Published in PLoS Med on December 09, 2014
An atlas of genetic correlations across human diseases and traits. Nat Genet (2015) 3.90
Metabolomic Profiling of Statin Use and Genetic Inhibition of HMG-CoA Reductase. J Am Coll Cardiol (2016) 1.49
Effect of Insulin Resistance on Monounsaturated Fatty Acid Levels: A Multi-cohort Non-targeted Metabolomics and Mendelian Randomization Study. PLoS Genet (2016) 1.38
Detection and interpretation of shared genetic influences on 42 human traits. Nat Genet (2016) 1.32
Metabolite profiling and cardiovascular event risk: a prospective study of 3 population-based cohorts. Circulation (2015) 1.25
Genetic Evidence for Causal Relationships Between Maternal Obesity-Related Traits and Birth Weight. JAMA (2016) 1.00
Mendelian randomization in cardiometabolic disease: challenges in evaluating causality. Nat Rev Cardiol (2017) 0.90
Metabolomic Profiles of Body Mass Index in the Framingham Heart Study Reveal Distinct Cardiometabolic Phenotypes. PLoS One (2016) 0.90
Genetic Predisposition to an Impaired Metabolism of the Branched-Chain Amino Acids and Risk of Type 2 Diabetes: A Mendelian Randomisation Analysis. PLoS Med (2016) 0.88
MR-PheWAS: hypothesis prioritization among potential causal effects of body mass index on many outcomes, using Mendelian randomization. Sci Rep (2015) 0.86
Obesity and Multiple Sclerosis: A Mendelian Randomization Study. PLoS Med (2016) 0.85
Effects of hormonal contraception on systemic metabolism: cross-sectional and longitudinal evidence. Int J Epidemiol (2016) 0.81
Causal Associations of Adiposity and Body Fat Distribution with Coronary Heart Disease, Stroke Subtypes and Type 2 Diabetes: A Mendelian Randomization Analysis. Circulation (2017) 0.80
Metabolic profiling of fatty liver in young and middle-aged adults - cross-sectional and prospective analyses of the Young Finns Study. Hepatology (2016) 0.80
The association between metabolic health, obesity phenotype and the risk of breast cancer. Int J Cancer (2017) 0.79
Metabolic profiling of alcohol consumption in 9778 young adults. Int J Epidemiol (2016) 0.78
Healthy obesity and risk of accelerated functional decline and disability. Int J Obes (Lond) (2017) 0.77
Metabolic Characterization of a Rare Genetic Variation Within APOC3 and Its Lipoprotein Lipase-Independent Effects. Circ Cardiovasc Genet (2016) 0.77
Metabolic signatures of birthweight in 18 288 adolescents and adults. Int J Epidemiol (2016) 0.77
Mendelian randomization to assess causal effects of blood lipids on coronary heart disease: lessons from the past and applications to the future. Curr Opin Endocrinol Diabetes Obes (2016) 0.76
Metabolic profiling of pregnancy: cross-sectional and longitudinal evidence. BMC Med (2016) 0.76
Using Genetic Variation to Explore the Causal Effect of Maternal Pregnancy Adiposity on Future Offspring Adiposity: A Mendelian Randomisation Study. PLoS Med (2017) 0.76
Metabolomics in epidemiology: from metabolite concentrations to integrative reaction networks. Int J Epidemiol (2016) 0.76
Natural Course of Metabolically Healthy Overweight/Obese Subjects and the Impact of Weight Change. Nutrients (2016) 0.76
Homozygous carriers of the TCF7L2 rs7903146 T-allele show altered postprandial response in triglycerides and triglyceride-rich lipoproteins. Sci Rep (2017) 0.75
Commentary: One size fits all: are there standard rules for the use of genetic instruments in Mendelian randomization? Int J Epidemiol (2016) 0.75
Metabolic profiling-multitude of technologies with great research potential, but (when) will translation emerge? Int J Epidemiol (2016) 0.75
The effect of standardized food intake on the association between BMI and (1)H-NMR metabolites. Sci Rep (2016) 0.75
Early and Long-term Undernutrition in Female Rats Exacerbates the Metabolic Risk Associated with Nutritional Rehabilitation. J Biol Chem (2015) 0.75
Circulating MicroRNA-122 is Associated With the Risk of New-Onset Metabolic Syndrome and Type-2-Diabetes. Diabetes (2016) 0.75
Genetic and epigenetic studies of adiposity and cardiometabolic disease. Genome Med (2017) 0.75
Genetic Support for a Causal Role of Insulin Resistance on Circulating Branched-Chain Amino Acids and Inflammation. Diabetes Care (2017) 0.75
Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance. N Engl J Med (2001) 56.11
Body-mass index and cause-specific mortality in 900 000 adults: collaborative analyses of 57 prospective studies. Lancet (2009) 26.09
