Mechanisms of alternative pre-messenger RNA splicing.

Alternative isoform regulation in human tissue transcriptomes. Nature (2008) 52.76

Evolutionarily conserved elements in vertebrate, insect, worm, and yeast genomes. Genome Res (2005) 44.08

Determination of tag density required for digital transcriptome analysis: application to an androgen-sensitive prostate cancer model. Proc Natl Acad Sci U S A (2008) 11.86

The MicroRNA miR-124 promotes neuronal differentiation by triggering brain-specific alternative pre-mRNA splicing. Mol Cell (2007) 7.99

Mechanisms of alternative splicing regulation: insights from molecular and genomics approaches. Nat Rev Mol Cell Biol (2009) 7.11

An RNA code for the FOX2 splicing regulator revealed by mapping RNA-protein interactions in stem cells. Nat Struct Mol Biol (2009) 6.37

Splicing regulation: from a parts list of regulatory elements to an integrated splicing code. RNA (2008) 6.29

Deciphering the splicing code. Nature (2010) 6.27

The gene encoding the splicing factor SF2/ASF is a proto-oncogene. Nat Struct Mol Biol (2007) 6.16

Chromatin organization marks exon-intron structure. Nat Struct Mol Biol (2009) 5.90

A post-transcriptional regulatory switch in polypyrimidine tract-binding proteins reprograms alternative splicing in developing neurons. Genes Dev (2007) 5.83

MADS: a new and improved method for analysis of differential alternative splicing by exon-tiling microarrays. RNA (2008) 5.78

Variation in alternative splicing across human tissues. Genome Biol (2004) 5.70

Alternative splicing and differential gene expression in colon cancer detected by a whole genome exon array. BMC Genomics (2006) 5.59

Discovery of tissue-specific exons using comprehensive human exon microarrays. Genome Biol (2007) 5.53

Identification and analysis of alternative splicing events conserved in human and mouse. Proc Natl Acad Sci U S A (2005) 5.26

Characterizing the RNA targets and position-dependent splicing regulation by TDP-43. Nat Neurosci (2011) 5.24

ESRP1 and ESRP2 are epithelial cell-type-specific regulators of FGFR2 splicing. Mol Cell (2009) 5.03

Homologues of the Caenorhabditis elegans Fox-1 protein are neuronal splicing regulators in mammals. Mol Cell Biol (2005) 5.03

Spatial preferences of microRNA targets in 3' untranslated regions. BMC Genomics (2007) 4.99

Multiple links between transcription and splicing. RNA (2004) 4.90

Ultraconserved elements are associated with homeostatic control of splicing regulators by alternative splicing and nonsense-mediated decay. Genes Dev (2007) 4.75

Genome-wide analysis of PTB-RNA interactions reveals a strategy used by the general splicing repressor to modulate exon inclusion or skipping. Mol Cell (2009) 4.71

Unusual intron conservation near tissue-regulated exons found by splicing microarrays. PLoS Comput Biol (2006) 4.63

Computational definition of sequence motifs governing constitutive exon splicing. Genes Dev (2004) 4.59

Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme. Mol Cell (2007) 4.58

SMN deficiency causes tissue-specific perturbations in the repertoire of snRNAs and widespread defects in splicing. Cell (2008) 4.54

Genomewide comparative analysis of alternative splicing in plants. Proc Natl Acad Sci U S A (2006) 4.51

Understanding protein non-folding. Biochim Biophys Acta (2010) 4.33

Alternative splicing and evolution: diversification, exon definition and function. Nat Rev Genet (2010) 4.30

Defining the regulatory network of the tissue-specific splicing factors Fox-1 and Fox-2. Genes Dev (2008) 4.24

Tissue-dependent isoforms of mammalian Fox-1 homologs are associated with tissue-specific splicing activities. Nucleic Acids Res (2005) 4.06

Escaping the nuclear confines: signal-dependent pre-mRNA splicing in anucleate platelets. Cell (2005) 4.02

