Published in EMBO J on March 01, 2002
A silencing pathway to induce H3-K9 and H4-K20 trimethylation at constitutive heterochromatin. Genes Dev (2004) 8.66
Molecular basis for the discrimination of repressive methyl-lysine marks in histone H3 by Polycomb and HP1 chromodomains. Genes Dev (2003) 7.91
Centromeric chromatin exhibits a histone modification pattern that is distinct from both euchromatin and heterochromatin. Nat Struct Mol Biol (2004) 4.95
A cis-regulatory map of the Drosophila genome. Nature (2011) 4.80
Chromatin structure and the inheritance of epigenetic information. Nat Rev Genet (2010) 4.03
Dynamics and memory of heterochromatin in living cells. Cell (2012) 3.75
H3K9 methylation and RNA interference regulate nucleolar organization and repeated DNA stability. Nat Cell Biol (2006) 3.73
Distinct mechanisms determine transposon inheritance and methylation via small interfering RNA and histone modification. PLoS Biol (2003) 3.71
Lessons from the genome sequence of Neurospora crassa: tracing the path from genomic blueprint to multicellular organism. Microbiol Mol Biol Rev (2004) 3.67
Dual histone H3 methylation marks at lysines 9 and 27 required for interaction with CHROMOMETHYLASE3. EMBO J (2004) 3.51
Functional cooperation between HP1 and DNMT1 mediates gene silencing. Genes Dev (2007) 3.43
Arabidopsis TFL2/LHP1 specifically associates with genes marked by trimethylation of histone H3 lysine 27. PLoS Genet (2007) 3.11
Su(var) genes regulate the balance between euchromatin and heterochromatin in Drosophila. Genes Dev (2004) 3.08
Transcriptional silencing of transposons by Piwi and maelstrom and its impact on chromatin state and gene expression. Cell (2012) 3.04
Association of class II histone deacetylases with heterochromatin protein 1: potential role for histone methylation in control of muscle differentiation. Mol Cell Biol (2002) 2.93
Silencing chromatin: comparing modes and mechanisms. Nat Rev Genet (2011) 2.86
Relationship between histone H3 lysine 9 methylation, transcription repression, and heterochromatin protein 1 recruitment. Mol Cell Biol (2005) 2.86
ICBP90, a novel methyl K9 H3 binding protein linking protein ubiquitination with heterochromatin formation. Mol Cell Biol (2007) 2.69
Interphase chromosomes in Arabidopsis are organized as well defined chromocenters from which euchromatin loops emanate. Proc Natl Acad Sci U S A (2002) 2.60
PR-Set7-dependent methylation of histone H4 Lys 20 functions in repression of gene expression and is essential for mitosis. Genes Dev (2005) 2.51
The ribosomal protein genes and Minute loci of Drosophila melanogaster. Genome Biol (2007) 2.40
Histone methylation regulates memory formation. J Neurosci (2010) 2.30
HP1 proteins form distinct complexes and mediate heterochromatic gene silencing by nonoverlapping mechanisms. Mol Cell (2008) 2.28
Histone modification and the control of heterochromatic gene silencing in Drosophila. Chromosome Res (2006) 2.28
Variant histone H3.3 is deposited at sites of nucleosomal displacement throughout transcribed genes while active histone modifications show a promoter-proximal bias. Genes Dev (2005) 2.26
piRNA production requires heterochromatin formation in Drosophila. Curr Biol (2011) 2.16
Heterochromatin protein 1 (HP1) is associated with induced gene expression in Drosophila euchromatin. J Cell Biol (2003) 2.10
Histone H3 lysine 9 methylation is required for DNA elimination in developing macronuclei in Tetrahymena. Proc Natl Acad Sci U S A (2004) 2.10
The role of histone H2Av variant replacement and histone H4 acetylation in the establishment of Drosophila heterochromatin. Genes Dev (2005) 2.09
