Reliable single cell array CGH for clinical samples.

Molecular profiling of single circulating tumor cells with diagnostic intention. EMBO Mol Med (2014) 1.18

Quantitative measurement of melanoma spread in sentinel lymph nodes and survival. PLoS Med (2014) 0.95

Single cell mutational analysis of PIK3CA in circulating tumor cells and metastases in breast cancer reveals heterogeneity, discordance, and mutation persistence in cultured disseminated tumor cells from bone marrow. BMC Cancer (2014) 0.93

Tracing the origin of disseminated tumor cells in breast cancer using single-cell sequencing. Genome Biol (2016) 0.76

Approaches to isolation and molecular characterization of disseminated tumor cells. Oncotarget (2015) 0.76

Development of a test that measures real-time HER2 signaling function in live breast cancer cell lines and primary cells. BMC Cancer (2017) 0.75

Catch and Release: rare cell analysis from a functionalised medical wire. Sci Rep (2017) 0.75

[Chances and risks of blood-based molecular pathological analysis of circulating tumor cells (CTC) and cell-free DNA (cfDNA) in personalized cancer therapy: positional paper from the study group on liquid biopsy of the working group for molecular pathology in the German Society of Pathology (DGP)]. Pathologe (2015) 0.75

A census of human cancer genes. Nat Rev Cancer (2004) 36.20

Circular binary segmentation for the analysis of array-based DNA copy number data. Biostatistics (2004) 24.18

Clonal evolution in relapsed acute myeloid leukaemia revealed by whole-genome sequencing. Nature (2012) 14.33

Whole genome amplification from a single cell: implications for genetic analysis. Proc Natl Acad Sci U S A (1992) 9.15

Relationship of circulating tumor cells to tumor response, progression-free survival, and overall survival in patients with metastatic colorectal cancer. J Clin Oncol (2008) 8.72

Systemic spread is an early step in breast cancer. Cancer Cell (2008) 7.91

Cytokeratin-positive cells in the bone marrow and survival of patients with stage I, II, or III breast cancer. N Engl J Med (2000) 6.98

Circulating tumor cells: a novel prognostic factor for newly diagnosed metastatic breast cancer. J Clin Oncol (2005) 6.18

Parallel progression of primary tumours and metastases. Nat Rev Cancer (2009) 5.55

Genome-wide detection of single-nucleotide and copy-number variations of a single human cell. Science (2012) 5.50

From latent disseminated cells to overt metastasis: genetic analysis of systemic breast cancer progression. Proc Natl Acad Sci U S A (2003) 4.79

A census of amplified and overexpressed human cancer genes. Nat Rev Cancer (2010) 4.47

Whole genome analysis of genetic alterations in small DNA samples using hyperbranched strand displacement amplification and array-CGH. Genome Res (2003) 4.10

Chromosome instability is common in human cleavage-stage embryos. Nat Med (2009) 3.85

Comparative genomic hybridization, loss of heterozygosity, and DNA sequence analysis of single cells. Proc Natl Acad Sci U S A (1999) 3.74

Genetic heterogeneity of single disseminated tumour cells in minimal residual cancer. Lancet (2002) 3.45

Direct genetic analysis of single disseminated cancer cells for prediction of outcome and therapy selection in esophageal cancer. Cancer Cell (2008) 3.01

Review: Biological relevance of disseminated tumor cells in cancer patients. Int J Cancer (2008) 2.72

Probing meiotic recombination and aneuploidy of single sperm cells by whole-genome sequencing. Science (2012) 2.14

Preclinical validation of a microarray method for full molecular karyotyping of blastomeres in a 24-h protocol. Hum Reprod (2010) 2.07

Genomic analysis of single cytokeratin-positive cells from bone marrow reveals early mutational events in breast cancer. Cancer Cell (2005) 2.03

Accurate single cell 24 chromosome aneuploidy screening using whole genome amplification and single nucleotide polymorphism microarrays. Fertil Steril (2010) 1.93

Whole-genome multiple displacement amplification from single cells. Nat Protoc (2006) 1.88

High independent prognostic and predictive value of circulating tumor cells compared with serum tumor markers in a large prospective trial in first-line chemotherapy for metastatic breast cancer patients. Ann Oncol (2011) 1.82

A concept for the standardized detection of disseminated tumor cells in bone marrow from patients with primary breast cancer and its clinical implementation. Cancer (2006) 1.82

High resolution array-CGH analysis of single cells. Nucleic Acids Res (2006) 1.79

Meta-analysis of the prognostic value of circulating tumor cells in breast cancer. Clin Cancer Res (2012) 1.79

Single-cell chromosomal imbalances detection by array CGH. Nucleic Acids Res (2006) 1.78

Persistence of disseminated tumor cells in the bone marrow of breast cancer patients predicts increased risk for relapse--a European pooled analysis. Clin Cancer Res (2011) 1.56

Selection and adaptation during metastatic cancer progression. Nature (2013) 1.46

Genomic profiling of viable and proliferative micrometastatic cells from early-stage breast cancer patients. Clin Cancer Res (2004) 1.40

Identification of small gains and losses in single cells after whole genome amplification on tiling oligo arrays. Nucleic Acids Res (2009) 1.37

Successful pregnancies after application of array-comparative genomic hybridization in PGS-aneuploidy screening. Reprod Biomed Online (2008) 1.35

Visualization of oligonucleotide probes and point mutations in interphase nuclei and DNA fibers using rolling circle DNA amplification. Proc Natl Acad Sci U S A (2001) 1.26

Detection of chromosomal structural alterations in single cells by SNP arrays: a systematic survey of amplification bias and optimized workflow. PLoS One (2007) 1.25

High-resolution genomic profiling of occult micrometastatic tumor cells. Genes Chromosomes Cancer (2003) 1.25

Clonal evolution and devolution after chemotherapy in adult acute myelogenous leukemia. Blood (2012) 1.15

The systemic progression of human cancer: a focus on the individual disseminated cancer cell--the unit of selection. Adv Cancer Res (2003) 1.14

High-resolution array comparative genomic hybridization of single micrometastatic tumor cells. Nucleic Acids Res (2008) 1.12

High-resolution analyses of copy number changes in disseminated tumor cells of patients with breast cancer. Int J Cancer (2011) 1.02

Microarray analysis of copy number variation in single cells. Nat Protoc (2012) 1.01

A molecular strategy for routine preimplantation genetic diagnosis in both reciprocal and Robertsonian translocation carriers. Mol Hum Reprod (2010) 0.96

Malignant potential and cytogenetic characteristics of occult disseminated tumor cells in esophageal cancer. Cancer Res (2000) 0.91

Single-cell copy number variation detection. Genome Biol (2011) 0.91

Detection of ≥1Mb microdeletions and microduplications in a single cell using custom oligonucleotide arrays. Prenat Diagn (2012) 0.90

A robust method to analyze copy number alterations of less than 100 kb in single cells using oligonucleotide array CGH. PLoS One (2013) 0.88

Evaluation of genome coverage and fidelity of multiple displacement amplification from single cells by SNP array. Mol Hum Reprod (2009) 0.87

Improved detection of aneuploid blastocysts using a new 12-chromosome FISH test. Reprod Biomed Online (2009) 0.81

Comparison of whole genome amplification methods for analysis of DNA extracted from microdissected early breast lesions in formalin-fixed paraffin-embedded tissue. ISRN Oncol (2012) 0.78