Published in ACS Chem Biol on December 30, 2013
NTR1 is required for transcription elongation checkpoints at alternative exons in Arabidopsis. EMBO J (2015) 0.86
Interchangeable SF3B1 inhibitors interfere with pre-mRNA splicing at multiple stages. RNA (2016) 0.85
Therapeutic targeting of splicing in cancer. Nat Med (2016) 0.85
Pharmacodynamic assays to facilitate preclinical and clinical development of pre-mRNA splicing modulatory drug candidates. Pharmacol Res Perspect (2015) 0.81
Total synthesis of GEX1Q1, assignment of C-5 stereoconfiguration and evaluation of spliceosome inhibitory activity. Org Lett (2014) 0.79
Spliceostatin hemiketal biosynthesis in Burkholderia spp. is catalyzed by an iron/α-ketoglutarate-dependent dioxygenase. Proc Natl Acad Sci U S A (2014) 0.79
Modulating splicing with small molecular inhibitors of the spliceosome. Wiley Interdiscip Rev RNA (2016) 0.77
High-throughput single-molecule screen for small-molecule perturbation of splicing and transcription kinetics. Methods (2015) 0.75
Design, synthesis and in vitro splicing inhibition of desmethyl and carba-derivatives of herboxidiene. Org Biomol Chem (2016) 0.75
A triple exon-skipping luciferase reporter assay identifies a new CLK inhibitor pharmacophore. Bioorg Med Chem Lett (2016) 0.75
Microbial and Natural Metabolites That Inhibit Splicing: A Powerful Alternative for Cancer Treatment. Biomed Res Int (2016) 0.75
Mechanisms of alternative pre-messenger RNA splicing. Annu Rev Biochem (2003) 21.11
Spliceostatin A targets SF3b and inhibits both splicing and nuclear retention of pre-mRNA. Nat Chem Biol (2007) 4.95
Splicing factor SF3b as a target of the antitumor natural product pladienolide. Nat Chem Biol (2007) 3.97
The spliceosome as a target of novel antitumour drugs. Nat Rev Drug Discov (2012) 2.51
Reduced fidelity of branch point recognition and alternative splicing induced by the anti-tumor drug spliceostatin A. Genes Dev (2011) 2.45
New antitumor substances, FR901463, FR901464 and FR901465. II. Activities against experimental tumors in mice and mechanism of action. J Antibiot (Tokyo) (1996) 1.87
Sudemycins, novel small molecule analogues of FR901464, induce alternative gene splicing. ACS Chem Biol (2011) 1.77
Pladienolides, new substances from culture of Streptomyces platensis Mer-11107. III. In vitro and in vivo antitumor activities. J Antibiot (Tokyo) (2004) 1.74
Total syntheses, fragmentation studies, and antitumor/antiproliferative activities of FR901464 and its low picomolar analogue. J Am Chem Soc (2007) 1.66
New antitumor substances, FR901463, FR901464 and FR901465. I. Taxonomy, fermentation, isolation, physico-chemical properties and biological activities. J Antibiot (Tokyo) (1996) 1.56
Identification of SAP155 as the target of GEX1A (Herboxidiene), an antitumor natural product. ACS Chem Biol (2011) 1.34
FR901464: total synthesis, proof of structure, and evaluation of synthetic analogues. J Am Chem Soc (2001) 1.30
Synthetic mRNA splicing modulator compounds with in vivo antitumor activity. J Med Chem (2009) 1.28
GEX1 compounds, novel antitumor antibiotics related to herboxidiene, produced by Streptomyces sp. II. The effects on cell cycle progression and gene expression. J Antibiot (Tokyo) (2002) 1.27
Structure-activity relationship for FR901464: a versatile method for the conversion and preparation of biologically active biotinylated probes. Biosci Biotechnol Biochem (2004) 1.23
Antitumor compounds based on a natural product consensus pharmacophore. J Med Chem (2008) 1.17