Dynamics of the epigenetic landscape during erythroid differentiation after GATA1 restoration. Genome Res (2011) 2.07
Pivotal role of AtSUVH2 in heterochromatic histone methylation and gene silencing in Arabidopsis. EMBO J (2005) 2.04
Comparison of dot chromosome sequences from D. melanogaster and D. virilis reveals an enrichment of DNA transposon sequences in heterochromatic domains. Genome Biol (2006) 1.98
Does heterochromatin protein 1 always follow code? Proc Natl Acad Sci U S A (2002) 1.97
Distinct HP1 and Su(var)3-9 complexes bind to sets of developmentally coexpressed genes depending on chromosomal location. Genes Dev (2003) 1.96
Histone H4 lysine 20 monomethylation promotes transcriptional repression by L3MBTL1. Oncogene (2008) 1.90
A major epigenetic programming mechanism guided by piRNAs. Dev Cell (2013) 1.89
Mechanism of histone lysine methyl transfer revealed by the structure of SET7/9-AdoMet. EMBO J (2003) 1.89
Plasticity in patterns of histone modifications and chromosomal proteins in Drosophila heterochromatin. Genome Res (2010) 1.87
Histone H3 lysine 4 methylation is mediated by Set1 and promotes maintenance of active chromatin states in fission yeast. Proc Natl Acad Sci U S A (2002) 1.87
Drosophila Piwi functions downstream of piRNA production mediating a chromatin-based transposon silencing mechanism in female germ line. Proc Natl Acad Sci U S A (2011) 1.85
ASH1, a Drosophila trithorax group protein, is required for methylation of lysine 4 residues on histone H3. Proc Natl Acad Sci U S A (2003) 1.84
HP1 binding to chromatin methylated at H3K9 is enhanced by auxiliary factors. Mol Cell Biol (2006) 1.84
Retrotransposon silencing and telomere integrity in somatic cells of Drosophila depends on the cytosine-5 methyltransferase DNMT2. Nat Genet (2009) 1.78
Position-effect variegation, heterochromatin formation, and gene silencing in Drosophila. Cold Spring Harb Perspect Biol (2013) 1.76
cis-Acting determinants of heterochromatin formation on Drosophila melanogaster chromosome four. Mol Cell Biol (2004) 1.71
The dot chromosome of Drosophila: insights into chromatin states and their change over evolutionary time. Chromosome Res (2006) 1.70
Heterochromatic genome stability requires regulators of histone H3 K9 methylation. PLoS Genet (2009) 1.69
Relics of repeat-induced point mutation direct heterochromatin formation in Neurospora crassa. Genome Res (2008) 1.61
The HP1alpha-CAF1-SetDB1-containing complex provides H3K9me1 for Suv39-mediated K9me3 in pericentric heterochromatin. EMBO Rep (2009) 1.61
High-resolution mapping reveals links of HP1 with active and inactive chromatin components. PLoS Genet (2007) 1.59
Accessibility of the Drosophila genome discriminates PcG repression, H4K16 acetylation and replication timing. Nat Struct Mol Biol (2010) 1.57
RNA polymerase II-mediated transcription at active loci does not require histone H3S10 phosphorylation in Drosophila. Development (2008) 1.55
Chromatin-modifying genetic interventions suppress age-associated transposable element activation and extend life span in Drosophila. Proc Natl Acad Sci U S A (2016) 1.53
The contradictory definitions of heterochromatin: transcription and silencing. Chromosoma (2006) 1.52
Linker histone H1 is essential for Drosophila development, the establishment of pericentric heterochromatin, and a normal polytene chromosome structure. Genes Dev (2009) 1.50
Identification of histone H3 lysine 36 acetylation as a highly conserved histone modification. J Biol Chem (2006) 1.50
