Published in Mol Cell Proteomics on January 09, 2014
Biochemical and cellular analysis of Ogden syndrome reveals downstream Nt-acetylation defects. Hum Mol Genet (2014) 1.02
De novo missense mutations in the NAA10 gene cause severe non-syndromic developmental delay in males and females. Eur J Hum Genet (2014) 0.99
Loss of amino-terminal acetylation suppresses a prion phenotype by modulating global protein folding. Nat Commun (2014) 0.95
NAA10 mutation causing a novel intellectual disability syndrome with Long QT due to N-terminal acetyltransferase impairment. Sci Rep (2015) 0.87
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Depletion of histone N-terminal-acetyltransferase Naa40 induces p53-independent apoptosis in colorectal cancer cells via the mitochondrial pathway. Apoptosis (2016) 0.78
Microscopy-based Saccharomyces cerevisiae complementation model reveals functional conservation and redundancy of N-terminal acetyltransferases. Sci Rep (2016) 0.76
Proteomic and genomic characterization of a yeast model for Ogden syndrome. Yeast (2016) 0.75
Loss of Nat4 and its associated histone H4 N-terminal acetylation mediates calorie restriction-induced longevity. EMBO Rep (2016) 0.75
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N-terminal acetylation of cellular proteins creates specific degradation signals. Science (2010) 4.56
Proteomics analyses reveal the evolutionary conservation and divergence of N-terminal acetyltransferases from yeast and humans. Proc Natl Acad Sci U S A (2009) 4.09
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Using VAAST to identify an X-linked disorder resulting in lethality in male infants due to N-terminal acetyltransferase deficiency. Am J Hum Genet (2011) 3.43
The ARD1 gene of yeast functions in the switch between the mitotic cell cycle and alternative developmental pathways. Cell (1985) 3.28
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The yeast N(alpha)-acetyltransferase NatA is quantitatively anchored to the ribosome and interacts with nascent polypeptides. Mol Cell Biol (2003) 2.36
Identification and functional characterization of N-terminally acetylated proteins in Drosophila melanogaster. PLoS Biol (2009) 2.25
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N-terminal acetylation acts as an avidity enhancer within an interconnected multiprotein complex. Science (2011) 1.78
An N-terminally acetylated Arf-like GTPase is localised to lysosomes and affects their motility. J Cell Sci (2006) 1.71
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NatF contributes to an evolutionary shift in protein N-terminal acetylation and is important for normal chromosome segregation. PLoS Genet (2011) 1.57
Analysis of ARD1 function in hypoxia response using retroviral RNA interference. J Biol Chem (2005) 1.56
Human arrest defective 1 acetylates and activates beta-catenin, promoting lung cancer cell proliferation. Cancer Res (2006) 1.53
N-terminal acetylation inhibits protein targeting to the endoplasmic reticulum. PLoS Biol (2011) 1.48
MAK3 encodes an N-acetyltransferase whose modification of the L-A gag NH2 terminus is necessary for virus particle assembly. J Biol Chem (1992) 1.45
Knockdown of human N alpha-terminal acetyltransferase complex C leads to p53-dependent apoptosis and aberrant human Arl8b localization. Mol Cell Biol (2009) 1.37
Identification of the human N(alpha)-acetyltransferase complex B (hNatB): a complex important for cell-cycle progression. Biochem J (2008) 1.37
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Nat3p and Mdm20p are required for function of yeast NatB Nalpha-terminal acetyltransferase and of actin and tropomyosin. J Biol Chem (2003) 1.35
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NatC Nalpha-terminal acetyltransferase of yeast contains three subunits, Mak3p, Mak10p, and Mak31p. J Biol Chem (2001) 1.30
Human Naa50p (Nat5/San) displays both protein N alpha- and N epsilon-acetyltransferase activity. J Biol Chem (2009) 1.29
Proteome-derived peptide libraries allow detailed analysis of the substrate specificities of N(alpha)-acetyltransferases and point to hNaa10p as the post-translational actin N(alpha)-acetyltransferase. Mol Cell Proteomics (2011) 1.27
Selecting protein N-terminal peptides by combined fractional diagonal chromatography. Nat Protoc (2011) 1.26
Comparative large scale characterization of plant versus mammal proteins reveals similar and idiosyncratic N-α-acetylation features. Mol Cell Proteomics (2012) 1.23
Genetic manipulation indicates that ARD1 is an essential N(alpha)-acetyltransferase in Trypanosoma brucei. Mol Biochem Parasitol (2000) 1.19
Molecular basis for N-terminal acetylation by the heterodimeric NatA complex. Nat Struct Mol Biol (2013) 1.16
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hNaa10p contributes to tumorigenesis by facilitating DNMT1-mediated tumor suppressor gene silencing. J Clin Invest (2010) 1.11
Structure of a ternary Naa50p (NAT5/SAN) N-terminal acetyltransferase complex reveals the molecular basis for substrate-specific acetylation. J Biol Chem (2011) 1.11
Protein N-terminal processing: substrate specificity of Escherichia coli and human methionine aminopeptidases. Biochemistry (2010) 1.08
A review of COFRADIC techniques targeting protein N-terminal acetylation. BMC Proc (2009) 1.06
Protein N-terminal acetyltransferases in cancer. Oncogene (2012) 1.05
The human N-alpha-acetyltransferase 40 (hNaa40p/hNatD) is conserved from yeast and N-terminally acetylates histones H2A and H4. PLoS One (2011) 1.02
Properties of Nat4, an N(alpha)-acetyltransferase of Saccharomyces cerevisiae that modifies N termini of histones H2A and H4. Mol Cell Biol (2009) 1.02
Hypoxia-inducible factor-1alpha obstructs a Wnt signaling pathway by inhibiting the hARD1-mediated activation of beta-catenin. Cancer Res (2008) 1.01
Drosophila variable nurse cells encodes arrest defective 1 (ARD1), the catalytic subunit of the major N-terminal acetyltransferase complex. Dev Dyn (2010) 0.99
Depletion of the human Nα-terminal acetyltransferase A induces p53-dependent apoptosis and p53-independent growth inhibition. Int J Cancer (2010) 0.95
MAK10, a glucose-repressible gene necessary for replication of a dsRNA virus of Saccharomyces cerevisiae, has T cell receptor alpha-subunit motifs. Genetics (1992) 0.94
Bioinformatics analysis of a Saccharomyces cerevisiae N-terminal proteome provides evidence of alternative translation initiation and post-translational N-terminal acetylation. J Proteome Res (2011) 0.93
Application of reverse-phase HPLC to quantify oligopeptide acetylation eliminates interference from unspecific acetyl CoA hydrolysis. BMC Proc (2009) 0.93
Implications for the evolution of eukaryotic amino-terminal acetyltransferase (NAT) enzymes from the structure of an archaeal ortholog. Proc Natl Acad Sci U S A (2013) 0.85
Proteomic amino-termini profiling reveals targeting information for protein import into complex plastids. PLoS One (2013) 0.85
Specificity and versatility of substrate binding sites in four catalytic domains of human N-terminal acetyltransferases. PLoS One (2012) 0.78
C-terminomics screen for natural substrates of cytosolic carboxypeptidase 1 reveals processing of acidic protein C termini. Mol Cell Proteomics (2014) 0.76