Published in Hum Mol Genet on February 04, 2014
Pluripotent stem cells in disease modelling and drug discovery. Nat Rev Mol Cell Biol (2016) 1.24
Concise Review: Patient-Specific Stem Cells to Interrogate Inherited Eye Disease. Stem Cells Transl Med (2015) 1.08
Gene therapy in patient-specific stem cell lines and a preclinical model of retinitis pigmentosa with membrane frizzled-related protein defects. Mol Ther (2014) 1.05
The impact of the human genome project on complex disease. Genes (Basel) (2014) 0.85
CRISPR Repair Reveals Causative Mutation in a Preclinical Model of Retinitis Pigmentosa. Mol Ther (2016) 0.85
Cellular models and therapies for age-related macular degeneration. Dis Model Mech (2015) 0.82
Induced Pluripotent Stem Cell Therapies for Degenerative Disease of the Outer Retina: Disease Modeling and Cell Replacement. J Ocul Pharmacol Ther (2016) 0.81
Using Stem Cells to Model Diseases of the Outer Retina. Comput Struct Biotechnol J (2015) 0.81
Inhibition of autophagy induces retinal pigment epithelial cell damage by the lipofuscin fluorophore A2E. FEBS Open Bio (2014) 0.80
Stem Cell Therapies in Retinal Disorders. Cells (2017) 0.78
PGC-1α Induces Human RPE Oxidative Metabolism and Antioxidant Capacity. Invest Ophthalmol Vis Sci (2016) 0.78
Proceedings: consideration of genetics in the design of induced pluripotent stem cell-based models of complex disease. Stem Cells Transl Med (2014) 0.77
Stem cells as tools for studying the genetics of inherited retinal degenerations. Cold Spring Harb Perspect Med (2014) 0.77
Induced Pluripotent Stem Cells and Outer Retinal Disease. Stem Cells Int (2016) 0.76
Patient-Specific iPSC-Derived RPE for Modeling of Retinal Diseases. J Clin Med (2015) 0.76
Looking into the future: Using induced pluripotent stem cells to build two and three dimensional ocular tissue for cell therapy and disease modeling. Brain Res (2015) 0.76
Skin Biopsy and Patient-Specific Stem Cell Lines. Methods Mol Biol (2016) 0.75
Joint Effect of CFH and ARMS2/HTRA1 Polymorphisms on Neovascular Age-Related Macular Degeneration in Chinese Population. J Ophthalmol (2015) 0.75
Nicotinamide Ameliorates Disease Phenotypes in a Human iPSC Model of Age-Related Macular Degeneration. Cell Stem Cell (2017) 0.75
Repressed SIRT1/PGC-1α pathway and mitochondrial disintegration in iPSC-derived RPE disease model of age-related macular degeneration. J Transl Med (2016) 0.75
Drusen in patient-derived hiPSC-RPE models of macular dystrophies. Proc Natl Acad Sci U S A (2017) 0.75
Prevalence of age-related macular degeneration in the United States. Arch Ophthalmol (2004) 18.86
Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase. Science (2004) 17.38
Functional interaction between beta-catenin and FOXO in oxidative stress signaling. Science (2005) 4.61
RPE lipofuscin and its role in retinal pathobiology. Exp Eye Res (2005) 3.52
A variant of mitochondrial protein LOC387715/ARMS2, not HTRA1, is strongly associated with age-related macular degeneration. Proc Natl Acad Sci U S A (2007) 3.50
Transplantation of adult mouse iPS cell-derived photoreceptor precursors restores retinal structure and function in degenerative mice. PLoS One (2011) 2.86
Oxidative stress-induced mitochondrial DNA damage in human retinal pigment epithelial cells: a possible mechanism for RPE aging and age-related macular degeneration. Exp Eye Res (2003) 2.51
Lipofuscin and melanin of human retinal pigment epithelium. Fluorescence, enzyme cytochemical, and ultrastructural studies. Invest Ophthalmol Vis Sci (1978) 2.41
Drusen, choroidal neovascularization, and retinal pigment epithelium dysfunction in SOD1-deficient mice: a model of age-related macular degeneration. Proc Natl Acad Sci U S A (2006) 2.40
Simultaneous qualitative and quantitative analysis of the Escherichia coli proteome: a sweet tale. Mol Cell Proteomics (2006) 2.11
