modulated in telomerase-immortalized human urothelial cells. Mol Cancer Res (2008) 1.18

p53 mediates interstitial cystitis antiproliferative factor (APF)-induced growth inhibition of human urothelial cells. FEBS Lett (2007) 1.14

Use of exogenous hTERT to immortalize primary human cells. Cytotechnology (2004) 1.06

Karyotypic characterization of urinary bladder transitional cell carcinomas. Genes Chromosomes Cancer (2000) 0.90

A signaling network in phenylephrine-induced benign prostatic hyperplasia. Endocrinology (2009) 0.88

Integrated genomic and transcriptional analysis of the in vitro evolution of telomerase-immortalized urothelial cells (TERT-NHUC). Genes Chromosomes Cancer (2009) 0.86

Articles by these authors

Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease. Nature (2011) 13.53

Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis. Nat Med (2013) 9.44

Protein carbamylation links inflammation, smoking, uremia and atherogenesis. Nat Med (2007) 4.30

Single-port laparoscopic surgery in urology: initial experience. Urology (2008) 3.18

Purely transvaginal/perineal management of complications from commercial prolapse kits using a new prostheses/grafts complication classification system. J Urol (2012) 2.98

Previously unidentified changes in renal cell carcinoma gene expression identified by parametric analysis of microarray data. BMC Cancer (2003) 2.90

Cholesterol targeting alters lipid raft composition and cell survival in prostate cancer cells and xenografts. J Clin Invest (2005) 2.89

Single photon-emission computed tomography. J Nucl Cardiol (2010) 2.57

Identifying mRNA targets of microRNA dysregulated in cancer: with application to clear cell Renal Cell Carcinoma. BMC Syst Biol (2010) 2.49

Identification of a microRNA panel for clear-cell kidney cancer. Urology (2009) 2.32

Proteome scale characterization of human S-acylated proteins in lipid raft-enriched and non-raft membranes. Mol Cell Proteomics (2009) 2.16

Cholesterol-rich lipid rafts mediate akt-regulated survival in prostate cancer cells. Cancer Res (2002) 2.11

Management of iatrogenic foreign bodies of the bladder and urethra following pelvic floor surgery. Neurourol Urodyn (2008) 2.08

Oncosome formation in prostate cancer: association with a region of frequent chromosomal deletion in metastatic disease. Cancer Res (2009) 2.07

Ontario multidetector computed tomographic coronary angiography study: field evaluation of diagnostic accuracy. Arch Intern Med (2011) 1.97

Impact of circulating cholesterol levels on growth and intratumoral androgen concentration of prostate tumors. PLoS One (2012) 1.89

Overactive bladder: a better understanding of pathophysiology, diagnosis and management. J Urol (2006) 1.89

An absence of stromal caveolin-1 is associated with advanced prostate cancer, metastatic disease and epithelial Akt activation. Cell Cycle (2009) 1.88

MyD88 is essential for clearance of Leishmania major: possible role for lipophosphoglycan and Toll-like receptor 2 signaling. Eur J Immunol (2003) 1.82

Do the cholesterol-lowering properties of statins affect cancer risk? Trends Endocrinol Metab (2008) 1.74

Over expression of stem cell homing cytokines in urogenital organs following vaginal distention. J Urol (2007) 1.72

NOTES transvaginal nephrectomy: first human experience. Urology (2009) 1.70

The pro-apoptotic kinase Mst1 and its caspase cleavage products are direct inhibitors of Akt1. EMBO J (2007) 1.69

Signaling through PI3K/Akt mediates stretch and PDGF-BB-dependent DNA synthesis in bladder smooth muscle cells. J Urol (2003) 1.65

Single-port laparoscopic abdominal sacral colpopexy: initial experience and comparative outcomes. Urology (2009) 1.63

Differential protein profiling in renal-cell carcinoma. Mol Carcinog (2004) 1.62

Large oncosomes in human prostate cancer tissues and in the circulation of mice with metastatic disease. Am J Pathol (2012) 1.60

