Published in Proc Natl Acad Sci U S A on July 18, 2012
Control of protein quality and stoichiometries by N-terminal acetylation and the N-end rule pathway. Mol Cell (2013) 1.64
Molecular basis for N-terminal acetylation by the heterodimeric NatA complex. Nat Struct Mol Biol (2013) 1.16
N-terminal proteomics and ribosome profiling provide a comprehensive view of the alternative translation initiation landscape in mice and men. Mol Cell Proteomics (2014) 1.07
Biochemical and cellular analysis of Ogden syndrome reveals downstream Nt-acetylation defects. Hum Mol Genet (2014) 1.02
A Saccharomyces cerevisiae model reveals in vivo functional impairment of the Ogden syndrome N-terminal acetyltransferase NAA10 Ser37Pro mutant. Mol Cell Proteomics (2014) 0.89
N-terminal acetylation of the yeast Derlin Der1 is essential for Hrd1 ubiquitin-ligase activity toward luminal ER substrates. Mol Biol Cell (2013) 0.88
The biological functions of Naa10 - From amino-terminal acetylation to human disease. Gene (2015) 0.87
Structural insight into the TRIAP1/PRELI-like domain family of mitochondrial phospholipid transfer complexes. EMBO Rep (2015) 0.86
Structure of human RNA N⁶-methyladenine demethylase ALKBH5 provides insights into its mechanisms of nucleic acid recognition and demethylation. Nucleic Acids Res (2014) 0.83
The molecular basis for histone H4- and H2A-specific amino-terminal acetylation by NatD. Structure (2015) 0.82
N-terminal modifications of cellular proteins: The enzymes involved, their substrate specificities and biological effects. Proteomics (2015) 0.82
N-terminal acetylation by NatC is not a general determinant for substrate subcellular localization in Saccharomyces cerevisiae. PLoS One (2013) 0.82
Proteases and protease inhibitors of urinary extracellular vesicles in diabetic nephropathy. J Diabetes Res (2015) 0.80
Loss of the scavenger mRNA decapping enzyme DCPS causes syndromic intellectual disability with neuromuscular defects. Hum Mol Genet (2015) 0.79
Protein N-terminal acetyltransferases act as N-terminal propionyltransferases in vitro and in vivo. Mol Cell Proteomics (2012) 0.79
Image analysis for the quantitative comparison of stress fibers and focal adhesions. PLoS One (2014) 0.79
Absence of N-terminal acetyltransferase diversification during evolution of eukaryotic organisms. Sci Rep (2016) 0.78
Positional proteomics reveals differences in N-terminal proteoform stability. Mol Syst Biol (2016) 0.77
Crystal Structure of the Golgi-Associated Human Nα-Acetyltransferase 60 Reveals the Molecular Determinants for Substrate-Specific Acetylation. Structure (2016) 0.77
Microscopy-based Saccharomyces cerevisiae complementation model reveals functional conservation and redundancy of N-terminal acetyltransferases. Sci Rep (2016) 0.76
Identification of a Novel Regulatory Mechanism of Nutrient Transport Controlled by TORC1-Npr1-Amu1/Par32. PLoS Genet (2015) 0.76
N-Terminal Acetylation-Targeted N-End Rule Proteolytic System: The Ac/N-End Rule Pathway. Mol Cells (2016) 0.76
A Role for Human N-alpha Acetyltransferase 30 (Naa30) in Maintaining Mitochondrial Integrity. Mol Cell Proteomics (2016) 0.76
N-terminal acetylation promotes synaptonemal complex assembly in C. elegans. Genes Dev (2016) 0.75
Naa50/San-dependent N-terminal acetylation of Scc1 is potentially important for sister chromatid cohesion. Sci Rep (2016) 0.75
Mdm20 Modulates Actin Remodeling through the mTORC2 Pathway via Its Effect on Rictor Expression. PLoS One (2015) 0.75
Exploring transcriptomic diversity in muscle revealed that cellular signaling pathways mainly differentiate five Western porcine breeds. BMC Genomics (2015) 0.75
Human Naa50 Protein Displays Broad Substrate Specificity for Amino-terminal Acetylation: DETAILED STRUCTURAL AND BIOCHEMICAL ANALYSIS USING TETRAPEPTIDE LIBRARY. J Biol Chem (2016) 0.75
