Published in J Biomed Res on December 28, 2013
Elevated Glucose Levels Promote Contractile and Cytoskeletal Gene Expression in Vascular Smooth Muscle via Rho/Protein Kinase C and Actin Polymerization. J Biol Chem (2015) 0.80
TGF-β1 induces human aortic vascular smooth muscle cell phenotype switch through PI3K/AKT/ID2 signaling. Am J Transl Res (2015) 0.77
Role of Mechanical Cues in Cell Differentiation and Proliferation: A 3D Numerical Model. PLoS One (2015) 0.77
Smooth muscle FGF/TGFβ cross talk regulates atherosclerosis progression. EMBO Mol Med (2016) 0.77
Folic acid inhibits dedifferentiation of PDGF-BB-induced vascular smooth muscle cells by suppressing mTOR/P70S6K signaling. Am J Transl Res (2017) 0.76
From nerve to blood vessel: a new role of Olfm2 in smooth muscle differentiation from human embryonic stem cell-derived mesenchymal cells. J Biomed Res (2015) 0.76
Fibroblast growth factor (FGF) signaling regulates transforming growth factor beta (TGFβ)-dependent smooth muscle cell phenotype modulation. Sci Rep (2016) 0.76
The Role of Krüppel-like Factor 4 in Renal Fibrosis. Front Physiol (2015) 0.75
The activation of p38 MAPK limits the abnormal proliferation of vascular smooth muscle cells induced by high sodium concentrations. Int J Mol Med (2015) 0.75
Functional and Proteomic Investigations Reveal Major Royal Jelly Protein 1 Associated with Anti-hypertension Activity in Mouse Vascular Smooth Muscle Cells. Sci Rep (2016) 0.75
NLRP3 inflammasome activation contributes to VSMC phenotypic transformation and proliferation in hypertension. Cell Death Dis (2017) 0.75
Chicoric acid prevents PDGF-BB-induced VSMC dedifferentiation, proliferation and migration by suppressing ROS/NFκB/mTOR/P70S6K signaling cascade. Redox Biol (2017) 0.75
The role of tumor necrosis factor-like weak inducer of apoptosis in atherosclerosis via its two different receptors. Exp Ther Med (2017) 0.75
Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell (2006) 120.51
Reprogramming of human somatic cells to pluripotency with defined factors. Nature (2007) 30.84
Molecular regulation of vascular smooth muscle cell differentiation in development and disease. Physiol Rev (2004) 16.52
Genetic control of the cell division cycle in yeast. Science (1974) 13.83
Genetic Control of the Cell Division Cycle in Yeast: V. Genetic Analysis of cdc Mutants. Genetics (1973) 10.99
Regulation of differentiation of vascular smooth muscle cells. Physiol Rev (1995) 6.60
Initiation of eukaryotic DNA replication in vitro. Annu Rev Cell Biol (1989) 5.58
PDGF, TGF-beta, and heterotypic cell-cell interactions mediate endothelial cell-induced recruitment of 10T1/2 cells and their differentiation to a smooth muscle fate. J Cell Biol (1998) 5.21
The smooth muscle cell in culture. Physiol Rev (1979) 5.03
Cell cycle control of DNA replication. Science (1996) 4.47
The structure and function of MCM from archaeal M. Thermoautotrophicum. Nat Struct Biol (2003) 4.27
Developmental basis of vascular smooth muscle diversity. Arterioscler Thromb Vasc Biol (2007) 4.09
Pericardial mesoderm generates a population of coronary smooth muscle cells migrating into the heart along with ingrowth of the epicardial organ. Dev Biol (1996) 3.70
Cell cycle regulation of the yeast Cdc7 protein kinase by association with the Dbf4 protein. Mol Cell Biol (1993) 3.39
Interaction of Dbf4, the Cdc7 protein kinase regulatory subunit, with yeast replication origins in vivo. Science (1994) 3.16
Mcm2 is a target of regulation by Cdc7-Dbf4 during the initiation of DNA synthesis. Genes Dev (1997) 3.05
mcm5/cdc46-bob1 bypasses the requirement for the S phase activator Cdc7p. Proc Natl Acad Sci U S A (1997) 3.01
Kruppel-like factor 4 abrogates myocardin-induced activation of smooth muscle gene expression. J Biol Chem (2004) 2.94
