Published in PLoS Pathog on January 02, 2014
Accumulation of human-adapting mutations during circulation of A(H1N1)pdm09 influenza virus in humans in the United Kingdom. J Virol (2014) 1.04
Influenza Vaccine Effectiveness Against 2009 Pandemic Influenza A(H1N1) Virus Differed by Vaccine Type During 2013-2014 in the United States. J Infect Dis (2016) 1.02
Seasonal Effectiveness of Live Attenuated and Inactivated Influenza Vaccine. Pediatrics (2016) 0.98
Viral factors in influenza pandemic risk assessment. Elife (2016) 0.94
Structural stability of influenza A(H1N1)pdm09 virus hemagglutinins. J Virol (2014) 0.94
2014-2015 Influenza Vaccine Effectiveness in the United States by Vaccine Type. Clin Infect Dis (2016) 0.90
Efficacy of a Russian-backbone live attenuated influenza vaccine among children in Senegal: a randomised, double-blind, placebo-controlled trial. Lancet Glob Health (2016) 0.87
One health, multiple challenges: The inter-species transmission of influenza A virus. One Health (2015) 0.87
Characterization of H5N1 influenza virus variants with hemagglutinin mutations isolated from patients. MBio (2015) 0.87
Universal influenza vaccines: Shifting to better vaccines. Vaccine (2016) 0.87
The matrix gene segment destabilizes the acid and thermal stability of the hemagglutinin of pandemic live attenuated influenza virus vaccines. J Virol (2014) 0.86
Molecular requirements for a pandemic influenza virus: An acid-stable hemagglutinin protein. Proc Natl Acad Sci U S A (2016) 0.86
Molecular mechanism of the airborne transmissibility of H9N2 avian influenza A viruses in chickens. J Virol (2014) 0.85
Letter to the editor: Potential causes of the decreased effectiveness of the influenza A(H1N1)pdm09 strain in live attenuated influenza vaccines. Euro Surveill (2016) 0.85
Variations in pH sensitivity, acid stability, and fusogenicity of three influenza virus H3 subtypes. J Virol (2014) 0.82
Influenza hemagglutinin (HA) stem region mutations that stabilize or destabilize the structure of multiple HA subtypes. J Virol (2015) 0.82
Genetic Adaptation of Influenza A Viruses in Domestic Animals and Their Potential Role in Interspecies Transmission: A Literature Review. Ecohealth (2015) 0.80
Influenza virus M2 protein ion channel activity helps to maintain pandemic 2009 H1N1 virus hemagglutinin fusion competence during transport to the cell surface. J Virol (2014) 0.80
Environmental Stability of Swine and Human Pandemic Influenza Viruses in Water under Variable Conditions of Temperature, Salinity, and pH. Appl Environ Microbiol (2016) 0.79
The hemagglutinin of the influenza A(H1N1)pdm09 is mutating towards stability. Adv Appl Bioinform Chem (2014) 0.77
Akt inhibitor MK2206 prevents influenza pH1N1 virus infection in vitro. Antimicrob Agents Chemother (2014) 0.77
H1N1 Swine Influenza Viruses Differ from Avian Precursors by a Higher pH Optimum of Membrane Fusion. J Virol (2015) 0.76
Modulation of the pH Stability of Influenza Virus Hemagglutinin: A Host Cell Adaptation Strategy. Biophys J (2016) 0.76
Influenza Vaccine Effectiveness: Mysteries, Enigmas, and a Few Clues. J Infect Dis (2016) 0.75
H1N1 influenza viruses varying widely in hemagglutinin stability transmit efficiently from swine to swine and to ferrets. PLoS Pathog (2017) 0.75
Amino acid substitutions in hemagglutinin of the 2009 pandemic influenza A(H1N1) viruses that might affect the viral antigenicity. BMC Res Notes (2014) 0.75
Intermonomer Interactions in Hemagglutinin Subunits HA1 and HA2 Affecting Hemagglutinin Stability and Influenza Virus Infectivity. J Virol (2015) 0.75
A New Strategy to Reduce Influenza Escape: Detecting Therapeutic Targets Constituted of Invariance Groups. Viruses (2017) 0.75
Influenza overcomes cellular blocks to productively replicate impacting macrophage function. J Virol (2016) 0.75
Differential gene expression elicited by children in response to the 2015-16 live attenuated versus inactivated influenza vaccine. Vaccine (2017) 0.75
Antigenic and genetic characteristics of swine-origin 2009 A(H1N1) influenza viruses circulating in humans. Science (2009) 25.61
Cross-reactive antibody responses to the 2009 pandemic H1N1 influenza virus. N Engl J Med (2009) 15.02
Structure of influenza haemagglutinin at the pH of membrane fusion. Nature (1994) 14.61
Experimental adaptation of an influenza H5 HA confers respiratory droplet transmission to a reassortant H5 HA/H1N1 virus in ferrets. Nature (2012) 14.17