Pladienolides, new substances from culture of Streptomyces platensis Mer-11107. I. Taxonomy, fermentation, isolation and screening. J Antibiot (Tokyo) (2004) 1.17
Targeting RNA splicing for disease therapy. Wiley Interdiscip Rev RNA (2013) 1.17
GEX1 compounds, novel antitumor antibiotics related to herboxidiene, produced by Streptomyces sp. I. Taxonomy, production, isolation, physicochemical properties and biological activities. J Antibiot (Tokyo) (2002) 1.12
Structural requirements for the antiproliferative activity of pre-mRNA splicing inhibitor FR901464. Chemistry (2010) 1.12
The development and application of small molecule modulators of SF3b as therapeutic agents for cancer. Drug Discov Today (2012) 1.10
Total synthesis of the potent antitumor macrolides pladienolide B and D. Angew Chem Int Ed Engl (2007) 1.07
Comparison of splicing factor 3b inhibitors in human cells. Chembiochem (2012) 1.02
RNA splicing: disease and therapy. Brief Funct Genomics (2011) 1.02
Genomics-guided discovery of thailanstatins A, B, and C As pre-mRNA splicing inhibitors and antiproliferative agents from Burkholderia thailandensis MSMB43. J Nat Prod (2013) 1.00
A stereoselective synthesis of (+)-herboxidiene/GEX1A. Org Lett (2010) 0.99
Total synthesis of herboxidiene/GEX 1A. Org Lett (2007) 0.98
Alternative RNA splicing and cancer. Wiley Interdiscip Rev RNA (2013) 0.96
Enantioselective total synthesis of pladienolide B: a potent spliceosome inhibitor. Org Lett (2012) 0.95
Total synthesis of GEX1A. Org Lett (2008) 0.94
Electrophile-induced ether transfer: stereoselective synthesis of 2,6-disubstituted-3,4-dihydropyrans. J Org Chem (2008) 0.94
Design, synthesis and initial biological evaluation of a novel pladienolide analog scaffold. Medchemcomm (2011) 0.91
Structure of FD-895 revealed through total synthesis. Org Lett (2012) 0.86
Enantioselective syntheses of FR901464 and spliceostatin A: potent inhibitors of spliceosome. Org Lett (2013) 0.86
Stabilized cyclopropane analogs of the splicing inhibitor FD-895. J Med Chem (2013) 0.84
Large-scale synthesis of all stereoisomers of a 2,3-unsaturated C-glycoside scaffold. J Org Chem (2011) 0.84
Total synthesis of (+)-herboxidiene from two chiral lactate-derived ketones. Org Lett (2011) 0.84
Stereospecific synthesis of cryptophycin 1. Org Lett (2002) 0.81
Enantioselective construction of cis-2,6-disubstituted dihydropyrans: total synthesis of (-)-centrolobine. J Org Chem (2010) 0.81
Enantioselective synthesis of pladienolide B and truncated analogues as new anticancer agents. Org Lett (2013) 0.80
A metagenomic survey of microbes in honey bee colony collapse disorder. Science (2007) 11.72
Activating mutations in ALK provide a therapeutic target in neuroblastoma. Nature (2008) 6.80
Genetic detection and characterization of Lujo virus, a new hemorrhagic fever-associated arenavirus from southern Africa. PLoS Pathog (2009) 4.88
MassTag polymerase-chain-reaction detection of respiratory pathogens, including a new rhinovirus genotype, that caused influenza-like illness in New York State during 2004-2005. J Infect Dis (2006) 4.12
Coding Variation in ANGPTL4, LPL, and SVEP1 and the Risk of Coronary Disease. N Engl J Med (2016) 3.88
Proposal for a revised taxonomy of the family Filoviridae: classification, names of taxa and viruses, and virus abbreviations. Arch Virol (2010) 3.77
Diagnostic system for rapid and sensitive differential detection of pathogens. Emerg Infect Dis (2005) 3.02
Discovery of an ebolavirus-like filovirus in europe. PLoS Pathog (2011) 2.99
Molecular Evidence of Sexual Transmission of Ebola Virus. N Engl J Med (2015) 2.71
