Proof of principle for epitope-focused vaccine design.

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🔗 View Article (PMC 4260937)

Published in Nature on February 05, 2014

Authors

Bruno E Correia1, John T Bates2, Rebecca J Loomis3, Gretchen Baneyx4, Chris Carrico5, Joseph G Jardine6, Peter Rupert5, Colin Correnti5, Oleksandr Kalyuzhniy7, Vinayak Vittal4, Mary J Connell3, Eric Stevens4, Alexandria Schroeter4, Man Chen8, Skye Macpherson6, Andreia M Serra7, Yumiko Adachi7, Margaret A Holmes9, Yuxing Li10, Rachel E Klevit4, Barney S Graham8, Richard T Wyatt10, David Baker4, Roland K Strong5, James E Crowe11, Philip R Johnson3, William R Schief6

Author Affiliations

1: 1] Department of Biochemistry, University of Washington, Seattle, Washington 98195, USA [2] PhD Program in Computational Biology, Instituto Gulbenkian Ciência and Instituto de Tecnologia Química e Biológica, Universidade Nova de Lisboa, Oeiras 2780-157, Portugal [3] Department of Chemical Physiology, The Scripps Research Institute, La Jolla, California 92037, USA.
2: The Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA.
3: The Children's Hospital of Philadelphia Research Institute, Philadelphia, Pennsylvania 19104, USA.
4: Department of Biochemistry, University of Washington, Seattle, Washington 98195, USA.
5: Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109-1024, USA.
6: 1] Department of Biochemistry, University of Washington, Seattle, Washington 98195, USA [2] Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California 92037, USA [3] IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, California 92037, USA [4] Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute, La Jolla, California 92037, USA.
7: 1] Department of Biochemistry, University of Washington, Seattle, Washington 98195, USA [2] IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, California 92037, USA [3] Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute, La Jolla, California 92037, USA.
8: Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA.
9: 1] Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109-1024, USA [2].
10: 1] Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California 92037, USA [2] IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, California 92037, USA [3] Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute, La Jolla, California 92037, USA.
11: 1] The Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA [2] Department of Pathology, Microbiology and Immunology, Vanderbilt Medical Center, Nashville, Tennessee 37232, USA [3] Department of Pediatrics, Vanderbilt Medical Center, Nashville, Tennessee 37232, USA.

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