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet (2010) 23.08
Global, regional, and national prevalence of overweight and obesity in children and adults during 1980-2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet (2014) 22.33
Association of all-cause mortality with overweight and obesity using standard body mass index categories: a systematic review and meta-analysis. JAMA (2013) 18.86
'Mendelian randomization': can genetic epidemiology contribute to understanding environmental determinants of disease? Int J Epidemiol (2003) 16.71
Abdominal obesity and metabolic syndrome. Nature (2006) 14.20
Body-mass index and mortality among 1.46 million white adults. N Engl J Med (2010) 13.34
Metabolite profiles and the risk of developing diabetes. Nat Med (2011) 12.22
Genome-wide association analysis of metabolic traits in a birth cohort from a founder population. Nat Genet (2008) 12.07
A branched-chain amino acid-related metabolic signature that differentiates obese and lean humans and contributes to insulin resistance. Cell Metab (2009) 11.46
Mendelian randomization: using genes as instruments for making causal inferences in epidemiology. Stat Med (2008) 9.39
The metabochip, a custom genotyping array for genetic studies of metabolic, cardiovascular, and anthropometric traits. PLoS Genet (2012) 6.15
Thirty-five-year trends in cardiovascular risk factors in Finland. Int J Epidemiol (2009) 5.37
2013 AHA/ACC/TOS guideline for the management of overweight and obesity in adults: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and The Obesity Society. Circulation (2013) 5.02
Genome-wide association study identifies multiple loci influencing human serum metabolite levels. Nat Genet (2012) 4.08
Common variation in the FTO gene alters diabetes-related metabolic traits to the extent expected given its effect on BMI. Diabetes (2008) 3.76
Screening for and management of obesity in adults: U.S. Preventive Services Task Force recommendation statement. Ann Intern Med (2012) 3.27
Differential metabolic impact of gastric bypass surgery versus dietary intervention in obese diabetic subjects despite identical weight loss. Sci Transl Med (2011) 3.20
Mendelian randomization: genetic anchors for causal inference in epidemiological studies. Hum Mol Genet (2014) 2.58
Cohort profile: the cardiovascular risk in Young Finns Study. Int J Epidemiol (2008) 2.51
High-throughput serum NMR metabonomics for cost-effective holistic studies on systemic metabolism. Analyst (2009) 2.49
Mortality, health outcomes, and body mass index in the overweight range: a science advisory from the American Heart Association. Circulation (2009) 2.49
Metabonomic, transcriptomic, and genomic variation of a population cohort. Mol Syst Biol (2010) 2.17
The effect of elevated body mass index on ischemic heart disease risk: causal estimates from a Mendelian randomisation approach. PLoS Med (2012) 2.09
Does greater adiposity increase blood pressure and hypertension risk?: Mendelian randomization using the FTO/MC4R genotype. Hypertension (2009) 2.01
Association of lipidome remodeling in the adipocyte membrane with acquired obesity in humans. PLoS Biol (2011) 1.89
Long-term leisure-time physical activity and serum metabolome. Circulation (2012) 1.81
Metabolic signatures of insulin resistance in 7,098 young adults. Diabetes (2012) 1.80
Changes in lipoprotein subfractions during diet-induced and exercise-induced weight loss in moderately overweight men. Circulation (1990) 1.72
The role of adiposity in cardiometabolic traits: a Mendelian randomization analysis. PLoS Med (2013) 1.70
Biomarker profiling by nuclear magnetic resonance spectroscopy for the prediction of all-cause mortality: an observational study of 17,345 persons. PLoS Med (2014) 1.60
Circulating metabolite predictors of glycemia in middle-aged men and women. Diabetes Care (2012) 1.57
C-reactive protein levels and body mass index: elucidating direction of causation through reciprocal Mendelian randomization. Int J Obes (Lond) (2010) 1.53
A diabetes-predictive amino acid score and future cardiovascular disease. Eur Heart J (2012) 1.47
Causal effects of body mass index on cardiometabolic traits and events: a Mendelian randomization analysis. Am J Hum Genet (2014) 1.45
The association between BMI and mortality using offspring BMI as an indicator of own BMI: large intergenerational mortality study. BMJ (2009) 1.43
