Published in Medchemcomm on November 01, 2013
Discovery and development of potent and selective inhibitors of histone methyltransferase g9a. ACS Med Chem Lett (2014) 1.05
The EED protein-protein interaction inhibitor A-395 inactivates the PRC2 complex. Nat Chem Biol (2017) 0.89
Selective Inhibition of CBX6: A Methyllysine Reader Protein in the Polycomb Family. ACS Med Chem Lett (2015) 0.87
The L3MBTL3 Methyl-Lysine Reader Domain Functions As a Dimer. ACS Chem Biol (2015) 0.79
Chemical probes for methyl lysine reader domains. Curr Opin Chem Biol (2016) 0.78
A fast, open source implementation of adaptive biasing potentials uncovers a ligand design strategy for the chromatin regulator BRD4. J Chem Phys (2016) 0.75
VMD: visual molecular dynamics. J Mol Graph (1996) 117.02
Translating the histone code. Science (2001) 56.77
The language of covalent histone modifications. Nature (2000) 44.92
Active genes are tri-methylated at K4 of histone H3. Nature (2002) 15.68
Transcription regulation by histone methylation: interplay between different covalent modifications of the core histone tails. Genes Dev (2001) 9.54
Methylation of histone H3 Lys 4 in coding regions of active genes. Proc Natl Acad Sci U S A (2002) 7.67
Polycomb silencing mechanisms and the management of genomic programmes. Nat Rev Genet (2007) 7.61
Central role of Drosophila SU(VAR)3-9 in histone H3-K9 methylation and heterochromatic gene silencing. EMBO J (2002) 5.70
The Tudor domain 'Royal Family': Tudor, plant Agenet, Chromo, PWWP and MBT domains. Trends Biochem Sci (2003) 5.19
Tudor, MBT and chromo domains gauge the degree of lysine methylation. EMBO Rep (2006) 5.19
The art of the chemical probe. Nat Chem Biol (2010) 3.85
A chromatin-wide transition to H4K20 monomethylation impairs genome integrity and programmed DNA rearrangements in the mouse. Genes Dev (2008) 3.16
Relationship between histone H3 lysine 9 methylation, transcription repression, and heterochromatin protein 1 recruitment. Mol Cell Biol (2005) 2.86
Cation-pi interactions in ligand recognition and catalysis. Trends Pharmacol Sci (2002) 2.75
Readers of histone modifications. Cell Res (2011) 2.40
Discovery of a chemical probe for the L3MBTL3 methyllysine reader domain. Nat Chem Biol (2013) 1.72
Palladium-Catalyzed Coupling of Functionalized Primary and Secondary Amines with Aryl and Heteroaryl Halides: Two Ligands Suffice in Most Cases. Chem Sci (2011) 1.46
Small-molecule ligands of methyl-lysine binding proteins. J Med Chem (2011) 1.45
Screening for inhibitors of low-affinity epigenetic peptide-protein interactions: an AlphaScreen-based assay for antagonists of methyl-lysine binding proteins. J Biomol Screen (2009) 1.27
L3MBTL1 polycomb protein, a candidate tumor suppressor in del(20q12) myeloid disorders, is essential for genome stability. Proc Natl Acad Sci U S A (2010) 1.27
Chromatin protein L3MBTL1 is dispensable for development and tumor suppression in mice. J Biol Chem (2010) 1.06
Unrestrained computation of free energy along a path. J Phys Chem B (2012) 0.94
A novel de novo 1.1 Mb duplication of 17q21.33 associated with cognitive impairment and other anomalies. Am J Med Genet A (2009) 0.81