Conformational behavior of polyalanine peptides with and without protecting groups of varying chain lengths: population of PP-II structure! J Mol Model (2015) 0.75
Actin regulation by tropomodulin and tropomyosin in neuronal morphogenesis and function. Mol Cell Neurosci (2017) 0.75
Cell adhesion: integrating cytoskeletal dynamics and cellular tension. Nat Rev Mol Cell Biol (2010) 7.27
Cell mechanics and the cytoskeleton. Nature (2010) 5.24
N-terminal acetylation of cellular proteins creates specific degradation signals. Science (2010) 4.56
Proteomics analyses reveal the evolutionary conservation and divergence of N-terminal acetyltransferases from yeast and humans. Proc Natl Acad Sci U S A (2009) 4.09
N-terminal acetyltransferases and sequence requirements for N-terminal acetylation of eukaryotic proteins. J Mol Biol (2003) 3.87
Myosin II activity regulates vinculin recruitment to focal adhesions through FAK-mediated paxillin phosphorylation. J Cell Biol (2010) 3.56
Using VAAST to identify an X-linked disorder resulting in lethality in male infants due to N-terminal acetyltransferase deficiency. Am J Hum Genet (2011) 3.43
Amino-terminal processing of mutant forms of yeast iso-1-cytochrome c. The specificities of methionine aminopeptidase and acetyltransferase. J Biol Chem (1985) 3.13
Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. Nat Biotechnol (2003) 3.10
Distinct roles of MLCK and ROCK in the regulation of membrane protrusions and focal adhesion dynamics during cell migration of fibroblasts. J Cell Biol (2004) 3.03
Biochemistry and biomechanics of cell motility. Annu Rev Biomed Eng (2005) 2.08
The mechanism of N-terminal acetylation of proteins. CRC Crit Rev Biochem (1985) 2.02
Mechanisms of actin stress fibre assembly. J Microsc (2008) 1.91
Force transmission in migrating cells. J Cell Biol (2010) 1.89
The specificities of yeast methionine aminopeptidase and acetylation of amino-terminal methionine in vivo. Processing of altered iso-1-cytochromes c created by oligonucleotide transformation. J Biol Chem (1990) 1.79
A synopsis of eukaryotic Nalpha-terminal acetyltransferases: nomenclature, subunits and substrates. BMC Proc (2009) 1.60
Composition and function of the eukaryotic N-terminal acetyltransferase subunits. Biochem Biophys Res Commun (2003) 1.58
NatF contributes to an evolutionary shift in protein N-terminal acetylation and is important for normal chromosome segregation. PLoS Genet (2011) 1.57
N-terminal acetylation inhibits protein targeting to the endoplasmic reticulum. PLoS Biol (2011) 1.48
Identification of the human N(alpha)-acetyltransferase complex B (hNatB): a complex important for cell-cycle progression. Biochem J (2008) 1.37
Nat3p and Mdm20p are required for function of yeast NatB Nalpha-terminal acetyltransferase and of actin and tropomyosin. J Biol Chem (2003) 1.35
Yeast N(alpha)-terminal acetyltransferases are associated with ribosomes. J Cell Biochem (2008) 1.28
New insights into the regulation of the actin cytoskeleton by tropomyosin. Int Rev Cell Mol Biol (2010) 1.28
Targeted analysis of protein termini. J Proteome Res (2007) 1.28
Profiling of N-acetylated protein termini provides in-depth insights into the N-terminal nature of the proteome. Mol Cell Proteomics (2010) 1.28
Proteome-derived peptide libraries allow detailed analysis of the substrate specificities of N(alpha)-acetyltransferases and point to hNaa10p as the post-translational actin N(alpha)-acetyltransferase. Mol Cell Proteomics (2011) 1.27
Tropomyosin isoform expression regulates the transition of adhesions to determine cell speed and direction. Mol Cell Biol (2009) 1.26
The stress-induced Tfs1p requires NatB-mediated acetylation to inhibit carboxypeptidase Y and to regulate the protein kinase A pathway. J Biol Chem (2004) 1.23
