Generation of iPSCs from genetically corrected Brca2 hypomorphic cells: implications in cell reprogramming and stem cell therapy.

PubWeight™: 0.80‹?›

🔗 View Article (PMID 24420904)

Published in Stem Cells on February 01, 2014

Authors

S Navarro1, V Moleiro, F J Molina-Estevez, M L Lozano, R Chinchon, E Almarza, O Quintana-Bustamante, G Mostoslavsky, T Maetzig, M Galla, N Heinz, B Schiedlmeier, Y Torres, U Modlich, E Samper, P Río, J C Segovia, A Raya, G Güenechea, J C Izpisua-Belmonte, J A Bueren

Author Affiliations

1: Hematopoietic Innovative Therapies Division, Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas (CIEMAT), Madrid, Spain; Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBER-ER), Madrid, Spain.

Articles by these authors

Telomere shortening and tumor formation by mouse cells lacking telomerase RNA. Cell (1997) 13.34

Role of the NF-ATc transcription factor in morphogenesis of cardiac valves and septum. Nature (1998) 4.18

Disease states associated with telomerase deficiency appear earlier in mice with short telomeres. EMBO J (1999) 3.29

Conservation of the Notch signalling pathway in mammalian neurogenesis. Development (1997) 3.13

IKK1-deficient mice exhibit abnormal development of skin and skeleton. Genes Dev (1999) 2.92

Increased epidermal tumors and increased skin wound healing in transgenic mice overexpressing the catalytic subunit of telomerase, mTERT, in basal keratinocytes. EMBO J (2001) 2.83

Telomere length dynamics and chromosomal instability in cells derived from telomerase null mice. J Cell Biol (1999) 2.70

Telomerase-deficient mice with short telomeres are resistant to skin tumorigenesis. Nat Genet (2000) 2.68

Delta4, an endothelial specific notch ligand expressed at sites of physiological and tumor angiogenesis. Differentiation (2001) 2.46

Delayed engraftment of nonobese diabetic/severe combined immunodeficient mice transplanted with ex vivo-expanded human CD34(+) cord blood cells. Blood (1999) 2.33

The absence of the dna-dependent protein kinase catalytic subunit in mice results in anaphase bridges and in increased telomeric fusions with normal telomere length and G-strand overhang. Mol Cell Biol (2001) 1.94

Safety of retroviral gene marking with a truncated NGF receptor. Nat Med (2003) 1.60

Telomere length abnormalities in mammalian radiosensitive cells. Cancer Res (2001) 1.54

Telomere shortening in mTR-/- embryos is associated with failure to close the neural tube. EMBO J (1999) 1.49

Short telomeres result in organismal hypersensitivity to ionizing radiation in mammals. J Exp Med (2000) 1.49

In vitro toxicity of ET-743 and aplidine, two marine-derived antineoplastics, on human bone marrow haematopoietic progenitors. comparison with the clinical results. Eur J Cancer (2002) 1.48

Overcoming promoter competition in packaging cells improves production of self-inactivating retroviral vectors. Gene Ther (2006) 1.44

Correction of SCID-X1 using an enhancerless Vav promoter. Hum Gene Ther (2011) 1.43

[Use of laboratories for healthy persons at the primary care level]. Aten Primaria (1993) 1.40

CD34+AC133+ cells isolated from cord blood are highly enriched in long-term culture-initiating cells, NOD/SCID-repopulating cells and dendritic cell progenitors. Stem Cells (1998) 1.40

Leukemia induction after a single retroviral vector insertion in Evi1 or Prdm16. Leukemia (2008) 1.35

Lipoic acid improves nerve blood flow, reduces oxidative stress, and improves distal nerve conduction in experimental diabetic neuropathy. Diabetes Care (1995) 1.31

Ovarian angiogenesis. Phenotypic characterization of endothelial cells in a physiological model of blood vessel growth and regression. Am J Pathol (1995) 1.23

Culture of human mesenchymal stem cells at low oxygen tension improves growth and genetic stability by activating glycolysis. Cell Death Differ (2011) 1.23

Self-inactivating retroviral vectors with improved RNA processing. Gene Ther (2004) 1.23

Embryonic stem cell-like cells derived from adult human testis. Hum Reprod (2009) 1.22

ERCP in complete situs inversus viscerum using a "mirror image" technique. Endoscopy (2010) 1.17

Phenotypic and functional characteristics of hematopoietic cell lineages in CD69-deficient mice. Blood (2000) 1.17

Human mesenchymal stem cell-replicative senescence and oxidative stress are closely linked to aneuploidy. Cell Death Dis (2013) 1.16

