Published in Proc Natl Acad Sci U S A on December 23, 2013
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Allosteric binding site in a Cys-loop receptor ligand-binding domain unveiled in the crystal structure of ELIC in complex with chlorpromazine. Proc Natl Acad Sci U S A (2016) 0.75
A mechanism for acetylcholine receptor gating based on structure, coupling, phi, and flip. J Gen Physiol (2016) 0.75
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Ketamine Inhibition of the Pentameric Ligand-Gated Ion Channel GLIC. Biophys J (2017) 0.75
A cost-effective protocol for the over-expression and purification of fully-functional and more stable Erwinia chrysanthemi ligand-gated ion channel. Protein Expr Purif (2017) 0.75
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Nicotine and carbamylcholine binding to nicotinic acetylcholine receptors as studied in AChBP crystal structures. Neuron (2004) 7.48
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A prokaryotic proton-gated ion channel from the nicotinic acetylcholine receptor family. Nature (2006) 3.04
X-ray structures of general anaesthetics bound to a pentameric ligand-gated ion channel. Nature (2011) 3.00
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A solution NMR study showing that active site ligands and nucleotides directly perturb the allosteric equilibrium in aspartate transcarbamoylase. Proc Natl Acad Sci U S A (2007) 1.46
A new era of GPCR structural and chemical biology. Nat Chem Biol (2012) 1.41
Mutations that stabilize the open state of the Erwinia chrisanthemi ligand-gated ion channel fail to change the conformation of the pore domain in crystals. Proc Natl Acad Sci U S A (2012) 1.38
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Multisite binding of a general anesthetic to the prokaryotic pentameric Erwinia chrysanthemi ligand-gated ion channel (ELIC). J Biol Chem (2013) 1.22
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50 years of allosteric interactions: the twists and turns of the models. Nat Rev Mol Cell Biol (2013) 1.17
A gating mechanism of pentameric ligand-gated ion channels. Proc Natl Acad Sci U S A (2013) 1.15
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Thinking in cycles: MWC is a good model for acetylcholine receptor-channels. J Physiol (2011) 1.13
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Crystal structure of the extracellular domain of a bacterial ligand-gated ion channel. J Mol Biol (2009) 1.07
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Entropic mechanism of large fluctuation in allosteric transition. Proc Natl Acad Sci U S A (2010) 0.98
Inhibition of the prokaryotic pentameric ligand-gated ion channel ELIC by divalent cations. PLoS Biol (2012) 0.96
Decrypting the sequence of structural events during the gating transition of pentameric ligand-gated ion channels based on an interpolated elastic network model. PLoS Comput Biol (2011) 0.94
Packing of the extracellular domain hydrophobic core has evolved to facilitate pentameric ligand-gated ion channel function. J Biol Chem (2010) 0.88
Effect of cobratoxin binding on the normal mode vibration within acetylcholine binding protein. J Chem Inf Model (2008) 0.86
Coarse-grained and all-atom modeling of structural states and transitions in hemoglobin. Proteins (2012) 0.86
Computing free energy of a large-scale allosteric transition in adenylate kinase using all atom explicit solvent simulations. J Phys Chem B (2012) 0.83
X-ray structure of a pentameric ligand-gated ion channel in an apparently open conformation. Nature (2008) 5.77
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A prokaryotic proton-gated ion channel from the nicotinic acetylcholine receptor family. Nature (2006) 3.04
X-ray structures of general anaesthetics bound to a pentameric ligand-gated ion channel. Nature (2011) 3.00
Subunit composition of functional nicotinic receptors in dopaminergic neurons investigated with knock-out mice. J Neurosci (2003) 2.85
A neuronal network model linking subjective reports and objective physiological data during conscious perception. Proc Natl Acad Sci U S A (2003) 2.79
Hierarchical control of dopamine neuron-firing patterns by nicotinic receptors. Neuron (2006) 2.69
Normal mode analysis suggests a quaternary twist model for the nicotinic receptor gating mechanism. Biophys J (2005) 2.33
NOMAD-Ref: visualization, deformation and refinement of macromolecular structures based on all-atom normal mode analysis. Nucleic Acids Res (2006) 2.21
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Nicotine upregulates its own receptors through enhanced intracellular maturation. Neuron (2005) 1.89
