Integrative regulation of human brain blood flow.

PubWeight™: 1.85‹?› | Rank: Top 3%

🔗 View Article (PMC 3948549)

Published in J Physiol on January 06, 2014

Authors

Christopher K Willie1, Yu-Chieh Tzeng, Joseph A Fisher, Philip N Ainslie

Author Affiliations

1: Centre for Heart, Lung and Vascular Health, School of Health and Exercise Sciences, University of British Columbia - Okanagan, Kelowna, British Columbia, Canada V1V 1V7. ckwillie@gmail.com.

Articles citing this

Impact of intraoperative hypotension and blood pressure fluctuations on early postoperative delirium after non-cardiac surgery. Br J Anaesth (2015) 1.44

Attenuated cerebral vasodilatory capacity in response to hypercapnia in college-aged African Americans. Exp Physiol (2014) 1.40

Dehydration affects cerebral blood flow but not its metabolic rate for oxygen during maximal exercise in trained humans. J Physiol (2014) 1.05

Transfer function analysis of dynamic cerebral autoregulation: A white paper from the International Cerebral Autoregulation Research Network. J Cereb Blood Flow Metab (2016) 1.02

False positives and false negatives in functional near-infrared spectroscopy: issues, challenges, and the way forward. Neurophotonics (2016) 1.00

Factors affecting the determination of cerebrovascular reactivity. Brain Behav (2014) 0.97

Influence of high altitude on cerebral blood flow and fuel utilization during exercise and recovery. J Physiol (2014) 0.93

Lack of linear correlation between dynamic and steady-state cerebral autoregulation. J Physiol (2017) 0.88

Effect of acute hypoxia on regional cerebral blood flow: effect of sympathetic nerve activity. J Appl Physiol (1985) (2014) 0.88

Effect of acute resistance exercise on carotid artery stiffness and cerebral blood flow pulsatility. Front Physiol (2014) 0.87

Regulation of brain blood flow and oxygen delivery in elite breath-hold divers. J Cereb Blood Flow Metab (2014) 0.87

Cardiovascular control during whole body exercise. J Appl Physiol (1985) (2016) 0.86

Striatal vessels receive phosphorylated tyrosine hydroxylase-rich innervation from midbrain dopaminergic neurons. Front Neuroanat (2014) 0.86

Impact of hypocapnia and cerebral perfusion on orthostatic tolerance. J Physiol (2014) 0.85

Regulation of the cerebral circulation: bedside assessment and clinical implications. Crit Care (2016) 0.83

Arterial pressure variations as parameters of brain perfusion in response to central blood volume depletion and repletion. Front Physiol (2014) 0.83

The major cerebral arteries proximal to the Circle of Willis contribute to cerebrovascular resistance in humans. J Cereb Blood Flow Metab (2015) 0.82

The contribution of arterial blood gases in cerebral blood flow regulation and fuel utilization in man at high altitude. J Cereb Blood Flow Metab (2015) 0.82

Carotid artery stiffness and hemodynamic pulsatility during cognitive engagement in healthy adults: a pilot investigation. Am J Hypertens (2014) 0.81

Regional Brain Water Content and Distribution During Diabetic Ketoacidosis. J Pediatr (2016) 0.80

High-intensity interval exercise and cerebrovascular health: curiosity, cause, and consequence. J Cereb Blood Flow Metab (2015) 0.80

A novel mouse model of ischemic carotid artery disease. PLoS One (2014) 0.79

Effects of hypercapnia on peripheral vascular reactivity in elderly patients with acute exacerbation of chronic obstructive pulmonary disease. Clin Interv Aging (2014) 0.79

Association of age and admission mean arterial blood pressure in patients with stroke-data from a national stroke registry. Hypertens Res (2016) 0.79

Neurovascular coupling in humans: Physiology, methodological advances and clinical implications. J Cereb Blood Flow Metab (2015) 0.79

Sympathetic Activation Does Not Affect the Cardiac and Respiratory Contribution to the Relationship between Blood Pressure and Pial Artery Pulsation Oscillations in Healthy Subjects. PLoS One (2015) 0.78

Hypoxemia, oxygen content, and the regulation of cerebral blood flow. Am J Physiol Regul Integr Comp Physiol (2015) 0.78

