Published in Philos Trans R Soc Lond B Biol Sci on February 03, 2014
Ion channels in cancer: future perspectives and clinical potential. Philos Trans R Soc Lond B Biol Sci (2014) 0.95
Molecular mechanisms of tumour invasion: regulation by calcium signals. J Physiol (2017) 0.84
Protease-activated receptors (PARs)-biology and role in cancer invasion and metastasis. Cancer Metastasis Rev (2015) 0.80
Bioelectrical regulation of cell cycle and the planarian model system. Biochim Biophys Acta (2015) 0.77
Functional expression of calcium-permeable Canonical Transient Receptor Potential 4-containing channels promotes migration of medulloblastoma cells. J Physiol (2017) 0.76
Usefulness of dynamic contrast-enhanced magnetic resonance imaging for predicting treatment response to vinorelbine-cisplatin with or without recombinant human endostatin in bone metastasis of non-small cell lung cancer. Am J Cancer Res (2016) 0.75
Hallmarks of cancer: the next generation. Cell (2011) 140.01
Tumor angiogenesis: therapeutic implications. N Engl J Med (1971) 35.36
Angiogenesis in life, disease and medicine. Nature (2005) 15.36
Transient receptor potential cation channels in disease. Physiol Rev (2007) 6.91
Basic and therapeutic aspects of angiogenesis. Cell (2011) 6.40
Principles and mechanisms of vessel normalization for cancer and other angiogenic diseases. Nat Rev Drug Discov (2011) 5.59
Sodium/calcium exchange: its physiological implications. Physiol Rev (1999) 5.42
Impairment of angiogenesis and cell migration by targeted aquaporin-1 gene disruption. Nature (2005) 4.20
Endothelial cell diversity revealed by global expression profiling. Proc Natl Acad Sci U S A (2003) 3.98
Antiangiogenic therapy: impact on invasion, disease progression, and metastasis. Nat Rev Clin Oncol (2011) 3.58
Nicotinic receptors: allosteric transitions and therapeutic targets in the nervous system. Nat Rev Drug Discov (2009) 3.26
Ion channels and their functional role in vascular endothelium. Physiol Rev (2001) 3.26
Voltage-gated potassium channels as therapeutic targets. Nat Rev Drug Discov (2009) 3.12
Cell swelling, heat, and chemical agonists use distinct pathways for the activation of the cation channel TRPV4. Proc Natl Acad Sci U S A (2003) 2.95
The role of disturbed pH dynamics and the Na+/H+ exchanger in metastasis. Nat Rev Cancer (2005) 2.82
Stim1 and Orai1 mediate CRAC currents and store-operated calcium entry important for endothelial cell proliferation. Circ Res (2008) 2.60
Amazing chloride channels: an overview. Acta Physiol Scand (2003) 2.42
Role of TRPM2 channel in mediating H2O2-induced Ca2+ entry and endothelial hyperpermeability. Circ Res (2007) 2.24
A novel angiogenic pathway mediated by non-neuronal nicotinic acetylcholine receptors. J Clin Invest (2002) 2.19
The vanilloid transient receptor potential channel TRPV4: from structure to disease. Prog Biophys Mol Biol (2009) 2.13
Voltage-gated Na+ channel SCN5A is a key regulator of a gene transcriptional network that controls colon cancer invasion. Cancer Res (2010) 2.01
Aquaporins in clinical medicine. Annu Rev Med (2012) 1.90
TRPV4 channels mediate cyclic strain-induced endothelial cell reorientation through integrin-to-integrin signaling. Circ Res (2009) 1.84
Arterial response to shear stress critically depends on endothelial TRPV4 expression. PLoS One (2007) 1.79
Recent developments in vascular endothelial cell transient receptor potential channels. Circ Res (2005) 1.73
Acidic extracellular pH induces vascular endothelial growth factor (VEGF) in human glioblastoma cells via ERK1/2 MAPK signaling pathway: mechanism of low pH-induced VEGF. J Biol Chem (2001) 1.72
Targeting ion channels in cancer: a novel frontier in antineoplastic therapy. Curr Med Chem (2009) 1.70
Increased aquaporin 1 water channel expression in human brain tumours. Br J Cancer (2002) 1.61
Altered angiogenesis and survival in human tumor-derived endothelial cells. FASEB J (2003) 1.61
