Published in Am J Physiol Endocrinol Metab on January 07, 2014
Female rats selectively bred for high intrinsic aerobic fitness are protected from ovariectomy-associated metabolic dysfunction. Am J Physiol Regul Integr Comp Physiol (2015) 0.99
Maximal oxidative capacity during exercise is associated with skeletal muscle fuel selection and dynamic changes in mitochondrial protein acetylation. Cell Metab (2015) 0.98
Intrinsic aerobic capacity impacts susceptibility to acute high-fat diet-induced hepatic steatosis. Am J Physiol Endocrinol Metab (2014) 0.92
Exercise activates compensatory thermoregulatory reaction in rats: a modeling study. J Appl Physiol (1985) (2015) 0.90
Ventromedial hypothalamic melanocortin receptor activation: regulation of activity energy expenditure and skeletal muscle thermogenesis. J Physiol (2016) 0.85
Oxytocin in the ventromedial hypothalamic nucleus reduces feeding and acutely increases energy expenditure. Am J Physiol Regul Integr Comp Physiol (2014) 0.84
Physically active rats lose more weight during calorie restriction. Physiol Behav (2014) 0.82
Ovariectomy results in differential shifts in gut microbiota in low versus high aerobic capacity rats. Physiol Rep (2015) 0.80
Continuous Aerobic Training in Individualized Intensity Avoids Spontaneous Physical Activity Decline and Improves MCT1 Expression in Oxidative Muscle of Swimming Rats. Front Physiol (2016) 0.77
Neural Control of Energy Expenditure. Handb Exp Pharmacol (2016) 0.76
Rodent models for resolving extremes of exercise and health. Physiol Genomics (2015) 0.76
Contribution of regional brain melanocortin receptor subtypes to elevated activity energy expenditure in lean, active rats. Neuroscience (2015) 0.76
Aerobic capacity mediates susceptibility for the transition from steatosis to steatohepatitis. J Physiol (2017) 0.75
Voluntary Running Aids to Maintain High Body Temperature in Rats Bred for High Aerobic Capacity. Front Physiol (2016) 0.75
Physical Activity, Energy Expenditure, and Defense of Body Weight in Melanocortin 4 Receptor-Deficient Male Rats. Sci Rep (2016) 0.75
Influence of the Environment on Body Temperature of Racing Greyhounds. Front Vet Sci (2016) 0.75
Amphetamine enhances endurance by increasing heat dissipation. Physiol Rep (2016) 0.75
Metabolic risk factors in mice divergently selected for BMR fed high fat and high carb diets. PLoS One (2017) 0.75
Suppressed sympathetic outflow to skeletal muscle, muscle thermogenesis, and activity energy expenditure with calorie restriction. Physiol Rep (2017) 0.75
Why is it easier to run in the cold? Temperature (Austin) (2016) 0.75
Prevalence of obesity and trends in the distribution of body mass index among US adults, 1999-2010. JAMA (2012) 33.54
Prevalence and trends in obesity among US adults, 1999-2000. JAMA (2002) 33.23
Brown adipose tissue: function and physiological significance. Physiol Rev (2004) 23.00
Exercise capacity and mortality among men referred for exercise testing. N Engl J Med (2002) 14.30
Years of life lost due to obesity. JAMA (2003) 12.18
The preventable causes of death in the United States: comparative risk assessment of dietary, lifestyle, and metabolic risk factors. PLoS Med (2009) 12.13
Annual deaths attributable to obesity in the United States. JAMA (1999) 8.62
Cardiorespiratory fitness as a quantitative predictor of all-cause mortality and cardiovascular events in healthy men and women: a meta-analysis. JAMA (2009) 7.26
Misunderstanding analysis of covariance. J Abnorm Psychol (2001) 6.99
Interindividual variation in posture allocation: possible role in human obesity. Science (2005) 6.26
A role for brown adipose tissue in diet-induced thermogenesis. Nature (1979) 6.20
Role of nonexercise activity thermogenesis in resistance to fat gain in humans. Science (1999) 6.02
KATP channels as molecular sensors of cellular metabolism. Nature (2006) 5.34