Mdm20 protein functions with Nat3 protein to acetylate Tpm1 protein and regulate tropomyosin-actin interactions in budding yeast. Proc Natl Acad Sci U S A (2003) 1.21
Implication of human N-alpha-acetyltransferase 5 in cellular proliferation and carcinogenesis. Oncogene (2008) 1.15
N(alpha)-acetylation and proteolytic activity of the yeast 20 S proteasome. J Biol Chem (2000) 1.13
The action of N-terminal acetyltransferases on yeast ribosomal proteins. J Biol Chem (1999) 1.10
What makes tropomyosin an actin binding protein? A perspective. J Struct Biol (2009) 1.06
A review of COFRADIC techniques targeting protein N-terminal acetylation. BMC Proc (2009) 1.06
Perturbation of the yeast N-acetyltransferase NatB induces elevation of protein phosphorylation levels. BMC Genomics (2010) 1.05
Protein alpha-N-acetylation studied by N-terminomics. FEBS J (2011) 1.03
Properties of Nat4, an N(alpha)-acetyltransferase of Saccharomyces cerevisiae that modifies N termini of histones H2A and H4. Mol Cell Biol (2009) 1.02
The actin-associating protein Tm5NM1 blocks mesenchymal motility without transition to amoeboid motility. Oncogene (2010) 0.96
Tropomyosin isoform modulation of focal adhesion structure and cell migration. Cell Adh Migr (2010) 0.95
Bioinformatics analysis of a Saccharomyces cerevisiae N-terminal proteome provides evidence of alternative translation initiation and post-translational N-terminal acetylation. J Proteome Res (2011) 0.93
Functional homodimers and heterodimers of recombinant smooth muscle tropomyosin. Biochemistry (2006) 0.89
Physiological importance and identification of novel targets for the N-terminal acetyltransferase NatB. Eukaryot Cell (2006) 0.89
Characterization of the human Nalpha-terminal acetyltransferase B enzymatic complex. BMC Proc (2009) 0.80
PRIDE: the proteomics identifications database. Proteomics (2005) 7.52
Human Proteinpedia enables sharing of human protein data. Nat Biotechnol (2008) 4.21
Proteomics analyses reveal the evolutionary conservation and divergence of N-terminal acetyltransferases from yeast and humans. Proc Natl Acad Sci U S A (2009) 4.09
N-terminal acetyltransferases and sequence requirements for N-terminal acetylation of eukaryotic proteins. J Mol Biol (2003) 3.87
Morphological and biochemical characterization of a human liver in a uPA-SCID mouse chimera. Hepatology (2005) 3.72
Improved visualization of protein consensus sequences by iceLogo. Nat Methods (2009) 3.64
Using VAAST to identify an X-linked disorder resulting in lethality in male infants due to N-terminal acetyltransferase deficiency. Am J Hum Genet (2011) 3.43
Large-scale identification of N-terminal peptides in the halophilic archaea Halobacterium salinarum and Natronomonas pharaonis. J Proteome Res (2007) 3.30
Caspase-14 protects against epidermal UVB photodamage and water loss. Nat Cell Biol (2007) 2.82
Targeted peptidecentric proteomics reveals caspase-7 as a substrate of the caspase-1 inflammasomes. Mol Cell Proteomics (2008) 2.64
A clinical trial of CTLA-4 blockade with tremelimumab in patients with hepatocellular carcinoma and chronic hepatitis C. J Hepatol (2013) 2.63
Listeria monocytogenes impairs SUMOylation for efficient infection. Nature (2010) 2.57
LRRK2 controls an EndoA phosphorylation cycle in synaptic endocytosis. Neuron (2012) 2.49
Polyadenylation of rRNA in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A (2004) 2.49
LNCipedia: a database for annotated human lncRNA transcript sequences and structures. Nucleic Acids Res (2012) 2.40
The diversity of acetylated proteins. Genome Biol (2002) 2.40
The miR-17-92 microRNA cluster regulates multiple components of the TGF-β pathway in neuroblastoma. Mol Cell (2010) 2.38
Caspase-specific and nonspecific in vivo protein processing during Fas-induced apoptosis. Nat Methods (2005) 2.33