Calcium channels and pumps in cancer: changes and consequences. J Biol Chem (2012) 1.49
Orai1 and CRAC channel dependence of VEGF-activated Ca2+ entry and endothelial tube formation. Circ Res (2011) 1.47
Monoclonal antibody blockade of the human Eag1 potassium channel function exerts antitumor activity. Cancer Res (2007) 1.47
Angiopoietin-1 opposes VEGF-induced increase in endothelial permeability by inhibiting TRPC1-dependent Ca2 influx. Circ Res (2005) 1.44
RhoA interaction with inositol 1,4,5-trisphosphate receptor and transient receptor potential channel-1 regulates Ca2+ entry. Role in signaling increased endothelial permeability. J Biol Chem (2003) 1.43
TRP channel and cardiovascular disease. Pharmacol Ther (2008) 1.42
Eag1 expression interferes with hypoxia homeostasis and induces angiogenesis in tumors. J Biol Chem (2008) 1.41
Tumor necrosis factor-alpha-induced TRPC1 expression amplifies store-operated Ca2+ influx and endothelial permeability. Am J Physiol Lung Cell Mol Physiol (2004) 1.41
Water channel (aquaporin 1) expression and distribution in mammary carcinomas and glioblastomas. Microvasc Res (1999) 1.34
Molecular characterization of human breast tumor vascular cells. Am J Pathol (2008) 1.32
Ion channels and transporters in cancer. 1. Ion channels and cell proliferation in cancer. Am J Physiol Cell Physiol (2011) 1.29
Vascular endothelial growth factor stimulates endothelial colony forming cells proliferation and tubulogenesis by inducing oscillations in intracellular Ca2+ concentration. Stem Cells (2011) 1.24
T-type calcium channels and tumor proliferation. Cell Calcium (2006) 1.19
Receptor channel TRPC6 is a key mediator of Notch-driven glioblastoma growth and invasiveness. Cancer Res (2009) 1.18
Store-operated Ca2+ entry is remodelled and controls in vitro angiogenesis in endothelial progenitor cells isolated from tumoral patients. PLoS One (2012) 1.18
Silencing TRPM7 promotes growth/proliferation and nitric oxide production of vascular endothelial cells via the ERK pathway. Cardiovasc Res (2009) 1.16
Microvessel overexpression of aquaporin 1 parallels bone marrow angiogenesis in patients with active multiple myeloma. Br J Haematol (2001) 1.16
Identification of novel sense and antisense transcription at the TRPM2 locus in cancer. Cell Res (2008) 1.15
Critical role of TRPC6 channels in VEGF-mediated angiogenesis. Cancer Lett (2009) 1.12
Na+-H+ exchanger, pH regulation and cancer. Recent Pat Anticancer Drug Discov (2013) 1.11
Heterogeneity of tumor endothelial cells: comparison between tumor endothelial cells isolated from high- and low-metastatic tumors. Am J Pathol (2012) 1.11
A central role for nicotinic cholinergic regulation of growth factor-induced endothelial cell migration. Arterioscler Thromb Vasc Biol (2006) 1.10
Tumor exploits alternative strategies to achieve vascularization. FASEB J (2011) 1.07
Evidence of a role for TRPC channels in VEGF-mediated increased vascular permeability in vivo. Am J Physiol Heart Circ Physiol (2003) 1.07
Recent developments in the regulation of the angiogenic switch by cellular stress factors in tumors. Cancer Lett (2005) 1.06
Angiogenic activity of nicotinic acetylcholine receptors: implications in tobacco-related vascular diseases. Pharmacol Ther (2008) 1.05
VEGF-mediated elevated intracellular calcium and angiogenesis in human microvascular endothelial cells in vitro are inhibited by dominant negative TRPC6. Microcirculation (2008) 1.05
TRPC1 is essential for in vivo angiogenesis in zebrafish. Circ Res (2010) 1.04
Angiogenic functions of voltage-gated Na+ Channels in human endothelial cells: modulation of vascular endothelial growth factor (VEGF) signaling. J Biol Chem (2011) 1.04
Identification of novel vascular markers through gene expression profiling of tumor-derived endothelium. BMC Genomics (2008) 1.03
Dynamical systems approach to endothelial heterogeneity. Circ Res (2012) 1.03
Organization and function of TRPC channelosomes. Pflugers Arch (2007) 1.01