Cardiovascular risk factors emerge after artificial selection for low aerobic capacity. Science (2005) 4.76
Molecular diversity of K+ channels. Ann N Y Acad Sci (1999) 4.63
A guide to analysis of mouse energy metabolism. Nat Methods (2011) 3.82
Molecular biology of adenosine triphosphate-sensitive potassium channels. Endocr Rev (1999) 3.51
Reduced rate of energy expenditure as a risk factor for body-weight gain. N Engl J Med (1988) 3.19
Endothermy and activity in vertebrates. Science (1979) 3.07
A recurring problem with the analysis of energy expenditure in genetic models expressing lean and obese phenotypes. Diabetes (2010) 3.04
The central melanocortin system directly controls peripheral lipid metabolism. J Clin Invest (2007) 2.97
The TRAP220 component of a thyroid hormone receptor- associated protein (TRAP) coactivator complex interacts directly with nuclear receptors in a ligand-dependent fashion. Proc Natl Acad Sci U S A (1998) 2.76
Artificial selection for intrinsic aerobic endurance running capacity in rats. Physiol Genomics (2001) 2.72
Inverse relationship between VO2max and economy/efficiency in world-class cyclists. Med Sci Sports Exerc (2002) 2.69
The biology of mitochondrial uncoupling proteins. Diabetes (2004) 2.66
Skeletal muscle metabolism is a major determinant of resting energy expenditure. J Clin Invest (1990) 2.63
Epidemic obesity and the metabolic syndrome. Circulation (2003) 2.53
Enhanced metabolic efficiency contributes to weight regain after weight loss in obesity-prone rats. Am J Physiol Regul Integr Comp Physiol (2004) 2.44
Physical activity energy expenditure predicts progression toward the metabolic syndrome independently of aerobic fitness in middle-aged healthy Caucasians: the Medical Research Council Ely Study. Diabetes Care (2005) 2.23
Exercise capacity and mortality in black and white men. Circulation (2008) 2.17
Physical activity, sedentary behavior, and health: paradigm paralysis or paradigm shift? Diabetes (2010) 2.05
Spontaneous activity, economy of activity, and resistance to diet-induced obesity in rats bred for high intrinsic aerobic capacity. Horm Behav (2010) 1.98
Associations between physical activity dose and health-related quality of life. Med Sci Sports Exerc (2004) 1.86
Brown fat and the myth of diet-induced thermogenesis. Cell Metab (2010) 1.82
Potassium channels: molecular defects, diseases, and therapeutic opportunities. Pharmacol Rev (2000) 1.81
Sympathetic and sensory innervation of brown adipose tissue. Int J Obes (Lond) (2010) 1.71
Melanocortin 4 receptors reciprocally regulate sympathetic and parasympathetic preganglionic neurons. Cell (2013) 1.71
Obesity and quality of life: mediating effects of pain and comorbidities. Obes Res (2003) 1.52
Hypothalamic orexin stimulates feeding-associated glucose utilization in skeletal muscle via sympathetic nervous system. Cell Metab (2009) 1.51
The use of a running wheel to measure activity in rodents: relationship to energy balance, general activity, and reward. Neurosci Biobehav Rev (2012) 1.45
The specific force of single intact extensor digitorum longus and soleus mouse muscle fibers declines with aging. J Membr Biol (2000) 1.40
Genetic analysis of physical activity in twins. Am J Clin Nutr (2005) 1.40
Increasing overall physical activity and aerobic fitness is associated with improvements in metabolic risk: cohort analysis of the ProActive trial. Diabetologia (2008) 1.39
Uncoupling protein-3: clues in an ongoing mitochondrial mystery. FASEB J (2007) 1.38
Retracted Ligand type-specific interactions of peroxisome proliferator-activated receptor gamma with transcriptional coactivators. J Biol Chem (2000) 1.35
Intrinsic aerobic capacity sets a divide for aging and longevity. Circ Res (2011) 1.33
Distinct effects of leptin and a melanocortin receptor agonist injected into medial hypothalamic nuclei on glucose uptake in peripheral tissues. Diabetes (2009) 1.33