Association between cardiovagal baroreflex sensitivity and baseline cerebral perfusion of the hippocampus. Clin Auton Res (2015) 0.78

The impact of cerebrovascular aging on vascular cognitive impairment and dementia. Ageing Res Rev (2016) 0.77

Role of cerebral blood flow in extreme breath holding. Transl Neurosci (2016) 0.77

Dehydration accelerates reductions in cerebral blood flow during prolonged exercise in the heat without compromising brain metabolism. Am J Physiol Heart Circ Physiol (2015) 0.77

Lack of effect of nitroglycerin on the diameter response of larger retinal arterioles in normal persons during hypoxia. Graefes Arch Clin Exp Ophthalmol (2015) 0.76

Middle cerebral artery diameter changes during rhythmic handgrip exercise in humans. J Cereb Blood Flow Metab (2016) 0.76

Cerebrovascular Responsiveness to Hypercapnia Is Stable over Six Months in Older Adults. PLoS One (2015) 0.76

Vigilance Task-Related Change in Brain Functional Connectivity as Revealed by Wavelet Phase Coherence Analysis of Near-Infrared Spectroscopy Signals. Front Hum Neurosci (2016) 0.76

Fluid and ion transfer across the blood-brain and blood-cerebrospinal fluid barriers; a comparative account of mechanisms and roles. Fluids Barriers CNS (2016) 0.76

Rho kinase as a target for cerebral vascular disorders. Future Med Chem (2015) 0.76

Big brain, small body: towards a better understanding of cerebrovascular physiology in children. J Physiol (2016) 0.75

Fine tuning breath-hold-based cerebrovascular reactivity analysis models. Brain Behav (2016) 0.75

Effects of short-term exposure to head-down tilt on cerebral hemodynamics: a prospective evaluation of a spaceflight analog using phase-contrast MRI. J Appl Physiol (1985) (2016) 0.75

Cerebrovascular hemodynamics during pranayama techniques. J Neurosci Rural Pract (2017) 0.75

The effects of superimposed tilt and lower body negative pressure on anterior and posterior cerebral circulations. Physiol Rep (2016) 0.75

A longitudinal study of cerebral blood flow under hypoxia at high altitude using 3D pseudo-continuous arterial spin labeling. Sci Rep (2017) 0.75

Uncoupling between cerebral perfusion and oxygenation during incremental exercise in an athlete with postconcussion syndrome: a case report. Physiol Rep (2017) 0.75

Cerebral ambiguity. Brain Behav (2014) 0.75

Neurocardiovascular Instability and Cognition. Yale J Biol Med (2016) 0.75

Measuring cerebral auto-variability. J Physiol (2016) 0.75

Effects of midodrine and L-NAME on systemic and cerebral hemodynamics during cognitive activation in spinal cord injury and intact controls. Physiol Rep (2016) 0.75

Postural effects on cerebral blood flow and autoregulation. Physiol Rep (2017) 0.75

Role of endothelial nitric oxide synthase and endothelin-1 polymorphism genes with the pathogenesis of intraventricular hemorrhage in preterm infants. Sci Rep (2017) 0.75

Physiome approach for the analysis of vascular flow reserve in the heart and brain. Pflugers Arch (2017) 0.75

Cerebrovascular and ventilatory responses to acute normobaric hypoxia in girls and women. Physiol Rep (2017) 0.75

Gradient adjustment method for better discriminating correlating and non-correlating regions of physiological signals: application to the partitioning of impaired and intact zones of cerebral autoregulation. J Clin Monit Comput (2016) 0.75

Aging modifies the effect of cardiac output on middle cerebral artery blood flow velocity. Physiol Rep (2017) 0.75

Effects of a compound from the group of substituted thiadiazines with hypothermia inducing properties on brain metabolism in rats, a study in vivo and in vitro. PLoS One (2017) 0.75

Articles cited by this

(truncated to the top 100)

THE EFFECTS OF ALTERED ARTERIAL TENSIONS OF CARBON DIOXIDE AND OXYGEN ON CEREBRAL BLOOD FLOW AND CEREBRAL OXYGEN CONSUMPTION OF NORMAL YOUNG MEN. J Clin Invest (1948) 22.75