Astrovirus encephalitis in boy with X-linked agammaglobulinemia. Emerg Infect Dis (2010) 2.69
Pulmonary bioassay studies with nanoscale and fine-quartz particles in rats: toxicity is not dependent upon particle size but on surface characteristics. Toxicol Sci (2006) 2.57
Pulmonary toxicity study in rats with three forms of ultrafine-TiO2 particles: differential responses related to surface properties. Toxicology (2006) 2.47
Possible sexual transmission of Ebola virus - Liberia, 2015. MMWR Morb Mortal Wkly Rep (2015) 2.45
Pulmonary instillation studies with nanoscale TiO2 rods and dots in rats: toxicity is not dependent upon particle size and surface area. Toxicol Sci (2006) 2.34
p53's mitochondrial translocation and MOMP action is independent of Puma and Bax and severely disrupts mitochondrial membrane integrity. Cell Res (2008) 2.27
Small molecules that reactivate p53 in renal cell carcinoma reveal a NF-kappaB-dependent mechanism of p53 suppression in tumors. Proc Natl Acad Sci U S A (2005) 2.14
Novel borna virus in psittacine birds with proventricular dilatation disease. Emerg Infect Dis (2008) 2.10
Global distribution of novel rhinovirus genotype. Emerg Infect Dis (2008) 2.03
Sudemycins, novel small molecule analogues of FR901464, induce alternative gene splicing. ACS Chem Biol (2011) 1.77
Multiplex MassTag-PCR for respiratory pathogens in pediatric nasopharyngeal washes negative by conventional diagnostic testing shows a high prevalence of viruses belonging to a newly recognized rhinovirus clade. J Clin Virol (2008) 1.69
Negevirus: a proposed new taxon of insect-specific viruses with wide geographic distribution. J Virol (2012) 1.67
Detection of respiratory viruses and subtype identification of influenza A viruses by GreeneChipResp oligonucleotide microarray. J Clin Microbiol (2007) 1.59
Virus nomenclature below the species level: a standardized nomenclature for natural variants of viruses assigned to the family Filoviridae. Arch Virol (2012) 1.59
Greene SCPrimer: a rapid comprehensive tool for designing degenerate primers from multiple sequence alignments. Nucleic Acids Res (2006) 1.54
High prevalence of human enterovirus a infections in natural circulation of human enteroviruses. J Clin Microbiol (2006) 1.47
Monitoring of Ebola Virus Makona Evolution through Establishment of Advanced Genomic Capability in Liberia. Emerg Infect Dis (2015) 1.45
Asymptomatic circulation of HEV71 in Norway. Virus Res (2006) 1.31
Structural and biochemical basis for development of influenza virus inhibitors targeting the PA endonuclease. PLoS Pathog (2012) 1.30
Implication of a retrovirus-like glycoprotein peptide in the immunopathogenesis of Ebola and Marburg viruses. FASEB J (2006) 1.28
Ebola virus genome plasticity as a marker of its passaging history: a comparison of in vitro passaging to non-human primate infection. PLoS One (2012) 1.28
Synthetic mRNA splicing modulator compounds with in vivo antitumor activity. J Med Chem (2009) 1.28
Novel flaviviruses detected in different species of mosquitoes in Spain. Vector Borne Zoonotic Dis (2011) 1.27
Genetic diversity of Toscana virus. Emerg Infect Dis (2009) 1.23
NS1 protein secretion during the acute phase of West Nile virus infection. J Virol (2005) 1.22
Real-time polymerase chain reaction for detecting SARS coronavirus, Beijing, 2003. Emerg Infect Dis (2004) 1.21
Eilat virus, a unique alphavirus with host range restricted to insects by RNA replication. Proc Natl Acad Sci U S A (2012) 1.20