Plasma lipid profiling in a large population-based cohort. J Lipid Res (2013) 1.35
Quantitative serum nuclear magnetic resonance metabolomics in cardiovascular epidemiology and genetics. Circ Cardiovasc Genet (2015) 1.32
Assessing causality in the association between child adiposity and physical activity levels: a Mendelian randomization analysis. PLoS Med (2014) 1.19
A metabolic view on menopause and ageing. Nat Commun (2014) 1.07
Physical activity and obesity mediate the association between childhood motor function and adolescents' academic achievement. Proc Natl Acad Sci U S A (2012) 1.05
Toward new biomarkers of cardiometabolic diseases. Cell Metab (2013) 1.02
Distribution and medical impact of loss-of-function variants in the Finnish founder population. PLoS Genet (2014) 2.89
A comprehensive 1000 Genomes-based genome-wide association meta-analysis of coronary artery disease. Nat Genet (2015) 2.84
Association of vitamin D status with arterial blood pressure and hypertension risk: a mendelian randomisation study. Lancet Diabetes Endocrinol (2014) 2.10
Biomarker profiling by nuclear magnetic resonance spectroscopy for the prediction of all-cause mortality: an observational study of 17,345 persons. PLoS Med (2014) 1.60
Metabolomic Profiling of Statin Use and Genetic Inhibition of HMG-CoA Reductase. J Am Coll Cardiol (2016) 1.49
Association of Genetic Variants Related to CETP Inhibitors and Statins With Lipoprotein Levels and Cardiovascular Risk. JAMA (2017) 1.47
Molecular mechanisms underlying variations in lung function: a systems genetics analysis. Lancet Respir Med (2015) 1.40
Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci. Nat Genet (2015) 1.39
Chromosome X-wide association study identifies Loci for fasting insulin and height and evidence for incomplete dosage compensation. PLoS Genet (2014) 1.09
Genome-wide association analysis identifies six new loci associated with forced vital capacity. Nat Genet (2014) 1.07
Effects of BMI, fat mass, and lean mass on asthma in childhood: a Mendelian randomization study. PLoS Med (2014) 1.02
Genome-wide meta-analysis identifies six novel loci associated with habitual coffee consumption. Mol Psychiatry (2014) 1.01
High risk population isolate reveals low frequency variants predisposing to intracranial aneurysms. PLoS Genet (2014) 0.98
Myopia and level of education: results from the Gutenberg Health Study. Ophthalmology (2014) 0.93
Vigorous physical activity and carotid distensibility in young and mid-aged adults. Hypertens Res (2015) 0.90
Associations of multiple lipoprotein and apolipoprotein measures with worsening of glycemia and incident type 2 diabetes in 6607 non-diabetic Finnish men. Atherosclerosis (2015) 0.89
Serum vitamin D, vitamin D binding protein, and risk of colorectal cancer. PLoS One (2014) 0.89
Cell Specific eQTL Analysis without Sorting Cells. PLoS Genet (2015) 0.87
Genetic determinants of circulating interleukin-1 receptor antagonist levels and their association with glycemic traits. Diabetes (2014) 0.86
Age- and sex-specific causal effects of adiposity on cardiovascular risk factors. Diabetes (2015) 0.86
Genome wide association identifies common variants at the SERPINA6/SERPINA1 locus influencing plasma cortisol and corticosteroid binding globulin. PLoS Genet (2014) 0.86
Gene × dietary pattern interactions in obesity: analysis of up to 68 317 adults of European ancestry. Hum Mol Genet (2015) 0.84
Genome-wide analysis identifies 12 loci influencing human reproductive behavior. Nat Genet (2016) 0.84
Blood microRNA profile associates with the levels of serum lipids and metabolites associated with glucose metabolism and insulin resistance and pinpoints pathways underlying metabolic syndrome: the cardiovascular risk in Young Finns Study. Mol Cell Endocrinol (2014) 0.84
Serum vitamin D, vitamin D binding protein, and lung cancer survival. Lung Cancer (2014) 0.82
Childhood predictors of adult fatty liver. The Cardiovascular Risk in Young Finns Study. J Hepatol (2016) 0.81
Multiple measures of adiposity are associated with mean leukocyte telomere length in the northern Finland birth cohort 1966. PLoS One (2014) 0.81
1-stearoylglycerol is associated with risk of prostate cancer: results from serum metabolomic profiling. Metabolomics (2014) 0.81
Effects of hormonal contraception on systemic metabolism: cross-sectional and longitudinal evidence. Int J Epidemiol (2016) 0.81