MoSET1 (Histone H3K4 Methyltransferase in Magnaporthe oryzae) Regulates Global Gene Expression during Infection-Related Morphogenesis. PLoS Genet (2015) 1.49
Telomeric trans-silencing: an epigenetic repression combining RNA silencing and heterochromatin formation. PLoS Genet (2007) 1.46
Genome-wide HP1 binding in Drosophila: developmental plasticity and genomic targeting signals. Genome Res (2005) 1.46
The endogenous siRNA pathway is involved in heterochromatin formation in Drosophila. Proc Natl Acad Sci U S A (2009) 1.44
GTP/GDP exchange by Sec12p enables COPII vesicle bud formation on synthetic liposomes. EMBO J (2004) 1.43
The condensin I subunit Barren/CAP-H is essential for the structural integrity of centromeric heterochromatin during mitosis. Mol Cell Biol (2005) 1.42
Regulation of chromatin structure by histone H3S10 phosphorylation. Chromosome Res (2006) 1.40
Genome-wide profiling of diel and circadian gene expression in the malaria vector Anopheles gambiae. Proc Natl Acad Sci U S A (2011) 1.39
The B-type lamin is required for somatic repression of testis-specific gene clusters. Proc Natl Acad Sci U S A (2009) 1.37
Plant SET domain-containing proteins: structure, function and regulation. Biochim Biophys Acta (2007) 1.36
HP1 modulates the transcription of cell-cycle regulators in Drosophila melanogaster. Nucleic Acids Res (2005) 1.31
Heterochromatin protein 1 (HP1a) positively regulates euchromatic gene expression through RNA transcript association and interaction with hnRNPs in Drosophila. PLoS Genet (2009) 1.30
Drosophila SETDB1 is required for chromosome 4 silencing. PLoS Genet (2007) 1.29
Regulation of secondary metabolism by chromatin structure and epigenetic codes. Fungal Genet Biol (2010) 1.28
HP1 controls genomic targeting of four novel heterochromatin proteins in Drosophila. EMBO J (2007) 1.27
A high-resolution whole-genome map of key chromatin modifications in the adult Drosophila melanogaster. PLoS Genet (2011) 1.27
Deregulation of histone lysine methyltransferases contributes to oncogenic transformation of human bronchoepithelial cells. Cancer Cell Int (2008) 1.26
POF and HP1 bind expressed exons, suggesting a balancing mechanism for gene regulation. PLoS Genet (2007) 1.25
Painting of fourth and chromosome-wide regulation of the 4th chromosome in Drosophila melanogaster. EMBO J (2007) 1.24
Direct interaction with a nuclear protein and regulation of gene silencing by a variant of the Ca2+-channel beta 4 subunit. Proc Natl Acad Sci U S A (2002) 1.24
Multiscale analysis of dynamics and interactions of heterochromatin protein 1 by fluorescence fluctuation microscopy. Biophys J (2009) 1.23
Cathepsin L stabilizes the histone modification landscape on the Y chromosome and pericentromeric heterochromatin. Mol Cell Biol (2006) 1.22
SET for life: biochemical activities and biological functions of SET domain-containing proteins. Trends Biochem Sci (2013) 1.22
Molecular landscape of modified histones in Drosophila heterochromatic genes and euchromatin-heterochromatin transition zones. PLoS Genet (2007) 1.21
Heterochromatin formation promotes longevity and represses ribosomal RNA synthesis. PLoS Genet (2012) 1.20
Loss-of-function alleles of the JIL-1 histone H3S10 kinase enhance position-effect variegation at pericentric sites in Drosophila heterochromatin. Genetics (2007) 1.20
H3K9 methylation regulates growth and development in Aspergillus fumigatus. Eukaryot Cell (2008) 1.19
Noncoding RNAs prevent spreading of a repressive histone mark. Nat Struct Mol Biol (2013) 1.18
