Published in Proc Natl Acad Sci U S A on November 12, 1996
H5 avian and H9 swine influenza virus haemagglutinin structures: possible origin of influenza subtypes. EMBO J (2002) 2.69
Analysis of residues near the fusion peptide in the influenza hemagglutinin structure for roles in triggering membrane fusion. Virology (2007) 1.83
The complete influenza hemagglutinin fusion domain adopts a tight helical hairpin arrangement at the lipid:water interface. Proc Natl Acad Sci U S A (2010) 1.75
The pH of activation of the hemagglutinin protein regulates H5N1 influenza virus pathogenicity and transmissibility in ducks. J Virol (2009) 1.50
Receptor binding by a ferret-transmissible H5 avian influenza virus. Nature (2013) 1.43
Novel inhibitors of influenza virus fusion: structure-activity relationship and interaction with the viral hemagglutinin. J Virol (2010) 1.42
Minimal aggregate size and minimal fusion unit for the first fusion pore of influenza hemagglutinin-mediated membrane fusion. Biophys J (2000) 1.40
Amino acid residues in the fusion peptide pocket regulate the pH of activation of the H5N1 influenza virus hemagglutinin protein. J Virol (2009) 1.39
Morphological changes and fusogenic activity of influenza virus hemagglutinin. Biophys J (1998) 1.34
Specific single or double proline substitutions in the "spring-loaded" coiled-coil region of the influenza hemagglutinin impair or abolish membrane fusion activity. J Cell Biol (1998) 1.33
Influenza virus drug resistance: a time-sampled population genetics perspective. PLoS Genet (2014) 1.32
Influenza-virus membrane fusion by cooperative fold-back of stochastically induced hemagglutinin intermediates. Elife (2013) 1.31
A single amino acid in the stalk region of the H1N1pdm influenza virus HA protein affects viral fusion, stability and infectivity. PLoS Pathog (2014) 1.29
pH-induced activation of arenavirus membrane fusion is antagonized by small-molecule inhibitors. J Virol (2008) 1.25
Attenuation of Murray Valley encephalitis virus by site-directed mutagenesis of the hinge and putative receptor-binding regions of the envelope protein. J Virol (2001) 1.19
Intersubunit interactions modulate pH-induced activation of membrane fusion by the Junin virus envelope glycoprotein GPC. J Virol (2009) 1.15
Second-site changes affect viability of amphotropic/ecotropic chimeric enveloped murine leukemia viruses. J Virol (2000) 1.09
N-linked glycans with similar location in the fusion protein head modulate paramyxovirus fusion. J Virol (2003) 1.07
Reversible stages of the low-pH-triggered conformational change in influenza virus hemagglutinin. EMBO J (2002) 1.07
pH-induced conformational changes of membrane-bound influenza hemagglutinin and its effect on target lipid bilayers. Protein Sci (1998) 0.99
Matriptase proteolytically activates influenza virus and promotes multicycle replication in the human airway epithelium. J Virol (2013) 0.95
Role of electrostatic repulsion in controlling pH-dependent conformational changes of viral fusion proteins. Structure (2013) 0.95
Viral factors in influenza pandemic risk assessment. Elife (2016) 0.94
The final conformation of the complete ectodomain of the HA2 subunit of influenza hemagglutinin can by itself drive low pH-dependent fusion. J Biol Chem (2011) 0.91
The matrix gene segment destabilizes the acid and thermal stability of the hemagglutinin of pandemic live attenuated influenza virus vaccines. J Virol (2014) 0.86
Molecular mechanism of the airborne transmissibility of H9N2 avian influenza A viruses in chickens. J Virol (2014) 0.85
An induced pocket for the binding of potent fusion inhibitor CL-385319 with H5N1 influenza virus hemagglutinin. PLoS One (2012) 0.84
Two Escape Mechanisms of Influenza A Virus to a Broadly Neutralizing Stalk-Binding Antibody. PLoS Pathog (2016) 0.82