Regulation and function of TRPM7 in human endothelial cells: TRPM7 as a potential novel regulator of endothelial function. PLoS One (2013) 1.00
TRPM7: a unique channel involved in magnesium homeostasis. Int J Biochem Cell Biol (2012) 1.00
Role of non-neuronal nicotinic acetylcholine receptors in angiogenesis. Int J Biochem Cell Biol (2009) 1.00
STIM1 controls endothelial barrier function independently of Orai1 and Ca2+ entry. Sci Signal (2013) 0.99
Isolation and characterization of human breast tumor-derived endothelial cells. Oncol Rep (2006) 0.99
TRPV4 mediates tumor-derived endothelial cell migration via arachidonic acid-activated actin remodeling. Oncogene (2011) 0.99
VEGF activates receptor-operated cation channels in human microvascular endothelial cells. Arterioscler Thromb Vasc Biol (2006) 0.97
Cellular and molecular mechanisms of nicotine's pro-angiogenesis activity and its potential impact on cancer. J Cell Biochem (2006) 0.96
Nicotine: specific role in angiogenesis, proliferation and apoptosis. Crit Rev Toxicol (2011) 0.96
Voltage-gated sodium channel activity promotes prostate cancer metastasis in vivo. Cancer Lett (2012) 0.96
Knockdown of transient receptor potential canonical-1 reduces the proliferation and migration of endothelial progenitor cells. Stem Cells Dev (2011) 0.96
Persistent current blockers of voltage-gated sodium channels: a clinical opportunity for controlling metastatic disease. Recent Pat Anticancer Drug Discov (2013) 0.96
A new role for PTEN in regulating transient receptor potential canonical channel 6-mediated Ca2+ entry, endothelial permeability, and angiogenesis. J Biol Chem (2010) 0.95
Ion channels and transporters in cancer. 6. Vascularizing the tumor: TRP channels as molecular targets. Am J Physiol Cell Physiol (2011) 0.95
Hydrogen sulfide promotes calcium signals and migration in tumor-derived endothelial cells. Free Radic Biol Med (2011) 0.95
Orai1 calcium channels in the vasculature. Pflugers Arch (2012) 0.95
Cholinergic modulation of angiogenesis: role of the 7 nicotinic acetylcholine receptor. J Cell Biochem (2009) 0.94
Trpv4 induces collateral vessel growth during regeneration of the arterial circulation. J Cell Mol Med (2009) 0.92
The Ca(2+) channel antagonists mibefradil and pimozide inhibit cell growth via different cytotoxic mechanisms. Mol Pharmacol (2002) 0.92
Nanotherapeutics in angiogenesis: synthesis and in vivo assessment of drug efficacy and biocompatibility in zebrafish embryos. Int J Nanomedicine (2011) 0.91
TRP channels in prostate cancer: the good, the bad and the ugly? Asian J Androl (2011) 0.91
Transient receptor potential melastatin 7 (TRPM7) cation channels, magnesium and the vascular system in hypertension. Circ J (2010) 0.91
Aquaporins: another piece in the osmotic puzzle. FEBS Lett (2012) 0.91
Short Hairpin RNA (shRNA) Ether à go-go 1 (Eag1) inhibition of human osteosarcoma angiogenesis via VEGF/PI3K/AKT signaling. Int J Mol Sci (2012) 0.89
Silencing TRPM7 mimics the effects of magnesium deficiency in human microvascular endothelial cells. Angiogenesis (2011) 0.89
Systemic amiloride inhibits experimentally induced neovascularization. Arch Ophthalmol (1990) 0.88
Inhibition of aquaporin-1 dependent angiogenesis impairs tumour growth in a mouse model of melanoma. J Mol Med (Berl) (2012) 0.88
Nifedipine-induced vascular endothelial growth factor secretion from coronary smooth muscle cells promotes endothelial tube formation via the kinase insert domain-containing receptor/fetal liver kinase-1/NO pathway. Hypertens Res (2005) 0.88
Potassium channels: novel emerging biomarkers and targets for therapy in cancer. Recent Pat Anticancer Drug Discov (2013) 0.88
Arachidonic acid-induced Ca2+ entry is involved in early steps of tumor angiogenesis. Mol Cancer Res (2008) 0.88
Role of TRPM2 in H(2)O(2)-induced cell apoptosis in endothelial cells. PLoS One (2012) 0.88
