A new computational strategy for predicting essential genes.

Identifying and characterising key alternative splicing events in Drosophila development. BMC Genomics (2015) 0.78

Predicting Essential Genes and Proteins Based on Machine Learning and Network Topological Features: A Comprehensive Review. Front Physiol (2016) 0.78

An Approach for Predicting Essential Genes Using Multiple Homology Mapping and Machine Learning Algorithms. Biomed Res Int (2016) 0.76

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Functional profiling of the Saccharomyces cerevisiae genome. Nature (2002) 36.10

The Pfam protein families database. Nucleic Acids Res (2011) 33.46

The STRING database in 2011: functional interaction networks of proteins, globally integrated and scored. Nucleic Acids Res (2010) 18.73

Essential Bacillus subtilis genes. Proc Natl Acad Sci U S A (2003) 14.01

A review of feature selection techniques in bioinformatics. Bioinformatics (2007) 13.51

Creation of a bacterial cell controlled by a chemically synthesized genome. Science (2010) 13.45

HMMER web server: interactive sequence similarity searching. Nucleic Acids Res (2011) 13.00

Role of duplicate genes in genetic robustness against null mutations. Nature (2003) 7.81

Systematic screen for human disease genes in yeast. Nat Genet (2002) 4.97

Systematic identification of human mitochondrial disease genes through integrative genomics. Nat Genet (2006) 4.67

Prioritizing candidate disease genes by network-based boosting of genome-wide association data. Genome Res (2011) 4.39

Analysis of a genome-wide set of gene deletions in the fission yeast Schizosaccharomyces pombe. Nat Biotechnol (2010) 4.26

Metabolic network analysis of the causes and evolution of enzyme dispensability in yeast. Nature (2004) 4.06

eggNOG v3.0: orthologous groups covering 1133 organisms at 41 different taxonomic ranges. Nucleic Acids Res (2011) 3.94

Comparative genomics of centrality and essentiality in three eukaryotic protein-interaction networks. Mol Biol Evol (2004) 3.73

Genomic analysis of essentiality within protein networks. Trends Genet (2004) 3.52

Global transposon mutagenesis and essential gene analysis of Helicobacter pylori. J Bacteriol (2004) 3.25

Genotype to phenotype: a complex problem. Science (2010) 2.92

Large-scale essential gene identification in Candida albicans and applications to antifungal drug discovery. Mol Microbiol (2003) 2.84

The universal distribution of evolutionary rates of genes and distinct characteristics of eukaryotic genes of different apparent ages. Proc Natl Acad Sci U S A (2009) 2.50

DEG: a database of essential genes. Nucleic Acids Res (2004) 2.42

New genes in Drosophila quickly become essential. Science (2010) 2.39

Functional topology in a network of protein interactions. Bioinformatics (2004) 2.38

Essential genes on metabolic maps. Curr Opin Biotechnol (2006) 2.18

Mouse duplicate genes are as essential as singletons. Trends Genet (2007) 2.12

The relationship of protein conservation and sequence length. BMC Evol Biol (2002) 1.95

Indirect and suboptimal control of gene expression is widespread in bacteria. Mol Syst Biol (2013) 1.81

An estimation of minimal genome size required for life. FEBS Lett (1995) 1.79

The complex relationship of gene duplication and essentiality. Trends Genet (2009) 1.76

How essential are nonessential genes? Mol Biol Evol (2005) 1.63

OGEE: an online gene essentiality database. Nucleic Acids Res (2011) 1.54

Genome-wide screening for gene function using RNAi in mammalian cells. Immunol Cell Biol (2005) 1.41

Towards the identification of essential genes using targeted genome sequencing and comparative analysis. BMC Genomics (2006) 1.39

Mining predicted essential genes of Brugia malayi for nematode drug targets. PLoS One (2007) 1.35

Predicting essential genes in fungal genomes. Genome Res (2006) 1.34

Genome-wide essential gene identification in Streptococcus sanguinis. Sci Rep (2011) 1.31