Variations in pH sensitivity, acid stability, and fusogenicity of three influenza virus H3 subtypes. J Virol (2014) 0.82
Characterizing a histidine switch controlling pH-dependent conformational changes of the influenza virus hemagglutinin. Biophys J (2013) 0.82
Influenza hemagglutinin (HA) stem region mutations that stabilize or destabilize the structure of multiple HA subtypes. J Virol (2015) 0.82
Lowered pH Leads to Fusion Peptide Release and a Highly Dynamic Intermediate of Influenza Hemagglutinin. J Phys Chem B (2016) 0.77
Influence of calcium on lipid mixing mediated by influenza hemagglutinin. Arch Biochem Biophys (2007) 0.76
Myristoylation of the Arenavirus Envelope Glycoprotein Stable Signal Peptide Is Critical for Membrane Fusion but Dispensable for Virion Morphogenesis. J Virol (2016) 0.75
Intermonomer Interactions in Hemagglutinin Subunits HA1 and HA2 Affecting Hemagglutinin Stability and Influenza Virus Infectivity. J Virol (2015) 0.75
Rapid and efficient site-specific mutagenesis without phenotypic selection. Methods Enzymol (1987) 66.52
Structure of the haemagglutinin membrane glycoprotein of influenza virus at 3 A resolution. Nature (1981) 24.17
Structure of influenza haemagglutinin at the pH of membrane fusion. Nature (1994) 14.61
General method for production and selection of infectious vaccinia virus recombinants expressing foreign genes. J Virol (1984) 10.98
A spring-loaded mechanism for the conformational change of influenza hemagglutinin. Cell (1993) 8.26
Changes in the conformation of influenza virus hemagglutinin at the pH optimum of virus-mediated membrane fusion. Proc Natl Acad Sci U S A (1982) 7.34
Crystalline antigen from the influenza virus envelope. Nat New Biol (1972) 5.77
Fusion mutants of the influenza virus hemagglutinin glycoprotein. Cell (1985) 4.84
The use of double mutants to detect structural changes in the active site of the tyrosyl-tRNA synthetase (Bacillus stearothermophilus). Cell (1984) 4.75
Distinctive nucleotide sequences adjacent to multiple initiation and termination sites of an early vaccinia virus gene. Cell (1981) 4.42
High-efficiency formation of influenza virus transfectants. J Virol (1991) 4.34
Additivity of mutational effects in proteins. Biochemistry (1990) 4.05
Anti-peptide antibodies detect steps in a protein conformational change: low-pH activation of the influenza virus hemagglutinin. J Cell Biol (1987) 3.52
Analyses of the antigenicity of influenza haemagglutinin at the pH optimum for virus-mediated membrane fusion. J Gen Virol (1983) 3.43
The receptor-binding and membrane-fusion properties of influenza virus variants selected using anti-haemagglutinin monoclonal antibodies. EMBO J (1987) 3.03
Refinement of the influenza virus hemagglutinin by simulated annealing. J Mol Biol (1990) 2.61
Structure of influenza virus haemagglutinin complexed with a neutralizing antibody. Nature (1995) 2.55
Introduction of intersubunit disulfide bonds in the membrane-distal region of the influenza hemagglutinin abolishes membrane fusion activity. Cell (1992) 2.47
A soluble domain of the membrane-anchoring chain of influenza virus hemagglutinin (HA2) folds in Escherichia coli into the low-pH-induced conformation. Proc Natl Acad Sci U S A (1995) 2.24
Studies on the structure of the influenza virus haemagglutinin at the pH of membrane fusion. J Gen Virol (1988) 2.21
Conformational changes in the hemagglutinin of influenza virus which accompany heat-induced fusion of virus with liposomes. Virology (1986) 2.13
Studies of the membrane fusion activities of fusion peptide mutants of influenza virus hemagglutinin. J Virol (1995) 1.96
Amantadine selection of a mutant influenza virus containing an acid-stable hemagglutinin glycoprotein: evidence for virus-specific regulation of the pH of glycoprotein transport vesicles. Proc Natl Acad Sci U S A (1991) 1.79