Spliceosome structure and function. Cold Spring Harb Perspect Biol (2011) 4.01

ESTGenes: alternative splicing from ESTs in Ensembl. Genome Res (2004) 3.85

General and specific functions of exonic splicing silencers in splicing control. Mol Cell (2006) 3.76

Identification of alternative splicing regulators by RNA interference in Drosophila. Proc Natl Acad Sci U S A (2004) 3.58

Alternative splicing and disease. Biochim Biophys Acta (2008) 3.47

Ending the message: poly(A) signals then and now. Genes Dev (2011) 3.47

Deep RNA sequencing at single base-pair resolution reveals high complexity of the rice transcriptome. Genome Res (2010) 3.34

Polypyrimidine tract binding protein modulates efficiency of polyadenylation. Mol Cell Biol (2004) 3.28

ASD: the Alternative Splicing Database. Nucleic Acids Res (2004) 3.26

Noisy splicing drives mRNA isoform diversity in human cells. PLoS Genet (2010) 3.19

Quantitative microarray profiling provides evidence against widespread coupling of alternative splicing with nonsense-mediated mRNA decay to control gene expression. Genes Dev (2006) 3.18

Regulation of CD45 alternative splicing by heterogeneous ribonucleoprotein, hnRNPLL. Science (2008) 3.17

Support vector machines and kernels for computational biology. PLoS Comput Biol (2008) 3.16

Posttranscriptional regulation of BK channel splice variant stability by miR-9 underlies neuroadaptation to alcohol. Neuron (2008) 3.13

Transcriptome survey reveals increased complexity of the alternative splicing landscape in Arabidopsis. Genome Res (2012) 3.10

The alternative splicing repressors hnRNP A1/A2 and PTB influence pyruvate kinase isoform expression and cell metabolism. Proc Natl Acad Sci U S A (2010) 3.08

Splicing in action: assessing disease causing sequence changes. J Med Genet (2005) 3.07

Probe selection and expression index computation of Affymetrix Exon Arrays. PLoS One (2006) 3.03

Regulation of RNA splicing by the methylation-dependent transcriptional repressor methyl-CpG binding protein 2. Proc Natl Acad Sci U S A (2005) 2.90

Single-molecule imaging of transcriptionally coupled and uncoupled splicing. Cell (2011) 2.86

The architecture of pre-mRNAs affects mechanisms of splice-site pairing. Proc Natl Acad Sci U S A (2005) 2.78

Integrative genome-wide analysis reveals cooperative regulation of alternative splicing by hnRNP proteins. Cell Rep (2012) 2.76

The unfoldomics decade: an update on intrinsically disordered proteins. BMC Genomics (2008) 2.72

Alternative splicing events identified in human embryonic stem cells and neural progenitors. PLoS Comput Biol (2007) 2.71

3' end mRNA processing: molecular mechanisms and implications for health and disease. EMBO J (2008) 2.67

Depletion of TDP 43 overrides the need for exonic and intronic splicing enhancers in the human apoA-II gene. Nucleic Acids Res (2005) 2.55

Linking splicing to Pol II transcription stabilizes pre-mRNAs and influences splicing patterns. PLoS Biol (2006) 2.51

FIRMA: a method for detection of alternative splicing from exon array data. Bioinformatics (2008) 2.49

Diverse roles of hnRNP L in mammalian mRNA processing: a combined microarray and RNAi analysis. RNA (2007) 2.48

An alternative splicing network links cell-cycle control to apoptosis. Cell (2010) 2.43

RNA-seq analysis of prostate cancer in the Chinese population identifies recurrent gene fusions, cancer-associated long noncoding RNAs and aberrant alternative splicings. Cell Res (2012) 2.41

Splicing of a critical exon of human Survival Motor Neuron is regulated by a unique silencer element located in the last intron. Mol Cell Biol (2006) 2.41

The RNA-binding protein Sam68 modulates the alternative splicing of Bcl-x. J Cell Biol (2007) 2.39

