|
1
|
X-ray structure of a pentameric ligand-gated ion channel in an apparently open conformation.
|
Nature
|
2008
|
5.77
|
|
2
|
X-ray structures of general anaesthetics bound to a pentameric ligand-gated ion channel.
|
Nature
|
2011
|
3.00
|
|
3
|
Normal mode analysis suggests a quaternary twist model for the nicotinic receptor gating mechanism.
|
Biophys J
|
2005
|
2.33
|
|
4
|
NOMAD-Ref: visualization, deformation and refinement of macromolecular structures based on all-atom normal mode analysis.
|
Nucleic Acids Res
|
2006
|
2.21
|
|
5
|
One-microsecond molecular dynamics simulation of channel gating in a nicotinic receptor homologue.
|
Proc Natl Acad Sci U S A
|
2010
|
1.81
|
|
6
|
Structure and pharmacology of pentameric receptor channels: from bacteria to brain.
|
Structure
|
2012
|
1.69
|
|
7
|
A locally closed conformation of a bacterial pentameric proton-gated ion channel.
|
Nat Struct Mol Biol
|
2012
|
1.56
|
|
8
|
PDB_Hydro: incorporating dipolar solvents with variable density in the Poisson-Boltzmann treatment of macromolecule electrostatics.
|
Nucleic Acids Res
|
2006
|
1.45
|
|
9
|
Atomic structure and dynamics of pentameric ligand-gated ion channels: new insight from bacterial homologues.
|
J Physiol
|
2009
|
1.38
|
|
10
|
Structural basis for ion permeation mechanism in pentameric ligand-gated ion channels.
|
EMBO J
|
2013
|
1.37
|
|
11
|
Incorporating dipolar solvents with variable density in Poisson-Boltzmann electrostatics.
|
Biophys J
|
2008
|
1.36
|
|
12
|
Structural basis for potentiation by alcohols and anaesthetics in a ligand-gated ion channel.
|
Nat Commun
|
2013
|
1.35
|
|
13
|
Structural insights into the quinolone resistance mechanism of Mycobacterium tuberculosis DNA gyrase.
|
PLoS One
|
2010
|
1.35
|
|
14
|
Crystal structures of a pentameric ligand-gated ion channel provide a mechanism for activation.
|
Proc Natl Acad Sci U S A
|
2013
|
1.32
|
|
15
|
MinActionPath: maximum likelihood trajectory for large-scale structural transitions in a coarse-grained locally harmonic energy landscape.
|
Nucleic Acids Res
|
2007
|
1.32
|
|
16
|
AquaSAXS: a web server for computation and fitting of SAXS profiles with non-uniformally hydrated atomic models.
|
Nucleic Acids Res
|
2011
|
1.20
|
|
17
|
Refinement of docked protein-ligand and protein-DNA structures using low frequency normal mode amplitude optimization.
|
Nucleic Acids Res
|
2005
|
1.11
|
|
18
|
Crystal structure of the extracellular domain of a bacterial ligand-gated ion channel.
|
J Mol Biol
|
2009
|
1.07
|
|
19
|
AQUASOL: An efficient solver for the dipolar Poisson-Boltzmann-Langevin equation.
|
J Chem Phys
|
2010
|
1.03
|
|
20
|
Beyond the Poisson-Boltzmann model: modeling biomolecule-water and water-water interactions.
|
Phys Rev Lett
|
2009
|
0.97
|
|
21
|
Conferring a template-dependent polymerase activity to terminal deoxynucleotidyltransferase by mutations in the Loop1 region.
|
Nucleic Acids Res
|
2009
|
0.93
|
|
22
|
Independent saturation of three TrpRS subsites generates a partially assembled state similar to those observed in molecular simulations.
|
Proc Natl Acad Sci U S A
|
2009
|
0.92
|
|
23
|
Cryophotolysis of caged compounds: a technique for trapping intermediate states in protein crystals.
|
Acta Crystallogr D Biol Crystallogr
|
2002
|
0.86
|
|
24
|
Computational assembly of polymorphic amyloid fibrils reveals stable aggregates.
|
Biophys J
|
2013
|
0.85
|
|
25
|
Enhanced amino acid selection in fully evolved tryptophanyl-tRNA synthetase, relative to its urzyme, requires domain motion sensed by the D1 switch, a remote dynamic packing motif.
|
J Biol Chem
|
2014
|
0.85
|
|
26
|
Structures of intermediates along the catalytic cycle of terminal deoxynucleotidyltransferase: dynamical aspects of the two-metal ion mechanism.
|
J Mol Biol
|
2013
|
0.84
|
|
27
|
Structure of the archaeal pab87 peptidase reveals a novel self-compartmentalizing protease family.
|
PLoS One
|
2009
|
0.83
|
|
28
|
Molecular recognition of canonical and deaminated bases by P. abyssi family B DNA polymerase.
|
J Mol Biol
|
2012
|
0.83
|
|
29
|
Enzymatic and structural analysis of inhibitors designed against Mycobacterium tuberculosis thymidylate kinase. New insights into the phosphoryl transfer mechanism.
|
J Biol Chem
|
2002
|
0.81
|
|
30
|
Computing ion solvation free energies using the dipolar Poisson model.
|
J Phys Chem B
|
2009
|
0.81
|
|
31
|
Insights into the enzymatic mechanism of 6-phosphogluconolactonase from Trypanosoma brucei using structural data and molecular dynamics simulation.
|
J Mol Biol
|
2009
|
0.80
|
|
32
|
Database searching for thymidine and thymidylate kinase inhibitors using three-dimensional structure-based methods.
|
J Enzyme Inhib Med Chem
|
2002
|
0.80
|
|
33
|
New nucleotide-competitive non-nucleoside inhibitors of terminal deoxynucleotidyl transferase: discovery, characterization, and crystal structure in complex with the target.
|
J Med Chem
|
2013
|
0.78
|
|
34
|
2'-Deoxyribonucleoside phosphoramidate triphosphate analogues as alternative substrates for E. coli polymerase III.
|
Chembiochem
|
2012
|
0.77
|
|
35
|
Adapting Poisson-Boltzmann to the self-consistent mean field theory: application to protein side-chain modeling.
|
J Chem Phys
|
2011
|
0.76
|
|
36
|
[X-ray structures of general anesthetics bound to their molecular targets].
|
Med Sci (Paris)
|
2011
|
0.76
|
|
37
|
Determination of dihedral Psi angles in large proteins by combining NH(N)/C(alpha)H(alpha) dipole/dipole cross-correlation and chemical shifts.
|
Proteins
|
2006
|
0.75
|