Rapid molecular strategy for filovirus detection and characterization. J Clin Microbiol (2006) 1.18
Antitumor compounds based on a natural product consensus pharmacophore. J Med Chem (2008) 1.17
Diversity and distribution of hantaviruses in South America. J Virol (2012) 1.16
Virus nomenclature below the species level: a standardized nomenclature for laboratory animal-adapted strains and variants of viruses assigned to the family Filoviridae. Arch Virol (2013) 1.16
High diversity and ancient common ancestry of lymphocytic choriomeningitis virus. Emerg Infect Dis (2010) 1.14
Virus nomenclature below the species level: a standardized nomenclature for filovirus strains and variants rescued from cDNA. Arch Virol (2013) 1.10
Induction of sterilizing immunity against West Nile Virus (WNV), by immunization with WNV-like particles produced in insect cells. J Infect Dis (2004) 1.10
Granada virus: a natural phlebovirus reassortant of the sandfly fever Naples serocomplex with low seroprevalence in humans. Am J Trop Med Hyg (2010) 1.07
Identification of influenza endonuclease inhibitors using a novel fluorescence polarization assay. ACS Chem Biol (2012) 1.06
First report of sylvatic DENV-2-associated dengue hemorrhagic fever in West Africa. PLoS Negl Trop Dis (2011) 1.03
Molecular analysis of echovirus 13 isolates and aseptic meningitis, Spain. Emerg Infect Dis (2003) 1.01
Genomic and phylogenetic characterization of Leanyer virus, a novel orthobunyavirus isolated in northern Australia. J Gen Virol (2011) 0.98
First report of sudden death due to myocarditis caused by adenovirus serotype 3. J Clin Microbiol (2009) 0.97
A role of HAUSP in tumor suppression in a human colon carcinoma xenograft model. Cell Cycle (2008) 0.97
Comprehensive viral oligonucleotide probe design using conserved protein regions. Nucleic Acids Res (2007) 0.96
Meta-analysis of randomized controlled trials on hydrocolloid occlusive dressing versus conventional gauze dressing in the healing of chronic wounds. Asian J Surg (2004) 0.96
Polymer-supported synthesis of pyridone-focused libraries as inhibitors of anaplastic lymphoma kinase. J Comb Chem (2006) 0.95
Genomic and phylogenetic characterization of viruses included in the Manzanilla and Oropouche species complexes of the genus Orthobunyavirus, family Bunyaviridae. J Gen Virol (2014) 0.94
Genomic and phylogenetic characterization of Brazilian yellow fever virus strains. J Virol (2012) 0.93
Molecular surveillance of circulating dengue genotypes through European travelers. J Travel Med (2011) 0.92
Are all melanomas the same? Spitzoid melanoma is a distinct subtype of melanoma. Cancer (2006) 0.92
Optimization of antitumor modulators of pre-mRNA splicing. J Med Chem (2013) 0.91
Design, synthesis and initial biological evaluation of a novel pladienolide analog scaffold. Medchemcomm (2011) 0.91
Loss of p73 promotes dissemination of Myc-induced B cell lymphomas in mice. J Clin Invest (2010) 0.90
Modulation of a Schistosoma mansoni multidrug transporter by the antischistosomal drug praziquantel. FASEB J (2009) 0.90
Sudemycin E influences alternative splicing and changes chromatin modifications. Nucleic Acids Res (2014) 0.88
Evaluation of Diarylureas for Activity Against Plasmodium falciparum. ACS Med Chem Lett (2010) 0.88
Sensitivity and specificity of immunoglobulin G titer for the diagnosis of mumps virus in infected patients depending on vaccination status. APMIS (2006) 0.87
Design and synthesis of 5-aryl-pyridone-carboxamides as inhibitors of anaplastic lymphoma kinase. J Med Chem (2006) 0.86