THE EFFECTS OF ACTIVE AND PASSIVE HYPERVENTILATION ON CEREBRAL BLOOD FLOW, CEREBRAL OXYGEN CONSUMPTION, CARDIAC OUTPUT, AND BLOOD PRESSURE OF NORMAL YOUNG MEN. J Clin Invest (1946) 21.94

On the Regulation of the Blood-supply of the Brain. J Physiol (1890) 11.90

Neurovascular regulation in the normal brain and in Alzheimer's disease. Nat Rev Neurosci (2004) 9.29

Glial and neuronal control of brain blood flow. Nature (2010) 6.61

Cerebral blood flow and oxygen consumption in man. Physiol Rev (1959) 6.29

Glial regulation of the cerebral microvasculature. Nat Neurosci (2007) 5.91

Neurovascular coupling in the normal brain and in hypertension, stroke, and Alzheimer disease. J Appl Physiol (1985) (2006) 4.43

Brain metabolism dictates the polarity of astrocyte control over arterioles. Nature (2008) 4.32

Cerebral autoregulation dynamics in humans. Stroke (1989) 4.16

Perivascular nerves and the regulation of cerebrovascular tone. J Appl Physiol (1985) (2006) 3.42

Influence of changes in blood pressure on cerebral perfusion and oxygenation. Hypertension (2010) 3.00

Regulation of the cerebral circulation: role of endothelium and potassium channels. Physiol Rev (1998) 2.98

Single-neuron activity and tissue oxygenation in the cerebral cortex. Science (2003) 2.96

THE EFFECT OF BILATERAL STELLATE GANGLION BLOCK ON THE CEREBRAL CIRCULATION IN NORMOTENSIVE AND HYPERTENSIVE PATIENTS. J Clin Invest (1949) 2.84

Regulation of large cerebral arteries and cerebral microvascular pressure. Circ Res (1990) 2.82

Responses of cerebral arteries and arterioles to acute hypotension and hypertension. Am J Physiol (1978) 2.76

Cerebral arterial diameters during changes in blood pressure and carbon dioxide during craniotomy. Neurosurgery (1993) 2.51

Autonomic neural control of dynamic cerebral autoregulation in humans. Circulation (2002) 2.38

Regional brain blood flow in man during acute changes in arterial blood gases. J Physiol (2012) 2.34

Integration of cerebrovascular CO2 reactivity and chemoreflex control of breathing: mechanisms of regulation, measurement, and interpretation. Am J Physiol Regul Integr Comp Physiol (2009) 2.24

Cerebral blood flow in vascular disease of the brain; with observations on the effects of stellate ganglion block. Am J Med (1950) 2.23

On Intra-Cranial Pressure and the Cerebral Circulation: Part I. Physiological; Part II. Histological. J Physiol (1895) 2.20

Astrocyte glycogen and brain energy metabolism. Glia (2007) 2.17

Effect of alterations in the arterial carbon dioxide tension on the blood flow through the cerebral cortex at normal and low arterial blood pressures. J Neurol Neurosurg Psychiatry (1965) 2.04

Increased cortical oxidative metabolism due to sensory stimulation: implications for functional brain imaging. Science (1999) 1.93

Autonomic neural control of the cerebral vasculature: acute hypotension. Stroke (2008) 1.87

Syncope, cerebral perfusion, and oxygenation. J Appl Physiol (1985) (2003) 1.87

Sympathetic control of the cerebral vasculature in humans. Stroke (2009) 1.85

Steal physiology is spatially associated with cortical thinning. J Neurol Neurosurg Psychiatry (2010) 1.73

Cerebrovascular regulation during transient hypotension and hypertension in humans. Hypertension (2010) 1.71

Cerebral artery dilatation maintains cerebral oxygenation at extreme altitude and in acute hypoxia--an ultrasound and MRI study. J Cereb Blood Flow Metab (2011) 1.71

Activity-induced tissue oxygenation changes in rat cerebellar cortex: interplay of postsynaptic activation and blood flow. J Physiol (2005) 1.70

Cerebral sympathetic nerve activity has a major regulatory role in the cerebral circulation in REM sleep. J Appl Physiol (1985) (2009) 1.66

The cerebrovascular response to carbon dioxide in humans. J Physiol (2011) 1.66

Assessment and prognostic relevance of right ventricular contractile reserve in patients with severe pulmonary hypertension. Circulation (2013) 1.62