Identification and functional characterization of N-terminally acetylated proteins in Drosophila melanogaster. PLoS Biol (2009) 2.25
Protein N-terminal acetyltransferases: when the start matters. Trends Biochem Sci (2012) 2.19
Lysophosphatidic acid is a potential mediator of cholestatic pruritus. Gastroenterology (2010) 2.18
Analysis of protein processing by N-terminal proteomics reveals novel species-specific substrate determinants of granzyme B orthologs. Mol Cell Proteomics (2008) 2.01
Global analysis of the mitochondrial N-proteome identifies a processing peptidase critical for protein stability. Cell (2009) 1.96
Caspase-14 is required for filaggrin degradation to natural moisturizing factors in the skin. J Invest Dermatol (2011) 1.93
A multidrug resistance 3 gene mutation causing cholelithiasis, cholestasis of pregnancy, and adulthood biliary cirrhosis. Gastroenterology (2003) 1.90
Improved recovery of proteome-informative, protein N-terminal peptides by combined fractional diagonal chromatography (COFRADIC). Proteomics (2008) 1.81
Combined immunostimulation and conditional cytotoxic gene therapy provide long-term survival in a large glioma model. Cancer Res (2005) 1.74
Safety and liver transduction efficacy of rAAV5-cohPBGD in nonhuman primates: a potential therapy for acute intermittent porphyria. Hum Gene Ther (2013) 1.62
Degradation of normal mRNA in the nucleus of Saccharomyces cerevisiae. Mol Cell Biol (2003) 1.61
Radioembolization using 90Y-resin microspheres for patients with advanced hepatocellular carcinoma. Int J Radiat Oncol Biol Phys (2006) 1.61
A synopsis of eukaryotic Nalpha-terminal acetyltransferases: nomenclature, subunits and substrates. BMC Proc (2009) 1.60
Composition and function of the eukaryotic N-terminal acetyltransferase subunits. Biochem Biophys Res Commun (2003) 1.58
NatF contributes to an evolutionary shift in protein N-terminal acetylation and is important for normal chromosome segregation. PLoS Genet (2011) 1.57
Methylation of proteins involved in translation. Mol Microbiol (2007) 1.56
Improving the reliability and throughput of mass spectrometry-based proteomics by spectrum quality filtering. Proteomics (2006) 1.52
T-cell receptor-induced JNK activation requires proteolytic inactivation of CYLD by MALT1. EMBO J (2011) 1.52
Virus-induced unfolded protein response attenuates antiviral defenses via phosphorylation-dependent degradation of the type I interferon receptor. Cell Host Microbe (2009) 1.46
Effect of adeno-associated virus serotype and genomic structure on liver transduction and biodistribution in mice of both genders. Hum Gene Ther (2009) 1.37
Knockdown of human N alpha-terminal acetyltransferase complex C leads to p53-dependent apoptosis and aberrant human Arl8b localization. Mol Cell Biol (2009) 1.37
Identification of the human N(alpha)-acetyltransferase complex B (hNatB): a complex important for cell-cycle progression. Biochem J (2008) 1.37
Redox proteomics of protein-bound methionine oxidation. Mol Cell Proteomics (2011) 1.37
ms_lims, a simple yet powerful open source laboratory information management system for MS-driven proteomics. Proteomics (2010) 1.36
The tight junction-associated protein occludin is required for a postbinding step in hepatitis C virus entry and infection. J Virol (2009) 1.36
Parkin interacts with Ambra1 to induce mitophagy. J Neurosci (2011) 1.36
Listeria comet tails: the actin-based motility machinery at work. Trends Cell Biol (2008) 1.35
Nat3p and Mdm20p are required for function of yeast NatB Nalpha-terminal acetyltransferase and of actin and tropomyosin. J Biol Chem (2003) 1.35
Proteome-wide Identification of HtrA2/Omi Substrates. J Proteome Res (2007) 1.34
Blockade of Wnt signaling inhibits angiogenesis and tumor growth in hepatocellular carcinoma. Cancer Res (2009) 1.33