Sarcolemmal ATP-sensitive K(+) channels control energy expenditure determining body weight. Cell Metab (2010) 1.31
A two-step procedure for efficient electrotransfer of both high-molecular-weight (greater than 400,000) and low-molecular-weight (less than 20,000) proteins. Anal Biochem (1987) 1.30
Age-related changes in contractile properties of single skeletal fibers from the soleus muscle. J Appl Physiol (1985) (1999) 1.30
Nonexercise activity thermogenesis (NEAT): environment and biology. Am J Physiol Endocrinol Metab (2004) 1.28
Central neural and endocrine mechanisms of non-exercise activity thermogenesis and their potential impact on obesity. J Neuroendocrinol (2007) 1.23
Metabolic adjustments with the development, treatment, and recurrence of obesity in obesity-prone rats. Am J Physiol Regul Integr Comp Physiol (2004) 1.22
NEAT--non-exercise activity thermogenesis--egocentric & geocentric environmental factors vs. biological regulation. Acta Physiol Scand (2005) 1.19
Neuroregulation of nonexercise activity thermogenesis and obesity resistance. Am J Physiol Regul Integr Comp Physiol (2007) 1.18
The efficiency of cellular energy transduction and its implications for obesity. Annu Rev Nutr (2008) 1.14
Determinants of the energy costs of light activities: inferences for interpreting doubly labeled water data. Int J Obes Relat Metab Disord (2002) 1.14
A muscle-specific knockout implicates nuclear receptor coactivator MED1 in the regulation of glucose and energy metabolism. Proc Natl Acad Sci U S A (2010) 1.14
Low intrinsic running capacity is associated with reduced skeletal muscle substrate oxidation and lower mitochondrial content in white skeletal muscle. Am J Physiol Regul Integr Comp Physiol (2011) 1.11
A rat model system to study complex disease risks, fitness, aging, and longevity. Trends Cardiovasc Med (2012) 1.11
Impaired skeletal muscle beta-adrenergic activation and lipolysis are associated with whole-body insulin resistance in rats bred for low intrinsic exercise capacity. Endocrinology (2009) 1.09
Endurance capacity, not body size, determines physical activity levels: role of skeletal muscle PEPCK. PLoS One (2009) 1.09
Is there evidence for an age-related reduction in metabolic rate? J Appl Physiol (1985) (1998) 1.09
Lower oxidative DNA damage despite greater ROS production in muscles from rats selectively bred for high running capacity. Am J Physiol Regul Integr Comp Physiol (2010) 1.05
Differences in daily energy expenditure in lean and obese women: the role of posture allocation. Obesity (Silver Spring) (2008) 1.05
Energy balance in obesity. Proc Nutr Soc (2003) 1.05
Central melanocortin signaling restores skeletal muscle AMP-activated protein kinase phosphorylation in mice fed a high-fat diet. Cell Metab (2007) 1.04
Skeletal muscle mitochondrial and metabolic responses to a high-fat diet in female rats bred for high and low aerobic capacity. Appl Physiol Nutr Metab (2010) 1.03
Extracellular signal-regulated kinase in the ventromedial hypothalamus mediates leptin-induced glucose uptake in red-type skeletal muscle. Diabetes (2013) 1.02
Mitochondrial uncoupling protein 3 and its role in cardiac- and skeletal muscle metabolism. Physiol Behav (2007) 1.01
Effect of CART in the hypothalamic paraventricular nucleus on feeding and uncoupling protein gene expression. Neuroreport (2000) 0.95
Exercise training reverses impaired skeletal muscle metabolism induced by artificial selection for low aerobic capacity. Am J Physiol Regul Integr Comp Physiol (2010) 0.94
Biased parameter estimates and inflated Type I error rates in analysis of covariance (and analysis of partial variance) arising from unreliability: alternatives and remedial strategies. J Abnorm Psychol (2010) 0.94
Genomics, genes, and environmental interaction: the role of exercise. J Appl Physiol (1985) (2000) 0.93