Topological properties of protein interaction networks from a structural perspective. Biochem Soc Trans (2008) 1.28

Mining housekeeping genes with a Naive Bayes classifier. BMC Genomics (2006) 1.22

Computational prediction of essential genes in an unculturable endosymbiotic bacterium, Wolbachia of Brugia malayi. BMC Microbiol (2009) 1.22

Towards the prediction of essential genes by integration of network topology, cellular localization and biological process information. BMC Bioinformatics (2009) 1.22

Investigating the predictability of essential genes across distantly related organisms using an integrative approach. Nucleic Acids Res (2010) 1.21

Comparative mycobacterial genomics as a tool for drug target and antigen discovery. Eur Respir J Suppl (2002) 1.19

Younger genes are less likely to be essential than older genes, and duplicates are less likely to be essential than singletons of the same age. Mol Biol Evol (2012) 1.19

Are essential genes really essential? Trends Microbiol (2009) 1.18

Defining the role of essential genes in human disease. PLoS One (2011) 1.17

Identifying essential genes in bacterial metabolic networks with machine learning methods. BMC Syst Biol (2010) 1.01

Tools for target identification and validation. Curr Opin Chem Biol (2004) 0.98

Rational identification of new antibacterial drug targets that are essential for viability using a genomics-based approach. Pharmacol Ther (2002) 0.96

Dynamic transcriptional and metabolic responses in yeast adapting to temperature stress. OMICS (2010) 0.95

A combined bioinformatics and chemoinformatics approach for the development of new antiparasitic drugs. Genomics (2006) 0.94

Concordance analysis of microbial genomes. Nucleic Acids Res (1998) 0.94

Duplication and retention biases of essential and non-essential genes revealed by systematic knockdown analyses. PLoS Genet (2013) 0.93

Profiling of Escherichia coli Chromosome database. Methods Mol Biol (2008) 0.90

The global transcriptional response of fission yeast to hydrogen sulfide. PLoS One (2011) 0.79

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Grid Binary LOgistic REgression (GLORE): building shared models without sharing data. J Am Med Inform Assoc (2012) 1.92

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Pharmacokinetic parameters and tissue distribution of magnetic Fe(3)O(4) nanoparticles in mice. Int J Nanomedicine (2010) 1.51

EXpectation Propagation LOgistic REgRession (EXPLORER): distributed privacy-preserving online model learning. J Biomed Inform (2013) 1.38

Gender-specific response to isoflurane preconditioning in focal cerebral ischemia. J Cereb Blood Flow Metab (2007) 1.38

Efficacy and safety of accelerated partial breast irradiation after breast-conserving surgery: a meta-analysis of published comparative studies. Breast J (2013) 1.38

A community assessment of privacy preserving techniques for human genomes. BMC Med Inform Decis Mak (2014) 1.37

Reversal in multidrug resistance by magnetic nanoparticle of Fe3O4 loaded with adriamycin and tetrandrine in K562/A02 leukemic cells. Int J Nanomedicine (2008) 1.29

Dose-dependent effects of androgens on outcome after focal cerebral ischemia in adult male mice. J Cereb Blood Flow Metab (2009) 1.25

Association of intussusception and celiac disease in adults. Dig Dis Sci (2009) 1.17

Magnetic nanoparticle of Fe3O4 and 5-bromotetrandrin interact synergistically to induce apoptosis by daunorubicin in leukemia cells. Int J Nanomedicine (2009) 1.17

Phylogenetic analysis of the hemagglutinin genes of twenty-six avian influenza viruses of subtype H9N2 isolated from chickens in China during 1996-2001. Avian Dis (2003) 1.16

Reversal of multidrug resistance by magnetic Fe3O4 nanoparticle copolymerizating daunorubicin and 5-bromotetrandrine in xenograft nude-mice. Int J Nanomedicine (2009) 1.13

Biocompatibility of Fe3O4/DNR magnetic nanoparticles in the treatment of hematologic malignancies. Int J Nanomedicine (2010) 1.11

