Missense variant in TREML2 protects against Alzheimer's disease.

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Published in Neurobiol Aging on December 21, 2013

Authors

Bruno A Benitez1, Sheng Chih Jin1, Rita Guerreiro2, Rob Graham3, Jenny Lord4, Denise Harold5, Rebecca Sims5, Jean-Charles Lambert6, J Raphael Gibbs2, Jose Bras7, Celeste Sassi2, Oscar Harari1, Sarah Bertelsen1, Michelle K Lupton8, John Powell8, Celine Bellenguez6, Kristelle Brown4, Christopher Medway4, Patrick C G Haddick3, Marcel P van der Brug3, Tushar Bhangale9, Ward Ortmann10, Tim Behrens10, Richard Mayeux11, Margaret A Pericak-Vance12, Lindsay A Farrer13, Gerard D Schellenberg14, Jonathan L Haines15, Jim Turton4, Anne Braae4, Imelda Barber4, Anne M Fagan16, David M Holtzman17, John C Morris18, 3C Study Group, EADI consortium, Alzheimer's Disease Genetic Consortium (ADGC), Alzheimer's Disease Neuroimaging Initiative (ADNI), GERAD Consortium, Julie Williams5, John S K Kauwe19, Philippe Amouyel6, Kevin Morgan4, Andy Singleton10, John Hardy10, Alison M Goate20, Carlos Cruchaga21

Author Affiliations

1: Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.
2: Department of Molecular Neuroscience, UCL Institute of Neurology, London, UK; Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.
3: Diagnostic Discovery Department, Genentech Inc, South San Francisco, CA, USA.
4: Human Genetics, School of Molecular Medical Sciences, University of Nottingham, Nottingham, UK.
5: Institute of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK.
6: Inserm, Lille, France; Universite Lille 2, Lille, France; Institut Pasteur de Lille, Lille, France.
7: Department of Molecular Neuroscience, UCL Institute of Neurology, London, UK.
8: Institute of Psychiatry, King's College London, London, UK.
9: Department of Bioinformatics and Computational Biology, Genentech Inc, South San Francisco, CA, USA.
10: Human Genetics Department, Genentech Inc, South San Francisco, CA, USA.
11: Department of Neurology, Taub Institute on Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, USA; Gertrude H. Sergievsky Center, Columbia University, New York, NY, USA.
12: The John P. Hussman Institute for Human Genomics, University of Miami, Miami, FL, USA; Dr John T. Macdonald Foundation Department of Human Genetics, University of Miami, Miami, FL, USA.
13: Department of Medicine, Boston University Schools of Medicine and Public Health, Boston, MA, USA; Department of Biomedical Genetics, Boston University Schools of Medicine and Public Health, Boston, MA, USA; Department of Neurology, Boston University Schools of Medicine and Public Health, Boston, MA, USA; Department of Ophthalmology, Boston University Schools of Medicine and Public Health, Boston, MA, USA; Department of Epidemiology, Boston University Schools of Medicine and Public Health, Boston, MA, USA; Department of Biostatistics, Boston University Schools of Medicine and Public Health, Boston, MA, USA.
14: Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
15: Department of Molecular Physiology and Biophysics, Vanderbilt Center for Human Genetics Research, Vanderbilt University, Nashville, TN, USA.
16: Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA; Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St. Louis, MO, USA; Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO, USA.
17: Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA; Department of Developmental Biology, Washington University School of Medicine, St. Louis, MO, USA; Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St. Louis, MO, USA; Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO, USA.
18: Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA; Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St. Louis, MO, USA; Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO, USA.
19: Department of Biology, Brigham Young University, Provo, UT, USA.
20: Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA; Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA; Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA; Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St. Louis, MO, USA; Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO, USA. Electronic address: goatea@psychiatry.wustl.edu.
21: Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA; Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO, USA; Universite Lille 2, Lille, France. Electronic address: cruchagac@psychiatry.wustl.edu.

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