One-microsecond molecular dynamics simulation of channel gating in a nicotinic receptor homologue. Proc Natl Acad Sci U S A (2010) 1.81
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The beta2 but not alpha7 subunit of the nicotinic acetylcholine receptor is required for nicotine-conditioned place preference in mice. Psychopharmacology (Berl) (2006) 1.76
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Structural basis of potent Zika-dengue virus antibody cross-neutralization. Nature (2016) 1.52
Structural basis for alcohol modulation of a pentameric ligand-gated ion channel. Proc Natl Acad Sci U S A (2011) 1.52
A neuronal model of predictive coding accounting for the mismatch negativity. J Neurosci (2012) 1.48
Ongoing spontaneous activity controls access to consciousness: a neuronal model for inattentional blindness. PLoS Biol (2005) 1.47
Peptides targeting the PDZ domain of PTPN4 are efficient inducers of glioblastoma cell death. Structure (2011) 1.46
PDB_Hydro: incorporating dipolar solvents with variable density in the Poisson-Boltzmann treatment of macromolecule electrostatics. Nucleic Acids Res (2006) 1.45
Structural plasticity and catalysis regulation of a thermosensor histidine kinase. Proc Natl Acad Sci U S A (2009) 1.45
Distinct contributions of nicotinic acetylcholine receptor subunit alpha4 and subunit alpha6 to the reinforcing effects of nicotine. Proc Natl Acad Sci U S A (2011) 1.44
Executive and social behaviors under nicotinic receptor regulation. Proc Natl Acad Sci U S A (2003) 1.44
Altered map of visual space in the superior colliculus of mice lacking early retinal waves. J Neurosci (2005) 1.38
Atomic structure and dynamics of pentameric ligand-gated ion channels: new insight from bacterial homologues. J Physiol (2009) 1.38
Structural basis for ion permeation mechanism in pentameric ligand-gated ion channels. EMBO J (2013) 1.37
The crystal structure of the mouse apoptosis-inducing factor AIF. Nat Struct Biol (2002) 1.36
Incorporating dipolar solvents with variable density in Poisson-Boltzmann electrostatics. Biophys J (2008) 1.36
Structural basis for potentiation by alcohols and anaesthetics in a ligand-gated ion channel. Nat Commun (2013) 1.35
Structural insights into the quinolone resistance mechanism of Mycobacterium tuberculosis DNA gyrase. PLoS One (2010) 1.35
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Experimentally based model of a complex between a snake toxin and the alpha 7 nicotinic receptor. Proc Natl Acad Sci U S A (2002) 1.32
MinActionPath: maximum likelihood trajectory for large-scale structural transitions in a coarse-grained locally harmonic energy landscape. Nucleic Acids Res (2007) 1.32
Conformational selection or induced fit? 50 years of debate resolved. F1000 Biol Rep (2011) 1.31
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Nicotine and serotonin in immune regulation and inflammatory processes: a perspective. J Leukoc Biol (2006) 1.22
Pentameric ligand-gated ion channel ELIC is activated by GABA and modulated by benzodiazepines. Proc Natl Acad Sci U S A (2012) 1.22
AquaSAXS: a web server for computation and fitting of SAXS profiles with non-uniformally hydrated atomic models. Nucleic Acids Res (2011) 1.20
An H-bond between two residues from different loops of the acetylcholine binding site contributes to the activation mechanism of nicotinic receptors. EMBO J (2003) 1.19
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Monitoring protein interactions in the living cell through the fluorescence decays of the cyan fluorescent protein. Chemphyschem (2006) 1.18
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Nicotine activates immature "silent" connections in the developing hippocampus. Proc Natl Acad Sci U S A (2003) 1.17
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Refinement of docked protein-ligand and protein-DNA structures using low frequency normal mode amplitude optimization. Nucleic Acids Res (2005) 1.11
Prefrontal nicotinic receptors control novel social interaction between mice. FASEB J (2011) 1.11
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Knockout and knockin mice to investigate the role of nicotinic receptors in the central nervous system. Prog Brain Res (2004) 1.05
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Genome-wide regulon and crystal structure of BlaI (Rv1846c) from Mycobacterium tuberculosis. Mol Microbiol (2009) 1.03
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Nicotinic receptors regulate the survival of newborn neurons in the adult olfactory bulb. Proc Natl Acad Sci U S A (2004) 1.01