Norepinephrine turnover in brown and white adipose tissue after partial lipectomy. Physiol Behav (2004) 0.93
Distribution and function of melanocortin receptors within the brain. Adv Exp Med Biol (2010) 0.93
Metabolic correlates of selection on aerobic capacity in laboratory mice: a test of the model for the evolution of endothermy. J Exp Biol (2009) 0.92
Divergent skeletal muscle respiratory capacities in rats artificially selected for high and low running ability: a role for Nor1? J Appl Physiol (1985) (2012) 0.91
Interorgan signaling between adipose tissue metabolism and skeletal muscle uncoupling protein homologs: is there a role for circulating free fatty acids? Diabetes (1998) 0.90
The influence of dietary composition on energy intake and body weight. J Am Coll Nutr (2002) 0.89
Urocortin in the hypothalamic PVN increases leptin and affects uncoupling proteins-1 and -3 in rats. Am J Physiol Regul Integr Comp Physiol (2002) 0.88
Intraspecific correlations of basal and maximal metabolic rates in birds and the aerobic capacity model for the evolution of endothermy. PLoS One (2012) 0.87
The energetic implications of uncoupling protein-3 in skeletal muscle. Appl Physiol Nutr Metab (2007) 0.86
Age and aerobic performance in deer mice. J Exp Biol (2003) 0.86
Effects of genetic selection and voluntary activity on the medial gastrocnemius muscle in house mice. J Appl Physiol (1985) (1999) 0.85
Effect of the estrous cycle and surgical ovariectomy on energy balance, fuel utilization, and physical activity in lean and obese female rats. Am J Physiol Regul Integr Comp Physiol (2010) 0.85
Walking and running economy: inverse association with peak oxygen uptake. Med Sci Sports Exerc (2010) 0.83
Metabolic complications of obesity. Pathophysiologic considerations. Med Clin North Am (2000) 0.82
The national obesity crisis: a call for action. Gastroenterology (2004) 0.81
Noradrenergic projections to the ventromedial hypothalamus regulate fat metabolism during endurance exercise. Neuroscience (2011) 0.81
Region-specific differences in brain melanocortin receptors in rats of the lean phenotype. Neuroreport (2012) 0.81
Effect of NPY in the hypothalamic paraventricular nucleus on uncoupling proteins 1, 2, and 3 in the rat. Am J Physiol Regul Integr Comp Physiol (2000) 0.80
Thermic effect of food in hypothyroid rats. J Endocrinol (1996) 0.79
UCP3 and its putative function: consistencies and controversies. Biochem Soc Trans (2001) 0.79
Fat mass in predicting resting metabolic rate. Am J Clin Nutr (1992) 0.78
Role of brown adipose tissue thermogenesis in overfeeding: a review. J R Soc Med (1983) 0.77
Cardiovascular risk factors emerge after artificial selection for low aerobic capacity. Science (2005) 4.76
Using molecular classification to predict gains in maximal aerobic capacity following endurance exercise training in humans. J Appl Physiol (1985) (2010) 2.74
A transcriptional map of the impact of endurance exercise training on skeletal muscle phenotype. J Appl Physiol (1985) (2010) 2.07
Spontaneous activity, economy of activity, and resistance to diet-induced obesity in rats bred for high intrinsic aerobic capacity. Horm Behav (2010) 1.98
Deleted in breast cancer-1 regulates SIRT1 activity and contributes to high-fat diet-induced liver steatosis in mice. J Clin Invest (2010) 1.97
Rats selectively bred for low aerobic capacity have reduced hepatic mitochondrial oxidative capacity and susceptibility to hepatic steatosis and injury. J Physiol (2009) 1.95
Artificial selection for high-capacity endurance running is protective against high-fat diet-induced insulin resistance. Am J Physiol Endocrinol Metab (2007) 1.81
Continued divergence in VO2max of rats artificially selected for running endurance is mediated by greater convective blood O2 delivery. J Appl Physiol (1985) (2006) 1.76
The enzyme CD38 (a NAD glycohydrolase, EC 3.2.2.5) is necessary for the development of diet-induced obesity. FASEB J (2007) 1.57