Studies of influenza haemagglutinin-mediated membrane fusion. Virology (1986) 1.78
Electron microscopy of antibody complexes of influenza virus haemagglutinin in the fusion pH conformation. EMBO J (1995) 1.74
A poxvirus-derived vector that directs high levels of expression of cloned genes in mammalian cells. Proc Natl Acad Sci U S A (1988) 1.72
Staphylococcal nuclease: a showcase of m-value effects. Adv Protein Chem (1995) 1.51
Deacylation of the hemagglutinin of influenza A/Aichi/2/68 has no effect on membrane fusion properties. Virology (1991) 1.50
Toward a simplification of the protein folding problem: a stabilizing polyalanine alpha-helix engineered in T4 lysozyme. Biochemistry (1991) 1.42
Stabilization of lambda repressor against thermal denaturation by site-directed Gly----Ala changes in alpha-helix 3. Proteins (1986) 1.37
Patterns of nonadditivity between pairs of stability mutations in staphylococcal nuclease. Biochemistry (1993) 1.33
Influenza virus haemagglutinin. Structural predictions suggest that the fibrillar appearance is due to the presence of a coiled-coil. Aust J Biol Sci (1980) 1.19
Improvement in the alkaline stability of subtilisin using an efficient random mutagenesis and screening procedure. Protein Eng (1989) 1.13
Membrane fusion by influenza hemagglutinin. Cold Spring Harb Symp Quant Biol (1995) 1.10
Engineering multiple properties of a protein by combinatorial mutagenesis. Proc Natl Acad Sci U S A (1993) 1.08
Combining thermostable mutations increases the stability of lambda repressor. Biochemistry (1988) 0.89
Structure of the haemagglutinin membrane glycoprotein of influenza virus at 3 A resolution. Nature (1981) 24.17
Receptor binding and membrane fusion in virus entry: the influenza hemagglutinin. Annu Rev Biochem (2000) 19.03
Atomic structure of the ectodomain from HIV-1 gp41. Nature (1997) 16.31
Virus-specific CD8+ cytotoxic T-lymphocyte activity associated with control of viremia in primary human immunodeficiency virus type 1 infection. J Virol (1994) 15.93
Structural identification of the antibody-binding sites of Hong Kong influenza haemagglutinin and their involvement in antigenic variation. Nature (1981) 15.85
Structure of influenza haemagglutinin at the pH of membrane fusion. Nature (1994) 14.61
Structure of the human class I histocompatibility antigen, HLA-A2. Nature (1987) 14.54
The foreign antigen binding site and T cell recognition regions of class I histocompatibility antigens. Nature (1987) 12.43
Antiviral pressure exerted by HIV-1-specific cytotoxic T lymphocytes (CTLs) during primary infection demonstrated by rapid selection of CTL escape virus. Nat Med (1997) 12.08
The structure and function of the hemagglutinin membrane glycoprotein of influenza virus. Annu Rev Biochem (1987) 11.99
Selection of genetic variants of lymphocytic choriomeningitis virus in spleens of persistently infected mice. Role in suppression of cytotoxic T lymphocyte response and viral persistence. J Exp Med (1984) 10.66
Three-dimensional structure of the human class II histocompatibility antigen HLA-DR1. Nature (1993) 8.75
Cellular localization of human immunodeficiency virus infection within the brains of acquired immune deficiency syndrome patients. Proc Natl Acad Sci U S A (1986) 8.45
Structure of the influenza virus haemagglutinin complexed with its receptor, sialic acid. Nature (1988) 8.32
Single amino acid substitutions in influenza haemagglutinin change receptor binding specificity. Nature (1983) 8.28
The structure and receptor binding properties of the 1918 influenza hemagglutinin. Science (2004) 7.74
Changes in the conformation of influenza virus hemagglutinin at the pH optimum of virus-mediated membrane fusion. Proc Natl Acad Sci U S A (1982) 7.34
Crystal structure of the human class II MHC protein HLA-DR1 complexed with an influenza virus peptide. Nature (1994) 7.13