Soluble epoxide hydrolase: regulation by estrogen and role in the inflammatory response to cerebral ischemia. Front Biosci (2008) 1.11

Daunorubicin-loaded magnetic nanoparticles of Fe3O4 overcome multidrug resistance and induce apoptosis of K562-n/VCR cells in vivo. Int J Nanomedicine (2009) 1.10

Reactive oxygen species stimulated human hepatoma cell proliferation via cross-talk between PI3-K/PKB and JNK signaling pathways. Arch Biochem Biophys (2002) 1.08

The effect of magnetic nanoparticles of Fe(3)O(4) on immune function in normal ICR mice. Int J Nanomedicine (2010) 1.08

The reversal effect of magnetic Fe3O4 nanoparticles loaded with cisplatin on SKOV3/DDP ovarian carcinoma cells. Int J Nanomedicine (2009) 1.08

Privacy-preserving heterogeneous health data sharing. J Am Med Inform Assoc (2012) 1.06

Sigma receptor agonists provide neuroprotection in vitro by preserving bcl-2. Anesth Analg (2007) 1.05

Transcriptome analysis of alternative splicing events regulated by SRSF10 reveals position-dependent splicing modulation. Nucleic Acids Res (2014) 1.04

Depletion of DNMT3A suppressed cell proliferation and restored PTEN in hepatocellular carcinoma cell. J Biomed Biotechnol (2010) 1.03

Anomaly and signature filtering improve classifier performance for detection of suspicious access to EHRs. AMIA Annu Symp Proc (2011) 1.01

WebGLORE: a web service for Grid LOgistic REgression. Bioinformatics (2013) 1.01

Multifunctional magnetic Fe3O4 nanoparticles combined with chemotherapy and hyperthermia to overcome multidrug resistance. Int J Nanomedicine (2012) 1.01

Preserving Institutional Privacy in Distributed binary Logistic Regression. AMIA Annu Symp Proc (2012) 1.01

Synergistic effect of magnetic nanoparticles of Fe(3)O(4) with gambogic acid on apoptosis of K562 leukemia cells. Int J Nanomedicine (2009) 0.96

Red blood cell extrudes nucleus and mitochondria against oxidative stress. IUBMB Life (2011) 0.96

The plastid hexokinase pHXK: a node of convergence for sugar and plastid signals in Arabidopsis. FEBS Lett (2010) 0.94

[Preparation of Fe3O4-magnetic nanoparticles loaded with adriamycin and its reversal of multidrug resistance in vitro]. Zhongguo Shi Yan Xue Ye Xue Za Zhi (2007) 0.93

Reversal of multidrug resistance by magnetic Fe3O4 nanoparticle copolymerizating daunorubicin and MDR1 shRNA expression vector in leukemia cells. Int J Nanomedicine (2010) 0.92

Synergistic effect of the combination of nanoparticulate Fe3O4 and Au with daunomycin on K562/A02 cells. Int J Nanomedicine (2008) 0.92

Pre-treatment with isoflurane ameliorates renal ischemic-reperfusion injury in mice. Life Sci (2011) 0.91

Non-syndromic tooth agenesis in two Chinese families associated with novel missense mutations in the TNF domain of EDA (ectodysplasin A). PLoS One (2008) 0.91

Trends in biomedical informatics: most cited topics from recent years. J Am Med Inform Assoc (2011) 0.91

[Comparison of reversal effects of 5-bromotetrandrine and tetrandrine on P-glycoprotein-dependent Resistance to adriamycin in human lukemia cell line K562/A02]. Ai Zheng (2008) 0.91

Transient accumulation of Mg-protoporphyrin IX regulates expression of PhANGs - New evidence for the signaling role of tetrapyrroles in mature Arabidopsis plants. J Plant Physiol (2011) 0.91

Reversal of multidrug resistance by cisplatin-loaded magnetic Fe3O4 nanoparticles in A549/DDP lung cancer cells in vitro and in vivo. Int J Nanomedicine (2013) 0.89

Hydrogen sulfide protects blood-brain barrier integrity following cerebral ischemia. J Neurochem (2014) 0.89

