Causal effects of body mass index on cardiometabolic traits and events: a Mendelian randomization analysis.

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Published in Am J Hum Genet on January 23, 2014

Authors

Michael V Holmes1, Leslie A Lange2, Tom Palmer3, Matthew B Lanktree4, Kari E North5, Berta Almoguera6, Sarah Buxbaum7, Hareesh R Chandrupatla6, Clara C Elbers8, Yiran Guo6, Ron C Hoogeveen9, Jin Li6, Yun R Li6, Daniel I Swerdlow10, Mary Cushman11, Tom S Price12, Sean P Curtis13, Myriam Fornage14, Hakon Hakonarson6, Sanjay R Patel15, Susan Redline15, David S Siscovick16, Michael Y Tsai17, James G Wilson18, Yvonne T van der Schouw19, Garret A FitzGerald12, Aroon D Hingorani10, Juan P Casas20, Paul I W de Bakker21, Stephen S Rich22, Eric E Schadt23, Folkert W Asselbergs24, Alex P Reiner25, Brendan J Keating26

Author Affiliations

1: Division of Transplantation, Department of Surgery, Perelman School of Medicine, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA; Genetic Epidemiology Group, Institute of Cardiovascular Science, Faculty of Population Health Sciences, University College London, 1-19 Torrington Place, London WC1E 6BT, UK. Electronic address: michael.holmes@uphs.upenn.edu.
2: Department of Genetics, University of North Carolina School of Medicine at Chapel Hill, Chapel Hill, NC 27514, USA.
3: Division of Health Sciences, Warwick Medical School, University of Warwick, Coventry CV4 7AL, UK.
4: Department of Medicine, McMaster University, Hamilton, ON L8S 4L8, Canada.
5: Department of Epidemiology, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27514, USA.
6: Center for Applied Genomics, Abramson Research Center, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
7: Jackson Heart Study Coordinating Center, Jackson State University, 350 West Woodrow Wilson Avenue, Suite 701, Jackson, MS 39213, USA.
8: Complex Genetics Section, Department of Medical Genetics, University Medical Center Utrecht, 3584 CX Utrecht, the Netherlands.
9: Division of Atherosclerosis & Vascular Medicine, Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA.
10: Genetic Epidemiology Group, Institute of Cardiovascular Science, Faculty of Population Health Sciences, University College London, 1-19 Torrington Place, London WC1E 6BT, UK.
11: Departments of Medicine and Pathology, University of Vermont, 208 South Park Drive, Colchester, VT 05446 USA.
12: The Institute for Translational Medicine and Therapeutics, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
13: Merck Research Laboratories, P.O. Box 2000, Rahway, NJ 07065, USA.
14: The University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
15: Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.
16: Cardiovascular Health Research Unit, Departments of Medicine and Epidemiology, University of Washington, Seattle, WA 98101, USA.
17: Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55414, USA.
18: Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS 39216, USA.
19: Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, 3584 CX Utrecht, the Netherlands.
20: Genetic Epidemiology Group, Institute of Cardiovascular Science, Faculty of Population Health Sciences, University College London, 1-19 Torrington Place, London WC1E 6BT, UK; Faculty of Epidemiology and Public Health, London School of Hygiene & Tropical Medicine, London WC1E 7HT, UK.
21: Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, 3584 CX Utrecht, the Netherlands; Brigham and Women's Hospital, 77 Avenue Louis Pasteur, New Research Building, Room 168, Boston, MA 02115, USA.
22: Center for Public Health Genomics, University of Virginia, Charlottesville, VA 22908, USA.
23: Department of Genomics, Mount Sinai School of Medicine, New York, NY 10029, USA.
24: Division of Heart and Lungs, Department of Cardiology, University Medical Centre Utrecht, Heidelberglaan 100, 3584 CX Utrecht, the Netherlands; Durrer Center for Cardiogenetic Research, ICIN - Netherlands Heart Institute, Catharijnesingel 52, Postbus 19258, 3501 DG Utrecht, the Netherlands; Faculty of Population Health Sciences, Institute of Cardiovascular Science, University College London, London WC1E 6BT, UK.
25: Center for Public Health Genomics, University of Virginia, Charlottesville, VA 22908, USA; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
26: Division of Transplantation, Department of Surgery, Perelman School of Medicine, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA; Center for Applied Genomics, Abramson Research Center, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA. Electronic address: bkeating@mail.med.upenn.edu.

Associated clinical trials:

A Study to Evaluate the Safety of an Investigational Drug (Etoricoxib) in Patients With Osteoarthritis (OA) or Rheumatoid Arthritis (RA)(0663-066) | NCT00250445

Investigational Drug Versus an Approved Drug in Patients With Osteoarthritis (0663-061)(COMPLETED) | NCT00092703

Investigational Drug Versus an Approved Drug in Patients With Rheumatoid Arthritis (0663-072) | NCT00092742

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