Published in Trends Genet on June 07, 2007
Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes. Cell (2013) 3.47
Identification and characterization of essential genes in the human genome. Science (2015) 3.14
DEG 5.0, a database of essential genes in both prokaryotes and eukaryotes. Nucleic Acids Res (2008) 2.94
Null mutations in human and mouse orthologs frequently result in different phenotypes. Proc Natl Acad Sci U S A (2008) 2.60
Prevalent positive epistasis in Escherichia coli and Saccharomyces cerevisiae metabolic networks. Nat Genet (2010) 2.16
DEG 10, an update of the database of essential genes that includes both protein-coding genes and noncoding genomic elements. Nucleic Acids Res (2013) 2.01
OGEE: an online gene essentiality database. Nucleic Acids Res (2011) 1.54
Human allelic variation: perspective from protein function, structure, and evolution. Curr Opin Struct Biol (2010) 1.47
Phylomedicine: an evolutionary telescope to explore and diagnose the universe of disease mutations. Trends Genet (2011) 1.38
Functional characterization of genetic variants in NPC1L1 supports the sequencing extremes strategy to identify complex trait genes. Hum Mol Genet (2008) 1.37
Abundant indispensable redundancies in cellular metabolic networks. Genome Biol Evol (2009) 1.23
Younger genes are less likely to be essential than older genes, and duplicates are less likely to be essential than singletons of the same age. Mol Biol Evol (2012) 1.19
A comprehensive dataset of genes with a loss-of-function mutant phenotype in Arabidopsis. Plant Physiol (2012) 1.18
Predicting the proportion of essential genes in mouse duplicates based on biased mouse knockout genes. J Mol Evol (2008) 1.11
Correlating traits of gene retention, sequence divergence, duplicability and essentiality in vertebrates, arthropods, and fungi. Genome Biol Evol (2010) 1.07
Are sex-biased genes more dispensable? Biol Lett (2009) 1.07
Modification of gene duplicability during the evolution of protein interaction network. PLoS Comput Biol (2011) 1.05
Evolutionary persistence of functional compensation by duplicate genes in Arabidopsis. Genome Biol Evol (2009) 1.04
Impact of extracellularity on the evolutionary rate of mammalian proteins. Genome Biol Evol (2010) 1.02
Functional compensation of primary and secondary metabolites by duplicate genes in Arabidopsis thaliana. Mol Biol Evol (2010) 0.97
Functional compensation by duplicated genes in mouse. Trends Genet (2009) 0.97
Evolution by gene loss. Nat Rev Genet (2016) 0.96
Human coding RNA editing is generally nonadaptive. Proc Natl Acad Sci U S A (2014) 0.96
Contrast features of CpG islands in the promoter and other regions in the dog genome. Genomics (2009) 0.92
How old is my gene? Trends Genet (2013) 0.91
Predicting the lethal phenotype of the knockout mouse by integrating comprehensive genomic data. Bioinformatics (2012) 0.91
Gene family size conservation is a good indicator of evolutionary rates. Mol Biol Evol (2010) 0.89
Buffering by gene duplicates: an analysis of molecular correlates and evolutionary conservation. BMC Genomics (2008) 0.89
Human dominant disease genes are enriched in paralogs originating from whole genome duplication. PLoS Comput Biol (2014) 0.86
Manic fringe is not required for embryonic development, and fringe family members do not exhibit redundant functions in the axial skeleton, limb, or hindbrain. Dev Dyn (2009) 0.86
MamPhEA: a web tool for mammalian phenotype enrichment analysis. Bioinformatics (2010) 0.85
Evolutionary origins of human apoptosis and genome-stability gene networks. Nucleic Acids Res (2008) 0.83
G-NEST: a gene neighborhood scoring tool to identify co-conserved, co-expressed genes. BMC Bioinformatics (2012) 0.82
Investigating different duplication pattern of essential genes in mouse and human. PLoS One (2015) 0.81
Evolution of vertebrate tissues driven by differential modes of gene duplication. DNA Res (2012) 0.81
Network compensation of cyclic GMP-dependent protein kinase II knockout in the hippocampus by Ca2+-permeable AMPA receptors. Proc Natl Acad Sci U S A (2015) 0.80
The CaMKII/GluN2B Protein Interaction Maintains Synaptic Strength. J Biol Chem (2016) 0.80
Gene duplicability-connectivity-complexity across organisms and a neutral evolutionary explanation. PLoS One (2012) 0.79
A new computational strategy for predicting essential genes. BMC Genomics (2013) 0.79
Natural selection drives rapid evolution of mouse embryonic heart enhancers. BMC Syst Biol (2012) 0.78