GAMUT: GPU accelerated microRNA analysis to uncover target genes through CUDA-miRanda. BMC Med Genomics (2014) 0.88

I-spline Smoothing for Calibrating Predictive Models. AMIA Jt Summits Transl Sci Proc (2012) 0.88

Apoptotic mechanism of human leukemia K562/A02 cells induced by magnetic iron oxide nanoparticles co-loaded with daunorubicin and 5-bromotetrandrin. Int J Nanomedicine (2011) 0.88

Multi-atlas based representations for Alzheimer's disease diagnosis. Hum Brain Mapp (2014) 0.87

FORESEE: Fully Outsourced secuRe gEnome Study basEd on homomorphic Encryption. BMC Med Inform Decis Mak (2015) 0.87

HUGO: Hierarchical mUlti-reference Genome cOmpression for aligned reads. J Am Med Inform Assoc (2013) 0.87

Male fertility is compatible with an Arg(840)Cys substitution in the AR in a large Chinese family affected with divergent phenotypes of AR insensitivity syndrome. J Clin Endocrinol Metab (2002) 0.87

Association of thymidylate synthase gene 3'-untranslated region polymorphism with sensitivity of non-small cell lung cancer to pemetrexed treatment: TS gene polymorphism and pemetrexed sensitivity in NSCLC. J Biomed Sci (2013) 0.86

Patterns of insertion and deletion in Mammalian genomes. Curr Genomics (2007) 0.86

Privacy-preserving GWAS analysis on federated genomic datasets. BMC Med Inform Decis Mak (2015) 0.86

Private and Efficient Query Processing on Outsourced Genomic Databases. IEEE J Biomed Health Inform (2016) 0.85

Impacts of mutation effects and population size on mutation rate in asexual populations: a simulation study. BMC Evol Biol (2010) 0.85

Effect of magnetic nanoparticles on apoptosis and cell cycle induced by wogonin in Raji cells. Int J Nanomedicine (2012) 0.85

Differentially private distributed logistic regression using private and public data. BMC Med Genomics (2014) 0.85

Statistical distributions of optimal global alignment scores of random protein sequences. BMC Bioinformatics (2005) 0.85

Effect of D, L-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol and tetrandrine on the reversion of multidrug resistance in K562/A02 cells. Hematology (2011) 0.84

Deciphering the rules by which dynamics of mRNA secondary structure affect translation efficiency in Saccharomyces cerevisiae. Nucleic Acids Res (2014) 0.84

Defected expression of E-cadherin in non-small cell lung cancer. Lung Cancer (2002) 0.84

A collaborative framework for Distributed Privacy-Preserving Support Vector Machine learning. AMIA Annu Symp Proc (2012) 0.84

A novel role for cyanide in the control of cucumber (Cucumis sativus L.) seedlings response to environmental stress. Plant Cell Environ (2012) 0.84

Emulsified isoflurane preconditioning protects against liver and lung injury in rat model of hemorrhagic shock. J Surg Res (2010) 0.83

CaMKKβ-dependent activation of AMP-activated protein kinase is critical to suppressive effects of hydrogen sulfide on neuroinflammation. Antioxid Redox Signal (2014) 0.83

The roles of two transcription factors, ABI4 and CBFA, in ABA and plastid signalling and stress responses. Plant Mol Biol (2013) 0.83

Identifying inference attacks against healthcare data repositories. AMIA Jt Summits Transl Sci Proc (2013) 0.83

LRTV: MR Image Super-Resolution With Low-Rank and Total Variation Regularizations. IEEE Trans Med Imaging (2015) 0.83

Conservation and evolution in and among SRF- and MEF2-type MADS domains and their binding sites. Mol Biol Evol (2010) 0.83

Ghrelin Attenuated Lipotoxicity via Autophagy Induction and Nuclear Factor-κB Inhibition. Cell Physiol Biochem (2015) 0.83

Rapid identification and high sensitive detection of cancer cells on the gold nanoparticle interface by combined contact angle and electrochemical measurements. Talanta (2008) 0.82