The ubiquitin-specific protease USP2a enhances tumor progression by targeting cyclin A1 in bladder cancer. Cell Cycle (2012) 1.56

Marked disturbance of calcium homeostasis in mice with targeted disruption of the Trpv6 calcium channel gene. J Bone Miner Res (2007) 1.56

Flagellin acting via TLR5 is the major activator of key signaling pathways leading to NF-kappa B and proinflammatory gene program activation in intestinal epithelial cells. BMC Microbiol (2004) 1.53

Laparoscopic and abdominal sacral colpopexies: a comparative cohort study. Am J Obstet Gynecol (2005) 1.51

Modification of high density lipoprotein by myeloperoxidase generates a pro-inflammatory particle. J Biol Chem (2009) 1.51

Patient perceived effectiveness of a new male sling as treatment for post-prostatectomy incontinence. J Urol (2010) 1.49

Effects of resveratrol on gene expression in renal cell carcinoma. Cancer Biol Ther (2004) 1.46

Tissue-engineered bone serves as a target for metastasis of human breast cancer in a mouse model. Cancer Res (2007) 1.46

Cholesterol sensitivity of endogenous and myristoylated Akt. Cancer Res (2007) 1.45

CKAP4/p63 is a receptor for the frizzled-8 protein-related antiproliferative factor from interstitial cystitis patients. J Biol Chem (2006) 1.44

The role of cholesterol in prostate cancer. Curr Opin Clin Nutr Metab Care (2006) 1.43

A Tbx1-Six1/Eya1-Fgf8 genetic pathway controls mammalian cardiovascular and craniofacial morphogenesis. J Clin Invest (2011) 1.39

Pharmacologic management of painful bladder syndrome/interstitial cystitis: a systematic review. Arch Intern Med (2007) 1.38

A comparison of multiple urine markers for interstitial cystitis. J Urol (2002) 1.37

Reflex UroVysion testing of bladder cancer surveillance patients with equivocal or negative urine cytology: a prospective study with focus on the natural history of anticipatory positive findings. Am J Clin Pathol (2007) 1.36

Do the National Institute of Diabetes and Digestive and Kidney Diseases cystoscopic criteria associate with other clinical and objective features of interstitial cystitis? J Urol (2005) 1.33

Post-transcriptional regulation of the androgen receptor by Mammalian target of rapamycin. Cancer Res (2005) 1.31

Calcium-selective ion channel, CaT1, is apically localized in gastrointestinal tract epithelia and is aberrantly expressed in human malignancies. Lab Invest (2002) 1.30

Multitarget fluorescence in situ hybridization assay detects transitional cell carcinoma in the majority of patients with bladder cancer and atypical or negative urine cytology. J Urol (2003) 1.29

Temporal activation of NF-kappaB regulates an interferon-independent innate antiviral response against cytoplasmic RNA viruses. Proc Natl Acad Sci U S A (2003) 1.28

Identification of CKAP4/p63 as a major substrate of the palmitoyl acyltransferase DHHC2, a putative tumor suppressor, using a novel proteomics method. Mol Cell Proteomics (2008) 1.28

Cholesterol and prostate cancer. Curr Opin Pharmacol (2012) 1.28

Phosphoinositide 3-kinase-independent non-genomic signals transit from the androgen receptor to Akt1 in membrane raft microdomains. J Biol Chem (2007) 1.23

The cardioprotective protein apolipoprotein A1 promotes potent anti-tumorigenic effects. J Biol Chem (2013) 1.22

Myeloperoxidase, paraoxonase-1, and HDL form a functional ternary complex. J Clin Invest (2013) 1.21

Single-port transvesical excision of foreign body in the bladder. Urology (2009) 1.21

Caveolin-1 interacts with a lipid raft-associated population of fatty acid synthase. Cell Cycle (2008) 1.20

The zinc finger protein ras-responsive element binding protein-1 is a coregulator of the androgen receptor: implications for the role of the Ras pathway in enhancing androgenic signaling in prostate cancer. Mol Endocrinol (2007) 1.20