Genome-wide dynamics of SAPHIRE, an essential complex for gene activation and chromatin boundaries. Mol Cell Biol (2007) 1.18
Epigenetic regulation of the Drosophila chromosome 4 by the histone H3K9 methyltransferase dSETDB1. Proc Natl Acad Sci U S A (2007) 1.17
Bayesian network analysis of targeting interactions in chromatin. Genome Res (2009) 1.17
A lot about a little dot - lessons learned from Drosophila melanogaster chromosome 4. Biochem Cell Biol (2009) 1.14
Histone H3 lysine-to-methionine mutants as a paradigm to study chromatin signaling. Science (2014) 1.13
Chromatin domains in higher eukaryotes: insights from genome-wide mapping studies. Chromosoma (2008) 1.12
Heterochromatin protein 1 (HP1) modulates replication timing of the Drosophila genome. Genome Res (2010) 1.12
Reduced levels of Su(var)3-9 but not Su(var)2-5 (HP1) counteract the effects on chromatin structure and viability in loss-of-function mutants of the JIL-1 histone H3S10 kinase. Genetics (2007) 1.11
Notch1 counteracts WNT/β-catenin signaling through chromatin modification in colorectal cancer. J Clin Invest (2012) 1.10
Heterochromatin protein 2 (HP2), a partner of HP1 in Drosophila heterochromatin. Proc Natl Acad Sci U S A (2002) 1.10
A glue for heterochromatin maintenance: stable SUV39H1 binding to heterochromatin is reinforced by the SET domain. J Cell Biol (2005) 1.10
Multiple SET methyltransferases are required to maintain normal heterochromatin domains in the genome of Drosophila melanogaster. Genetics (2009) 1.10
dSETDB1 and SU(VAR)3-9 sequentially function during germline-stem cell differentiation in Drosophila melanogaster. PLoS One (2008) 1.08
Identification of three histone methyltransferases in Drosophila: dG9a is a suppressor of PEV and is required for gene silencing. Mol Genet Genomics (2006) 1.07
Chromatin proteins are determinants of centromere function. Curr Top Microbiol Immunol (2003) 1.07
The Wnt-NLK signaling pathway inhibits A-Myb activity by inhibiting the association with coactivator CBP and methylating histone H3. Mol Biol Cell (2005) 1.07
Translating the histone code. Science (2001) 56.77
Improved method for high efficiency transformation of intact yeast cells. Nucleic Acids Res (1992) 34.33
Genetic transformation of Drosophila with transposable element vectors. Science (1982) 27.36
Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins. Nature (2001) 19.67
Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain. Nature (2001) 19.54
Regulation of chromatin structure by site-specific histone H3 methyltransferases. Nature (2000) 18.26
Cdi1, a human G1 and S phase protein phosphatase that associates with Cdk2. Cell (1993) 15.70
Role of histone H3 lysine 9 methylation in epigenetic control of heterochromatin assembly. Science (2001) 13.55
Identification of a nonhistone chromosomal protein associated with heterochromatin in Drosophila melanogaster and its gene. Mol Cell Biol (1986) 5.77
Mutation in a heterochromatin-specific chromosomal protein is associated with suppression of position-effect variegation in Drosophila melanogaster. Proc Natl Acad Sci U S A (1990) 5.55
Heterochromatin and gene expression in Drosophila. Annu Rev Genet (1995) 4.90
Position effect variegation in Drosophila is associated with an altered chromatin structure. Genes Dev (1995) 4.41
The protein encoded by the Drosophila position-effect variegation suppressor gene Su(var)3-9 combines domains of antagonistic regulators of homeotic gene complexes. EMBO J (1994) 4.36
Functional mammalian homologues of the Drosophila PEV-modifier Su(var)3-9 encode centromere-associated proteins which complex with the heterochromatin component M31. EMBO J (1999) 4.34