Plasma metabolomics reveals biomarkers of the atherosclerosis. J Sep Sci (2010) 0.86
Genomic and antigenic characterization of Jos virus. J Gen Virol (2011) 0.85
Evaluation of two molecular methods for the detection of Yellow fever virus genome. J Virol Methods (2011) 0.85
Rapid sequence-based diagnosis of viral infection. Antiviral Res (2008) 0.84
Enterovirus 75 and aseptic meningitis, Spain, 2005. Emerg Infect Dis (2006) 0.84
Genetic and epidemiological characterization of Stretch Lagoon orbivirus, a novel orbivirus isolated from Culex and Aedes mosquitoes in northern Australia. J Gen Virol (2009) 0.83
Revisiting the role of the immunoproteasome in the activation of the canonical NF-κB pathway. Mol Biosyst (2012) 0.83
Nonparametric methods for the analysis of single-color pathogen microarrays. BMC Bioinformatics (2010) 0.82
Microarray-based detection of viruses causing vesicular or vesicular-like lesions in livestock animals. Vet Microbiol (2008) 0.81
2-Substituted-4,5-dihydroxypyrimidine-6-carboxamide antiviral targeted libraries. J Comb Chem (2009) 0.81
Targeted deletion of p73 in mice reveals its role in T cell development and lymphomagenesis. PLoS One (2009) 0.81
Identifying hosts of families of viruses: a machine learning approach. PLoS One (2011) 0.80
Advantages of tandem LC-MS for the rapid assessment of tissue-specific metabolic complexity using a pentafluorophenylpropyl stationary phase. J Proteome Res (2011) 0.80
Lymphocytic choriomeningitis virus-associated meningitis, southern Spain. Emerg Infect Dis (2012) 0.80
Molecular characterization of severe and mild cases of influenza A (H1N1) 2009 strain from Argentina. Medicina (B Aires) (2010) 0.80
New recognition of Enterovirus infections in bottlenose dolphins (Tursiops truncatus). Vet Microbiol (2009) 0.80
Viral diversity and clonal evolution from unphased genomic data. BMC Genomics (2014) 0.80
Synthesis and SAR of 8-arylquinolines as potent corticotropin-releasing factor1 (CRF1) receptor antagonists. Bioorg Med Chem Lett (2003) 0.80
Diagnostics and discovery in viral hemorrhagic fevers. Ann N Y Acad Sci (2009) 0.79
Bonding along a linear B...N...B triad. J Org Chem (2004) 0.79
A FRET-based approach for identification of proteasome catalytic subunit composition. Mol Biosyst (2014) 0.79
Assessing the role of neutrophil apoptosis in the resolution of particle-induced pulmonary inflammation. Inhal Toxicol (2003) 0.79
Synthesis of new 2'-beta-C-methyl related triciribine analogues as anti-HCV agents. Bioorg Med Chem Lett (2004) 0.78
High diversity of rabies viruses associated with insectivorous bats in Argentina: presence of several independent enzootics. PLoS Negl Trop Dis (2012) 0.78
Efficient synthesis of pyrazolopyrimidine libraries. J Comb Chem (2010) 0.78
Metabolomic analysis characterizes tissue specific indomethacin-induced metabolic perturbations of rats. Analyst (2011) 0.78
Design and synthesis of a novel tyrosine kinase inhibitor template. Bioorg Med Chem (2009) 0.77
Structure-activity relationships of substituted 1-pyridyl-2-phenyl-1,2-ethanediones: potent, selective carboxylesterase inhibitors. J Med Chem (2010) 0.77
Transcriptome reconstruction and annotation of cynomolgus and African green monkey. BMC Genomics (2014) 0.77
Application of a novel design paradigm to generate general nonpeptide combinatorial scaffolds mimicking beta turns: synthesis of ligands for somatostatin receptors. Bioorg Med Chem (2003) 0.77
Alteration of de novo glucose production contributes to fasting hypoglycaemia in Fyn deficient mice. PLoS One (2013) 0.76