Calcium regulates the PI3K-Akt pathway in stretched osteoblasts. FEBS Lett (2003) 1.19

Urethral diverticula in 90 female patients: a study with emphasis on neoplastic alterations. J Urol (2008) 1.19

Evaluation of gel spun silk-based biomaterials in a murine model of bladder augmentation. Biomaterials (2010) 1.18

Optimizing sample handling for urinary proteomics. J Proteome Res (2008) 1.18

Ezetimibe is an inhibitor of tumor angiogenesis. Am J Pathol (2009) 1.18

Mechanical stretch is a highly selective regulator of gene expression in human bladder smooth muscle cells. Physiol Genomics (2004) 1.17

A quantitative proteomic analysis of growth factor-induced compositional changes in lipid rafts of human smooth muscle cells. Proteomics (2005) 1.15

Proteomic analysis of palmitoylated platelet proteins. Blood (2011) 1.14

p53 mediates interstitial cystitis antiproliferative factor (APF)-induced growth inhibition of human urothelial cells. FEBS Lett (2007) 1.14

The phosphoinositide kinase PIKfyve mediates epidermal growth factor receptor trafficking to the nucleus. Cancer Res (2007) 1.13

Fluidization and resolidification of the human bladder smooth muscle cell in response to transient stretch. PLoS One (2010) 1.13

Recurrent pelvic organ prolapse in a woman with bladder exstrophy: a case report of surgical management and review of the literature. Int Urogynecol J Pelvic Floor Dysfunct (2004) 1.13

The complex interplay between cholesterol and prostate malignancy. Urol Clin North Am (2011) 1.13

Surgically corrected urethral diverticula: long-term voiding dysfunction and reoperation rates. Urology (2010) 1.12

Large oncosomes mediate intercellular transfer of functional microRNA. Cell Cycle (2013) 1.12

Recent pattern of Co-infection amongst HIV seropositive individuals in tertiary care hospital, Kolkata. Virol J (2011) 1.12

Safety of zoster vaccine in elderly adults following documented herpes zoster. J Infect Dis (2013) 1.09

Bladder tissue regeneration using acellular bi-layer silk scaffolds in a large animal model of augmentation cystoplasty. Biomaterials (2013) 1.08

Measurement of plasma levels of vascular endothelial growth factor in prostate cancer patients: relationship with clinical stage, Gleason score, prostate volume, and serum prostate-specific antigen. Clinics (Sao Paulo) (2006) 1.07

All-trans retinoic acid directs urothelial specification of murine embryonic stem cells via GATA4/6 signaling mechanisms. PLoS One (2010) 1.07

Induction of smooth muscle cell-like phenotype in marrow-derived cells among regenerating urinary bladder smooth muscle cells. Am J Pathol (2005) 1.07

Prognostic importance of resection margin width after nephron-sparing surgery for renal cell carcinoma. Urology (2002) 1.07

Caveolin-1alpha and -1beta perform nonredundant roles in early vertebrate development. Am J Pathol (2006) 1.06

Urinary bromotyrosine measures asthma control and predicts asthma exacerbations in children. J Pediatr (2011) 1.05

Urine markers do not predict biopsy findings or presence of bladder ulcers in interstitial cystitis/painful bladder syndrome. J Urol (2008) 1.05

Suppression of NF-kappa B survival signaling by nitrosylcobalamin sensitizes neoplasms to the anti-tumor effects of Apo2L/TRAIL. J Biol Chem (2003) 1.04

GATA-6 mediates human bladder smooth muscle differentiation: involvement of a novel enhancer element in regulating alpha-smooth muscle actin gene expression. Am J Physiol Cell Physiol (2007) 1.04

Trafficking of nuclear heparin-binding epidermal growth factor-like growth factor into an epidermal growth factor receptor-dependent autocrine loop in response to oxidative stress. Cancer Res (2005) 1.04

MicroRNA-185 and 342 inhibit tumorigenicity and induce apoptosis through blockade of the SREBP metabolic pathway in prostate cancer cells. PLoS One (2013) 1.03