Cervical sympathetic block to reverse delayed ischemic neurological deficits after aneurysmal subarachnoid hemorrhage. Stroke (2003) 1.61

Human cerebral venous outflow pathway depends on posture and central venous pressure. J Physiol (2004) 1.60

Relationship between middle cerebral artery blood velocity and end-tidal PCO2 in the hypocapnic-hypercapnic range in humans. J Appl Physiol (1985) (2003) 1.57

Defining the characteristic relationship between arterial pressure and cerebral flow. J Appl Physiol (1985) (2012) 1.51

Brain adenosine concentration during hypoxia in rats. Am J Physiol (1981) 1.48

Interaction of carbon dioxide and sympathetic nervous system activity in the regulation of cerebral perfusion in humans. Hypertension (2000) 1.45

The effects of intravenously administered aminophylline on cerebral circulation and metabolism in man. J Clin Invest (1950) 1.44

Differential blood flow responses to CO₂ in human internal and external carotid and vertebral arteries. J Physiol (2012) 1.43

Observations on the extrinsic neural control of cerebral blood flow in the baboon. Circ Res (1969) 1.42

Determinants of human cerebral pressure-flow velocity relationships: new insights from vascular modelling and Ca²⁺ channel blockade. J Physiol (2011) 1.42

ATP: a vasoactive signal in the pericyte-containing microvasculature of the rat retina. J Physiol (2003) 1.41

Dynamic pressure-flow relationship of the cerebral circulation during acute increase in arterial pressure. J Physiol (2009) 1.37

Effects of hypoxia and normocarbia on cerebral blood flow and metabolism in conscious man. J Appl Physiol (1967) 1.37

Analysis of vasoactivity of local pH, PCO2 and bicarbonate on pial vessels. Stroke (1977) 1.36

Low blood pressure and risk of dementia in the Kungsholmen project: a 6-year follow-up study. Arch Neurol (2003) 1.36

Selective reduction of blood flow to white matter during hypercapnia corresponds with leukoaraiosis. Stroke (2008) 1.31

Differential responses to CO2 and sympathetic stimulation in the cerebral and femoral circulations in humans. J Physiol (2005) 1.31

Integration of blood flow control to skeletal muscle: key role of feed arteries. Acta Physiol Scand (2000) 1.30

Hypoxic preconditioning and tolerance via hypoxia inducible factor (HIF) 1alpha-linked induction of P450 2C11 epoxygenase in astrocytes. J Cereb Blood Flow Metab (2005) 1.29

H and pCO2 as chemical factors in respiratory and cerebral circulatory control. J Appl Physiol (1961) 1.29

Fundamental importance of arterial oxygen content in the regulation of cerebral blood flow in man. Brain (1985) 1.28

The role of myogenic mechanisms in human cerebrovascular regulation. J Physiol (2013) 1.25

Cholinergic modulation of the cortical microvascular bed. Prog Brain Res (2004) 1.23

Local mechanism of CO2 action of cat pial arterioles. Stroke (1977) 1.21

Acidosis dilates brain parenchymal arterioles by conversion of calcium waves to sparks to activate BK channels. Circ Res (2011) 1.19

Mechanisms of the cerebrovascular response to apnoea in humans. J Physiol (2003) 1.19

Gray matter blood flow change is unevenly distributed during moderate isocapnic hypoxia in humans. J Appl Physiol (1985) (2007) 1.19

Modelling vascular reactivity to investigate the basis of the relationship between cerebral blood volume and flow under CO2 manipulation. Neuroimage (2007) 1.17

Blood pressure and late-life cognitive function change: a biracial longitudinal population study. Neurology (2004) 1.17

Brain extracellular pH: the main factor controlling cerebral blood flow. Scand J Clin Lab Invest (1968) 1.15

Sympathetic nerve activity in the superior cervical ganglia increases in response to imposed increases in arterial pressure. Am J Physiol Regul Integr Comp Physiol (2008) 1.15

Asymmetric dynamic cerebral autoregulatory response to cyclic stimuli. Stroke (2007) 1.14

Measuring cerebrovascular reactivity: what stimulus to use? J Physiol (2013) 1.13

Contribution of arterial Windkessel in low-frequency cerebral hemodynamics during transient changes in blood pressure. J Appl Physiol (1985) (2011) 1.12