Transgenic expression of cholesterol 7alpha-hydroxylase in the liver prevents high-fat diet-induced obesity and insulin resistance in mice. Hepatology (2010) 1.55
Gene expression profiling of skeletal muscle in exercise-trained and sedentary rats with inborn high and low VO2max. Physiol Genomics (2008) 1.54
Sympathetic innervation of white adipose tissue and its regulation of fat cell number. Am J Physiol Regul Integr Comp Physiol (2004) 1.48
Effects of reduction of renal mass on renal oxygen tension and erythropoietin production in the rat. Kidney Int (2002) 1.41
Aerobic interval training vs. continuous moderate exercise in the metabolic syndrome of rats artificially selected for low aerobic capacity. Cardiovasc Res (2008) 1.37
Intrinsic aerobic capacity sets a divide for aging and longevity. Circ Res (2011) 1.33
Brain-adipose tissue cross talk. Proc Nutr Soc (2005) 1.29
Aerobic metabolism underlies complexity and capacity. J Physiol (2007) 1.28
Evaluation of a quantitative magnetic resonance imaging system for whole body composition analysis in rodents. Obesity (Silver Spring) (2010) 1.22
Loss of FXR protects against diet-induced obesity and accelerates liver carcinogenesis in ob/ob mice. Mol Endocrinol (2012) 1.21
Selected contribution: skeletal muscle capillarity and enzyme activity in rats selectively bred for running endurance. J Appl Physiol (1985) (2002) 1.16
Determinants of maximal O(2) uptake in rats selectively bred for endurance running capacity. J Appl Physiol (1985) (2002) 1.14
Resveratrol enhances exercise training responses in rats selectively bred for high running performance. Food Chem Toxicol (2013) 1.12
Low intrinsic running capacity is associated with reduced skeletal muscle substrate oxidation and lower mitochondrial content in white skeletal muscle. Am J Physiol Regul Integr Comp Physiol (2011) 1.11
A rat model system to study complex disease risks, fitness, aging, and longevity. Trends Cardiovasc Med (2012) 1.11
Peripheral oxygen transport and utilization in rats following continued selective breeding for endurance running capacity. J Appl Physiol (1985) (2008) 1.09
Gene expression centroids that link with low intrinsic aerobic exercise capacity and complex disease risk. FASEB J (2010) 1.09
Endurance capacity, not body size, determines physical activity levels: role of skeletal muscle PEPCK. PLoS One (2009) 1.09
Impaired skeletal muscle beta-adrenergic activation and lipolysis are associated with whole-body insulin resistance in rats bred for low intrinsic exercise capacity. Endocrinology (2009) 1.09
Development of animal models to test the fundamental basis of gene-environment interactions. Obesity (Silver Spring) (2008) 1.09
Aerobic capacity-dependent differences in cardiac gene expression. Physiol Genomics (2008) 1.08
Metabolic consequences of pregnancy-associated plasma protein-A deficiency in mice: exploring possible relationship to the longevity phenotype. J Endocrinol (2008) 1.06
Lower oxidative DNA damage despite greater ROS production in muscles from rats selectively bred for high running capacity. Am J Physiol Regul Integr Comp Physiol (2010) 1.05
The effect of exercise training on transverse tubules in normal, remodeled, and reverse remodeled hearts. J Cell Physiol (2011) 1.05
Skeletal muscle mitochondrial and metabolic responses to a high-fat diet in female rats bred for high and low aerobic capacity. Appl Physiol Nutr Metab (2010) 1.03
Dysfunction of inflammation-resolving pathways is associated with exaggerated postoperative cognitive decline in a rat model of the metabolic syndrome. Mol Med (2013) 1.03
Surgery results in exaggerated and persistent cognitive decline in a rat model of the Metabolic Syndrome. Anesthesiology (2013) 1.03
Resistance to aerobic exercise training causes metabolic dysfunction and reveals novel exercise-regulated signaling networks. Diabetes (2013) 1.02