Position effect variegation and chromatin proteins. Bioessays (1992) 4.24
Dosage-dependent modifiers of position effect variegation in Drosophila and a mass action model that explains their effect. Genetics (1988) 3.99
SET domain proteins modulate chromatin domains in eu- and heterochromatin. Cell Mol Life Sci (1998) 3.78
Dependence of position-effect variegation in Drosophila on dose of a gene encoding an unusual zinc-finger protein. Nature (1990) 3.33
The heterochromatin-associated protein HP-1 is an essential protein in Drosophila with dosage-dependent effects on position-effect variegation. Genetics (1992) 3.32
The genetics of position-effect variegation modifying loci in Drosophila melanogaster. Mol Gen Genet (1989) 2.90
The heterochromatin protein 1 prevents telomere fusions in Drosophila. Mol Cell (1998) 2.88
Isolation of dominant suppressor mutations for position-effect variegation in Drosophila melanogaster. Mol Gen Genet (1981) 2.67
Unfolding the mysteries of heterochromatin. Curr Opin Genet Dev (1998) 2.61
Mammalian chromodomain proteins: their role in genome organisation and expression. Bioessays (2000) 2.36
The chromo and SET domains of the Clr4 protein are essential for silencing in fission yeast. Nat Genet (1998) 2.25
A chromodomain protein, Swi6, performs imprinting functions in fission yeast during mitosis and meiosis. Cell (2000) 2.13
SU(VAR)3-7, a Drosophila heterochromatin-associated protein and companion of HP1 in the genomic silencing of position-effect variegation. EMBO J (1997) 2.08
Histones of polytene and nonpolytene nuclei of Drosophila melanogaster. J Biol Chem (1971) 1.97
Physical and functional association of SU(VAR)3-9 and HDAC1 in Drosophila. EMBO Rep (2001) 1.97
Structure-function analysis of SUV39H1 reveals a dominant role in heterochromatin organization, chromosome segregation, and mitotic progression. Mol Cell Biol (2000) 1.93
Set domain-dependent regulation of transcriptional silencing and growth control by SUV39H1, a mammalian ortholog of Drosophila Su(var)3-9. Mol Cell Biol (2000) 1.84
Derivation-dependent distribution of insertion sites for a Drosophila transposon. Cold Spring Harb Symp Quant Biol (1981) 1.83
In vivo assay for protein-protein interactions using Drosophila chromosomes. Chromosoma (1996) 1.75
Nuclear organization and gene expression: homologous pairing and long-range interactions. Curr Opin Cell Biol (1997) 1.74
Isolation, properties and cellular distribution of D1, a chromosomal protein of Drosophila. Chromosoma (1980) 1.70
Conservation of heterochromatin protein 1 function. Mol Cell Biol (2000) 1.70
Chromosomal proteins of Drosophila embryos. Biochemistry (1973) 1.57
Painting of fourth, a chromosome-specific protein in Drosophila. Proc Natl Acad Sci U S A (2001) 1.57
Gene activation and DNA binding by Drosophila Ubx and abd-A proteins. Cell (1989) 1.53
Cytogenetic analysis of the second chromosome heterochromatin of Drosophila melanogaster. Genetics (1991) 1.43
The genomic silencing of position-effect variegation in Drosophila melanogaster: interaction between the heterochromatin-associated proteins Su(var)3-7 and HP1. J Cell Sci (2000) 1.37
Controlled expression of tagged proteins in Drosophila using a new modular P-element vector system. Mol Gen Genet (2000) 1.11
Two genes become one: the genes encoding heterochromatin protein Su(var)3-9 and translation initiation factor subunit eIF-2gamma are joined to a dicistronic unit in holometabolic insects. Genetics (2000) 1.08