Smad3 mediates transforming growth factor-beta-induced alpha-smooth muscle actin expression. Am J Respir Cell Mol Biol (2003) 2.69
Oxidized phospholipids induce phenotypic switching of vascular smooth muscle cells in vivo and in vitro. Circ Res (2007) 2.55
Central role for Rho in TGF-beta1-induced alpha-smooth muscle actin expression during epithelial-mesenchymal transition. Am J Physiol Renal Physiol (2002) 2.36
Molecular determinants of vascular smooth muscle cell diversity. Circ Res (2005) 2.33
DNA replication licensing and human cell proliferation. J Cell Sci (2001) 2.30
Conditional deletion of Krüppel-like factor 4 delays downregulation of smooth muscle cell differentiation markers but accelerates neointimal formation following vascular injury. Circ Res (2008) 2.30
Cell cycle exit upon myogenic differentiation. Curr Opin Genet Dev (1997) 2.22
Secondary heart field contributes myocardium and smooth muscle to the arterial pole of the developing heart. Dev Biol (2005) 2.15
Thrombin stimulates proliferation of cultured rat aortic smooth muscle cells by a proteolytically activated receptor. J Clin Invest (1993) 2.11
Control of SRF binding to CArG box chromatin regulates smooth muscle gene expression in vivo. J Clin Invest (2006) 2.04
Transforming growth factor-beta1 signaling contributes to development of smooth muscle cells from embryonic stem cells. Am J Physiol Cell Physiol (2004) 1.93
Regulation of vascular smooth muscle cell differentiation. J Vasc Surg (2007) 1.92
Transforming growth factor-beta-induced differentiation of smooth muscle from a neural crest stem cell line. Circ Res (2004) 1.85
Human Cdc7-related kinase complex. In vitro phosphorylation of MCM by concerted actions of Cdks and Cdc7 and that of a criticial threonine residue of Cdc7 bY Cdks. J Biol Chem (2000) 1.85
Human and Xenopus cDNAs encoding budding yeast Cdc7-related kinases: in vitro phosphorylation of MCM subunits by a putative human homologue of Cdc7. EMBO J (1997) 1.78
A G/C element mediates repression of the SM22alpha promoter within phenotypically modulated smooth muscle cells in experimental atherosclerosis. Circ Res (2004) 1.76
Purification of Hsk1, a minichromosome maintenance protein kinase from fission yeast. J Biol Chem (1998) 1.65
Transforming growth factor-beta1-induced expression of smooth muscle marker genes involves activation of PKN and p38 MAPK. J Biol Chem (2005) 1.52
Expressional regulation of smooth muscle cell-specific genes in association with phenotypic modulation. Mol Cell Biochem (1999) 1.51
The CDC7 protein of Saccharomyces cerevisiae is a phosphoprotein that contains protein kinase activity. Proc Natl Acad Sci U S A (1991) 1.41
A fission yeast gene, him1(+)/dfp1(+), encoding a regulatory subunit for Hsk1 kinase, plays essential roles in S-phase initiation as well as in S-phase checkpoint control and recovery from DNA damage. Mol Cell Biol (1999) 1.39
Notch and transforming growth factor-beta (TGFbeta) signaling pathways cooperatively regulate vascular smooth muscle cell differentiation. J Biol Chem (2010) 1.38
Cdc7 inhibition reveals a p53-dependent replication checkpoint that is defective in cancer cells. Cancer Res (2004) 1.37
TGF-beta through Smad3 signaling stimulates vascular smooth muscle cell proliferation and neointimal formation. Am J Physiol Heart Circ Physiol (2009) 1.36
Sp1-dependent activation of KLF4 is required for PDGF-BB-induced phenotypic modulation of smooth muscle. Am J Physiol Heart Circ Physiol (2009) 1.32
Regulation of Saccharomyces cerevisiae CDC7 function during the cell cycle. Mol Biol Cell (1993) 1.29
Characterization of the yeast Cdc7p/Dbf4p complex purified from insect cells. Its protein kinase activity is regulated by Rad53p. J Biol Chem (2000) 1.23