Control of brain capillary blood flow. J Cereb Blood Flow Metab (2012) 1.12

Baroreflex-induced sympathetic activation does not alter cerebrovascular CO2 responsiveness in humans. J Physiol (2003) 1.12

Role of large arteries in regulation of cerebral blood flow in dogs. J Clin Invest (1978) 1.11

Ventilatory, cerebrovascular, and cardiovascular interactions in acute hypoxia: regulation by carbon dioxide. J Appl Physiol (1985) (2004) 1.11

Assessment of cerebral autoregulation: the quandary of quantification. Am J Physiol Heart Circ Physiol (2012) 1.10

Cerebral autoregulation of blood velocity and volumetric flow during steady-state changes in arterial pressure. Hypertension (2013) 1.10

Role of astrocytes in matching blood flow to neuronal activity. Curr Top Dev Biol (2007) 1.10

Effects of sympathetic stimulation and changes in arterial pressure on segmental resistance of cerebral vessels in rabbits and cats. Circ Res (1983) 1.08

Changes in cerebral blood flow estimated after stellate ganglion block by single photon emission computed tomography. J Auton Nerv Syst (1995) 1.08

Flow patterns and distributions of fluid velocity and wall shear stress in the human internal carotid and middle cerebral arteries. World Neurosurg (2009) 1.08

Assessment of autoregulation by means of periodic changes in blood pressure. Stroke (1995) 1.07

The lower limit of autoregulation: time to revise our thinking? Anesthesiology (1997) 1.07

Neurovascular coupling and distribution of cerebral blood flow during exercise. J Neurosci Methods (2011) 1.06

Cerebral autoregulation in Alzheimer's disease. J Cereb Blood Flow Metab (2011) 1.05

Central nervous system mechanisms of ventilatory acclimatization to hypoxia. Respir Physiol (2000) 1.05

Role of adenosine in regulation of cerebral blood flow: effects of theophylline during normoxia and hypoxia. Am J Physiol (1987) 1.05

Cerebral microvascular dilation during hypotension and decreased oxygen tension: a role for nNOS. Am J Physiol Heart Circ Physiol (2007) 1.05

Effects of sympathetic nerves on cerebral vessels in dog, cat, and monkey. Am J Physiol (1978) 1.05

The cerebral vascular response to reduction in arterial carbon dioxide tension. J Clin Invest (1961) 1.04

Mechanisms of cerebral vasodilatation in hypoxia. J Appl Physiol (1970) 1.04

Role of adenosine and its receptors in the vasodilatation induced in the cerebral cortex of the rat by systemic hypoxia. J Physiol (1998) 1.03

Effect of aminophylline on brain tissue oxygenation in patients with chronic obstructive lung disease. Thorax (1992) 1.03

THE RELATIONSHIP BETWEEN THE BLOOD PRESSURE AND THE TONIC REGULATION OF THE PIAL ARTERIES. J Neurol Psychiatry (1938) 1.02

Nitric oxide mediates hypoxia-induced cerebral vasodilation in humans. J Appl Physiol (1985) (2002) 1.02

Role of 20-HETE in the hypoxia-induced activation of Ca2+-activated K+ channel currents in rat cerebral arterial muscle cells. Am J Physiol Heart Circ Physiol (2007) 1.02

VASCULAR MECHANISMS PERTAINING TO THE INTRINSIC REGULATION OF THE CEREBRAL CIRCULATION. Circulation (1964) 1.02

Cholinergic control of the cerebral vasculature in humans. J Physiol (2012) 1.01

Dampening of blood-flow pulsatility along the carotid siphon: does form follow function? AJNR Am J Neuroradiol (2011) 1.01

Impaired vascular regulation in patients with obstructive sleep apnea: effects of continuous positive airway pressure treatment. Am J Respir Crit Care Med (2009) 1.01

Nitric oxide synthesis and regional cerebral blood flow responses to hypercapnia and hypoxia in the rat. J Cereb Blood Flow Metab (1993) 1.01

Articles by these authors

Influence of changes in blood pressure on cerebral perfusion and oxygenation. Hypertension (2010) 3.00

The in-vivo oxyhaemoglobin dissociation curve at sea level and high altitude. Respir Physiol Neurobiol (2013) 2.64