In vivo chromatin accessibility correlates with gene silencing in Drosophila. Genetics (1998) 1.08
pitkin(D), a novel gain-of-function enhancer of position-effect variegation, affects chromatin regulation during oogenesis and early embryogenesis in Drosophila. Genetics (2001) 0.95
Production and characterization of antisera against three individual NHC proteins; a case of a generally distributed NHC protein. Chromosoma (1978) 0.86
Dicer-deficient mouse embryonic stem cells are defective in differentiation and centromeric silencing. Genes Dev (2005) 12.15
Partitioning and plasticity of repressive histone methylation states in mammalian chromatin. Mol Cell (2003) 11.33
A stem cell-like chromatin pattern may predispose tumor suppressor genes to DNA hypermethylation and heritable silencing. Nat Genet (2007) 9.47
Oncogene-induced senescence as an initial barrier in lymphoma development. Nature (2005) 9.16
Suv39h-mediated histone H3 lysine 9 methylation directs DNA methylation to major satellite repeats at pericentric heterochromatin. Curr Biol (2003) 9.13
A silencing pathway to induce H3-K9 and H4-K20 trimethylation at constitutive heterochromatin. Genes Dev (2004) 8.66
Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer. Nat Genet (2005) 8.45
Establishment of histone h3 methylation on the inactive X chromosome requires transient recruitment of Eed-Enx1 polycomb group complexes. Dev Cell (2003) 7.11
The profile of repeat-associated histone lysine methylation states in the mouse epigenome. EMBO J (2005) 7.10
The many faces of histone lysine methylation. Curr Opin Cell Biol (2002) 6.01
Higher-order structure in pericentric heterochromatin involves a distinct pattern of histone modification and an RNA component. Nat Genet (2002) 5.86
Reversal of H3K9me2 by a small-molecule inhibitor for the G9a histone methyltransferase. Mol Cell (2007) 5.49
Essential function of histone deacetylase 1 in proliferation control and CDK inhibitor repression. EMBO J (2002) 5.33
Different EZH2-containing complexes target methylation of histone H1 or nucleosomal histone H3. Mol Cell (2004) 5.06
Maintenance of stable heterochromatin domains by dynamic HP1 binding. Science (2003) 4.74
p53 is regulated by the lysine demethylase LSD1. Nature (2007) 4.53
Repression of p53 activity by Smyd2-mediated methylation. Nature (2006) 4.51
An epigenetic road map for histone lysine methylation. J Cell Sci (2003) 4.43
A chromosomal memory triggered by Xist regulates histone methylation in X inactivation. PLoS Biol (2004) 4.23
Recruitment of PRC1 function at the initiation of X inactivation independent of PRC2 and silencing. EMBO J (2006) 4.16
Cooperative demethylation by JMJD2C and LSD1 promotes androgen receptor-dependent gene expression. Nat Cell Biol (2007) 3.89
Mutant nuclear lamin A leads to progressive alterations of epigenetic control in premature aging. Proc Natl Acad Sci U S A (2006) 3.86
The DrosDel collection: a set of P-element insertions for generating custom chromosomal aberrations in Drosophila melanogaster. Genetics (2004) 3.71
Epigenetic regulation of telomere length in mammalian cells by the Suv39h1 and Suv39h2 histone methyltransferases. Nat Genet (2003) 3.64
Silenced tumor suppressor genes reactivated by DNA demethylation do not return to a fully euchromatic chromatin state. Cancer Res (2006) 3.59
Dual histone H3 methylation marks at lysines 9 and 27 required for interaction with CHROMOMETHYLASE3. EMBO J (2004) 3.51
Histone H3 lysine 9 methylation is an epigenetic imprint of facultative heterochromatin. Nat Genet (2001) 3.46