Estimated global mortality associated with the first 12 months of 2009 pandemic influenza A H1N1 virus circulation: a modelling study. Lancet Infect Dis (2012) 8.02
Structural basis of preexisting immunity to the 2009 H1N1 pandemic influenza virus. Science (2010) 6.10
Fusion mutants of the influenza virus hemagglutinin glycoprotein. Cell (1985) 4.84
Influenza hemagglutinin is spring-loaded by a metastable native conformation. Proc Natl Acad Sci U S A (1997) 3.57
Multiple amino acid residues confer temperature sensitivity to human influenza virus vaccine strains (FluMist) derived from cold-adapted A/Ann Arbor/6/60. Virology (2003) 2.61
Generation of live attenuated novel influenza virus A/California/7/09 (H1N1) vaccines with high yield in embryonated chicken eggs. J Virol (2010) 2.34
Conformational changes in the hemagglutinin of influenza virus which accompany heat-induced fusion of virus with liposomes. Virology (1986) 2.13
Structure and Receptor binding properties of a pandemic H1N1 virus hemagglutinin. PLoS Curr (2010) 2.06
The pathogenesis of influenza virus infections: the contributions of virus and host factors. Curr Opin Immunol (2011) 1.95
The role of receptor binding specificity in interspecies transmission of influenza viruses. Curr Opin Virol (2012) 1.84
Amantadine selection of a mutant influenza virus containing an acid-stable hemagglutinin glycoprotein: evidence for virus-specific regulation of the pH of glycoprotein transport vesicles. Proc Natl Acad Sci U S A (1991) 1.79
Genetic diversity of the 2009 pandemic influenza A(H1N1) viruses in Finland. PLoS One (2010) 1.74
Influenza HA subtypes demonstrate divergent phenotypes for cleavage activation and pH of fusion: implications for host range and adaptation. PLoS Pathog (2013) 1.64
The pH of activation of the hemagglutinin protein regulates H5N1 influenza virus replication and pathogenesis in mice. J Virol (2013) 1.57
Minor changes in the hemagglutinin of influenza A(H1N1)2009 virus alter its antigenic properties. PLoS One (2011) 1.55
A new pandemic influenza A(H1N1) genetic variant predominated in the winter 2010 influenza season in Australia, New Zealand and Singapore. Euro Surveill (2010) 1.51
The pH of activation of the hemagglutinin protein regulates H5N1 influenza virus pathogenicity and transmissibility in ducks. J Virol (2009) 1.50
Studies using double mutants of the conformational transitions in influenza hemagglutinin required for its membrane fusion activity. Proc Natl Acad Sci U S A (1996) 1.43
Amino acid residues in the fusion peptide pocket regulate the pH of activation of the H5N1 influenza virus hemagglutinin protein. J Virol (2009) 1.39
A new common mutation in the hemagglutinin of the 2009 (H1N1) influenza A virus. PLoS Curr (2010) 1.37
Acid stability of the hemagglutinin protein regulates H5N1 influenza virus pathogenicity. PLoS Pathog (2011) 1.31
Adaptation of egg-grown and transfectant influenza viruses for growth in mammalian cells: selection of hemagglutinin mutants with elevated pH of membrane fusion. Virology (1997) 1.20
Mutations in the hemagglutinin and matrix genes of a virulent influenza virus variant, A/FM/1/47-MA, control different stages in pathogenesis. Virus Res (1996) 1.19
Comparison of in vitro replication features of H7N3 influenza viruses from wild ducks and turkeys: potential implications for interspecies transmission. J Gen Virol (2006) 1.14
Single HA2 mutation increases the infectivity and immunogenicity of a live attenuated H5N1 intranasal influenza vaccine candidate lacking NS1. PLoS One (2011) 1.14
Altered receptor specificity and fusion activity of the haemagglutinin contribute to high virulence of a mouse-adapted influenza A virus. J Gen Virol (2012) 1.10
Enhanced growth of influenza vaccine seed viruses in vero cells mediated by broadening the optimal pH range for virus membrane fusion. J Virol (2011) 1.00
Time and temperature dependence of influenza virus membrane fusion at neutral pH. J Gen Virol (1986) 0.94
Evolution of the haemagglutinin gene of the influenza A(H1N1)2009 virus isolated in Hong Kong, 2009-2011. Euro Surveill (2011) 0.88
Generation of recombinant pandemic H1N1 influenza virus with the HA cleavable by bromelain and identification of the residues influencing HA bromelain cleavage. Vaccine (2011) 0.87
Influenza H1N1pdm-specific maternal antibodies offer limited protection against wild-type virus replication and influence influenza vaccination in ferrets. Influenza Other Respir Viruses (2014) 0.83