Cerebral blood flow during exercise: mechanisms of regulation. J Appl Physiol (1985) (2009) 1.83

Human cardiorespiratory and cerebrovascular function during severe passive hyperthermia: effects of mild hypohydration. J Appl Physiol (1985) (2008) 1.80

Cerebrovascular regulation during transient hypotension and hypertension in humans. Hypertension (2010) 1.71

Prospective targeting and control of end-tidal CO2 and O2 concentrations. J Physiol (2007) 1.70

Mapping cerebrovascular reactivity using blood oxygen level-dependent MRI in Patients with arterial steno-occlusive disease: comparison with arterial spin labeling MRI. Stroke (2008) 1.69

Regulatory mechanisms of cerebral blood flow during exercise: new concepts. Exerc Sport Sci Rev (2009) 1.59

Impaired peri-nidal cerebrovascular reserve in seizure patients with brain arteriovenous malformations. Brain (2010) 1.56

Interactions between heart rate variability and pulmonary gas exchange efficiency in humans. Exp Physiol (2010) 1.49

Blood pressure regulation IX: cerebral autoregulation under blood pressure challenges. Eur J Appl Physiol (2013) 1.47

Vagal nerve activity contributes to improve the efficiency of pulmonary gas exchange in hypoxic humans. Exp Physiol (2006) 1.42

Determinants of human cerebral pressure-flow velocity relationships: new insights from vascular modelling and Ca²⁺ channel blockade. J Physiol (2011) 1.42

Rescuer position for tracheal intubation on the ground. Resuscitation (2003) 1.39

Influence of high altitude on cerebrovascular and ventilatory responsiveness to CO2. J Physiol (2009) 1.35

Selective reduction of blood flow to white matter during hypercapnia corresponds with leukoaraiosis. Stroke (2008) 1.31

BOLD-MRI cerebrovascular reactivity findings in cocaine-induced cerebral vasculitis. Nat Clin Pract Neurol (2008) 1.30

Alterations in cerebral blood flow and cerebrovascular reactivity during 14 days at 5050 m. J Physiol (2010) 1.29

Human cerebrovascular and ventilatory CO2 reactivity to end-tidal, arterial and internal jugular vein PCO2. J Physiol (2007) 1.25

Preoperative and postoperative mapping of cerebrovascular reactivity in moyamoya disease by using blood oxygen level-dependent magnetic resonance imaging. J Neurosurg (2005) 1.23

Initial orthostatic hypotension is unrelated to orthostatic tolerance in healthy young subjects. J Appl Physiol (1985) (2009) 1.15

CO2 blood oxygen level-dependent MR mapping of cerebrovascular reserve in a clinical population: safety, tolerability, and technical feasibility. Radiology (2012) 1.14

Contribution of arterial Windkessel in low-frequency cerebral hemodynamics during transient changes in blood pressure. J Appl Physiol (1985) (2011) 1.12

Interpretation of two-dimensional and tissue Doppler-derived strain (epsilon) and strain rate data: is there a need to normalize for individual variability in left ventricular morphology? Eur J Echocardiogr (2009) 1.12

Reductions in cerebral blood flow during passive heat stress in humans: partitioning the mechanisms. J Physiol (2011) 1.10

Precise control of end-tidal carbon dioxide and oxygen improves BOLD and ASL cerebrovascular reactivity measures. Magn Reson Med (2010) 1.10

Non-invasive prospective targeting of arterial P(CO2) in subjects at rest. J Physiol (2008) 1.10

Effects of acetazolamide on cerebrovascular function and breathing stability at 5050 m. J Physiol (2012) 1.08

Improved fMRI calibration: precisely controlled hyperoxic versus hypercapnic stimuli. Neuroimage (2010) 1.08

Multivariate system identification for cerebral autoregulation. Ann Biomed Eng (2007) 1.07

Impaired cerebrovascular reactivity with steal phenomenon is associated with increased diffusion in white matter of patients with Moyamoya disease. Stroke (2010) 1.04

Changes in respiratory control after 5 days at altitude. Respir Physiol Neurobiol (2005) 1.03

Cerebral blood flow and cerebrovascular reactivity at rest and during sub-maximal exercise: effect of age and 12-week exercise training. Age (Dordr) (2012) 1.02