Prolonged sleep restriction induces changes in pathways involved in cholesterol metabolism and inflammatory responses. Sci Rep (2016) 0.81
Associations between unprocessed red and processed meat, poultry, seafood and egg intake and the risk of prostate cancer: A pooled analysis of 15 prospective cohort studies. Int J Cancer (2016) 0.80
Pooled analysis of mitochondrial DNA copy number and lung cancer risk in three prospective studies. Cancer Epidemiol Biomarkers Prev (2014) 0.79
Lifetime measures of ideal cardiovascular health and their association with subclinical atherosclerosis: The Cardiovascular Risk in Young Finns Study. Int J Cardiol (2015) 0.79
Perceived Work Ability in the Light of Long-Term and Stress-Related Unhealthy Behaviors-a Prospective Cohort Study. Int J Behav Med (2016) 0.78
Mitochondrial DNA copy number and chronic lymphocytic leukemia/small lymphocytic lymphoma risk in two prospective studies. Cancer Epidemiol Biomarkers Prev (2014) 0.78
ST2 may not be a useful predictor for incident cardiovascular events, heart failure and mortality. Heart (2014) 0.78
Metabolic profiling of alcohol consumption in 9778 young adults. Int J Epidemiol (2016) 0.78
Genome-wide association analyses for lung function and chronic obstructive pulmonary disease identify new loci and potential druggable targets. Nat Genet (2017) 0.77
Metabolic signatures of birthweight in 18 288 adolescents and adults. Int J Epidemiol (2016) 0.77
Exploring causality between TV viewing and weight change in young and middle-aged adults. The Cardiovascular Risk in Young Finns study. PLoS One (2014) 0.76
Metabolic profiling of pregnancy: cross-sectional and longitudinal evidence. BMC Med (2016) 0.76
Integrative pathway genomics of lung function and airflow obstruction. Hum Mol Genet (2015) 0.76
Association of Genetic Risk Variants With Attention-Deficit/Hyperactivity Disorder Trajectories in the General Population. JAMA Psychiatry (2016) 0.76
No Association of Coronary Artery Disease with X-Chromosomal Variants in Comprehensive International Meta-Analysis. Sci Rep (2016) 0.76
Metabolomics analysis of serum 25-hydroxy-vitamin D in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Study. Int J Epidemiol (2016) 0.76
Experimental and Human Evidence for Lipocalin-2 (Neutrophil Gelatinase-Associated Lipocalin [NGAL]) in the Development of Cardiac Hypertrophy and heart failure. J Am Heart Assoc (2017) 0.76
Prospective study of serum cysteine and cysteinylglycine and cancer of the head and neck, esophagus, and stomach in a cohort of male smokers. Am J Clin Nutr (2016) 0.75
Assessing the effect of treatment duration on the association between anti-diabetic medication and cancer risk. PLoS One (2014) 0.75
Serum Metabolomic Response to Long-Term Supplementation with all-rac-α-Tocopheryl Acetate in a Randomized Controlled Trial. J Nutr Metab (2016) 0.75
Aortic sinus diameter in middle age is associated with body size in young adulthood. Heart (2017) 0.75
Cardiovascular risk prediction in children and adolescents. Clin Biochem (2014) 0.75
Low Vitamin B12 Increases Risk of Gastric Cancer: A Prospective Study of One-Carbon Metabolism Nutrients and Risk of Upper Gastrointestinal Tract Cancer. Int J Cancer (2017) 0.75
Evidence for large-scale gene-by-smoking interaction effects on pulmonary function. Int J Epidemiol (2017) 0.75
Incidence rates, correlates, and prognosis of electrocardiographic P-wave abnormalities - a nationwide population-based study. J Electrocardiol (2017) 0.75
Serum ghrelin is associated with risk of colorectal adenocarcinomas in the ATBC study. Gut (2017) 0.75
Serum gastrin and cholecystokinin are associated with subsequent development of gastric cancer in a prospective cohort of Finnish smokers. Int J Epidemiol (2017) 0.75
Insomnia does not mediate or modify the association between MTNR1B risk variant rs10830963 and glucose levels. Diabetologia (2016) 0.75
Genome-wide association meta-analysis of fish and EPA+DHA consumption in 17 US and European cohorts. PLoS One (2017) 0.75
Evolution of mitral valve procedural volumes in the advent of endovascular treatment options: Experience at an early-adopting center in Germany. Catheter Cardiovasc Interv (2015) 0.75
Cardiovascular Risk Factors From Childhood and Midlife Cognitive Performance: The Young Finns Study. J Am Coll Cardiol (2017) 0.75
Effects of Group Counseling Transmitted Through Videoconferencing on Changes in Eating Behaviors. J Nutr Educ Behav (2015) 0.75