Overexpression of DNA methyltransferase 1 and its biological significance in primary hepatocellular carcinoma. World J Gastroenterol (2009) 0.82

Vertebrate paralogous MEF2 genes: origin, conservation, and evolution. PLoS One (2011) 0.82

Developmental exposure to polychlorinated biphenyls influences stroke outcome in adult rats. Environ Health Perspect (2008) 0.82

Daunorubicin-loaded magnetic nanoparticles of Fe(3)O(4) greatly enhance the responses of multidrug-resistant K562 leukemic cells in a nude mouse xenograft model to chemotherapy. Zhongguo Shi Yan Xue Ye Xue Za Zhi (2009) 0.81

Quality of life of patients after allogeneic hematopoietic stem cell transplantation with antihuman thymocyte globulin. Biol Blood Marrow Transplant (2011) 0.81

A meta-analysis of the association between the hOGG1 Ser326Cys polymorphism and the risk of esophageal squamous cell carcinoma. PLoS One (2013) 0.81

Comparative analysis of essential genes and nonessential genes in Escherichia coli K12. Mol Genet Genomics (2007) 0.81

The 5-Lipoxygenase Inhibitor Zileuton Confers Neuroprotection against Glutamate Oxidative Damage by Inhibiting Ferroptosis. Biol Pharm Bull (2015) 0.80

Genomes in the cloud: balancing privacy rights and the public good. AMIA Jt Summits Transl Sci Proc (2013) 0.80

Patterns of nucleotides that flank substitutions in human orthologous genes. BMC Genomics (2010) 0.80

Sirtuin 1 facilitates chemoresistance of pancreatic cancer cells by regulating adaptive response to chemotherapy-induced stress. Cancer Sci (2014) 0.80

The influence of deleterious mutations on adaptation in asexual populations. PLoS One (2011) 0.80

Deciphering heterogeneity in pig genome assembly Sscrofa9 by isochore and isochore-like region analyses. PLoS One (2010) 0.79

Isolation, culture and biological characteristics of primordial germ cells from Beijing fatty chicken. J Reprod Dev (2010) 0.79

Handy, rapid and multiplex detection of tumor markers based on encoded silica-hydrogel hybrid beads array chip. Biosens Bioelectron (2013) 0.79

Genome-wide association study of antibody level response to NDV and IBV in Jinghai yellow chicken based on SLAF-seq technology. J Appl Genet (2015) 0.79

Study on characteristic parameters influencing laser-induced damage threshold of KH(2)PO(4) crystal surface machined by single point diamond turning. J Appl Phys (2011) 0.79

Peroxisomal biogenesis in ischemic brain. Antioxid Redox Signal (2015) 0.79

Expression of biologically active kringle 5 domain of human plasminogen in Escherichia coli. Prep Biochem Biotechnol (2005) 0.79

Coevolution in RNA molecules driven by selective constraints: evidence from 5S rRNA. PLoS One (2012) 0.79

Influence of surface cracks on laser-induced damage resistance of brittle KH₂PO₄ crystal. Opt Express (2014) 0.79

Designing single- and multiple-shell sampling schemes for diffusion MRI using spherical code. Med Image Comput Comput Assist Interv (2014) 0.79

Number variation of high stability regions is correlated with gene functions. Genome Biol Evol (2013) 0.78

[Reversal effect of Fe3O4-magnetic nanoparticles on multi-drug resistance of ovarian carcinoma cells and its correlation with apoptosis-associated genes]. Ai Zheng (2009) 0.78

[Comparison of sequences of the hemagglutinin gene and phylogenetical analysis of H9 subtype avian influenza viruses isolated from some regions in China]. Wei Sheng Wu Xue Bao (2002) 0.78

Biological characterization of chicken mesenchymal stem/progenitor cells from umbilical cord Wharton's jelly. Mol Cell Biochem (2012) 0.78

Universally increased mRNA stability downstream of the translation initiation site in eukaryotes and prokaryotes. Gene (2013) 0.78