Transient receptor potential canonical channels are required for in vitro endothelial tube formation. J Biol Chem (2011) 0.86
The water channels, new druggable targets to combat cancer cell survival, invasiveness and metastasis. Curr Drug Targets (2007) 0.84
Irresponsiveness of two retinoblastoma cases to conservative therapy correlates with up- regulation of hERG1 channels and of the VEGF-A pathway. BMC Cancer (2010) 0.83
Margatoxin inhibits VEGF-induced hyperpolarization, proliferation and nitric oxide production of human endothelial cells. J Vasc Res (2005) 0.83
Targeting calcium channels to block tumor vascularization. Recent Pat Anticancer Drug Discov (2013) 0.83
Aquaporin-1 promotes angiogenesis, fibrosis, and portal hypertension through mechanisms dependent on osmotically sensitive microRNAs. Am J Pathol (2011) 0.83
Ion channels and transporters in cancer. 6. Vascularizing the tumor: TRP channels as molecular targets. Am J Physiol Cell Physiol (2011) 0.95
Oxytocin induces proliferation and migration in immortalized human dermal microvascular endothelial cells and human breast tumor-derived endothelial cells. Mol Cancer Res (2006) 0.95
Hydrogen sulfide promotes calcium signals and migration in tumor-derived endothelial cells. Free Radic Biol Med (2011) 0.95
Expression and functional role of bTRPC1 channels in native endothelial cells. FEBS Lett (2002) 0.90
A multiscale hybrid approach for vasculogenesis and related potential blocking therapies. Prog Biophys Mol Biol (2011) 0.90
Arachidonic acid-induced Ca2+ entry is involved in early steps of tumor angiogenesis. Mol Cancer Res (2008) 0.88
Old and new gasotransmitters in the cardiovascular system: focus on the role of nitric oxide and hydrogen sulfide in endothelial cells and cardiomyocytes. Curr Pharm Biotechnol (2011) 0.87
Control of endothelial cell proliferation by calcium influx and arachidonic acid metabolism: a pharmacological approach. J Cell Physiol (2003) 0.87
Oxytocin is a growth factor for Kaposi's sarcoma cells: evidence of endocrine-immunological cross-talk. Cancer Res (2002) 0.87
A functional transient receptor potential vanilloid 4 (TRPV4) channel is expressed in human endothelial progenitor cells. J Cell Physiol (2015) 0.86
Hydrogen sulfide regulates intracellular Ca2+ concentration in endothelial cells from excised rat aorta. Curr Pharm Biotechnol (2011) 0.84
Role of calcium channels in the protective effect of hydrogen sulfide in rat cardiomyoblasts. Cell Physiol Biochem (2014) 0.82
Regulation of noncapacitative calcium entry by arachidonic acid and nitric oxide in endothelial cells. FASEB J (2005) 0.81
Multiple roles of protein kinase a in arachidonic acid-mediated Ca2+ entry and tumor-derived human endothelial cell migration. Mol Cancer Res (2010) 0.81
Interaction between TRPC channel subunits in endothelial cells. J Recept Signal Transduct Res (2006) 0.80
Cytosolic calcium microdomains by arachidonic acid and nitric oxide in endothelial cells. Cell Calcium (2006) 0.79
The role of ion channels and transporters in cell proliferation and cancer. Front Physiol (2013) 0.79
Paracrine crosstalk between human hair follicle dermal papilla cells and microvascular endothelial cells. Exp Dermatol (2015) 0.78
Calcium signals activated by arachidonic acid in embryonic chick ciliary ganglion neurons. Neurosignals (2005) 0.78
Hydrogen sulfide and endothelial dysfunction: relationship with nitric oxide. Curr Med Chem (2014) 0.77
Editorial: ion fluxes and cancer. Recent Pat Anticancer Drug Discov (2013) 0.77
Intracellular calcium signaling: holding the balance between health and disease. Curr Med Chem (2012) 0.77
Anti-angiogenic properties of calcium trifluoroacetate. Microvasc Res (2009) 0.75
Pleiotropic Effects of White Willow Bark and 1,2-Decanediol on Human Adult Keratinocytes. Skin Pharmacol Physiol (2017) 0.75
Arachidonic acid and calcium signals in human breast tumor-derived endothelial cells: a proteomic study. J Recept Signal Transduct Res (2009) 0.75