Tools for Predicting the Functional Impact of Nonsynonymous Genetic Variation. Genetics (2016) 0.77
Effect of duplicate genes on mouse genetic robustness: an update. Biomed Res Int (2014) 0.77
Duplicate dmbx1 genes regulate progenitor cell cycle and differentiation during zebrafish midbrain and retinal development. BMC Dev Biol (2010) 0.77
Comparing the retention mechanisms of tandem duplicates and retrogenes in human and mouse genomes. Genet Sel Evol (2010) 0.77
Dissecting the human protein-protein interaction network via phylogenetic decomposition. Sci Rep (2014) 0.77
The role of protein interactions in mediating essentiality and synthetic lethality. PLoS One (2013) 0.76
Mammalian transcriptional hotspots are enriched for tissue specific enhancers near cell type specific highly expressed genes and are predicted to act as transcriptional activator hubs. BMC Bioinformatics (2014) 0.76
Comments on "Human dominant disease genes are enriched in paralogs originating from whole genome duplication". PLoS Comput Biol (2014) 0.75
Purifying selection shapes the coincident SNP distribution of primate coding sequences. Sci Rep (2016) 0.75
Towards a compendium of essential genes - From model organisms to synthetic lethality in cancer cells. Crit Rev Biochem Mol Biol (2015) 0.75
Unraveling the association between mRNA expressions and mutant phenotypes in a genome-wide assessment of mice. Proc Natl Acad Sci U S A (2015) 0.75
Search for the Function of NWC, Third Gene Within RAG Locus: Generation and Characterization of NWC-Deficient Mice. Arch Immunol Ther Exp (Warsz) (2015) 0.75
Using Disease-Associated Coding Sequence Variation to Investigate Functional Compensation by Human Paralogous Proteins. Evol Bioinform Online (2015) 0.75
Prediction and analysis of essential genes using the enrichments of gene ontology and KEGG pathways. PLoS One (2017) 0.75
Rapid subfunctionalization accompanied by prolonged and substantial neofunctionalization in duplicate gene evolution. Genetics (2005) 3.98
Evolutionary conservation of expression profiles between human and mouse orthologous genes. Mol Biol Evol (2005) 3.62
Gene sequence-based criteria for identification of new rickettsia isolates and description of Rickettsia heilongjiangensis sp. nov. J Clin Microbiol (2003) 3.59
The pleiotropic structure of the genotype-phenotype map: the evolvability of complex organisms. Nat Rev Genet (2011) 3.57
Why do hubs tend to be essential in protein networks? PLoS Genet (2006) 3.29
Gene losses during human origins. PLoS Biol (2006) 3.17
RNA sequencing shows no dosage compensation of the active X-chromosome. Nat Genet (2010) 2.71
Null mutations in human and mouse orthologs frequently result in different phenotypes. Proc Natl Acad Sci U S A (2008) 2.60
Balanced codon usage optimizes eukaryotic translational efficiency. PLoS Genet (2012) 2.32
Impacts of gene essentiality, expression pattern, and gene compactness on the evolutionary rate of mammalian proteins. Mol Biol Evol (2006) 2.22
Genomic patterns of pleiotropy and the evolution of complexity. Proc Natl Acad Sci U S A (2010) 2.19
Prevalent positive epistasis in Escherichia coli and Saccharomyces cerevisiae metabolic networks. Nat Genet (2010) 2.16
More genes underwent positive selection in chimpanzee evolution than in human evolution. Proc Natl Acad Sci U S A (2007) 2.00
Low rates of expression profile divergence in highly expressed genes and tissue-specific genes during mammalian evolution. Mol Biol Evol (2006) 1.97
Dramatic variation of the vomeronasal pheromone receptor gene repertoire among five orders of placental and marsupial mammals. Proc Natl Acad Sci U S A (2005) 1.88
Toward a molecular understanding of pleiotropy. Genetics (2006) 1.88
Comparative genomic analysis identifies an evolutionary shift of vomeronasal receptor gene repertoires in the vertebrate transition from water to land. Genome Res (2007) 1.85
Adaptive diversification of bitter taste receptor genes in Mammalian evolution. Mol Biol Evol (2003) 1.82
Contrasting modes of evolution between vertebrate sweet/umami receptor genes and bitter receptor genes. Mol Biol Evol (2005) 1.77
Expression of hiwi gene in human gastric cancer was associated with proliferation of cancer cells. Int J Cancer (2006) 1.76
The hearing gene Prestin unites echolocating bats and whales. Curr Biol (2010) 1.62
Higher duplicability of less important genes in yeast genomes. Mol Biol Evol (2005) 1.57