The molecular basis of the specific anti-influenza action of amantadine. EMBO J (1985) 7.08
The virology and immunobiology of lymphocytic choriomeningitis virus infection. Adv Immunol (1980) 6.24
Structure of the complex between human T-cell receptor, viral peptide and HLA-A2. Nature (1996) 6.20
Pathogenesis of chronic disease associated with persistent lymphocytic choriomeningitis viral infection. I. Relationship of antibody production to disease in neonatally infected mice. J Exp Med (1969) 6.03
A hypothetical model of the foreign antigen binding site of class II histocompatibility molecules. Nature (1988) 5.99
X-ray structures of H5 avian and H9 swine influenza virus hemagglutinins bound to avian and human receptor analogs. Proc Natl Acad Sci U S A (2001) 5.92
Identification of alpha-dystroglycan as a receptor for lymphocytic choriomeningitis virus and Lassa fever virus. Science (1998) 5.83
Crystalline antigen from the influenza virus envelope. Nat New Biol (1972) 5.77
Differential regulation of antiviral T-cell immunity results in stable CD8+ but declining CD4+ T-cell memory. Nat Med (2001) 5.74
Biology of cloned cytotoxic T lymphocytes specific for lymphocytic choriomeningitis virus: clearance of virus in vivo. J Virol (1984) 5.57
Molecular mimicry and autoimmune disease. Cell (1987) 5.31
HLA-A2-peptide complexes: refolding and crystallization of molecules expressed in Escherichia coli and complexed with single antigenic peptides. Proc Natl Acad Sci U S A (1992) 5.02
Identification of self peptides bound to purified HLA-B27. Nature (1991) 4.88
Fusion mutants of the influenza virus hemagglutinin glycoprotein. Cell (1985) 4.84
Nucleotide sequences at the 5' termini of influenza virus RNAs and their transcripts. Nucleic Acids Res (1978) 4.83
The evolution of human influenza viruses. Philos Trans R Soc Lond B Biol Sci (2001) 4.74
Crystal structure of the Ebola virus membrane fusion subunit, GP2, from the envelope glycoprotein ectodomain. Mol Cell (1998) 4.73
Cytomegalovirus infects human lymphocytes and monocytes: virus expression is restricted to immediate-early gene products. Proc Natl Acad Sci U S A (1984) 4.56
Genomic and biological variation among commonly used lymphocytic choriomeningitis virus strains. J Gen Virol (1983) 4.45
Herpes simplex virus glycoprotein D bound to the human receptor HveA. Mol Cell (2001) 4.44
Refined structure of the human histocompatibility antigen HLA-A2 at 2.6 A resolution. J Mol Biol (1991) 4.44
A carbohydrate side chain on hemagglutinins of Hong Kong influenza viruses inhibits recognition by a monoclonal antibody. Proc Natl Acad Sci U S A (1984) 4.37
Specificity pockets for the side chains of peptide antigens in HLA-Aw68. Nature (1989) 4.34
Coiled coils in both intracellular vesicle and viral membrane fusion. Cell (1998) 4.26
Cytotoxic T cells to type A influenza virus; viral hemagglutinin induces A-strain specificity while infected cells confer cross-reactive cytotoxicity. Eur J Immunol (1977) 4.05
Transcription of the influenza virus genome. Virology (1977) 4.02
Cytoimmunotherapy for persistent virus infection reveals a unique clearance pattern from the central nervous system. Nature (1986) 4.01
Lymphocytic choriomeningitis: production of antibody by "tolerant" infected mice. Science (1967) 4.01
Virus-induced immunosuppression: immune system-mediated destruction of virus-infected dendritic cells results in generalized immune suppression. J Virol (1995) 3.90
N- and C-terminal residues combine in the fusion-pH influenza hemagglutinin HA(2) subunit to form an N cap that terminates the triple-stranded coiled coil. Proc Natl Acad Sci U S A (1999) 3.90
The structure of HLA-B27 reveals nonamer self-peptides bound in an extended conformation. Nature (1991) 3.84
Different length peptides bind to HLA-Aw68 similarly at their ends but bulge out in the middle. Nature (1992) 3.82