Deep proteome coverage based on ribosome profiling aids mass spectrometry-based protein and peptide discovery and provides evidence of alternative translation products and near-cognate translation initiation events. Mol Cell Proteomics (2013) 1.33
Vaccine-induced early control of hepatitis C virus infection in chimpanzees fails to impact on hepatic PD-1 and chronicity. Hepatology (2007) 1.32
PINK1 loss-of-function mutations affect mitochondrial complex I activity via NdufA10 ubiquinone uncoupling. Science (2014) 1.32
DBToolkit: processing protein databases for peptide-centric proteomics. Bioinformatics (2005) 1.30
Human Naa50p (Nat5/San) displays both protein N alpha- and N epsilon-acetyltransferase activity. J Biol Chem (2009) 1.29
Upregulation of indoleamine 2,3-dioxygenase in hepatitis C virus infection. J Virol (2007) 1.29
SitePredicting the cleavage of proteinase substrates. Trends Biochem Sci (2009) 1.29
Yeast N(alpha)-terminal acetyltransferases are associated with ribosomes. J Cell Biochem (2008) 1.28
Proteome-derived peptide libraries allow detailed analysis of the substrate specificities of N(alpha)-acetyltransferases and point to hNaa10p as the post-translational actin N(alpha)-acetyltransferase. Mol Cell Proteomics (2011) 1.27
Proteome-wide substrate analysis indicates substrate exclusion as a mechanism to generate caspase-7 versus caspase-3 specificity. Mol Cell Proteomics (2009) 1.27
Selecting protein N-terminal peptides by combined fractional diagonal chromatography. Nat Protoc (2011) 1.26
Phase I trial of intratumoral injection of an adenovirus encoding interleukin-12 for advanced digestive tumors. J Clin Oncol (2004) 1.25
MascotDatfile: an open-source library to fully parse and analyse MASCOT MS/MS search results. Proteomics (2007) 1.25
Complementary positional proteomics for screening substrates of endo- and exoproteases. Nat Methods (2010) 1.25
Comparative proteome analysis of Chlamydia trachomatis serovar A, D and L2. Proteomics (2002) 1.25
Analysis of the gamma-secretase interactome and validation of its association with tetraspanin-enriched microdomains. Nat Cell Biol (2009) 1.25
The role of thrombopoietin in the thrombocytopenia of patients with liver cirrhosis. Am J Gastroenterol (2005) 1.23
Hepatitis C virus envelope components alter localization of hepatocyte tight junction-associated proteins and promote occludin retention in the endoplasmic reticulum. Hepatology (2008) 1.23
MS-driven protease substrate degradomics. Proteomics (2010) 1.23
Prognostic factors and prevention of radioembolization-induced liver disease. Hepatology (2013) 1.21
A nuclear degradation pathway controls the abundance of normal mRNAs in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A (2005) 1.19
The transcriptional repressor Glis2 is a novel binding partner for p120 catenin. Mol Biol Cell (2007) 1.18
Matrix metalloproteinase 13 modulates intestinal epithelial barrier integrity in inflammatory diseases by activating TNF. EMBO Mol Med (2013) 1.17
Do we want our data raw? Including binary mass spectrometry data in public proteomics data repositories. Proteomics (2005) 1.17
In vitro and in vivo comparative study of chimeric liver-specific promoters. Mol Ther (2003) 1.17
In vitro and in vivo protein-bound tyrosine nitration characterized by diagonal chromatography. Mol Cell Proteomics (2009) 1.16
Characterization of a secreted Chlamydia protease. Cell Microbiol (2002) 1.16
Molecular basis for N-terminal acetylation by the heterodimeric NatA complex. Nat Struct Mol Biol (2013) 1.16
Global differential non-gel proteomics by quantitative and stable labeling of tryptic peptides with oxygen-18. J Proteome Res (2004) 1.16
The human platelet proteome mapped by peptide-centric proteomics: a functional protein profile. Proteomics (2005) 1.15