Jmjd2b antagonizes H3K9 trimethylation at pericentric heterochromatin in mammalian cells. Genes Dev (2006) 3.24
Role of the polycomb repressive complex 2 in acute promyelocytic leukemia. Cancer Cell (2007) 3.16
A chromatin-wide transition to H4K20 monomethylation impairs genome integrity and programmed DNA rearrangements in the mouse. Genes Dev (2008) 3.16
H3K27me3 forms BLOCs over silent genes and intergenic regions and specifies a histone banding pattern on a mouse autosomal chromosome. Genome Res (2008) 3.09
The DrosDel deletion collection: a Drosophila genomewide chromosomal deficiency resource. Genetics (2007) 3.08
Su(var) genes regulate the balance between euchromatin and heterochromatin in Drosophila. Genes Dev (2004) 3.08
Dimethylation of histone H3 lysine 9 is a critical mark for DNA methylation and gene silencing in Arabidopsis thaliana. Chromosoma (2004) 3.00
Ethyl 4-(3-bromo-2-thien-yl)-2-oxo-6-phenyl-cyclo-hex-3-ene-1-carboxyl-ate. Acta Crystallogr Sect E Struct Rep Online (2008) 2.95
Consequences of the depletion of zygotic and embryonic enhancer of zeste 2 during preimplantation mouse development. Development (2003) 2.91
In vivo control of CpG and non-CpG DNA methylation by DNA methyltransferases. PLoS Genet (2012) 2.70
hMOF histone acetyltransferase is required for histone H4 lysine 16 acetylation in mammalian cells. Mol Cell Biol (2005) 2.69
Active and repressive chromatin are interspersed without spreading in an imprinted gene cluster in the mammalian genome. Mol Cell (2007) 2.69
Silencing by plant Polycomb-group genes requires dispersed trimethylation of histone H3 at lysine 27. EMBO J (2006) 2.68
Heterochromatin formation in Drosophila is initiated through active removal of H3K4 methylation by the LSD1 homolog SU(VAR)3-3. Mol Cell (2007) 2.66
G9a and Glp methylate lysine 373 in the tumor suppressor p53. J Biol Chem (2010) 2.64
CTCF-binding elements mediate control of V(D)J recombination. Nature (2011) 2.62
The ribosomal protein genes and Minute loci of Drosophila melanogaster. Genome Biol (2007) 2.40
Position-effect variegation and the genetic dissection of chromatin regulation in Drosophila. Semin Cell Dev Biol (2003) 2.37
Histone modification and the control of heterochromatic gene silencing in Drosophila. Chromosome Res (2006) 2.28
Role of the RB1 family in stabilizing histone methylation at constitutive heterochromatin. Nat Cell Biol (2005) 2.27
Suv4-20h deficiency results in telomere elongation and derepression of telomere recombination. J Cell Biol (2007) 2.24
Histone demethylase UTX-1 regulates C. elegans life span by targeting the insulin/IGF-1 signaling pathway. Cell Metab (2011) 2.22
A transcription factor-based mechanism for mouse heterochromatin formation. Nat Struct Mol Biol (2012) 2.15
Epigenetic marking correlates with developmental potential in cloned bovine preimplantation embryos. Curr Biol (2003) 2.14
Generation and characterization of methyl-lysine histone antibodies. Methods Enzymol (2004) 2.09
Pivotal role of AtSUVH2 in heterochromatic histone methylation and gene silencing in Arabidopsis. EMBO J (2005) 2.04
Olfactory dysfunction in patients with idiopathic intracranial hypertension. Neurology (2013) 2.04
Dynamic Histone H1 Isotype 4 Methylation and Demethylation by Histone Lysine Methyltransferase G9a/KMT1C and the Jumonji Domain-containing JMJD2/KDM4 Proteins. J Biol Chem (2009) 2.02
Glutaminyl cyclase inhibition attenuates pyroglutamate Abeta and Alzheimer's disease-like pathology. Nat Med (2008) 2.01
Histone modification patterns associated with the human X chromosome. EMBO Rep (2006) 1.99