An improved method for acquiring cerebrovascular reactivity maps. Magn Reson Med (2010) 1.01

Cholinergic control of the cerebral vasculature in humans. J Physiol (2012) 1.01

Impact of extracranial-intracranial bypass on cerebrovascular reactivity and clinical outcome in patients with symptomatic moyamoya vasculopathy. Stroke (2011) 0.99

Effect of age on exercise-induced alterations in cognitive executive function: relationship to cerebral perfusion. Exp Gerontol (2012) 0.98

Human cerebral arteriovenous vasoactive exchange during alterations in arterial blood gases. J Appl Physiol (1985) (2008) 0.96

Cerebrovascular and corticomotor function during progressive passive hyperthermia in humans. J Appl Physiol (1985) (2011) 0.96

Elevated aerobic fitness sustained throughout the adult lifespan is associated with improved cerebral hemodynamics. Stroke (2013) 0.95

Influence of indomethacin on the ventilatory and cerebrovascular responsiveness to hypoxia. Eur J Appl Physiol (2010) 0.95

Regional changes in brain blood flow during severe passive hyperthermia: effects of PaCO2 and extracranial blood flow. J Appl Physiol (1985) (2013) 0.95

Impaired cerebral haemodynamic function associated with chronic traumatic brain injury in professional boxers. Clin Sci (Lond) (2013) 0.94

Interaction between the ventilatory and cerebrovascular responses to hypo- and hypercapnia at rest and during exercise. J Physiol (2008) 0.92

Measurement of cerebrovascular reactivity in pediatric patients with cerebral vasculopathy using blood oxygen level-dependent MRI. Stroke (2011) 0.92

Comparison of pulsed and pseudocontinuous arterial spin-labeling for measuring CO2 -induced cerebrovascular reactivity. J Magn Reson Imaging (2012) 0.91

Modified N95 mask delivers high inspired oxygen concentrations while effectively filtering aerosolized microparticles. Ann Emerg Med (2006) 0.91

Surgical revascularization reverses cerebral cortical thinning in patients with severe cerebrovascular steno-occlusive disease. Stroke (2011) 0.91

Influence of age on syncope following prolonged exercise: differential responses but similar orthostatic intolerance. J Physiol (2009) 0.91

Influence of baroreflex-mediated tachycardia on the regulation of dynamic cerebral perfusion during acute hypotension in humans. J Physiol (2009) 0.91

Differential cerebrovascular CO₂ reactivity in anterior and posterior cerebral circulations. Respir Physiol Neurobiol (2013) 0.90

Cardiorespiratory and cerebrovascular responses to head-up tilt I: influence of age and training status. Exp Gerontol (2010) 0.90

Morning attenuation in cerebrovascular CO2 reactivity in healthy humans is associated with a lowered cerebral oxygenation and an augmented ventilatory response to CO2. J Appl Physiol (1985) (2007) 0.90

Severely impaired cerebrovascular reserve in patients with cerebral proliferative angiopathy. J Neurosurg Pediatr (2011) 0.90

The interaction of carbon dioxide and hypoxia in the control of cerebral blood flow. Pflugers Arch (2012) 0.90

Indomethacin-induced impairment of regional cerebrovascular reactivity: implications for respiratory control. J Physiol (2015) 0.90

Fundamental relationships between arterial baroreflex sensitivity and dynamic cerebral autoregulation in humans. J Appl Physiol (1985) (2010) 0.89

Conduit artery structure and function in lowlanders and native highlanders: relationships with oxidative stress and role of sympathoexcitation. J Physiol (2013) 0.89

Evidence against redox regulation of energy homoeostasis in humans at high altitude. Clin Sci (Lond) (2004) 0.89

Dynamic cerebral autoregulation during and following acute hypoxia: role of carbon dioxide. J Appl Physiol (1985) (2013) 0.89

Post-stroke recovery: the role of activity-dependent release of brain-derived neurotrophic factor. Expert Rev Neurother (2014) 0.88

Retinal arteriolar and capillary vascular reactivity in response to isoxic hypercapnia. Exp Eye Res (2008) 0.88

The effect of Ventricular Assist Devices on cerebral autoregulation: A preliminary study. BMC Anesthesiol (2011) 0.88