Dbf4-Cdc7 phosphorylation of Mcm2 is required for cell growth. J Biol Chem (2009) 1.20
A human homolog of the yeast CDC7 gene is overexpressed in some tumors and transformed cell lines. Gene (1998) 1.17
Differentiated phenotype of smooth muscle cells depends on signaling pathways through insulin-like growth factors and phosphatidylinositol 3-kinase. J Biol Chem (1998) 1.14
Proliferative activity and alpha-smooth muscle actin expression in cultured rat aortic smooth muscle cells are differently modulated by transforming growth factor-beta 1 and heparin. Exp Cell Res (1994) 1.10
Single-strand DNA gaps trigger an ATR- and Cdc7-dependent checkpoint. Cell Cycle (2003) 1.09
Inactivation of Cdc7 kinase in mouse ES cells results in S-phase arrest and p53-dependent cell death. EMBO J (2002) 1.06
Developmentally timed expression of an embryonic growth phenotype in vascular smooth muscle cells. Circ Res (1994) 1.05
CDC7 protein kinase activity is required for mitosis and meiosis in Saccharomyces cerevisiae. Mol Gen Genet (1991) 1.05
Transforming growth factor-beta-dependent growth inhibition in primary vascular smooth muscle cells is p38-dependent. J Pharmacol Exp Ther (2005) 1.03
Cdc7-Dbf4 regulates NDT80 transcription as well as reductional segregation during budding yeast meiosis. Mol Biol Cell (2008) 1.02
Proliferation and differentiation of smooth muscle cell precursors occurs simultaneously during the development of the vessel wall. Dev Dyn (1997) 1.01
Interdependence between muscle differentiation and cell-cycle control. Biochim Biophys Acta (1997) 1.01
TGF-beta promotes proliferation of cultured SMC via both PDGF-AA-dependent and PDGF-AA-independent mechanisms. J Clin Invest (1994) 0.99
Smooth muscle stem cells. Anat Rec A Discov Mol Cell Evol Biol (2004) 0.99
Cdc7 kinase is a predictor of survival and a novel therapeutic target in epithelial ovarian carcinoma. Clin Cancer Res (2009) 0.98
Protein kinase C activation allows pulmonary artery smooth muscle cells to proliferate to hypoxia. Am J Physiol (1991) 0.96
Transforming growth factor-β increases vascular smooth muscle cell proliferation through the Smad3 and extracellular signal-regulated kinase mitogen-activated protein kinases pathways. J Vasc Surg (2012) 0.95
Invited review: the circle of life: cell cycle regulation in airway smooth muscle. J Appl Physiol (1985) (2001) 0.95
CDC7 kinase complex as a molecular switch for DNA replication. Front Biosci (1999) 0.93
Cell division cycle 7 is a novel regulator of transforming growth factor-β-induced smooth muscle cell differentiation. J Biol Chem (2012) 0.89
Analyses of Saccharomyces cerevisiae Cdc7 kinase point mutants: dominant-negative inhibition of DNA replication on overexpression of kinase-negative Cdc7 proteins. Mol Gen Genet (1997) 0.87
Cdc7-Dbf4 is a gene-specific regulator of meiotic transcription in yeast. Mol Cell Biol (2011) 0.86
Kruppel-like factor 4: transcriptional regulator of proliferation, or inflammation, or differentiation, or all three? Circ Res (2008) 0.86
Transforming growth factor beta 1-mediated inhibition of smooth muscle cell proliferation is associated with a late G1 cell cycle arrest. J Cell Physiol (1993) 0.86
Heparin, heparan sulfate, smooth muscle cells, and atherosclerosis. Ann N Y Acad Sci (1989) 0.83
Mechanisms of inhibition by heparin of vascular smooth muscle cell proliferation and migration. Haemostasis (1993) 0.80
From nerve to blood vessel: a new role of Olfm2 in smooth muscle differentiation from human embryonic stem cell-derived mesenchymal cells. J Biomed Res (2015) 0.76
Transforming growth factor-b signaling in systemic sclerosis. J Biomed Res (2017) 0.75
White adipose tissue browning and obesity. J Biomed Res (2016) 0.75