DNA methylation and complete transcriptional silencing of cancer genes persist after depletion of EZH2. Cancer Res (2007) 1.96
EZH2 and histone 3 trimethyl lysine 27 associated with Il4 and Il13 gene silencing in Th1 cells. J Biol Chem (2005) 1.93
PHF8 activates transcription of rRNA genes through H3K4me3 binding and H3K9me1/2 demethylation. Nat Struct Mol Biol (2010) 1.91
Selective interactions between vertebrate polycomb homologs and the SUV39H1 histone lysine methyltransferase suggest that histone H3-K9 methylation contributes to chromosomal targeting of Polycomb group proteins. Mol Cell Biol (2002) 1.85
Retrotransposon silencing and telomere integrity in somatic cells of Drosophila depends on the cytosine-5 methyltransferase DNMT2. Nat Genet (2009) 1.78
Prdm3 and Prdm16 are H3K9me1 methyltransferases required for mammalian heterochromatin integrity. Cell (2012) 1.78
Hypoxia-mediated activation of Dll4-Notch-Hey2 signaling in endothelial progenitor cells and adoption of arterial cell fate. Exp Cell Res (2006) 1.77
Position-effect variegation, heterochromatin formation, and gene silencing in Drosophila. Cold Spring Harb Perspect Biol (2013) 1.76
Human DNMT2 methylates tRNA(Asp) molecules using a DNA methyltransferase-like catalytic mechanism. RNA (2008) 1.76
rac-Ethyl 3-(3-bromo-2-thien-yl)-2-oxo-6-(4-propoxyphen-yl)cyclo-hex-3-ene-1-carboxyl-ate. Acta Crystallogr Sect E Struct Rep Online (2008) 1.75
Arabidopsis REF6 is a histone H3 lysine 27 demethylase. Nat Genet (2011) 1.74
Facile Ni(II)/ketoxime-mediated conversion of organonitriles into imidoylamidine ligands. Synthesis of imidoylamidines and acetyl amides. Inorg Chem (2003) 1.73
Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites. PLoS Pathog (2013) 1.72
Opposing roles of polycomb repressive complexes in hematopoietic stem and progenitor cells. Blood (2010) 1.71
Mouse gridlock: no aortic coarctation or deficiency, but fatal cardiac defects in Hey2 -/- mice. Curr Biol (2002) 1.70
Biosynthesis of novel thermoplastic polythioesters by engineered Escherichia coli. Nat Mater (2002) 1.69
Developmental patterning of the cardiac atrioventricular canal by Notch and Hairy-related transcription factors. Development (2006) 1.67
The polycomb group protein EZH2 is required for mammalian circadian clock function. J Biol Chem (2006) 1.67
Satb1 and Satb2 regulate embryonic stem cell differentiation and Nanog expression. Genes Dev (2009) 1.67
In vivo viscoelastic properties of the brain in normal pressure hydrocephalus. NMR Biomed (2010) 1.67
Cerebral cavernous malformation protein CCM1 inhibits sprouting angiogenesis by activating DELTA-NOTCH signaling. Proc Natl Acad Sci U S A (2010) 1.61
Flexible long-range loops in the VH gene region of the Igh locus facilitate the generation of a diverse antibody repertoire. Immunity (2013) 1.56
Tumor stroma-derived TGF-beta limits myc-driven lymphomagenesis via Suv39h1-dependent senescence. Cancer Cell (2010) 1.53
Cellular mechanism for targeting heterochromatin formation in Drosophila. Int Rev Cell Mol Biol (2009) 1.51
Synaptojanin-2 binding protein stabilizes the Notch ligands DLL1 and DLL4 and inhibits sprouting angiogenesis. Circ Res (2013) 1.50
The B-cell identity factor Pax5 regulates distinct transcriptional programmes in early and late B lymphopoiesis. EMBO J (2012) 1.50
Histone hypomethylation is an indicator of epigenetic plasticity in quiescent lymphocytes. EMBO J (2004) 1.49
SU(VAR)3-9 is a conserved key function in heterochromatic gene silencing. Genetica (2003) 1.45
Formation of facultative heterochromatin in the absence of HP1. EMBO J (2003) 1.45