Published in Front Physiol on January 24, 2014
The ubiquitin proteasomal system: a potential target for the management of Alzheimer's disease. J Cell Mol Med (2016) 0.81
Competing to coordinate cell fate decisions: the MST2-Raf-1 signaling device. Cell Cycle (2015) 0.81
DYVIPAC: an integrated analysis and visualisation framework to probe multi-dimensional biological networks. Sci Rep (2015) 0.79
Degradation Parameters from Pulse-Chase Experiments. PLoS One (2016) 0.75
Stratified ubiquitination of RIG-I creates robust immune response and induces selective gene expression. Sci Adv (2017) 0.75
The ubiquitin system. Annu Rev Biochem (1998) 43.36
Global quantification of mammalian gene expression control. Nature (2011) 22.36
Recognition of the polyubiquitin proteolytic signal. EMBO J (2000) 10.12
How proteolysis drives the cell cycle. Science (1996) 8.59
Positive feedback in eukaryotic gene networks: cell differentiation by graded to binary response conversion. EMBO J (2001) 7.03
A positive-feedback-based bistable 'memory module' that governs a cell fate decision. Nature (2003) 6.25
von Hippel-Lindau disease. Lancet (2003) 6.20
Building ubiquitin chains: E2 enzymes at work. Nat Rev Mol Cell Biol (2009) 5.41
Signaling switches and bistability arising from multisite phosphorylation in protein kinase cascades. J Cell Biol (2004) 5.02
The Angelman Syndrome protein Ube3A regulates synapse development by ubiquitinating arc. Cell (2010) 4.72
Analytical distributions for stochastic gene expression. Proc Natl Acad Sci U S A (2008) 3.48
Mechanism of lysine 48-linked ubiquitin-chain synthesis by the cullin-RING ubiquitin-ligase complex SCF-Cdc34. Cell (2005) 3.44
Inhibition of proteolysis and cell cycle progression in a multiubiquitination-deficient yeast mutant. Mol Cell Biol (1994) 3.27
MAPK-mediated bimodal gene expression and adaptive gradient sensing in yeast. Nature (2007) 3.23
Effects of molecular memory and bursting on fluctuations in gene expression. Science (2008) 3.20
ER stress-induced cell death mechanisms. Biochim Biophys Acta (2013) 3.07
Bistability in the JNK cascade. Curr Biol (2001) 2.93
A ubiquitin ligase transfers preformed polyubiquitin chains from a conjugating enzyme to a substrate. Nature (2007) 2.82
Why do protein kinase cascades have more than one level? Trends Biochem Sci (1997) 2.69
Dual E1 activation systems for ubiquitin differentially regulate E2 enzyme charging. Nature (2007) 2.36
Quantification of information transfer via cellular signal transduction pathways. FEBS Lett (1997) 2.33
Autoregulation of an E2 enzyme by ubiquitin-chain assembly on its catalytic residue. Nat Cell Biol (2007) 2.32
Detection of sequential polyubiquitylation on a millisecond timescale. Nature (2009) 2.25
Identification of mutations in CUL7 in 3-M syndrome. Nat Genet (2005) 2.10
The delicate balance between secreted protein folding and endoplasmic reticulum-associated degradation in human physiology. Physiol Rev (2012) 1.95
Transcriptional control: rheostat converted to on/off switch. Mol Cell (2000) 1.82
How responses get more switch-like as you move down a protein kinase cascade. Trends Biochem Sci (1997) 1.65
A sigmoidal transcriptional response: cooperativity, synergy and dosage effects. Biol Rev Camb Philos Soc (2003) 1.43
When ubiquitination meets phosphorylation: a systems biology perspective of EGFR/MAPK signalling. Cell Commun Signal (2013) 1.36
Emergence of bimodal cell population responses from the interplay between analog single-cell signaling and protein expression noise. BMC Syst Biol (2012) 1.25
Method for real-time monitoring of protein degradation at the single cell level. Biotechniques (2007) 1.22
Degradation of ubiquitin: the fate of the cellular reaper. Cell Cycle (2010) 1.22
Complex degradation processes lead to non-exponential decay patterns and age-dependent decay rates of messenger RNA. PLoS One (2013) 1.15
Bistable switches control memory and plasticity in cellular differentiation. Proc Natl Acad Sci U S A (2009) 1.13
Threshold-controlled ubiquitination of the EGFR directs receptor fate. EMBO J (2013) 1.11
Single-molecule denaturation and degradation of proteins by the AAA+ ClpXP protease. Proc Natl Acad Sci U S A (2009) 1.11
Ubiquitin degradation with its substrate, or as a monomer in a ubiquitination-independent mode, provides clues to proteasome regulation. Proc Natl Acad Sci U S A (2009) 1.06
A targeted siRNA screen identifies regulators of Cdc42 activity at the natural killer cell immunological synapse. Sci Signal (2011) 1.05
Switches, excitable responses and oscillations in the Ring1B/Bmi1 ubiquitination system. PLoS Comput Biol (2011) 1.00
Kinetic timing: a novel mechanism that improves the accuracy of GTPase timers in endosome fusion and other biological processes. Traffic (2002) 0.95
Applications of Little's Law to stochastic models of gene expression. Phys Rev E Stat Nonlin Soft Matter Phys (2010) 0.86
Cell biology: Stairway to the proteasome. Nature (2009) 0.76
Crosstalk and signaling switches in mitogen-activated protein kinase cascades. Front Physiol (2012) 1.16