A2E, a byproduct of the visual cycle. Vision Res (2003) 2.05
SOD2 knockdown mouse model of early AMD. Invest Ophthalmol Vis Sci (2007) 1.77
Oxidative stress affects the junctional integrity of retinal pigment epithelial cells. Invest Ophthalmol Vis Sci (2004) 1.75
Characterization of peroxy-A2E and furan-A2E photooxidation products and detection in human and mouse retinal pigment epithelial cell lipofuscin. J Biol Chem (2005) 1.65
iPS cell modeling of Best disease: insights into the pathophysiology of an inherited macular degeneration. Hum Mol Genet (2012) 1.59
Long-term safety and efficacy of human-induced pluripotent stem cell (iPS) grafts in a preclinical model of retinitis pigmentosa. Mol Med (2012) 1.24
SOD2 protects against oxidation-induced apoptosis in mouse retinal pigment epithelium: implications for age-related macular degeneration. Invest Ophthalmol Vis Sci (2005) 1.22
Transplantation of reprogrammed embryonic stem cells improves visual function in a mouse model for retinitis pigmentosa. Transplantation (2010) 1.17
Ocular pathology in mitochondrial superoxide dismutase (Sod2)-deficient mice. Invest Ophthalmol Vis Sci (2001) 1.11
Oxidative stress, polyunsaturated fatty acids-derived oxidation products and bisretinoids as potential inducers of CNS diseases: focus on age-related macular degeneration. Pharmacol Rep (2013) 1.09
Fluorescent pigments of the retinal pigment epithelium and age-related macular degeneration. Bioorg Med Chem Lett (2001) 1.09
Anthocyanins protect against A2E photooxidation and membrane permeabilization in retinal pigment epithelial cells. Photochem Photobiol (2005) 1.05
A2E, a pigment of RPE lipofuscin, is generated from the precursor, A2PE by a lysosomal enzyme activity. Adv Exp Med Biol (2008) 1.05
Bringing age-related macular degeneration into focus. Nat Genet (2008) 1.04
Wnt/β-catenin signaling protects mouse liver against oxidative stress-induced apoptosis through the inhibition of forkhead transcription factor FoxO3. J Biol Chem (2013) 1.00
Age pigment structure. Nature (1993) 0.97
Genetic susceptibility, dietary antioxidants, and long-term incidence of age-related macular degeneration in two populations. Ophthalmology (2013) 0.94
Oral supplementation of lutein/zeaxanthin and omega-3 long chain polyunsaturated fatty acids in persons aged 60 years or older, with or without AMD. Invest Ophthalmol Vis Sci (2008) 0.87
Involvement of c-Abl, p53 and the MAP kinase JNK in the cell death program initiated in A2E-laden ARPE-19 cells by exposure to blue light. Apoptosis (2009) 0.86
Chromosome 10q26 locus and age-related macular degeneration: a progress update. Exp Eye Res (2013) 0.86
FoxO3a modulates hypoxia stress induced oxidative stress and apoptosis in cardiac microvascular endothelial cells. PLoS One (2013) 0.86
[The multiple roles of FOXO transcription factors]. Med Sci (Paris) (2004) 0.82
Data-independent acquisition (MSE) with ion mobility provides a systematic method for analysis of a bacteriophage structural proteome. J Virol Methods (2013) 0.82
Biomarkers of oxidative stress in patients with wet age related macular degeneration. J Nutr Health Aging (2013) 0.82
Synthesis of antioxidants for prevention of age-related macular degeneration. J Nat Prod (2013) 0.81
Early changes in gene expression induced by blue light irradiation of A2E-laden retinal pigment epithelial cells. Acta Ophthalmol (2013) 0.80
Cu-NirK from Haloferax mediterranei as an example of metalloprotein maturation and exportation via Tat system. Biochim Biophys Acta (2013) 0.77
The structure of the age pigment, lipofuscin, and its accumulation site in the human eye. Nutr Rev (1993) 0.77
[Early experience of femtosecond laser assisted cataract surgery]. Zhonghua Yan Ke Za Zhi (2014) 0.79
Induced Pluripotent Stem Cells and Outer Retinal Disease. Stem Cells Int (2016) 0.76