Effect of acute hypoxia on regional cerebral blood flow: effect of sympathetic nerve activity. J Appl Physiol (1985) (2014) 0.88

Diurnal variation in the mechanical and neural components of the baroreflex. Hypertension (2011) 0.88

Influence of indomethacin on ventilatory and cerebrovascular responsiveness to CO2 and breathing stability: the influence of PCO2 gradients. Am J Physiol Regul Integr Comp Physiol (2009) 0.88

Wavelet phase synchronization analysis of cerebral blood flow autoregulation. IEEE Trans Biomed Eng (2010) 0.88

Direct effect of Pa(CO2) on respiratory sinus arrhythmia in conscious humans. Am J Physiol Heart Circ Physiol (2002) 0.88

The effect of partial acclimatization to high altitude on loop gain and central sleep apnoea severity. Respirology (2012) 0.87

Noninvasive MRI measures of microstructural and cerebrovascular changes during normal swine brain development. Pediatr Res (2011) 0.87

Isocapnic hyperpnoea shortens postanesthetic care unit stay after isoflurane anesthesia. Anesth Analg (2010) 0.87

Approaches to brain stress testing: BOLD magnetic resonance imaging with computer-controlled delivery of carbon dioxide. PLoS One (2012) 0.87

Circadian variation in the circulatory responses to exercise: relevance to the morning peaks in strokes and cardiac events. Eur J Appl Physiol (2009) 0.86

Onset responses of ventilation and cerebral blood flow to hypercapnia in humans: rest and exercise. J Appl Physiol (1985) (2009) 0.86

The effects of age on the spontaneous low-frequency oscillations in cerebral and systemic cardiovascular dynamics. Physiol Meas (2008) 0.86

Skin cooling aids cerebrovascular function more effectively under severe than moderate heat stress. Eur J Appl Physiol (2009) 0.86

Baroreflex function after spinal cord injury. J Neurotrauma (2012) 0.86

The impact of hypercapnia on retinal capillary blood flow assessed by scanning laser Doppler flowmetry. Microvasc Res (2005) 0.86

Alterations in sympathetic neurovascular transduction during acute hypoxia in humans. Am J Physiol Regul Integr Comp Physiol (2013) 0.85

Normocapnia improves cerebral oxygen delivery during conventional oxygen therapy in carbon monoxide-exposed research subjects. Ann Emerg Med (2002) 0.85

Efficiency of oxygen administration: sequential gas delivery versus "flow into a cone" methods. Crit Care Med (2006) 0.84

Effect of slosh mitigation on histologic markers of traumatic brain injury: laboratory investigation. J Neurosurg (2012) 0.84

Instability of the middle cerebral artery blood flow in response to CO2. PLoS One (2013) 0.84

Differential responses of circulating amylin to high-fat vs. high-carbohydrate meal in healthy men. Clin Endocrinol (Oxf) (2007) 0.84

Maintained cerebrovascular function during post-exercise hypotension. Eur J Appl Physiol (2013) 0.84

Reduced contralateral cerebrovascular reserve in patients with unilateral steno-occlusive disease. Cerebrovasc Dis (2014) 0.84

Syncope is unrelated to supine and postural hypotension following prolonged exercise. Eur J Appl Physiol (2010) 0.83

Accelerated recovery from sevoflurane anesthesia with isocapnic hyperpnoea. Anesth Analg (2008) 0.83

The effect of oxygen on dynamic cerebral autoregulation: critical role of hypocapnia. J Appl Physiol (1985) (2010) 0.83

Slow breathing as a means to improve orthostatic tolerance: a randomized sham-controlled trial. J Appl Physiol (1985) (2013) 0.83

Increased carbon monoxide clearance during exercise in humans. Med Sci Sports Exerc (2012) 0.83

Internal jugular vein compression mitigates traumatic axonal injury in a rat model by reducing the intracranial slosh effect. Neurosurgery (2012) 0.83

Hyperoxia-induced hypocapnia: an underappreciated risk. Chest (2005) 0.83

Supplementary oxygen for nonhypoxemic patients: O2 much of a good thing? Crit Care (2011) 0.83

Perturbed and spontaneous regional cerebral blood flow responses to changes in blood pressure after high-level spinal cord injury: the effect of midodrine. J Appl Physiol (1985) (2014) 0.82