Alu elements as regulators of gene expression. Nucleic Acids Res (2006) 2.31

Intronic CA-repeat and CA-rich elements: a new class of regulators of mammalian alternative splicing. EMBO J (2005) 2.30

Transcriptional suppression of mir-29b-1/mir-29a promoter by c-Myc, hedgehog, and NF-kappaB. J Cell Biochem (2010) 2.30

Co-transcriptional splicing of constitutive and alternative exons. RNA (2009) 2.29

Determinants of exon 7 splicing in the spinal muscular atrophy genes, SMN1 and SMN2. Am J Hum Genet (2005) 2.29

A sliding docking interaction is essential for sequential and processive phosphorylation of an SR protein by SRPK1. Mol Cell (2008) 2.29

An unappreciated role for RNA surveillance. Genome Biol (2004) 2.28

Alternative splicing and nonsense-mediated decay modulate expression of important regulatory genes in Arabidopsis. Nucleic Acids Res (2011) 2.26

Regulation of multiple core spliceosomal proteins by alternative splicing-coupled nonsense-mediated mRNA decay. Mol Cell Biol (2008) 2.25

RS domains contact splicing signals and promote splicing by a common mechanism in yeast through humans. Genes Dev (2006) 2.25

HnRNP L represses exon splicing via a regulated exonic splicing silencer. EMBO J (2005) 2.20

Evolution of a TRIM5-CypA splice isoform in old world monkeys. PLoS Pathog (2008) 2.20

"Nought may endure but mutability": spliceosome dynamics and the regulation of splicing. Mol Cell (2008) 2.19

Detection and evaluation of intron retention events in the human transcriptome. RNA (2004) 2.18

Context-dependent control of alternative splicing by RNA-binding proteins. Nat Rev Genet (2014) 2.17

Synonymous mutations in CFTR exon 12 affect splicing and are not neutral in evolution. Proc Natl Acad Sci U S A (2005) 2.12

The SR protein family. Genome Biol (2009) 2.09

ECgene: genome annotation for alternative splicing. Nucleic Acids Res (2005) 2.06

Specific CLK inhibitors from a novel chemotype for regulation of alternative splicing. Chem Biol (2011) 2.06

Polypyrimidine tract binding protein blocks the 5' splice site-dependent assembly of U2AF and the prespliceosomal E complex. Mol Cell (2005) 2.05

Global analysis of positive and negative pre-mRNA splicing regulators in Drosophila. Genes Dev (2005) 2.03

Exon inclusion is dependent on predictable exonic splicing enhancers. Mol Cell Biol (2005) 2.02

Structural insights into RNA recognition by the alternative-splicing regulator muscleblind-like MBNL1. Nat Struct Mol Biol (2008) 2.00

Regulation of CD44 alternative splicing by SRm160 and its potential role in tumor cell invasion. Mol Cell Biol (2006) 1.99

Functional coupling of RNAP II transcription to spliceosome assembly. Genes Dev (2006) 1.98

Nova autoregulation reveals dual functions in neuronal splicing. EMBO J (2005) 1.97

ECgene: genome-based EST clustering and gene modeling for alternative splicing. Genome Res (2005) 1.95

A correlation with exon expression approach to identify cis-regulatory elements for tissue-specific alternative splicing. Nucleic Acids Res (2007) 1.94

Alternative splicing in plants--coming of age. Trends Plant Sci (2012) 1.93

Sequence conservation, relative isoform frequencies, and nonsense-mediated decay in evolutionarily conserved alternative splicing. Proc Natl Acad Sci U S A (2005) 1.93

Transcriptional diversity during lineage commitment of human blood progenitors. Science (2014) 1.93

Darwinian evolution in the light of genomics. Nucleic Acids Res (2009) 1.92

Polypyrimidine tract binding protein controls the transition from exon definition to an intron defined spliceosome. Nat Struct Mol Biol (2008) 1.91

One hundred years of pleiotropy: a retrospective. Genetics (2010) 1.91