Efficient generation of A9 midbrain dopaminergic neurons by lentiviral delivery of LMX1A in human embryonic stem cells and induced pluripotent stem cells. Hum Gene Ther (2011) 1.15

Origin and development of the avian tongue muscles. Anat Embryol (Berl) (1999) 1.10

Serum amino acid concentrations in nine athletes before and after the 1993 Colmar ultra triathlon. Int J Sports Med (1995) 1.09

Retroviral vector-mediated expression of HoxB4 in hematopoietic cells using a novel coexpression strategy. Gene Ther (2001) 1.07

In vitro myelosuppressive effects of the parvovirus minute virus of mice (MVMi) on hematopoietic stem and committed progenitor cells. Blood (1991) 1.07

Focal adhesion kinase is required for CXCL12-induced chemotactic and pro-adhesive responses in hematopoietic precursor cells. Leukemia (2007) 1.06

Polymorphisms of platelet membrane glycoprotein Ib associated with arterial thrombotic disease. Blood (1998) 1.04

Severe leukopenia and dysregulated erythropoiesis in SCID mice persistently infected with the parvovirus minute virus of mice. J Virol (1999) 1.04

Flavonoids inhibit platelet function through binding to the thromboxane A2 receptor. J Thromb Haemost (2005) 1.03

Remarkable leukemogenic potency and quality of a constitutively active neurotrophin receptor, deltaTrkA. Leukemia (2007) 0.99

Application of a new enzyme-linked immunosorbent assay for detection of total hepatitis C virus core antigen in blood donors. Transfus Med (2003) 0.98

Goosecoid misexpression alters the morphology and Hox gene expression of the developing chick limb bud. Mech Dev (1997) 0.97

Control of digit formation by activin signalling. Development (1999) 0.95

IGF-I mediates regeneration of endocrine pancreas by increasing beta cell replication through cell cycle protein modulation in mice. Diabetologia (2008) 0.95

Epidermal growth factor improves lentivirus vector gene transfer into primary mouse hepatocytes. Gene Ther (2011) 0.94

Crescent, a novel chick gene encoding a Frizzled-like cysteine-rich domain, is expressed in anterior regions during early embryogenesis. Int J Dev Biol (1997) 0.93

CTF/NF1 transcription factors act as potent genetic insulators for integrating gene transfer vectors. Gene Ther (2011) 0.93

Mechanisms controlling titer and expression of bidirectional lentiviral and gammaretroviral vectors. Gene Ther (2009) 0.93

Towards hematopoietic stem cell-mediated protection against infection with human immunodeficiency virus. Gene Ther (2006) 0.91

Tenascin and aggrecan expression by articular chondrocytes is influenced by interleukin 1beta: a possible explanation for the changes in matrix synthesis during osteoarthritis. Ann Rheum Dis (2004) 0.91

Interferon decreases serum lipid peroxidation products of hepatitis C patients. Free Radic Biol Med (1994) 0.89

Efficient transduction of human hematopoietic repopulating cells generating stable engraftment of transgene-expressing cells in NOD/SCID mice. Blood (2000) 0.89

Salmonella dublin infection: a rare cause of spontaneous bacterial peritonitis and chronic colitis in alcoholic liver cirrhosis. Eur J Gastroenterol Hepatol (2001) 0.89

Production of high affinity autoantibodies in autoimmune New Zealand Black/New Zealand white F1 mice targeted with an anti-DNA heavy chain. J Immunol (1999) 0.89

Emergence and clinical relevance of mutations associated with zidovudine resistance in asymptomatic HIV-1 infected patients. Eur J Clin Microbiol Infect Dis (1995) 0.88

Myeloid depression follows infection of susceptible newborn mice with the parvovirus minute virus of mice (strain i). J Virol (1995) 0.87

Activation of Evi1 inhibits cell cycle progression and differentiation of hematopoietic progenitor cells. Leukemia (2012) 0.87

Apigenin inhibits platelet adhesion and thrombus formation and synergizes with aspirin in the suppression of the arachidonic acid pathway. J Agric Food Chem (2008) 0.87

Ex vivo expansion of umbilical cord blood (UCB) CD34(+) cells alters the expression and function of alpha 4 beta 1 and alpha 5 beta 1 integrins. Br J Haematol (2001) 0.87

Quantitative PCR analysis reveals a high incidence of large intragenic deletions in the FANCA gene in Spanish Fanconi anemia patients. Cytogenet Genome Res (2004) 0.86

Heterosexual transmission of hepatitis C virus and the possible role of coexistent human immunodeficiency virus infection in the index case. A multicentre study of 423 pairings. J Intern Med (1994) 0.86

Prophylactic cefamandole in orthopaedic surgery. J Bone Joint Surg Am (1984) 0.86