Pseudogenization of the umami taste receptor gene Tas1r1 in the giant panda coincided with its dietary switch to bamboo. Mol Biol Evol (2010) 1.53
Maintenance of duplicate genes and their functional redundancy by reduced expression. Trends Genet (2010) 1.51
Composition and evolution of the V2r vomeronasal receptor gene repertoire in mice and rats. Genomics (2005) 1.47
Impact of gene expression noise on organismal fitness and the efficacy of natural selection. Proc Natl Acad Sci U S A (2011) 1.46
The ribonuclease A superfamily of mammals and birds: identifying new members and tracing evolutionary histories. Genomics (2005) 1.43
Sex-specific splicing of the honeybee doublesex gene reveals 300 million years of evolution at the bottom of the insect sex-determination pathway. Genetics (2007) 1.43
Gene complexity and gene duplicability. Curr Biol (2005) 1.42
In search of the biological significance of modular structures in protein networks. PLoS Comput Biol (2007) 1.38
Relaxation of selective constraint and loss of function in the evolution of human bitter taste receptor genes. Hum Mol Genet (2004) 1.38
The genomic landscape and evolutionary resolution of antagonistic pleiotropy in yeast. Cell Rep (2012) 1.36
Evolution of the sweet taste receptor gene Tas1r2 in bats. Mol Biol Evol (2010) 1.36
Impact of translational error-induced and error-free misfolding on the rate of protein evolution. Mol Syst Biol (2010) 1.35
Origin of the genetic components of the vomeronasal system in the common ancestor of all extant vertebrates. Mol Biol Evol (2008) 1.33
Measuring the evolutionary rate of protein-protein interaction. Proc Natl Acad Sci U S A (2011) 1.32
MicroRNA let-7c inhibits migration and invasion of human non-small cell lung cancer by targeting ITGB3 and MAP4K3. Cancer Lett (2013) 1.31
Positive selection for elevated gene expression noise in yeast. Mol Syst Biol (2009) 1.30
Protein misinteraction avoidance causes highly expressed proteins to evolve slowly. Proc Natl Acad Sci U S A (2012) 1.29
Genomic and genetic evidence for the loss of umami taste in bats. Genome Biol Evol (2011) 1.27
Did brain-specific genes evolve faster in humans than in chimpanzees? Trends Genet (2006) 1.26
Positive selection on protein-length in the evolution of a primate sperm ion channel. Proc Natl Acad Sci U S A (2003) 1.26
Abundant indispensable redundancies in cellular metabolic networks. Genome Biol Evol (2009) 1.23
Gene dosage and gene duplicability. Genetics (2008) 1.23
Expression reduction in mammalian X chromosome evolution refutes Ohno's hypothesis of dosage compensation. Proc Natl Acad Sci U S A (2012) 1.22
Rapid turnover and species-specificity of vomeronasal pheromone receptor genes in mice and rats. Gene (2004) 1.21
p37 from Mycoplasma hyorhinis promotes cancer cell invasiveness and metastasis through activation of MMP-2 and followed by phosphorylation of EGFR. Mol Cancer Ther (2008) 1.21
Genomic evidence for elevated mutation rates in highly expressed genes. EMBO Rep (2012) 1.19
Largest vertebrate vomeronasal type 1 receptor gene repertoire in the semiaquatic platypus. Mol Biol Evol (2007) 1.19
Why are some human disease-associated mutations fixed in mice? Trends Genet (2003) 1.19
Why is the correlation between gene importance and gene evolutionary rate so weak? PLoS Genet (2009) 1.16
On the definition and measurement of pleiotropy. Trends Genet (2013) 1.14
Distinct evolutionary patterns between chemoreceptors of 2 vertebrate olfactory systems and the differential tuning hypothesis. Mol Biol Evol (2008) 1.13
No gene-specific optimization of mutation rate in Escherichia coli. Mol Biol Evol (2013) 1.13
Coexpression of linked genes in Mammalian genomes is generally disadvantageous. Mol Biol Evol (2008) 1.12
Nonneutral evolution of the transcribed pseudogene Makorin1-p1 in mice. Mol Biol Evol (2004) 1.11
Neuronal protein synuclein gamma predicts poor clinical outcome in breast cancer. Int J Cancer (2007) 1.10
Differential requirements for mRNA folding partially explain why highly expressed proteins evolve slowly. Proc Natl Acad Sci U S A (2013) 1.09
Diet shapes the evolution of the vertebrate bitter taste receptor gene repertoire. Mol Biol Evol (2013) 1.08
Positive selection for indel substitutions in the rodent sperm protein catsper1. Mol Biol Evol (2005) 1.07
Contrasting genetic paths to morphological and physiological evolution. Proc Natl Acad Sci U S A (2010) 1.05
Evolution of the complementary sex-determination gene of honey bees: balancing selection and trans-species polymorphisms. Genome Res (2006) 1.04