Overweight female rats selectively breed for low aerobic capacity exhibit increased myocardial fibrosis and diastolic dysfunction. Am J Physiol Heart Circ Physiol (2012) 1.01
Nitric oxide synthase type-1 modulates cardiomyocyte contractility and calcium handling: association with low intrinsic aerobic capacity. Eur J Cardiovasc Prev Rehabil (2007) 1.01
Low aerobic capacity and high-fat diet contribute to oxidative stress and IRS-1 degradation in the kidney. Am J Nephrol (2009) 1.00
Caloric restriction reverses hepatic insulin resistance and steatosis in rats with low aerobic capacity. Endocrinology (2010) 1.00
Enhanced cardiac protein glycosylation (O-GlcNAc) of selected mitochondrial proteins in rats artificially selected for low running capacity. Physiol Genomics (2012) 0.96
Reduced susceptibility to ventricular tachyarrhythmias in rats selectively bred for high aerobic capacity. Am J Physiol Heart Circ Physiol (2006) 0.96
Elevated central monoamine receptor mRNA in rats bred for high endurance capacity: implications for central fatigue. Behav Brain Res (2006) 0.95
Dissociation of diabetes and obesity in mice lacking orphan nuclear receptor small heterodimer partner. J Lipid Res (2011) 0.95
Exercise training reverses impaired skeletal muscle metabolism induced by artificial selection for low aerobic capacity. Am J Physiol Regul Integr Comp Physiol (2010) 0.94
Genetic analysis of a rat model of aerobic capacity and metabolic fitness. PLoS One (2013) 0.93
GABAA receptor activation suppresses Period 1 mRNA and Period 2 mRNA in the suprachiasmatic nucleus during the mid-subjective day. Eur J Neurosci (2006) 0.92
Galectin-3 stimulates preadipocyte proliferation and is up-regulated in growing adipose tissue. Obesity (Silver Spring) (2007) 0.92
Characterization of an MPS I-H knock-in mouse that carries a nonsense mutation analogous to the human IDUA-W402X mutation. Mol Genet Metab (2010) 0.91
Intrinsic aerobic capacity correlates with greater inherent mitochondrial oxidative and H2O2 emission capacities without major shifts in myosin heavy chain isoform. J Appl Physiol (1985) (2012) 0.91
Divergent skeletal muscle respiratory capacities in rats artificially selected for high and low running ability: a role for Nor1? J Appl Physiol (1985) (2012) 0.91
Selectively bred rat model system for low and high response to exercise training. Physiol Genomics (2013) 0.90
Nociception before and after exercise in rats bred for high and low aerobic capacity. Neurosci Lett (2008) 0.90
Continued artificial selection for running endurance in rats is associated with improved lung function. J Appl Physiol (1985) (2009) 0.90
Neuropeptides controlling energy balance: orexins and neuromedins. Handb Exp Pharmacol (2012) 0.90
Transplantation or removal of intra-abdominal adipose tissue prevents age-induced glucose insensitivity. Physiol Behav (2010) 0.89
Central expression and anorectic effect of brain-derived neurotrophic factor are regulated by circulating estradiol levels. Horm Behav (2013) 0.88
Enhanced angiogenesis of porous collagen scaffolds by incorporation of TMC/DNA complexes encoding vascular endothelial growth factor. Acta Biomater (2009) 0.88
Disrupted sleep and delayed recovery from chronic peripheral neuropathy are distinct phenotypes in a rat model of metabolic syndrome. Anesthesiology (2010) 0.87
Retracted Dysregulation of muscle lipid metabolism in rats selectively bred for low aerobic running capacity. Am J Physiol Endocrinol Metab (2007) 0.87
Determination of minimum alveolar concentration for isoflurane and sevoflurane in a rodent model of human metabolic syndrome. Anesth Analg (2011) 0.86
Test of the principle of initial value in rat genetic models of exercise capacity. Am J Physiol Regul Integr Comp Physiol (2004) 0.85
Label-free profiling of skeletal muscle using high-definition mass spectrometry. Proteomics (2014) 0.85