The polypeptide composition of influenza A viruses. Virology (1971) 3.79
Studies on the in vitro transcription of reovirus RNA catalyzed by reovirus cores. Virology (1969) 3.79
Selection of gp41-mediated HIV-1 cell entry inhibitors from biased combinatorial libraries of non-natural binding elements. Nat Struct Biol (1999) 3.72
Structure of the hemagglutinin precursor cleavage site, a determinant of influenza pathogenicity and the origin of the labile conformation. Cell (1998) 3.69
Detection of human cytomegalovirus in peripheral blood lymphocytes in a natural infection. Science (1985) 3.69
Amino acid homology between the encephalitogenic site of myelin basic protein and virus: mechanism for autoimmunity. Science (1985) 3.68
Cytotoxic T cells kill influenza virus infected cells but do not distinguish between serologically distinct type A viruses. Nature (1977) 3.67
Three-dimensional structure of a human class II histocompatibility molecule complexed with superantigen. Nature (1994) 3.60
Immunosuppression and resultant viral persistence by specific viral targeting of dendritic cells. J Exp Med (2000) 3.50
The antigenic identity of peptide-MHC complexes: a comparison of the conformations of five viral peptides presented by HLA-A2. Cell (1993) 3.44
Analyses of the antigenicity of influenza haemagglutinin at the pH optimum for virus-mediated membrane fusion. J Gen Virol (1983) 3.43
CD4-deficient mice have reduced levels of memory cytotoxic T lymphocytes after immunization and show diminished resistance to subsequent virus challenge. J Virol (1996) 3.39
The three-dimensional structure of HLA-B27 at 2.1 A resolution suggests a general mechanism for tight peptide binding to MHC. Cell (1992) 3.27
Structural basis for membrane fusion by enveloped viruses. Mol Membr Biol (1999) 3.26
Monoclonal antibodies to lymphocytic choriomeningitis and pichinde viruses: generation, characterization, and cross-reactivity with other arenaviruses. Virology (1981) 3.26
Virus-lymphocyte interactions. IV. Molecular characterization of LCMV Armstrong (CTL+) small genomic segment and that of its variant, Clone 13 (CTL-). Virology (1988) 3.22
Pathogenesis of of cytomegalovirus infection. I. Activation of virus from bone marrow-derived lymphocytes by in vitro allogenic reaction. J Exp Med (1975) 3.13
Atomic structure of a human MHC molecule presenting an influenza virus peptide. Nature (1992) 3.12
The receptor-binding and membrane-fusion properties of influenza virus variants selected using anti-haemagglutinin monoclonal antibodies. EMBO J (1987) 3.03
Binding of influenza virus hemagglutinin to analogs of its cell-surface receptor, sialic acid: analysis by proton nuclear magnetic resonance spectroscopy and X-ray crystallography. Biochemistry (1992) 3.03
Fine mapping of an immunodominant domain in the transmembrane glycoprotein of human immunodeficiency virus. J Virol (1987) 2.97
The structure of an intermediate in class II MHC maturation: CLIP bound to HLA-DR3. Nature (1995) 2.90
Studies on the primary structure of the influenza virus hemagglutinin. Proc Natl Acad Sci U S A (1975) 2.88
Four A6-TCR/peptide/HLA-A2 structures that generate very different T cell signals are nearly identical. Immunity (1999) 2.86
Molecular definition of a major cytotoxic T-lymphocyte epitope in the glycoprotein of lymphocytic choriomeningitis virus. J Virol (1988) 2.82
The influenza A virus nucleoprotein gene controls the induction of both subtype specific and cross-reactive cytotoxic T cells. J Exp Med (1984) 2.81
Molecular analyses of a five-amino-acid cytotoxic T-lymphocyte (CTL) epitope: an immunodominant region which induces nonreciprocal CTL cross-reactivity. J Virol (1989) 2.79
Neurologic disease induced in transgenic mice by cerebral overexpression of interleukin 6. Proc Natl Acad Sci U S A (1993) 2.79