Generation of novel monoclonal antibodies and their application for detecting ARD1 expression in colorectal cancer. Cancer Lett (2008) 1.02
The ortholog conjecture is untestable by the current gene ontology but is supported by RNA sequencing data. PLoS Comput Biol (2012) 1.02
Impact of extracellularity on the evolutionary rate of mammalian proteins. Genome Biol Evol (2010) 1.02
High expression hampers horizontal gene transfer. Genome Biol Evol (2012) 1.01
Evaluation of transovarial transmission and transmissibility of Ehrlichia chaffeensis (Rickettsiales: Anaplasmataceae) in Amblyomma americanum (Acari: Ixodidae). J Med Entomol (2003) 1.01
Suppression of tumor growth and metastasis by a VEGFR-1 antagonizing peptide identified from a phage display library. Int J Cancer (2004) 1.01
Remarkable expansions of an X-linked reproductive homeobox gene cluster in rodent evolution. Genomics (2006) 1.00
Evolutionary dynamics of nematode operons: easy come, slow go. Genome Res (2008) 1.00
Protein subcellular relocalization in the evolution of yeast singleton and duplicate genes. Genome Biol Evol (2009) 0.99
Human coding RNA editing is generally nonadaptive. Proc Natl Acad Sci U S A (2014) 0.96
Zebrafish ribonucleases are bactericidal: implications for the origin of the vertebrate RNase A superfamily. Mol Biol Evol (2007) 0.95
Rapid evolution of mammalian X-linked testis-expressed homeobox genes. Genetics (2004) 0.93
Evidence for escape from adaptive conflict? Nature (2009) 0.91
Origin and evolution of the vertebrate vomeronasal system viewed through system-specific genes. Bioessays (2006) 0.90
Diagnosis of gastric cancer using decision tree classification of mass spectral data. Cancer Sci (2007) 0.90
A big world inside small-world networks. PLoS One (2009) 0.90
Widespread losses of vomeronasal signal transduction in bats. Mol Biol Evol (2010) 0.89
Processed pseudogenes: the 'fossilized footprints' of past gene expression. Trends Genet (2009) 0.89
Ancient expansion of the ribonuclease A superfamily revealed by genomic analysis of placental and marsupial mammals. Gene (2006) 0.88
Mismatches between feeding ecology and taste receptor evolution: an inconvenient truth. Proc Natl Acad Sci U S A (2012) 0.85
Genetic evidence for the coexistence of pheromone perception and full trichromatic vision in howler monkeys. Mol Biol Evol (2004) 0.85
Elevated maspin expression is associated with better overall survival in esophageal squamous cell carcinoma (ESCC). PLoS One (2013) 0.84
Obligate intracellular bacterium Ehrlichia inhibiting mitochondrial activity. Microbes Infect (2010) 0.84
Transcriptional reprogramming and backup between duplicate genes: is it a genomewide phenomenon? Genetics (2005) 0.84
Genome-wide evolutionary conservation of N-glycosylation sites. Mol Biol Evol (2011) 0.84
Isolation, characterization, and evolutionary divergence of mouse RNase 6: evidence for unusual evolution in rodents. J Mol Evol (2004) 0.83
Positive selection, not negative selection, in the pseudogenization of rcsA in Yersinia pestis. Proc Natl Acad Sci U S A (2008) 0.83
Rapid evolution of primate ESX1, an X-linked placenta- and testis-expressed homeobox gene. Hum Mol Genet (2007) 0.82
IL1 receptor antagonist gene IL1-RN variable number of tandem repeats polymorphism and cancer risk: a literature review and meta-analysis. PLoS One (2012) 0.82
Preparation and characterization of monoclonal antibodies against nucleostemin, a protein that controls cell proliferation in stem cells and cancer cells. Hybridoma (Larchmt) (2005) 0.81
Accelerated evolution and loss of a domain of the sperm-egg-binding protein SED1 in ancestral primates. Mol Biol Evol (2006) 0.80
Phylogenetic evidence for parallel adaptive origins of digestive RNases in Asian and African leaf monkeys: a response to Xu et al. (2009). Mol Phylogenet Evol (2009) 0.79
Why are genes encoded on the lagging strand of the bacterial genome? Genome Biol Evol (2013) 0.79
Toward genome-wide identification of Bateson-Dobzhansky-Muller incompatibilities in yeast: a simulation study. Genome Biol Evol (2013) 0.78
On the growth of scientific knowledge: yeast biology as a case study. PLoS Comput Biol (2009) 0.78
The microevolution of V1r vomeronasal receptor genes in mice. Genome Biol Evol (2011) 0.77
A panorama of mammalian gene expression evolution. Mol Syst Biol (2011) 0.76
Erratic evolution of SRY in higher primates. Mol Biol Evol (2002) 0.76