The expression of Bcl-x is downregulated during differentiation of human hematopoietic progenitor cells along the granulocyte but not the monocyte/macrophage lineage. Blood (1997) 0.86

[Lipophilicity-protein binding relationship in cardenolides (author's transl)]. Arzneimittelforschung (1978) 0.86

Lentiviral vectors for induction of self-differentiation and conditional ablation of dendritic cells. Gene Ther (2011) 0.85

Ablation of Dido3 compromises lineage commitment of stem cells in vitro and during early embryonic development. Cell Death Differ (2011) 0.85

Population data of 13 STRS in southern Spain (Andalusia). Forensic Sci Int (2001) 0.85

Migraine and prothrombotic genetic risk factors. Cephalalgia (1998) 0.85

Differential effects of quercetin, apigenin and genistein on signalling pathways of protease-activated receptors PAR(1) and PAR(4) in platelets. Br J Pharmacol (2009) 0.85

Accelerated and long-term hematopoietic engraftment in mice transplanted with ex vivo expanded bone marrow. Bone Marrow Transplant (1994) 0.84

A simplified approach to improve the efficiency and safety of ex vivo hematopoietic gene therapy in fanconi anemia patients. Hum Gene Ther (2006) 0.84

A cutaneous gene therapy approach to human leptin deficiencies: correction of the murine ob/ob phenotype using leptin-targeted keratinocyte grafts. FASEB J (2001) 0.84

Hepatitis C virus infection among sexually promiscuous groups and the heterosexual partners of hepatitis C virus infected index cases. Eur J Clin Microbiol Infect Dis (1993) 0.84

Efficient in vivo regulation of cytidine deaminase expression in the haematopoietic system using a doxycycline-inducible lentiviral vector system. Gene Ther (2012) 0.84

Mobilization of hematopoietic progenitor cells with paclitaxel (taxol) as a single chemotheraupetic agent, associated with rhG-CSF. Bone Marrow Transplant (2000) 0.84

The venous thrombosis risk factor 20210 A allele of the prothrombin gene is not a major risk factor for arterial thrombotic disease. Br J Haematol (1997) 0.83

Acute nitrobenzene poisoning with severe associated methemoglobinemia: identification in whole blood by GC-FID and GC-MS. J Anal Toxicol (2003) 0.83

[Pancreatitis associated with visceral lupus erythematosus]. Gastroenterologia (1967) 0.83

Simultaneous determination of viloxazine, venlafaxine, imipramine, desipramine, sertraline, and amoxapine in whole blood: comparison of two extraction/cleanup procedures for capillary gas chromatography with nitrogen-phosphorus detection. J Anal Toxicol (2002) 0.83

MicroRNA-150-regulated vectors allow lymphocyte-sparing transgene expression in hematopoietic gene therapy. Gene Ther (2011) 0.83

Relationship between postprandial metabolomics and colon motility in children with constipation. Neurogastroenterol Motil (2013) 0.82

The sensitivity of acoustic cough recording relative to intraesophageal pressure recording and patient report during reflux testing. Neurogastroenterol Motil (2014) 0.82

Superior gene transfer into solid tumour cells than into human mobilised peripheral blood progenitor cells using helpervirus-free adeno-associated viral vector stocks. Eur J Cancer (1999) 0.82

STR data for the AmpFlSTR Profiler Plus and COfiler loci from the Maghreb (North Africa). Forensic Sci Int (2001) 0.82

Tumor necrosis factor beta and soluble APO-1/Fas independently predict progression to AIDS in HIV-seropositive patients. AIDS Res Hum Retroviruses (1998) 0.82

Peritoneal repairing cells: a type of bone marrow derived progenitor cells involved in mesothelial regeneration. J Cell Mol Med (2010) 0.81

Prophylaxis against infection. Single-dose cefonicid compared with multiple-dose cefamandole. J Bone Joint Surg Am (1991) 0.81

Persisting multilineage transgene expression in the clonal progeny of a hematopoietic stem cell. Leukemia (2002) 0.81

Does the granulocyte-macrophage colony-forming unit content in ex vivo-expanded grafts predict the recovery of the recipient leukocytes? Blood (1997) 0.81

In vitro and in vivo susceptibility of mouse megakaryocytic progenitors to strain i of parvovirus minute virus of mice. Exp Hematol (2001) 0.81

A comparative solid-phase extraction study for the simultaneous determination of fluoxetine, amitriptyline, nortriptyline, trimipramine, maprotiline, clomipramine, and trazodone in whole blood by capillary gas-liquid chromatography with nitrogen-phosphorus detection. J Anal Toxicol (2003) 0.81